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| 1 | Physical exercise in the prevention and treatment of Alzheimer’s disease显示文摘Dementia is one of the greatest global challenges for health and social care in the 21st century.Alzheimer’s disease(AD),the most common type of dementia,is by no means an inevitable consequence of growing old.Several lifestyle factors may increase,or reduce,an individual’s risk of developing AD.Much has been written over the ages about the benefits of exercise and physical activity.Among the risk factors associated with AD is a low level of physical activity.The relationship between physical and mental health was established several years ago.In this review,we discuss the role of exercise(aerobic and resistance)training as a therapeutic strategy for the treatment and prevention of AD.Older adults who exercise are more likely to maintain cognition.We address the main protective mechanism on brain function modulated by physical exercise by examining both human and animal studies.We will pay especial attention to the potential role of exercise in the modulation of amyloid b turnover,inflammation,synthesis and release of neurotrophins,and improvements in cerebral blood flow.Promoting changes in lifestyle in presymptomatic and predementia disease stages may have the potential for delaying one-third of dementias worldwide.Multimodal interventions that include the adoption of an active lifestyle should be recommended for older populations. | Adrian De la Rosa Gloria Olaso-Gonzalez Coralie Arc-Chagnaud Fernando Millan Andrea Salvador-Pascual Consolacion Garcıa-Lucerga Cristina Blasco-Lafarga Esther Garcia-Dominguez Aitor Carretero Angela G.Correas Jose Vina Mari Carmen Gomez-Cabrera | 2020 | Journal of Sport and Health Science2020，9，5： | 32 |
| 2 | 欧洲肿瘤内科协会对非上皮性卵巢癌的诊断、治疗和随访所制定的临床实践指南显示文摘非上皮性卵巢癌是一类少见的卵巢癌,因此,其诊断较难建立。然而,通过仔细观察各种肿瘤的标记物[尤其是人绒毛膜促性腺激素β亚单位(β-hCG)、α-甲胎蛋白(α-AFP)和乳酸脱氢酶(LDH)]、临床体征(如妊娠期体征, | Reed N Millan D Verheijen R Castiglione M On behalf of the ESMO Guidelines Working Group 杨华(译) 郎景和(审校) | 2011 | 国际妇产科学杂志2011，38，4： | 13 |
| 3 | Relationship between lipoprotein (a) and micro/macro complications in type 2 diabetes mellitus: a forgotten target显示文摘ObjectivesIncreased 脂蛋白(a) 浆液集中似乎是一个心血管的风险因素;这没在 extracoronary 动脉粥样硬化复杂并发症被证实。我们因此希望获得更深的卓见 into 在脂蛋白(a) 的血浆集中和类型 2 糖尿病 mellitus 并且到的微脉管、宏脉管的复杂并发症之间的关系在这 association.MethodsThis 识别可能的差别是描述的观察代表性的研究。二 -- 有类型 2 糖尿病 mellitus 的 117 个老病人从内部药 outclinic 被包括。人体测量的数据,分析数据(象高血压的胰岛素保守,基础、饭后的肽 C, glycosylated 血红素,肾的参数,类脂化合物侧面和临床的数据,肥胖,微 -- 并且 macrovascular 复杂并发症是 collected.ResultsPatients 根据类型被组织进化的 2 糖尿病 mellitus 时间。脂蛋白(a) 的吝啬的血浆集中是 22.2 ±17.3 mg/dL (22.1 ±为男性的 15.9 mg/dL,和 22.1 ±为女性的 18.4 mg/dL ) 。有高血压,冠的心疾病,脑血管的事故, microalbuminuria 和 proteinuria 的病人介绍了脂蛋白(a) 的统计上重要的增加的水平。同样,有 hyperlipoprotein (a) 的病人(≥30 mg/dL ) 脲和全部的胆固醇的介绍显著地增加的层次。在 multivariate 回归模型,脂蛋白(a) 的水平断然与冠的心疾病和糖尿病的 nephropathy 被相关(P <0.01 并且 P <0.005,分别地) 脂蛋白(a) 的血浆层次的 .ConclusionsThe 举起与冠的心疾病和 diabe tic nephropathy 的发展被联系。因此,我们认为脂蛋白(a) 的决心可以是在有类型 2 糖尿病 mellitus 的病人的脉管的复杂并发症的一个预示的标记。 | Rocio Toro Eduardo Segura Jesfis Millan Nunez-Cortes Juan Carlos Pedro-Botet Maribel Quezada-Feijoo Alipio Mangas | 2015 | Journal of Geriatric Cardiology2015，12，2： | 10 |
| 4 | Treatment of colorectal cancer in the elderly显示文摘Colorectal cancer has a high incidence, and approxi-mately 60% of colorectal cancer patients are older than 70, with this incidence likely increasing in the near future. Elderly patients(> 70-75 years of age) are a very heterogeneous group, ranging from the very fit to the very frail. Traditionally, these patients have often been under-treated and recruited less frequently to clinical trials than younger patients, and thus are underrepresented in publications about cancer treatment. Recent studies suggest that fit elderly patients can be treated in the same way as their younger counterparts, but the treatment of frail patients with comorbidities is still a matter of controversy. Many factors should be taken into account, including fitness for treatment, the wishes of the patient and family, and quality of life. This review will focus on the existing evidence for surgical, oncologic, and palliative treatment in patients over 70 years old with colorectal cancer. Careful patient assessment is necessary in order to individualize treatment approach, and this should rely on a multidisciplinary process. More well-designed controlled trials are needed in this patient population. | Monica Millan Sandra Merino Aleidis Caro Francesc Feliu Jordi Escuder Tani Francesch | 2015 | World Journal of Gastrointestinal Oncology2015，7，10： | 9 |
