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| 1 | Adoptive immunotherapy for acute leukemia:New insights in chimeric antigen receptors显示文摘Relapses remain a major concern in acute leukemia. It is well known that leukemia stem cells(LSCs) hide in hematopoietic niches and escape to the immune system surveillance through the outgrowth of poorly immunogenic tumor-cell variants and the suppression of the active immune response. Despitethe introduction of new reagents and new therapeutic approaches, no treatment strategies have been able to definitively eradicate LSCs. However, recent adoptive immunotherapy in cancer is expected to revolutionize our way to fight against this disease, by redirecting the immune system in order to eliminate relapse issues. Initially described at the onset of the 90's, chimeric antigen receptors(CARs) are recombinant receptors transferred in various T cell subsets, providing specific antigens binding in a non-major histocompatibility complex restricted manner, and effective on a large variety of human leukocyte antigen-divers cell populations. Once transferred, engineered T cells act like an expanding 'living drug' specifically targeting the tumor-associated antigen, and ensure long-term antitumor memory. Over the last decades, substantial improvements have been made in CARs design. CAR T cells have finally reached the clinical practice and first clinical trials have shown promising results. In acute lymphoblastic leukemia, high rate of complete and prolonged clinical responses have been observed after anti-CD19 CAR T cell therapy, with specific but manageable adverse events. In this review, our goal was to describe CAR structures and functions, and to summarize recent data regarding pre-clinical studies and clinical trials in acute leukemia. | Mael Heiblig Mohamed Elhamri Mauricette Michallet Xavier Thomas | 2015 | World Journal of Stem Cells2015，7，7： | 9 |
| 2 | Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis ofhurnan neutrophils 显示文摘 | Genestier AL Michallet MC Prevost G | 2005 | J Clin Invest2005，115，11： | 1 |
| 3 | Staphyloco -ccus aureus Panton-valentine leukocidin durectly targets mitochondria and induces Bax-independent apoptosis of human neutrophils显示文摘 | Genestier AL Michallet MC Prevost G | 2005 | J Clin Invest2005，115，11： | 1 |
| 4 | Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de novo multiple myeloma显示文摘 | Garban F Attal M Michallet M | 2006 | Blood2006，107，9： | 1 |
| 5 | Restriction of de novo nucleotide biosynthesis interferes with clonal expansion and differentiation into effector and memory CD8 T cells显示文摘 | Quemeneur L Beloeil L Michallet M C | 2004 | J Immunol2004，173，8： | 1 |
| 6 | Mobilization of CD34^+CD38^- hematopoietic stem cells after priming in acute myeloid leukemia显示文摘AIM: To evaluate quantitatively and qualitatively the different CD34+cell subsets after priming by chemotherapy granulocyte colony-stimulating factor(± G-CSF)in patients with acute myeloid leukemia.METHODS: Peripheral blood and bone marrow sampleswere harvested in 8 acute myeloid leukemia patients during and after induction chemotherapy. The CD34/CD38 cell profile was analyzed by multi-parameter flow cytometry. Adhesion profile was made using CXC chemokine receptor 4(CXCR4)(CD184), VLA-4(CD49d/CD29) and CD47.RESULTS: Chemotherapy ± G-CSF mobilized immature cells(CD34+CD38 population), while the more mature cells(CD34+CD38lowand CD34+CD38+populations) decreased progressively after treatment. Circulating CD34+cells tended to be more sensitive to chemotherapy after priming with G-CSF. CD34+cell mobilization was correlated with a gradual increase in CXCR4 and CD47expression, suggesting a role in cell protection and the capacity of homing back to the marrow.CONCLUSION: Chemotherapy ± G-CSF mobilizes into the circulation CD34+bone marrow cells, of which, the immature CD34+CD38-cell population. Further manipulations of these interactions may be a means with which to control the trafficking of leukemia stem cells to improve patients' outcomes. | Adriana Plesa Eve Mattei Charles Dumontet Youcef Chelghoum Hélène Labussière Giovanna Cannas Mauricette Michallet Xavier Thomas Mohamed Elhamri Stéphane Morisset Inès Tagoug | 2013 | World Journal of Stem Cells2013，5，4： | 1 |
| 7 | Func- tion of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses 显示文摘 | Ermolaeva M A Michallet M C Papadopoulou N | 2008 | Nat Immunol2008，9，9： | 1 |
| 8 | Allogeneic hematopoietic stem cell transplantations显示文摘 | Michallet M | 2011 | Transfus Clin Biol2011，18，2： | 1 |
| 9 | DCIV measurements of flow fields and turbulence in waves breaking over a bar显示文摘 | GOVENDERA K MICHALLET B H ALPORT M J | 2011 | European Journal of Mechanics B/Fluids2011，30，6： | 1 |
| 10 | Lenalidomide as salvage treatment for multiple myeloma relapsing after allogeneic hematopoietic stem cell transplantation:a report from the French Society of Bone Marrow and Cellular Therapy显示文摘 | Coman T Bachy E Michallet M | 2013 | Haematologica2013，98，5： | 1 |
| 11 | Staphylococcus aureus Panton -Valentine leukocidin directly targets mitochondria and induces Bax - independent apoptosis of human eutrophils 显示文摘 | Genestier AL Michallet MC Prevost G | 2005 | J Clin Invest2005，115，11： | 1 |
| 12 | Cathepsin-Dependent apoptosis triggered by supraoptimal activation of T lymphocytes: a possible mechanism of high dose tolerance显示文摘 | Michallet MC Saltel F Flacher M | 2004 | J Immunol2004，172，9： | 1 |
| 13 | Experimental study of large interfacial solitary waves显示文摘 | MICHALLET H BARTHELEMY E | 1998 | Journal of Fluid Mechanics1998，366，： | 1 |
| 14 | Autologous hematopoietic stemcell transplantation in chronic lymphocytic leukemia : results of Europe-an intergroup randomized trial comparing autografting versus observa-tion显示文摘 | Michallet M Dreger P Sutton L | 2011 | Blood2011，117，5： | 1 |
| 15 | Candida albicans and non-Candida albi- cans fungemia in an institutional hospital during a decade 显示文摘 | Parmeland L Gazon M Guerin C Argaud L Lehot JJ Bastien O Allaouchiche B Michallet M Picot S Bienvenu AL Study Group | 2013 | Med Mycol2013，51，1： | 1 |
| 16 | Experimental study of interfacial solitary waves显示文摘 | Michallet H Barthelemy E | 1998 | J Fluid Mech1998，366，： | 1 |
| 17 | Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils 显示文摘 | Genestier AL Michallet MC Prevost G | 2005 | J Clin Invest2005，115，11： | 1 |
| 18 | Ultrasonic probes and data processing to study interfacial solitary waves显示文摘 | Michallet H Barthelemy E | 1997 | Exp Fluid1997，22，： | 1 |
| 19 | Lenalidomide as salvage treatment for multiple myeloma relapsing after allogeneic hematopoietic stem cell transplantation: a report from the SFGM-TC显示文摘 | Coman T Bachy E Michallet M | 2013 | Haematologica2013，98，： | 1 |
| 20 | Preva- lence of malnutrition and current use of nutrition support in patients with cancer显示文摘 | Hebuterne X Lemarie E Michallet M | 2014 | JPEN J Parenter Enteral Nu- tr2014，38，2： | 1 |
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