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| 1 | Systemic interleukin-9 in inflammatory bowel disease: Association with mucosal healing in ulcerative colitis显示文摘AIM To evaluate circulating IL9 in inflammatory bowel disease and disease-associated anemia/cachexia and assess its potential as a mucosal healing marker.METHODS Serum IL9 as well as other cytokines(IL1β, IL6, IL13, IFNγ, TNFα, and VEGF-A) were determined in 293 individuals: 97 patients with Crohn's disease(CD) and 74 with ulcerative colitis(UC) and in 122 apparently healthy controls. The clinical activity of CD and UC was expressed in terms of the Crohn's Disease Activity Index(CDAI) and the Mayo Scoring System(MDAI), respectively, and the severity of bowel inflammation in UC patients was assessed using Mayo endoscopic score. Cytokine concentrations were measured by a flow cytometry-based method using Luminex x MAP? technology. Highsensitive C-reactive protein concentrations(hs CRP) were determined in CD and UC patients using the enhanced immunoturbidimetric method.RESULTS Systemic IL9 was significantly lower in healthy individuals [9 pg/m L(95%CI: 8.2-10)] than in patients with inflammatory bowel disease(IBD): both inactive [14.3 pg/m L(11.9-19.9)] and active [27.6 pg/m L(24.5-32), P < 0.0001]. Cytokine concentrations were significantly higher in active CD [27.4 pg/m L(23.4-32.2)] and in active UC [32.7 pg/m L(27-38.9)] compared to inactive diseases [15.9 pg/m L(10.8-23.4) in CD and 19.4 pg/m L(13.9-27.1) in UC, P = 0.001]. IL9 correlated weakly with CDAI(ρ = 0.32, P = 0.003) and MDAI(ρ = 0.35, P = 0.002) and strongly with endoscopic inflammation in UC(ρ = 0.74, P < 0.0001). As a negative marker of mucosal healing(MH), IL9 had an accuracy superior to hs CRP and IL6 [97%(P < 0.0001), 67%(P = 0.071), and 55%(P = 0.525), respectively]. IL9 was significantly higher in cachectic IBD patients [30.25 pg/m L(24.4-37.5) vs 21.88 pg/m L(18-26.5), P = 0.026] and negatively correlated with hemoglobin concentrations(ρ =-0.27, P < 0.001). Multiple regression showed IL1β and IL13 to be the independent predictors of circulating IL9 in healthy individuals, IFNγ or IL6 in active and inactive UC, respectively, and IL13 and VEGF-A in both active and inactive CD.CONCLUSION The systemic IL9 level is higher in IBD and corresponds with endoscopic inflammation, suggesting its possible application as a negative marker of mucosal healing in UC. | Malgorzata Matusiewicz Katarzyna Neubauer Iwona Bednarz-Misa Sabina Gorska Malgorzata Krzystek-Korpacka | 2017 | World Journal of Gastroenterology2017，23，22： | 9 |
| 2 | Structure and function of midkine, a novel heparin-hinding growth factor显示文摘 | Krzystek-Korpacka M Matusiewicz M Banas T | 2006 | Postepy Hig Med Dosw (Online)2006，60，4： | 1 |
| 3 | A Petri net system: An overview显示文摘 | Suraj Z Fryc B Matusiewicz Z | 2006 | Fundamenta Informaticae2006，71，1： | 1 |
| 4 | Situ hydride generation preconcentration of arsenic in a graphite fur- nace with sample vaporization into a microwave induced plasma for emission speetrometry显示文摘 | Matusiewicz H Sturgeon R E Berman S S | 1990 | Spectrochimica Acta Part B1990，45，12： | 1 |
| 5 | Even a mild anemia is related to tumora ggressiveness mediated by angiogenic factors显示文摘 | KRZYSTEK-KORPACKA M MATUSIEWICZ M DIA-KOWSKA D | 2009 | Exp On-col2009，31，1： | 1 |
