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| 1 | Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice显示文摘AIM: To study isolation and chemical characterization of pectin derived from the common cranberry Vaccinium oxycoccos L. (oxycoccusan OP) and the testing of its preventive effect on experimental colitis.METHODS: Mice were administrated orally with OP two days prior to a rectal injection of 5% acetic acid and examined for colonic damage 24 h later. Colonic inflammation was characterized by macroscopical injury and enhanced levels of myeloperoxidase activity measured spectrophotometrically with o-phenylene diamine as the substrate. The mucus contents of the colon were determined by the Alcian blue dye binding method. Vascular permeability was estimated using 4% Evans blue passage after i.p. injection of 0.05 mol/L acetic acid. RESULTS: In the mice treated with OP, colonic macroscopic scores (1.1 ± 0.4 vs 2.7, P < 0.01) and the total square area of damage (10 ± 2 vs 21 ± 7, P < 0.01) were significantly reduced when compared with the vehicle-treated colitis group. OP was shown to decrease the tissue myeloperoxidase activity in colons (42 ± 11 vs 112 ± 40, P < 0.01) and enhance the amount of mucus of colitis mice (0.9 ± 0.1 vs 0.4 ± 0.1, P < 0.01). The level of colonic malondialdehyde was noted to decrease in OP-pretreated mice (3.6 ± 0.7 vs 5.1 ± 0.8, P < 0.01). OP was found to decrease the inflammatory status of mice as was determined by reduction of vascular permeability (161 ± 34 vs 241 ± 21, P < 0.01). Adhesionof peritoneal neutrophils and macrophages was also shown to decrease after administration of OP (141 ± 50 vs 235 ± 37, P < 0.05).CONCLUSION: Thus, a preventive effect of pectin from the common cranberry, namely oxycoccusan OP, on acetic acid-induced colitis in mice was detected. A reduction of neutrophil infiltration and antioxidant action may be implicated in the protective effect of oxycoccusan. | Sergey V Popov Pavel A Markov Ida R Nikitina Sergey Petrishev Vasily Smirnov Yury S Ovodov | 2006 | World Journal of Gastroenterology2006，12，41： | 9 |
| 2 | Microsurgical DREZotomy for pain of spinal cord and Cauda equina injury origin: clinical characteristics of pain and implications for surgery in a series of 26 patients 显示文摘 | Spaic M Markovic N Tadic R | 2002 | Acta Neurochir (Wien)2002，144，5： | 1 |
| 3 | Chemical processes affecting alkalis and alkaline earths during continental weathering 显示文摘 | Nesbitt H W Markovics G and Price R C | 1980 | Geochimica et Cosmochimica Acta1980，44，11： | 1 |
| 4 | Formic acid oxidation on pure and Bi-modified Pt( 111): temper-ature effects 显示文摘 | Schmidt T J Behm R J Grgur B N Markovic N M Ross P N | 2000 | Langmuir2000，16，21： | 1 |
| 5 | Chemical processes af- fecting alkalis and alkaline earths during continental weath- ering 显示文摘 | Nesbitt H W Markovics G Price R C | 1980 | Geochim Cosmochim Acta1980，44，11： | 1 |
| 6 | Heterologous expression of leader-less pga gene in Pichia pastoris:intracellular production of prokaryotic enzyme显示文摘 | Maresová H Marková Z Valesová R | | 0，，： | 1 |
| 7 | Prospective randomised trial evaluating a paclitaxel-coated balloon in patients treated with endo- thelial progenitor cell capturing stents for de novo coronary artery dis- ease 显示文摘 | Wobrle J Birkemeyer R Markovic S | 2011 | Heart2011，97，16： | 1 |
| 8 | Sentinel lymph node biopsy may be used to support the decision to perform modified radi-cal neck dissection in differentiated thyroid carcinoma显示文摘 | Dzodic R Markovic I Inic M | | 0，，05： | 1 |
| 9 | Chemical processes affecting alkalis and alkaline earths during continental weathering显示文摘 | Nesbitt H W Markovics G Price R C | 1980 | Geochem Cosmochim Acta1980，44，11： | 1 |
| 10 | Sentinel lymph node biopsy may be used to support the decision to perform modified radical neck dissection in differentiated thyroid carcinoma显示文摘 | Dzodic R Markovic I Inic M | | 0，，05： | 1 |
| 11 | Chemical processes affecting alkalis and alkaline earths during continental weathering显示文摘 | Nesbitt H W Markovics G Price R C | 1980 | Geochimica et Cosmochimica Acta1980，44，11： | 1 |
| 12 | Chemical processes af fecting alkalis and alkaline earths during continental weathe ting显示文摘 | Nesbilt H W Markovics G Price R C | 1980 | Geochemica ET Cosmochimiea Acta1980，44，11： | 1 |
| 13 | Chemical processes affecting alkal is and alkaline earths during continental weathering显示文摘 | Nesbtt H W Markovics G Price R C | 1980 | Geochimica et Cosmochimiea Acta1980，44，16： | 1 |
| 14 | Bile in the esophagus:a factor in the pathogenesis of reflux esphagitis in children 显示文摘 | Orel R Markovic S | 2003 | J Pediatr Gastroenterol Nutr2003，36，2： | 1 |
| 15 | Bile in the esophagus: a factor in the pathogenesis of reflux esophagitis in children 显示文摘 | Orel R Markovic S | 2003 | J Pediatr Gastroenterol Nutr2003，36，2： | 1 |
| 16 | State of the art in the diagnosis and treatment of the upper urothelial cancer显示文摘 | I Ignjatovic R Cukuranovic N Markovic | 2002 | Medicine and Biology2002，9，3： | 1 |
| 17 | 查看详情显示文摘 | Stamenkovic V R Mun B S Arenz M Mayrhofer K J J Lucas C A Wang G F Ross P N Markovic N M | | 0，，： | 1 |
| 18 | Prospective ran- domised trial evaluating a paclitaxel-coated balloon in patients treated with endothelial progenitor cell capturing stents for de novo coronary artery disease 显示文摘 | Wohrle J Birkemeyer R Markovic S | 2011 | Heart2011，97，16： | 1 |
| 19 | Expression of 25 - hydro - xyvitamin D3 -1 alpha- hydroxylase in pancreatic islets 显示文摘 | Bland R Markovic D Claire EH | 2004 | J Ster- oid Biochem Mol Biol2004，89，10： | 1 |
| 20 | Nanotubular highways for intercellular organelle transport 显示文摘 | RUSTOM A SAFFRICH R MARKOVIC I | 2004 | Science2004，303，5660： | 1 |
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