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| 1 | Risk factors and outcomes of delayed graft function in renal transplant recipients receiving a steroid sparing immunosuppression protocol显示文摘AIM To analyse the risk factors and outcomes of delayed graft function(DGF) in patients receiving a steroid sparing protocol. METHODS Four hundred and twenty-seven recipients of deceased donor kidney transplants were studied of which 135(31.6%) experienced DGF. All patients received monoclonal antibody induction with a tacrolimus based, steroid sparing immunosuppression protocol.RESULTS Five year patient survival was 87.2% and 94.9% in the DGF and primary graft function(PGF) group respectively, P = 0.047. Allograft survival was 77.9% and 90.2% in the DGF and PGF group respectively, P < 0.001. Overall rejection free survival was no different between the DGF and PGF groups with a 1 and 5 year rejection free survival in the DGF group of 77.7% and 67.8% compared with 81.3% and 75.3% in the PGF group, P = 0.19. Patients with DGF who received IL2 receptor antibody induction were at significantly higher risk of rejection in the early post-transplant period than the group with DGF who received alemtuzumab induction. On multivariate analysis, risk factors for DGF were male recipients, recipients of black ethnicity, circulatory death donation, preformed DSA, increasing cold ischaemic time, older donor age and dialysis vintage.CONCLUSION Alemtuzumab induction may be of benefit in preventing early rejection episodes associated with DGF. Prospective trials are required to determine optimal immunotherapy protocols for patients at high risk of DGF. | Michelle Willicombe Anna Rizzello Dawn Goodall Vassilios Papalois Adam G Mc Lean David Taube | 2017 | World Journal of Transplantation2017，7，1： | 4 |
| 2 | Safety of telmisartan in patients with arterial hypertension: an own-label observational study 显示文摘 | Michel MC Bohner H Koster J | 2004 | Drug Saf2004，27，5： | 1 |
| 3 | a1-, a2- and b-adrenoceptors in the urinary bladder, urethra and prostate 显示文摘 | Michel MC Vrydag W | 2006 | Br J Pharmacol2006，147，5： | 1 |
| 4 | Effect of dia- betes on lower urinary tract symptoms in patients with benign prostatic hyperplasia 显示文摘 | Michel MC Mehlburger L Schumacher H | 2000 | J Urol2000，163，6： | 1 |
| 5 | 1Association ofhypertension with symp toms of benign p rostatic hyperplasia1显示文摘 | MICHEL MC HEEMANN U SCHUMACHER H | 2004 | J Urol2004，172，： | 1 |
| 6 | Safety of telmisartan in patients with arterial hypertension:an open-label observational study显示文摘 | MICHEL MC BOHNER H K(O)STER J | 2004 | Drug Saf2004，27，5： | 1 |
| 7 | Efficacy and safety of tamsulosin in the treat- ment of urological diseases 显示文摘 | Michel MC Rosette JJ | 2004 | Expert Opin Pharmacother2004，5，1： | 1 |
| 8 | Membrane damage-induced vesicle-vesicle fusion of dysferlincontaining vesicles in muscle cells requires microtubules and kinesin显示文摘 | Mc Dade JR Michele DE | 2013 | Hum Mol Genet2013，23，： | 1 |
| 9 | The impact of first trimester phthalate and phenol exposure on IGF2/H19 genomic imprinting and birth outcomes显示文摘 | LaRocca J Binder AM Mc Elrath TF Michels KB | 2014 | Environ Res2014，133，： | 1 |
| 10 | Effects of alpha(1)-adrenoceptor antagonists on male sexual function显示文摘 | van Dijk MM de la Rosette JJ Michel MC | 2006 | Drugs2006，66，3： | 1 |
| 11 | Comparison of problem- and lecture-based pharmacology teaehing 显示文摘 | Michel MC Bischoff A Jakobs KH | 2002 | Trends Pharmacol Sci2002，23，4： | 1 |
| 12 | Adrenergic and muscarine receptors in the human heart显示文摘 | Brodde OE and Michel MC | 1999 | Pharmacological Reviews1999，51，4： | 1 |
| 13 | Use of enriched stable isotopes to determine zinc and iron absorption in elderly men显示文摘 | Turnlund JR Michel MC Keyes WR | 1982 | Am J Clin Nutr1982，35，： | 1 |
| 14 | The odd sibling:features of β3-adrenoceptor pharmacology显示文摘 | Cernecka H Sand C Michel MC | 2014 | Mol Pharmacol2014，86，5： | 1 |
| 15 | Comparison of problemand lecture-based pharmacology teaching显示文摘 | Michel MC Bisehoff A Jakobs KH | 2002 | Trends Pharma- col Sci2002，23，4： | 1 |
| 16 | Vascular effects of sphingolipids 显示文摘 | Michel MC Mulders AC Jongsma M | 2007 | Acta Paediatr Suppl2007，96，455： | 1 |
| 17 | The pharmacokinetic profile of tamsulosinoral controlled absorption system(OCAS)显示文摘 | Michel MC Korstanje C Krauwinkel W | 2005 | Eur Urol Suppl2005，4，2： | 1 |
| 18 | Pulmonary dysfunction following traumatic qua iplegia : recognition, prevention, and treatment显示文摘 | Mc Michan JC Michel L Westbrook PR | 1980 | JAMA1980，243，6： | 1 |
| 19 | Effect of diabetes on lower urinary tract symptomsin patients with benign prostatichy perplasia 显示文摘 | Michel MC Mehlburger L Schumacher H | 2000 | Urol2000，163，5： | 1 |
| 20 | Worldwide experience with alfuzosin and tamsulosin 显示文摘 | Michel MC Flannery MT Narayan P | 2001 | Urology2001，58，4： | 1 |
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