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| 1 | 胆囊癌的临床诊疗现状与挑战显示文摘胆囊癌在胃肠道癌症中位居第五位,同时它也是胆道最常见的恶性肿瘤,约占80%~95%。这种肿瘤预后不佳,总体5年生存率低于5%,平均中位生存期〈6个月。因为胆囊癌在进展时可以没有任何症状,所以早期诊断是至关重要。术前诊断为胆囊结石,而术后确诊为胆囊癌的发生率为0.5%~1.5%。如果术前怀疑患者胆囊癌,则不应通过腹腔镜手术。流行病学研究已经确定了胆囊癌的发病率有地理和种族的显著差异:美洲的印第安人高发,东南亚地区也比较高,但在美洲和世界的其他地区发病率较低。环境诱发因素在胆囊癌的发展过程中发挥关键作用,胆石症、胆道和寄生虫感染的慢性炎症是最好的例证。在过去的10年里,改进成像技术和改良根治的手术方法可改善患者的预后,并帮助延长胆囊癌患者的存活时间。对于R0切除的胆囊癌患者,其总体5年生存率为21%~69%。在将来,潜在的诊断标志物的发展将对那些种族易感性或已知胆道解剖异常的人群提供早期筛查诊断的机会。 | Mislav Raki? Leonardo Patrlj Mario Kopljar Robert Kli?ek Marijan Kolovrat Bozo Loncar Zeljko Busic 冯铁诚 | 2016 | 中国普通外科杂志2016，25，2： | 24 |
| 2 | CRP and fibrinogen imply clinical outcome of patients with Type-2 diabetes and coronary artery disease显示文摘 | Marijan Bosevski Golubinka Bosevska Lily Stojanovska Vasso Apostolopoulos~ | 2017 | Acta Biochimica et Biophysica Sinica2017，49，3： | 8 |
| 3 | Inflammatory biomarkers: impact for diabetes and diabetic vascular disease显示文摘物理迟钝和坐着的生活方式被相信是为肥胖, type-2 糖尿病,和新陈代谢的症候群的出现的独立风险因素[13 ] 。type-2 糖尿病的发生由长期的多糖症和葡萄糖不耐描绘了,与肥胖同时增加了,并且 2010, 2.85 亿个人以前与 3000 万 25 年相比与 type-2 糖尿病被诊断[4 ] 。甚至与 statin 治疗, type-2 糖尿病被显示了导致加速的动脉粥样硬化和脉管的疾病的过多的风险[5 ] 。象多糖症和葡萄糖不耐, hyperlipidemia,肥胖,和高血压那样的风险因素导致糖尿病的脉管的疾病[6 ] 。有糖尿病和新陈代谢的控制的一样的持续时间的一些病人为什么有通过多重脉管的区域散布或限制了到仅仅一脉管的领土的动脉粥样硬化的不同程度,很好没被理解。在有 type-2 糖尿病的人的 statins 和 fibrates 的使用是有利的,尽管有糖尿病的脉管的疾病的前进[7 ] 。然而, pioglitazone 和 statins 的合作管理在 intima 媒介厚度和 endothelial 功能改进提供回归[8 ] 。另外,煽动性的标记的减少(C 反应的蛋白质;CRP, P-selectin, adiponectin,和高密度脂蛋白胆固醇) 并且 triglyceride 层次与增加的心血管的风险因素在病人被注意[8 ] 。 | Marijan Bosevski Lily Stojanovska Vasso Apostolopoulos | 2015 | Acta Biochimica et Biophysica Sinica2015，47，12： | 4 |
| 4 | Pentadecapeptide BPC 157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in ratsPentadecapeptide BPC 157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in rats显示文摘BACKGROUND Recently,as a possible therapy resolving solution,pentadecapeptide BPC 157 therapy,has been used in alleviating various vascular occlusion disturbances.BPC 157 was previously reviewed as novel mediator of Robert cytoprotection and endothelium protection in the stomach,and gut-brain axis,beneficial therapy in gastrointestinal tract,with particular reference to vascular recruitment,ulcerative colitis and tumor cachexia,and other tissues healing.Here we raised new hypothesis about BPC 157 therapy in the Budd-Chiari syndrome in rats,rapid bypassing of the suprahepatic inferior caval vein occlusion,and rats recovery with the active and effective pharmacotherapy treatment.AIM To investigate Budd-Chiari syndrome model(inferior caval vein suprahepatic occlusion)resolution,since BPC 157 resolves various rat vascular occlusion.METHODS We assessed the activated bypassing pathways between the inferior and superior caval veins and portocaval shunt,counteracted caval/portal hypertension,aortal hypotension,venous/arterial thrombosis,electrocardiogram disturbances,liver and gastrointestinal lesions(i.e.,stomach and duodenum hemorrhages,in particular,congestion).Rats with suprahepatic occlusion of the inferior vena cava by ligation were medicated at 1 min,15 min,24 h,or 48 h post-ligation.Medication consisted of 10μg/kg BPC 157,10 ng BPC 157 or 5 m L/kg saline,administered once as an abdominal bath or intragastric application.Gross and microscopic observations were made,in addition to assessments of electrical activity of the heart(electrocardiogram),portal and caval hypertension,aortal hypotension,thrombosis,hepatomegaly,splenomegaly and venography.Furthermore,levels of nitric oxide,malondialdehyde in the liver and serum enzymes were determined.RESULTS BPC 157 counteracted increased P wave amplitude,tachycardia and ST-elevation,i.e.,right heart failure from acute thrombotic coronary occlusion.The bypassing pathway of the inferior vena cava-azygos(hemiazygos)vein-superior vena cava and portocaval shunt occurred rapidly.Even with severe caval portal hypertension,BPC 157 antagonized portal and caval