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| 1 | Effects of selenomethionine on acute toxicities from concurrent chemoradiation for inoperable stage Ⅲ nonsmall cell lung cancer显示文摘AIM: To prospectively determine the safety and tolerability of oral L-selenomethionine(SLM) with concurrent chemoradiation(CCRT) for Stage Ⅲ non-small cell lung cancer(NSCLC) and estimate if the incidence and/or severity of adverse events could be reduced by its use.METHODS: Sixteen patients with stage Ⅲ NSCLC were accrued to this single arm, phase Ⅱ study. CCRT consisted of radiation given at 2 Gy per fraction for 30-33 fractions, 5 d per week with concurrent weekly Ⅳ paclitaxel 50 mg/m2 followed by carboplatin dosed at an area under the time-concentration curve of 2. SLM was dosed in a loading phase at 4800 μg twice daily for one week prior to CCRT followed by once daily dosing during treatment. RESULTS: No selenium-related toxicity was observed. Analysis revealed grade 3 or higher esophagitis in 3 of 16 patients(19%), pneumonitis in 0, leukopenia in 2(12.5%), and anemia in 1(6%); the latter two were significantly reduced when compared to the protocolstated expected rate of 35%(P = 0.045 for leukopenia, and P < 0.01 for anemia). Median overall survival was 14.9 mo and median failure-free survival was 9 mo(95%CI: 3.3-21.5).CONCLUSION: There may be some protective benefit of selenium in the setting of CCRT for inoperable NSCLC. The data suggests decreased rates of myelosuppression when compared to similarly-treated historical and contemporary controls. Further evaluation of selenium in this setting may be warranted. | Michael Mix Nithya Ramnath Jorge Gomez Charles de Groot Saju Rajan Shiva Dibaj Wei Tan Youcef Rustum Michael B Jameson Anurag K Singh | 2015 | World Journal of Clinical Oncology2015，6，5： | 4 |
| 2 | Matrix metalloproteinase as therapeutic targets in arthritic diseases 显示文摘 | Mengsho JA Mix KS Brinckerhoff CE | 2002 | Arthritis Rheum2002，46，： | 1 |
| 3 | Environmental processes of the ice age: land, oceans, glaciers (EPILOG) 显示文摘 | Mix A C Bard E Schneider R | 2001 | Quat Sci Rev2001，20，： | 1 |
| 4 | Expression of Leptin and Leptin receptor isoforms in the human stomach显示文摘 | Mix H Widjaja A Jandl O | 2000 | Gut2000，47，： | 1 |
| 5 | Diatoms in northeast Pacific surface sediments as paleoceanographic proxies显示文摘 | Lopes C Mix A C Abrantes F | 2006 | Marine Micropaleontology2006，60，1： | 1 |
| 6 | Gene-expression profiling of the early stages of MOG-induced EAE proves EAE-resistance as an active process显示文摘 | Mix E Ibrahim S Pahnke J | 2004 | J Neuroimmunol2004，151，： | 1 |
| 7 | General model for leucocyte cell renewal in bivalve mollusks显示文摘 | Mix M C A | 1976 | Mar Fish Rew1976，38，： | 1 |
| 8 | A clear look at the neuroimmunol ogy ofmuhiple sclerosis and beyond显示文摘 | Selmi C Mix E Zettl UK | 2012 | Autoimmun Rev2012，11，： | 1 |
| 9 | Management of aerobic vaginitis 显示文摘 | ' Mixed ' and therapy ofvaginM Ceska Gynekol Tempera G Furneri PM | 2010 | Gynecologic and obstertrics investigation2010，70，4： | 1 |
| 10 | Parkinson's disease and immunological abnormalities:increase of HLA-DR expression on monocytes in cerebrospinal fluid and of CD45RO+ T ceils in peripheral blood显示文摘 | Fiszer U Mix E Fredrikson S | 1994 | Acta Neurol Scand1994，90，3： | 1 |
| 11 | IL-18 deficiency inhibits both Thl and Th2 cytokine production but not the clinical symptoms in experimental autoimmune neuritis显示文摘 | Rui-Sheng Duan Xing-Mei Zhang Eilhard Mix | 2007 | J Neuroimmunol2007，183，12： | 1 |
| 12 | Ejection of material from shocked surfaces显示文摘 | Asay J R Mix L P Perry F C | | 0，，05： | 1 |
| 13 | Rapid rise of sea level 19,000 years ago and its global implications 显示文摘 | Clark P U McCabe A M Mix A C | 2004 | Science2004，304，： | 1 |
| 14 | 4显示文摘 | Jiyeon Chun Jong Sang Kim Jeong Hwan Kim Enrichment of isoflavone aglycones in soymilk by fermentation with single and mixed cultures of streptococcus infantarius 12 and weissella sp | 2008 | Food Chemistry2008，，109： | 1 |
| 15 | Dose dependency of fluvastatin pharmacokinetics in serum determined by reversed phase HPLC 显示文摘 | SIEKMEIER R LATTKE P MIX C | 2001 | J Cardiovasc Pharmacol Ther2001，6，2： | 1 |
| 16 | Aggression and psychiatric comorbidity in children with hypothalam- ic hamaromas and their unaffected siblings 显示文摘 | Weissenberger AA Dell Mix Liow K | 2001 | J Am Acad Child Adolesc Psychiatry2001，40，： | 1 |
| 17 | Lang- zeitlagerung alter Kartoffelsorten durch Kryokonservierung der Meristeme in fliissigem Stickstoff 显示文摘 | Schafer - Menuhr A Schumacher H M Mix - Wagner G | 1994 | Landbauforschung Volkenrode1994，44，： | 1 |
| 18 | Impact of FDG-PET on the primary staging of small-cell lung cancer显示文摘 | Brink I Schumacher T Mix M | 2004 | Eur J Nucl Med Mol Imaging2004，31，12： | 1 |
| 19 | , a long - term study显示文摘 | Dammacco F Tucci FA Lauletta G et aL Pegylated inter- feron- alpha ribavirin and rituximab combined therapy of hepatitis Cvirus - related mixed cryoglobulinemia | 2010 | Blood2010，116，3： | 1 |
| 20 | The(Me:Cs)Si+eation: a stable derivative of HSi+显示文摘 | Jutzi P Mix A Rummel B | 2004 | Science2004，305，5685： | 1 |
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