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| 1 | Taking advantage of the potential of mesenchymal stromal cells in liver regeneration:Cells and extracellular vesicles as therapeutic strategies显示文摘Cell-based therapies for acute and chronic liver diseases are under continuous progress. Mesenchymal stem/stromal cells(MSCs) are multipotent cells able to migrate selectively to damaged tissue and contribute to its healing and regeneration. The MSC pro-regenerative effect occurs due to their immunomodulatory capacity and their ability to produce factors that promote cell protection and survival. Likewise,it has been observed that part of their paracrine effect is mediated by MSC-derived extracellular vesicles(EVs). EVs contain proteins,lipids and nucleic acids(DNA,m RNA,mi RNA,lnc RNA) from the cell of origin,allowing for intercellular communication. Recently,different studies have demonstrated that MSC-derived EVs could reproduce,at least in part,the biological effects obtained by MSCbased therapies. Moreover,due to EVs' stability for long periods of time and easy isolation methods they have become a therapeutic option to MSCs treatments. This review summarizes the latest results achieved in clinical trials using MSCs as cell therapy for liver regeneration,the role of EVs in liver physiopathology and the potential of MSC-derived EVs as intercellular mediators and therapeutic tools in liver diseases. | Esteban Juan Fiore Luciana María Domínguez Juan Bayo Mariana Gabriela García Guillermo Daniel Mazzolini | 2018 | World Journal of Gastroenterology2018，24，23： | 9 |
| 2 | Immunotherapy and immunoescape in colorectal cancer显示文摘Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma. | Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero | 2007 | World Journal of Gastroenterology2007，13，44： | 4 |
| 3 | Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients显示文摘 | Penuelas I Mazzolini G Boan JF | 2005 | Gastroenterology2005，128，7： | 1 |
| 4 | Phase Ⅰ trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors显示文摘 | Sangro B Mazzolini G RuizJ | 2004 | J Clin Oncol2004，22，8： | 1 |
| 5 | Phase Ⅰ trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors 显示文摘 | Sangro B Mazzolini G Ruiz J | 2004 | J Clin Oncol2004，22，8： | 1 |
| 6 | Dendritic cells delivered inside human carcinomas are sequestered by interleukin-8显示文摘 | Feijoo E Alfaro C Mazzolini G | 2005 | Int J Cancer2005，116，2： | 1 |
| 7 | The Receptor Tyrosine Kinase EPHB4 Has Tumor Suppressor Activities in Intestinal Tumorigenesis 显示文摘 | Dopeso H Mateo-l ozano S Mazzolini R | 2009 | Cancer Res2009，69，18： | 1 |
| 8 | A method for the elimination of false positives generated by the mRNA differential display technique显示文摘 | Callard D Lescure B Mazzolini L | 1994 | Bio Techniques1994，16，6： | 1 |
| 9 | Pressure support noninvasive positive pressure ventilation treatment of acute cardiogenic pulmonary edema显示文摘 | Wigder H N Hoffmann P Mazzolini D | 2001 | Am J Emerg Med2001，19，： | 1 |
| 10 | Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12显示文摘 | Mazzolini G Genove G | 2001 | Hepatology2001，33，1： | 1 |
| 11 | Pressure support noninvasive positive pressure ventilation treatment of acute cardiogenic pulmonary edema显示文摘 | Wigder HN Hoffmunn P Mazzolini D | 2001 | Am J Emerg Med2001，19，3： | 1 |
| 12 | A new sensor for monitoring chest wall motion during high frequency oscillatory ventilation显示文摘 | Davis C Mazzolini A | 1999 | Medical Engineering & Physics1999，21，： | 1 |
| 13 | Dendritic cells delivered inside human carcinomas are sequestered by interleukin - 8 显示文摘 | Feijo6 E Alfaro C Mazzolini G | 2005 | Int J Cancer2005，116，2： | 1 |
| 14 | Heart rate variability today显示文摘 | XHYHERI B MANFRINI O MAZZOLINI M | 2012 | Prog Cardiovasc Dis2012，55，3： | 1 |
| 15 | Heart rate variability today显示文摘 | Xhyheri B Manfrini O Mazzolini M | 2012 | Prog Cardiovase Dis2012，55，3： | 1 |
| 16 | Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12显示文摘 | Barajas M Mazzolini G Genove G | 2001 | Hepatology2001，33，1： | 1 |
| 17 | Delaying the onset of type 2 diabetes mellitus in patients with prediabetes 显示文摘 | Irons BK Mazzolini TA Greene RS | 2004 | Pharmacotherapy2004，24，： | 1 |
| 18 | Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors显示文摘 | Sangro B Mazzolini G Ruiz J | 2004 | Clin Oncol2004，22，8： | 1 |
| 19 | Gene therapy of hepatocellular carcinoma显示文摘 | Ruiz J Mazzolini G Sangro B | 2001 | Dig Dis2001，19，4： | 1 |
| 20 | Homeopathic medicine for acute cough in upper respiratory tract infections and acute bronchitis:A randomized,double-blind,placebo-controlled trial显示文摘 | Zanasi A Mazzolini M Tursi F | 2014 | Pulm Pharmacol Ther2014，27，1： | 1 |
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