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| 1 | Unsedated ultrathin upper endoscopy is better than conventional endoscopy in routine outpatient gastroenterology practice:A randomized trial显示文摘AIM: to compare the feasibility and patients' tolerance of esophagogastroduodenoscopy (EGD) using a thin endoscope with those of conventional oral EGD and to determine the optimal route of introduction of small-caliber endoscopes. METHODS: One hundred and sixty outpatients referred for diagnostic EGD were randomly allocated to 3 groups: conventional (C)-EGD (9.8 mm in diameter), transnasal (TN)-EGD and transoral (TO)-EGD (5.9 mm in diameter). Pre-EGD anxiety was measured using a 100-mm visual analogue scale (VAS). After EGD, patients and endoscopists completed a questionnaire on the pain, nausea, choking, overall discomfort, and quality of the examination either using VAS or answering some questions. The duration of EGD was timed. Blood oxygen saturation (SaO2) and heart rate (HR) were monitored during EGD. RESULTS: Twenty-one patients refused to participate in the study. The 3 groups were well-matched for age, gender, experience with EGD, and anxiety. EGD was completed in 91.1% (41/45), 97.5% (40/41), and 96.2% (51/53) of cases in TN-EGD, TO-EGD, and C-EGD groups, respectively. TN-EGD lasted longer (3.11 ± 1.60 min) than TO-EGD (2.25 ± 1.45 min) and C-EGD (2.49 ± 1.64 min) (P < 0.05). The overall tolerance was higher (P < 0.05) and the overall discomfort was lower (P < 0.05) in TN-EGD group than in C-EGD group. EGD was tolerated 'better than expected' in 73.2% of patients in TN-EGD group and 55% and 39.2% of patients in TO-EGD and C-EGD groups, respectively (P < 0.05). Endoscopy was tolerated 'worst than expected' in 4.9% of patients in TN-EGD group and 17.5% and 23.5% of patients in TO-EGD and C-EGD groups, respectively (P < 0.05). TN-EGDcaused mild epistaxis in one case. The ability to insufflate air, wash the lens, and suction of the thin endoscope were lower than those of conventional instrument (P < 0.001). All biopsies performed were adequate for histological assessment. CONCLUSION: Diagnostic TN-EGD is better tolerated than C-EGD. Narrow-diameter endoscope has a level of diagnostic accuracy comparable to that of conventional gastroscope, even though some technical characteristics of these instruments should be improved. Transnasal EGD with narrow-diameter endoscope should be proposed to all patients undergoing diagnostic EGD. | Lucio Trevisani Viviana Cifalà Sergio Sartori Giuseppe Gilli Giancarlo Matarese Vincenzo Abbasciano | 2007 | World Journal of Gastroenterology2007，13，6： | 24 |
| 2 | Post-Anaesthetic Discharge Scoring System to assess patient recovery and discharge after colonoscopy显示文摘AIM: To investigate whether discharge scoring criteria are as safe as clinical criteria for discharge decision and allow for earlier discharge.METHODS: About 220 consecutive outpatients undergoing colonoscopy under sedation with Meperidine plus Midazolam were enrolled and assigned to 2 groups: in Control-group(110 subjects) discharge decision was based on the clinical assessment; in PADSS-group(110subjects) discharge decision was based on the modified Post-Anaesthetic Discharge Scoring System(PADSS).Measurements of the PADDS score were taken every20 min after colonoscopy, and patients were discharged after two consecutive PADSS scores ≥ 9. The investigator called each patient 24-48 h after discharge to administer a standardized questionnaire, to detect any delayed complications. Patients in which cecal intubation was not performed and those who were not found at follow-up phone call were excluded from the study.RESULTS: Thirteen patients(7 in Control-group and6 in PADSS-group) were excluded from the study. Recovery from sedation was faster in PADSS-group than in Control-group(58.75 ± 18.67 min vs 95.14 ± 10.85min, respectively; P < 0.001). Recovery time resulted shorter than 60 min in 39 patients of PADSS-group(37.5%), and in no patient of Control-group(P < 0.001).At follow-up phone call, no patient declared