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| 1 | Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses显示文摘His-tRNA synthetase (HARS) is targeted by autoantibodies in chronic and acute inflammatory anti-Jo-1-positive antisynthetase syndrome. The extensive activation and migration of immune cells into lung and muscle are associated with interstitial lung disease, myositis, and morbidity. It is unknown whether the sequestration of HARS is an epiphenomenon or plays a causal role in the disease. Here, we show that HARS circulates in healthy individuals, but it is largely undetectable in the serum of anti-Jo-1-positive antisynthetase syndrome patients. In cultured primary human skeletal muscle myoblasts (HSkMC), HARS is released in increasing amounts during their differentiation into myotubes. We further show that HARS regulates immune cell engagement and inhibits CD4+ and CD8+ T-cell activation. In mouse and rodent models of acute inflammatory diseases, HARS administration downregulates immune activation. In contrast, neutralization of extracellular HARS by high-titer antibody responses during tissue injury increases susceptibility to immune attack, similar to what is seen in humans with anti-Jo-1-positive disease. Collectively, these data suggest that extracellular HARS is homeostatic in normal subjects, and its sequestration contributes to the morbidity of the anti-Jo-1-positive antisynthetase syndrome. | Ryan AAdams Cátia Fernandes-Cerqueira Antonella Notarnicola Elisabeth Mertsching Zhiwen Xu Wing-Sze Lo Kathleen Ogilvie Kyle PChiang Jeanette Ampudia Sanna Rosengren Andrea Cubitt David JKing John DMendlein Xiang-Lei Yang Leslie ANangle Ingrid ELundberg Per-Johan Jakobsson Paul Schimmel | 2021 | Cellular & Molecular Immunology2021，18，6： | 2 |
| 2 | Construction of autologous human heart valves based on an acellular allograft matrix显示文摘 | Cebotari S Mertsching H Kallenbach K | 2002 | Circulation2002，106，1： | 1 |
| 3 | Dissecting the inter-substrate navigation of migrating glioblastoma cells with the stripe assay reveals a causative role of ROCK显示文摘 | Mertsch S Oellers P Wendling M | 2013 | Mol Neurobiol2013，48，1： | 1 |
| 4 | Constrction of autologous human heart valves based on an acellular allograft matrix显示文摘 | Cebotari S Mertsching H Kallenbach K | 2002 | Circulation2002，106，： | 1 |
| 5 | Construction of autologous human heart Valves based on an acellular allograft maxtrix显示文摘 | CebOtari S MertSching H Kallenbach K | 2002 | Circulation2002，106，1： | 1 |
| 6 | Phosphorylation of vasodilator-stimulated phosphoprotein: a consequence of nitric oxide- and cGMP-mediated signal transduction in brain capillary endothelial cells and astrocytes显示文摘 | Sporbert A Mertsch K Smolenski A | 1999 | Brain Res Mol Brain Res1999，，： | 1 |
| 7 | 查看详情显示文摘 | Mertsch P Sarkar S | | 0，，： | 1 |
| 8 | Opposing Signaling of ROCK1 and ROCK2 Determines the Switching of Substrate Specificity and the Mode of Migration of Glioblastoma Cells显示文摘 | Sonja Mertsch Solon Thanos | 2014 | Molecular Neurobiology2014，，2： | 1 |
| 9 | In vitro construction of urinary bladder wall using porcine prima- ry cells reseedad on acellularized bladder matrix and small intestinal submucosa显示文摘 | Gabouev AI Schultheiss D Mertsching H | 2003 | Int J Artif Organs2003，26，10： | 1 |
| 10 | Validating Vision and Robotic Algorithms for Dynamic Real World Environments 显示文摘 | Tobias Kotthiiuser Biirbel Mertsching | 2010 | Lecture Notes in Computer Science2010，6472，1： | 1 |
| 11 | Data and model-drivengaze control for an active-vision system显示文摘 | MERTSCHING G BACKER B BOLLMANN M | | IEEE Transactions on Pattern Analysis and Machine Intelligence0，23，12： | 1 |
| 12 | Engineering of a vascularized scaffold for artificial tissue and organ generation 显示文摘 | Mertsching H Walles T Hofinann M | 2005 | Biomaterials2005，26，33： | 1 |
| 13 | Bioreactor technology in cardiovascular tissue engineering显示文摘 | Mertsching H Hansmann J | 2009 | Adv Biochem Eng Biotechnol2009，112，： | 1 |
| 14 | Opposing Signaling of ROCK1 and ROCK2 Determines the Switching of Substrate Specificity and the Mode of Migration of Glioblastoma Cells 显示文摘 | Sonja Mertsch Solon Thanos | 2014 | Mol Neuro- biol2014，49，2： | 1 |
| 15 | Data-and model-driven gaze control for an active-vision system显示文摘 | BACKER G MERTSCHING B BOLLMANN M | 2001 | IEEE Trans on Pattern Anal & Machine Intelligence2001，23，12： | 1 |
| 16 | Construction of autologous human heart valves based on an acellular allograft matrix显示文摘 | Cebotari S Mertsching H Kallenbach K | 2002 | Circulation2002，106，121： | 1 |
| 17 | Engineering of a vascularized scaffold for artificial tissue and organ generation 显示文摘 | Mertsching H Walles T Hofmann M | 2005 | Biomaterials2005，26，33： | 1 |
| 18 | Construction of autologous human heart valves based on an acellular allograft matrix 显示文摘 | Cebotari S Mertsching H Kallenbach K | 2002 | Circulation2002，106，： | 1 |
| 19 | Construction of Autologous Human Heart Valves Based on an Acellular Allograft Matrix显示文摘 | Cebotari S Mertsching H Kallenbach K | 2002 | Circulation2002，106，： | 1 |
| 20 | In vitro construction of urinary bladder wall using porcine primary cells reseeded on acellularized bladder matrix and small intestinal submucosa 显示文摘 | Gabouev AO Schuhheiss D Mertsching H | 2003 | Int J Artif Organs2003，26，： | 1 |
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