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| 1 | Quantitative analysis using ELISA of vascular endothelial growth factor and basic fibroblast growth factor in human colorectal cancer,liver metastasis of colorectal cancer and hepatocellular carcinoma显示文摘TO THE EDITOR Angiogenesis consists of the sprouting of capillaries from pre-existing vessels . It is well-known that tumor growth is angiogenesis-dependent. Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) stimulated vascular endothelial cell proliferation and are involved in the neoplastic angiogenesis of several types of tumors including those of the intestinal tract.Authors usually investigated VEGF and bFGF protein expressions using immunohistochemistry or Western blotting and VEGF and bFGF transcripts using reverse transcriptase polymerase chain reaction (RT-PCR). We recently reported in a previous issue of the World Journal of Gastroenterology that cirrhotic liver tissue levels of these two | Muriel Mathonnet Bernard Descottes Denis Valleix Francois Labrousse Véronique Truffinet Yves Denizot | 2006 | World Journal of Gastroenterology2006，12，23： | 27 |
| 2 | Platelet-activating factor in cirrhotic liver and hepatocellular carcinoma显示文摘瞄准:激活血小板的因素(PAF ) 是一个支持 inflammatory 和 angiogenic 类脂化合物调停人。这里,我们试图调查 PAF 的层次, lyso-PAF ( PAF 先锋),磷脂酶 A ( 2 )( PLA ( 2 ),产生 lyso-PAF 的酶的活动), acetylhydrolase 活动(啊哈, PAF 降级的酶)并且在硬变肝和肝细胞癌( HCC )的 PAF 受体( PAF-R )抄本。方法:有 HCC 的 29 个病人在这研究被注册。肝硬化在十四个病人是在场的,七没有肝疾病。织物 PAF 层次被血小板聚集试金调查。Lyso-PAF 在它的化学乙酰化作用以后被估计进 PAF。啊哈被降级决定[(3 ) H ]-PAF。PLA (2 ) 层次被 EIA 估计。PAF-R 抄本用 RT-PCR 被调查。结果:PAF 和 PAF-R 抄本的提高的数量(白血球类型) 1 作为与非肝脏硬化症的相比在肝脏硬化症的纸巾被发现。PAF 和 PAF-R 抄本的更高的数量(织物类型) 1 和 2 作为与非肿瘤纸巾相比在 HCC 纸巾被发现。PLA (2 ) , lyso-PAF 和啊哈层次没在肝脏硬化症的纸巾和 HCC 被改变。结论:当 PAF 的角色在肝生理学当前是未知的时,这研究在在 HCC 期间在硬变肝并且在 angiogenic 反应发现的煽动性的网络建议它的潜在的参与。 | Muriel Mathonnet Bernard Descottes Denis Valleix Véronique Truffinet Franois Labrousse Yves Denizot | 2006 | World Journal of Gastroenterology2006，12，17： | 7 |
| 3 | VEGF in hepatocellular carcinoma and surrounding cirrhotic liver tissues显示文摘TO THE EDITORWe read with a great interest the recent work of Deli andcolleagues. in the World Journal of Gastroenterology reportingvascular endothelial growth factor (VEGF) expressionin hepatocellular carcinoma (HCC) and cirrhotic livertissues. This well-documented work shows that VEGFwas significantly higher in surrounding cirrhotic livertissues than in HCC. Authors assessed VEGF expressionusing immunohistochemistry.The | Muriel Mathonnet Bernard Descottes Denis Valleix Francois Labrousse Yves Denizot | 2006 | World Journal of Gastroenterology2006，12，5： | 5 |
| 4 | Hallmarks in colorectal cancer:Angiogenesis and cancer stem-like cells显示文摘Carcinogenesis is a multistep process that requires the accumulation of various genetic and epigenetic aberrations to drive the progressive malignant transformation of normal human cells.Two major hallmarks of carcinogenesis that have been described are angiogenesis and the stem cell characteristic of limitless replicative potential.These properties have been targeted over the past decade in the development of therapeutic treatments for colorectal cancer(CRC),one of the most commonly diagnosed and lethal cancers worldwide.The treatment of solid tumor cancers such as CRC has been challenging due to the heterogeneity of the tumor itself and the chemoresistance of the malignant cells.Furthermore,the same microenvironment that maintains the pool of intestinal stem cells that contribute to the continuous renewal of the intestinal epithelia also provides the necessary conditions for proliferative growth of cancer stem-like cells.These cancer stem-like cells are responsible for the resistance to therapy and cancer recurrence,though they represent less than 2.5%of the tumor mass.The stromal environment surrounding the tumor cells,referred to as the tumor niche,also supports angiogenesis,which supplies the oxygen and nutrients needed for tumor development.Anti-angiogenic therapy,such as with bevacizumab,a monoclonal antibody against vascular-endothelial growth factor,significantly prolongs the survival of metastatic CRC patients.However,such treatments are not completely curative,and a large proportion of patient tumors retain chemoresistance or show recurrence.This article reviews the current knowledge regarding the molecular phenotype of CRC cancer cells,as well as discusses the mechanisms contributing to their maintenance.Future personalized therapeutic approaches that are based on the interaction of the carcinogenic hallmarks,namely angiogenic and proliferative attributes,could improve survival and decrease adverse effects induced by unnecessary chemotherapy. | Muriel Mathonnet Aurelie Perraud Niki Christou Hussein Akil Carole Melin Serge Battu Marie-Odile Jauberteau Yves Denizot | 2014 | World Journal of Gastroenterology2014，20，15： | 5 |