| 6 | A novel sample introduction system for microwave-induced plasma optical emission spectrome- try显示文摘 | Matusiewicz H | 2002 | Spectrochimica Acta Part B2002，57，3： | 1 |
| 7 | Molecular evolu- tion of enolase 显示文摘 | Piast M Kustrzeba-Wojcicka I Matusiewicz M | 2005 | Acta Biochim Pol2005，52，2： | 1 |
| 8 | Up-regulation of VEGF-C secreted by cancer cells and not VEGF-A correlates with clinical evaluation of lymph node metastasis in esophageal squamous cell carcinoma (ESCC)显示文摘 | Krzystek-Korpacka M Matusiewicz M Diakowska D | 2007 | Cancer Lett2007，249，2： | 1 |
| 9 | Molecular evolu- tion of enolase 显示文摘 | Piast M Kustrzeba - Wojcicka l Matusiewicz M | 2005 | Acta Biochim Pol2005，52，2： | 1 |
| 10 | Acute -phase response proteins are related to cachexia and accelerated angiogenesis in gastroesophageal cancers 显示文摘 | Krzystek - Korpacka M Matusiewicz M Diakowska D | 2008 | Clin Chem Lab Med2008，46，3： | 1 |
| 11 | Simultaneous determination of macro and trace elements in biological reference materi als by microwave induced plasma optical emission spec- trometry with slurry sample introduction显示文摘 | Matusiewicz H Golik B | 2004 | Spectro- chimica Acta Part B: Atomic Spectroscopy2004，59，5： | 1 |
| 12 | Frequency of voice problems and cough in patients using pressurized aerosol inhaled steroid preparations 显示文摘 | Williamson I J Matusiewicz SP Brown PH | 1995 | Eur Respir J1995，8，4： | 1 |
| 13 | Acutephase response proteins are related to cachexia and accelerated angiogenesis in gastroesophageal cancers显示文摘 | Krzystek-Korpacka M Matusiewicz M Oiakowska 0 | 2008 | Clin Chem Lab Med2008，46，3： | 1 |
| 14 | Mercuryspecies determination by task specific ionic liquid-based ultra-sound-assisted dispersive liquid-liquid microextraction com-bined with cold vapour generation atomic absorption spec-trometry 显示文摘 | STANISZ E WEMER J MATUSIEWICZ H | 2013 | Microchemical Journal2013，110，9： | 1 |
| 15 | Re- spiratory insufficiency related to COPD accelerates systemic in- flammation, under-nutrition, and angiogenesis in esophageal malignancies显示文摘 | Krzystek-Korpacka M Matusiewicz M Diakowska D | 2008 | Exp Oncol2008，30，1： | 1 |
| 16 | Serum midkine depends on lymph node involvement and correlates with circu 1ating VEGF-C in oesophageal squamous cell carcinoma显示文摘 | Krzystek-Korpacka M Matusiewicz M Diakowska D | 2007 | Biomarkers2007，12，4： | 1 |
| 17 | Utilization of the bone/liver alkaline phosphatase activity ratio in blood plasma as an indicator of ascorbate deficiency in salmonid fish 显示文摘 | Matusiewicz M Dabrowski K | 1996 | Proceedings of the Society for Experimental Biology and Medicine1996，212，1： | 1 |
| 18 | Characterization of ascorbyl esters hydrolysis in fish 显示文摘 | Matusiewicz M Dabrowski K | 1995 | Comp Biochem Physiol1995，110，4： | 1 |
| 19 | Method develop-ment for simultaneous multi-element determination of hydride forming elements(As,Bi,Ge,Sb,Se,Sn)and Hg by mi-crowave induced plasma-optical emission spectrometry using integrated continuous-microflow ultrasonic nebulizer-hydride generator sample introduction system显示文摘 | Henryk Matusiewicz Mariusz lachciński | 2010 | Microchemical Journal2010，95，： | 1 |
| 20 | UV Reduction with Ultrasound-assisted Gas-llquid Separa- tion for the Determination of Mercury in Biotissnes by Atomic Absorption Spectrometry显示文摘 | Lopez-Rouco A Stanisz E Matusiewicz H | 2008 | J Anal At Spec- trom2008，，23： | 1 |
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