| 5 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 6 | Locomotor analysis identifies early compensatory changes during disease progression and subgroup classification in a mouse model of amyotrophic lateral sclerosis显示文摘Amyotrophic lateral sclerosis is a motoneuron degenerative disease that is challenging to diagnose and presents with considerable variability in survival.Early identification and enhanced understanding of symptomatic patterns could aid in diagnosis and provide an avenue for monitoring disease progression.Use of the m SOD1 G93 A mouse model provides control of the confounding environmental factors and genetic heterogeneity seen in amyotrophic lateral sclerosis patients,while investigating underlying disease-induced changes.In the present study,we performed a longitudinal behavioral assessment paradigm and identified an early hindlimb symptom,resembling the common gait abnormality foot drop,along with an accompanying forelimb compensatory mechanism in the m SOD1 G93 A mouse.Following these initial changes,m SOD1 mice displayed a temporary hindlimb compensatory mechanism resembling an exaggerated steppage gait.As the disease progressed,these compensatory mechanisms were not sufficient to sustain fundamental locomotor parameters and more severe deficits appeared.We next applied these initial findings to investigate the inherent variability in B6 SJL m SOD1 G93 A survival.We identified four behavioral variables that,when combined in a cluster analysis,identified two subpopulations with different disease progression rates:a fast progression group and a slow progression group.This behavioral assessment paradigm,with its analytical approaches,provides a method for monitoring disease progression and detecting m SOD1 subgroups with different disease severities.This affords researchers an opportunity to search for genetic modifiers or other factors that likely enhance or slow disease progression.Such factors are possible therapeutic targets with the potential to slow disease progression and provide insight into the underlying pathology and disease mechanisms. | Melissa M.Haulcomb Rena M.Meadows Whitney M.Miller Kathryn P.Mc Millan Me Kenzie J.Hilsmeyer Xuefu Wang Wesley T.Beaulieu Stephanie L.Dickinson Todd J.Brown Virginia M.Sanders Kathryn J.Jones | 2017 | Neural Regeneration Research2017，12，10： | 3 |
| 7 | Early Prediction of Anastomotic Leak in Colorectal Cancer Surgery by Intramucosal pH显示文摘 | Monica Millan M.D. Ph.D. Eduardo García-Granero M.D. Ph.D. Blas Flor M.D. Ph.D. Stephanie García-Botello M.D. Salvador Lledo M.D. Ph.D | 2006 | Diseases of the Colon & Rectum2006，，5： | 2 |
| 8 | The molecular structure of kappa-carrageenan and comparison with iota-carrageenan显示文摘 | Millane R P Chandrasekaran R Arnott S | 1988 | Carbohydrate Research1988，182，： | 1 |
| 9 | Genetic mapping of QTLs controlling horticultural traits in diploid roses 显示文摘 | Dugo M L Satovie Z Millan T | 2005 | Theor Appl Genet2005，111，3： | 1 |
| 10 | Partial agonist actions of aripiprazole and the candidate antipsychotics S33592, bifeprunox, N-desmethylclozapine and preclamol at dopamine D(2L) receptors are modified by co-transfection of D3 receptors: potential role of heterodimer formation显示文摘 | Novi F Millan MJ Corsini GU | 2007 | J Neurochem2007，102，4： | 1 |
| 11 | High serum levels of endothelin- 1 predict severe edema in patients with acute is- chemic stroke treated with t - PA显示文摘 | Modes O Sobrino T Millan M | 2008 | Stroke2008，39，7： | 1 |
| 12 | A prospectivestudy of the prevalence of the polycystic ovary syndrome inunselected Caucasian women from Spain显示文摘 | Asuncion M Calvo RM San Millan JL | 2000 | J Clin EndocrinolMeTab2000，85，7： | 1 |
| 13 | Automotive tribology o- verview of current advances and challenges for the future 显示文摘 | Simon C Tung M L Mc Millan | 2004 | Tribology International2004，1，37： | 1 |
| 14 | 显示文摘 | Vaillant F Millan A Millan P | 2000 | Process Biochem2000，35，9： | 1 |
| 15 | Opioids and opioid receptors mediating antinociception at various levels of the neuraxis 显示文摘 | Herz A Millan MJ | 1990 | Physiol Bohemoslov1990，39，5： | 1 |
| 16 | Effect of salivary secretory IgA on the adhesion of Candida albicans to polystyrene显示文摘 | Elguezabal N Regulez P et al | 2000 | Microbiology2000，146，9： | 1 |
| 17 | Deletions in L-type calcium channel alpha1 subunit testicular transcripts correlate with testicular cadmiumand apoptosis in infertile men with varicoceles显示文摘 | Goodwin LO Millan C | 2005 | Fertil Steril2005，83，3： | 1 |
| 18 | Determination of butyltin species in water and sediment by solid-phase microextraction-gas chromatography-flame ionization detection显示文摘 | Esmeralda Millan Janusz Pawliszyn | 2000 | J Chromatography A2000，873，1： | 1 |
| 19 | Oncogene HER 2 in canine mammary gland carcinomas An immunohistochemical and chromogenic in situ hybridization study 显示文摘 | Martin delas Mulas Ordas J Millan Y etal | 2003 | Breast Cancer Research and Treatment2003，80，： | 1 |
| 20 | Assessment of Cd, Pb and Zn contamination in roadside soils and grasses from Gipuzkoa (Spain)显示文摘 | GARCIA R MILLAN E | 1998 | Chemosphere1998，37，8： | 1 |
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