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| 1 | Circulating extracellular RNAs,myocardial remodeling,and heart failure in patients with acute coronary syndrome显示文摘Background:Given high on-treatment mortality in heart failure(HF),identifying molecular pathways that underlie adverse cardiac remodeling may offer novel biomarkers and therapeutic avenues.Circulating extracellular RNAs(ex-RNAs)regulate important biological processes and are emerging as biomarkers of disease,but less is known about their role in the acute setting,particularly in the setting of HF.Methods:We examined the ex-RNA profiles of 296 acute coronary syndrome(ACS)survivors enrolled in the Transitions,Risks,and Actions in Coronary Events Center for Outcomes Research and Education Cohort.We measured 374 ex-RNAs selected a priori,based on previous findings from a large population study.We employed a two-step,mechanism-driven approach to identify ex-RNAs associated with echocardiographic phenotypes(left ventricular[LV]ejection fraction,LV mass,LV end-diastolic volume,left atrial[LA]dimension,and LA volume index)then tested relations of these ex-RNAs with prevalent HF(N=31,10.5%).We performed further bioinformatics analysis of microRNA(miRNAs)predicted targets’genes ontology categories and molecular pathways.Results:We identified 44 ex-RNAs associated with at least one echocardiographic phenotype associated with HF.Of these 44 exRNAs,miR-29-3p,miR-584-5p,and miR-1247-5p were also associated with prevalent HF.The three microRNAs were implicated in the regulation p53 and transforming growth factor-βsignaling pathways and predicted to be involved in cardiac fibrosis and cell death;miRNA predicted targets were enriched in gene ontology categories including several involving the extracellular matrix and cellular differentiation.Conclusions:Among ACS survivors,we observed that miR-29-3p,miR-584-5p,and miR-1247-5p were associated with both echocardiographic markers of cardiac remodeling and prevalent HF.Relevance for Patients:miR-29c-3p,miR-584-5p,and miR-1247-5p were associated with echocardiographic phenotypes and prevalent HF and are potential biomarkers for adverse cardiac remodeling in HF. | Khanh-Van Tran Kahraman Tanriverdi Gerard P.Aurigemma Darleen Lessard Mayank Sardana Matthew Parker Amir Shaikh Matthew Gottbrecht Zachary Milstone Selim Tanriverdi Olga Vitseva John F.Keaney Catarina I.Kiefe David D.McManus Jane E.Freedman | 2019 | Journal of Clinical & Translational Research2019，5，1： | 7 |
| 2 | Cardiomyocyte-Specific Knockout and Agonist of Peroxisome Proliferator–Activated Receptor-γ Both Induce Cardiac Hypertrophy in Mice显示文摘 | Sheng Zhong Duan Christine Y. Ivashchenko Mark W. Russell David S. Milstone Richard M. Mortensen | 2005 | Circulation Research2005，，4： | 2 |
| 3 | Association of progressive structural changes in the bronchial epithelium with subepithelial fibrous remodeling: a potential role for hypoxia 显示文摘 | Polosukhin VV Lawson WE Milstone AP | 2007 | Virchows Arch2007，451，4： | 1 |
| 4 | A broad spectrum Kunitz type serine protease inhibitor secreted by the hookworm Ancylostoma ceylanicum显示文摘 | Milstone AM Harrison LM Bungiro RD | 2000 | J Biol Chem2000，275，29： | 1 |
| 5 | Strategies to prevent methicillin - resistant Staphylococcus aureus transmission and infection in acute care hospitals: 2014 update 显示文摘 | Calfee DP Salgado CD Milstone AM | 2014 | Infection Control and Hospital Epidemiology2014，35，7： | 1 |
| 6 | Probing the microstructure and water in composite cement blends显示文摘 | GORCE J P MILSTONE N B | 2007 | Cem Concr Res2007，37，： | 1 |
| 7 | Catheter dwell time and CLABSIs in neonates with PICCs :a multicenter cohort study显示文摘 | Milstone AM Reich NG Advani S | 2013 | Pediatrics2013，132，8： | 1 |
| 8 | Bronchovascular fistulaformation: a rare airway complication after lungtransplantation显示文摘 | Knight J Elwing JM Milstone A | 2008 | J Heart Lung Transplant2008，27，10： | 1 |
| 9 | Diagnosis of autosomal recessive lamekkar ichthyosis with mutations in the TGM1 gene 显示文摘 | Milstone LM Christiano AM | 2001 | Br J Dermatol2001，144，4： | 1 |
| 10 | Gene therapy for autosomal dominant disorders of keratin显示文摘 | Lewin AS Glazer PM Milstone LM | 2005 | J Investig Dermatol Symp Proc2005，10，1： | 1 |
| 11 | Classification and therapy of atrophie blanche显示文摘 | Milstone LM Braverman IM Lucky P | 1983 | Arch Dermatol1983，119，12： | 1 |
| 12 | Strategies to prevent methicillin-resistant Staphylococcus aureus transmission and infection in acute care hospitals: 2014 update 显示文摘 | Calfee D P Salgado C D Milstone A M | 2014 | Infect Control Hosp Epidemiol2014，35，7： | 1 |
| 13 | Chlorhexidine: expanding the armamentarium for infection control and prevention显示文摘 | Milstone AM Passaretti CL Perl TM | 2008 | Clin Infect Dis2008，46，2： | 1 |
| 14 | Mice Lacking E-selectin shaw normal numbers os rolling leukocyte but reduced leukocyte stable arrest on cytokine-a ctivated microvascular endothelium显示文摘 | Milstone DS Fukumura D Padgett R C | 1998 | Microcirculation1998，5，： | 1 |
| 15 | Association of progressive structural changes in the bronchial epitheli- um with subepithelial fibrous remodeling:a potential role for hypoxia显示文摘 | Polosukhin VV Lawson WE Milstone AP | 2007 | Virchows Arch2007，451，4： | 1 |
| 16 | Probing the microstructure andwater in composite cement blends 显示文摘 | GORCEJ P MILSTONE N B | 2007 | Cement Concrete Re-search2007，37，3： | 1 |
| 17 | Mice lacking E-sdectin show normal numbers of rolling leukocyte but reduced leukocyte stable arrest on cytoldne-activated microvascular endothelium 显示文摘 | Milstone D S Fukumura D Padgett R C | 1998 | Microcirculation1998，5，： | 1 |
| 18 | Strategies to prevent transmission of methicillin-resistant Staphylococcus aureus in acute care hospitals:2014update显示文摘 | Calfee DP Salqado CD Milstone AM | 2014 | Infect Control Hosp Epidemiol2014，35，7： | 1 |
| 19 | Flagellar and acrosomal abnormalities associated with testicular HSV-tk expression in the mouse显示文摘 | Huttner KM Pudney J Milstone DS | 1993 | Biol Reprod1993，49，2： | 1 |
| 20 | chlorhexidine:expanding the amrnn-ntarium for infection control arid prevention显示文摘 | Milstone AM Passareti CL Perl TM | 2008 | Olin Infect Dis2008，46，2： | 1 |
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