any hospital re-admission because of problems related to colonoscopy and/or sedation. Mild delayed post-discharge symptoms occurred in 57 patients in Control-group(55.3%)and in 32 in PADSS-group(30.7%). The most common symptoms were drowsiness, weakness, abdominal distension, and headache. Only 3 subjects needed to take some drugs because of post-discharge symptoms.CONCLUSION: The Post-Anaesthetic Discharge Scoring System is as safe as the clinical assessment and allows for an earlier patient discharge after colonoscopy performed under sedation. | Lucio Trevisani Viviana Cifalà Giuseppe Gilli Vincenzo Matarese Angelo Zelante Sergio Sartori | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，10： | 5 |
| 3 | Pathogenesis of endometriosis: natural immunity dysfunction or autoim- munedisease显示文摘 | Matarese G De Placido G Nikas Y | 2003 | Trends MolMed2003，9，5： | 1 |
| 4 | Requirement for leptin in induction and progression of experimental autoimmune encephalomyelitis显示文摘 | Matarese G Di Giacomo A Sanna V | 2001 | J Immunol2001，166，10： | 1 |
| 5 | Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression显示文摘 | Lord GM Matarese G Howard JK | 1998 | Nature1998，394，： | 1 |
| 6 | Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency显示文摘 | Farooqi IS Matarese G Lord GM | 2002 | The Journal of clinical investigation2002，110，： | 1 |
| 7 | Leptin in- crease in multiple sclerosis associates with reduced number of CD4 + CD25 + regulatory T cells显示文摘 | Matarese G Carrieri PB La Cava A | 2005 | Proc Natl Acad Sci USA2005，102，4： | 1 |
| 8 | Leptin modulates the Tcell immune response and reverses starvation-induced immunosuppression显示文摘 | Lord GM Matarese G Howard JK | 1998 | Nature1998，394，6696： | 1 |
| 9 | Differential regulation of metabolic, neuroendocrine, and immune function by leptin in humans显示文摘 | Chan JL Matarese G Shetty GK | 2006 | Proc Natl Acad Sci USA2006，103，22： | 1 |
| 10 | Leptin as an immuno-modulator显示文摘 | Procaccini C Jirillo E Matarese G | 2012 | Mol Aspects Med2012，33，1： | 1 |
| 11 | Role of the quantiferon?TB test in ruling out pleural tuberculosis: a multi-centre study显示文摘 | Losi M Bocchino M Matarese A | 2011 | Int J Immunopathol Pharmacol2011，24，1： | 1 |
| 12 | Beneficial effects of Leptin on obesity,T cell hyporesponsiveness,and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency显示文摘 | Farooqi I S Matarese G Lord G M | 2002 | J Clin Invest2002，110，8： | 1 |
| 13 | Leptin modulates the T-cell immune response and reverses starvation induced immunosuppression 显示文摘 | Lord G M Matarese G Howard J K | 1998 | Nature1998，349，6696： | 1 |
| 14 | Leptin modulates the T- cell immunt response and reverse starvation induced immunosuppression 显示文摘 | LORD G M MATARESE G BOWARD J K | 1998 | Nature1998，，6696： | 1 |
| 15 | Exon 6 and 2 peroxisome proliferator-activated receptor-gamma polymorphisms in polycystic ovary syndrome显示文摘 | Orio F Jr Matarese G Di Biase S | 2003 | J Clin Endocrinol Metab2003，88，58： | 1 |
| 16 | The Yinand Yang of CD4 ( + ) regulatory T cells in autoimmunityand cancer 显示文摘 | Galgani M Di Giacomo A Matarese G | 2009 | Curr Med Chem2009，16，35： | 1 |
| 17 | Efficacy and effects of Palifermin for the treatment of oral mucositis in patients affected by acute lymphoblastic leukemia 显示文摘 | Lucchese A Matarese G Ghislanzoni LH | 2015 | Leuk Lym-phoma2015，5，12： | 1 |
| 18 | Exon 6 and 2 peroxisome proliferator-activated receptor-gamma polymorphisms in polycystic ovary syndrome显示文摘 | Orio F J Matarese G Di B S | 2003 | J Clin Endocrinol Metab2003，88，12： | 1 |
| 19 | Performance of two commercial blood IFN-γ release assays for the detection of Mycobacterium tuberculosis infection in patient candidates for anti-TNF-α treatment显示文摘 | Bocchino M Matarese A Bellofiore B | 2008 | Eur J Clin Microbiol Infect Dis2008，27，10： | 1 |
| 20 | An immunohisto-chemical,histologi cal,and electron-microscopic study of the human periodontal ligament during orthodontic treatment显示文摘 | Anastasi G Cordasco G Matarese G | 2008 | Int J Mol Med2008，21，5： | 1 |
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