| 5 | Tropomyosin-related kinase B/brain derived-neurotrophicfactor signaling pathway as a potential therapeutic targetfor colorectal cancer显示文摘Colorectal cancer(CRC) is the second most common cause of cancer-related death in western countries. Approximately one-quarter of newly diagnosed patients for CRC have metastases, and a further 40%-50% experience disease recurrence or develop metastases after all standard therapies. Therefore, understanding the molecular mechanisms involved in the progression of CRC and subsequently developing novel therapeutic targets is crucial to improve management of CRC and patients' long-term survival. Several tyrosine kinase receptors have been implicated in CRC development, progression and metastasis, including epidermal growth factor receptor(EGFR) and vascular EGFR. Recently, tropomyosin-related kinase B(Trk B), a tyrosine kinase receptor, has been reported in CRC and found to clearly exert several biological and clinical features, such as tumor cell growth and survival in vitro and in vivo, metastasis formation and poor prognosis. Here we review the significance of Trk B and its ligand brain derived-neurotrophic factor in CRC. We focus on their expression in CRC tumor samples, and their functional roles in CRC cell lines and in in vivo models. Finally we discuss therapeutic approaches that can lead to the development of novel therapeutic agents for treating Trk B-expressing CRC tumors. | Hussein Akil Aurélie Perraud Marie-Odile Jauberteau Muriel Mathonnet | 2016 | World Journal of Gastroenterology2016，22，2： | 3 |
| 6 | Multicentric study of thyroid nodules in patients with Graves' disease显示文摘 | Kraimps JL Bovin-Pinean MH Mathonnet M | 2000 | BrJ Surg2000，87，： | 1 |
| 7 | Insuline-like growth factor 1 induced survial axotomized olfactory neurons in the chick显示文摘 | Mathonnet M Comte I Lalloue F | 2001 | Neurosci Lett2001，308，2： | 1 |
| 8 | Insulin-like growth factor I induced survival of axotomized olfactory neurons in the chick 显示文摘 | Mathonnet M Comet I Lalloue F | 2001 | Neurosci Lett2001，308，2： | 1 |
| 9 | Identification of five novel mutations in the factor Ⅺ gene (F11) of patients with factor XI deficiency显示文摘 | Que1in F Mathonnet F Potentini-Esnault C | 2006 | Blood Coagul Fibrinolysis2006，17，1： | 1 |
| 10 | Risk of childhood leukemia associated with diagnostic irradiation and polymorphisms in DNA repair genes 显示文摘 | Infante-Rivard C Mathonnet G Sinnett D | 2000 | Environ Health Perspect2000，108，6： | 1 |
| 11 | Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependentdeadenytation 显示文摘 | Fabian MR Mathonnet G Sundermeier T | 2009 | Molecular Cell2009，35，6： | 1 |
| 12 | Differential response ofolfactory neurons to axotomy at embryonic and postnatal stages显示文摘 | Mathonnet M Lalloue F Pettit B | 2002 | Neuroscience2002，109，2： | 1 |
| 13 | Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes, DNA repair enzymes, and response to treatment of childhood acute lymphoblastic leukemia1显示文摘 | Krajinovic M Labuda D Mathonnet G | 2002 | Clin Cancer Res2002，8，3： | 1 |
| 14 | Risk of childhood leukemia associated with diagnostic irradiation and polymorphisms in DNA repair genes 显示文摘 | Infante-Rivard C Mathonnet G Sinnet D | 2000 | Environ Health Perspect2000，108，6： | 1 |
| 15 | Differential response of olfactory neurons to axotomy at embryonic andpostnatal stages 显示文摘 | Mathonnet M Lalloue F Pettit B | 2002 | Neuroscience2002，109，2： | 1 |
| 16 | Risk of childhood leukemia associated with diagnostic irradiation and polymorphisms in DNA repair genes显示文摘 | Mathonnet G Sinnett D | 2000 | Environ Health Perspect2000，108，： | 1 |
| 17 | Identifica?tion of five novel mutaitons in the factor XI gene (Fll) of patients with factor XI deficiency显示文摘 | Quelin F Mathonnet F Potentini-Fsault C | 2006 | Blood Coagul Fibrino?lysis2006，17，1： | 1 |
| 18 | Role of DNA mismatch repair genetic polymorphisms in the risk of childhood acute lymphoblastic leukaemia 显示文摘 | Mathonnet G Krajinovic M Labuda D | 2003 | Br J Haematol2003，123，1： | 1 |
| 19 | Multicentre study of thyroid nodules in patients with Graves' disease显示文摘 | Kraimps JL Bouin-Pineau MH Mathonnet M | 2000 | Br J Surg2000，87，8： | 1 |
| 20 | Complications after total thyroid- ectomy显示文摘 | Christou N Mathonnet M | 2013 | J Visc Surg2013，50，4： | 1 |
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