hypertension and aortal hypotension,and also reduced refractory ascites.Thrombosis of portal vein tributaries,inferior vena cava,and hepatic and coronary arteries was attenuated.In addition,there was reduced pathology of the lungs(severe capillary congestion)and liver(dilated central veins and terminal portal venules),decreased intestine hemorrhagic lesions(substantial capillary congestion,submucosal edema and architecture loss),and increased liver and spleen weight.During the period of ligation,nitric oxide-and malondialdehyde-levels in the liver remained within normal healthy values,and increases in serum enzymes were markedly reduced.CONCLUSION BPC 157 counteracts Budd Chiari syndrome in rats. | Slaven Gojkovic Ivan Krezic Borna Vrdoljak Dominik Malekinusic Ivan Barisic andreja Petrovic Katarina Horvat Pavlov Marijan Kolovrat Antonija Duzel Mario Knezevic Katarina Kasnik Kovac Domagoj Drmic Lovorka Batelja Vuletic Antonio Kokot Alenka Boban Blagaic Sven Seiwerth Predrag Sikiric | 2020 | World Journal of Gastrointestinal Pathophysiology2020，11，1： | 2 |
| 5 | Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights显示文摘AIM To provide new insights in treatment of colitis and ischemia and reperfusion in rats using stable gastric pentadecapeptide BPC 157. METHODS Medication [BPC 157,L-NAME,L-arginine(alone/combined),saline] was bath at the blood deprived colon segment. During reperfusion,medication was BPC 157 or saline. We recorded(USB microscope camera) vessel presentation through next 15 min of ischemic colitis(ICrats) or reperfusion(removed ligations)(IC + RL-rats);oxidative stress as MDA(increased(IC-and IC + RLrats)) and NO levels(decreased(IC-rats);increased(IC + RL-rats)) in colon tissue. IC + OB-rats [IC-rats had additional colon obstruction(OB)] for 3 d(IC + OBrats),then received BPC 157 bath. RESULTS Commonly,in colon segment(25 mm,2 ligations on left colic artery and vein,3 arcade vessels within ligated segment),in IC-,IC + RL-,IC + OB-rats,BPC 157(10 μg/kg) bath(1 m L/rat) increased vessel presentation,inside/outside arcade interconnections quickly reappeared,mucosal folds were preserved and the pale areas were small and markedly reduced. BPC 157 counteracted worsening effects induced by L-NAME(5 mg) and L-arginine(100 mg). MDA-and NO-levels were normal in BPC 157 treated IC-rats and IC + RLrats. In addition,on day 10,BPC 157-treated IC + OBrats presented almost completely spared mucosa with very small pale areas and no gross mucosal defects;the treated colon segment was of normal diameter,and only small adhesions were present.CONCLUSION BPC 157 is a fundamental treatment that quickly restores blood supply to the ischemically injured area and rapidly activates collaterals. This effect involves the NO system. | Antonija Duzel Josipa Vlainic Marko Antunovic Dominik Malekinusic Borna Vrdoljak Mariam Samara Slaven Gojkovic Ivan Krezic Tinka Vidovic Zdenko Bilic Mario Knezevic Marko Sever Nermin Lojo Antonio Kokot Marijan Kolovrat Domagoj Drmic Jaksa Vukojevic Tamara Kralj Katarina Kasnik Marko Siroglavic Sven Seiwerth Predrag Sikiric | 2017 | World Journal of Gastroenterology2017，23，48： | 2 |
| 6 | Understanding the multifaceted etiopathogenesis of foot complications in individuals with diabetes显示文摘Diabetes mellitus,a chronic disease of metabolism,is characterized by a disordered production or cellular utilization of insulin.Diabetic foot disease,which comprises the spectrum of infection,ulceration,and gangrene,is one of the most severe complications of diabetes and is the most common cause of hospitalization in diabetic patients.The aim of this study is to provide an evidence-based overview of diabetic foot complications.Due to neuropathy,diabetic foot infections can occur in the form of ulcers and minor skin lesions.In patients with diabetic foot ulcers,ischemia and infection are the main causes of non-healing ulcers and amputations.Hyperglycemia compromises the immune system of individuals with diabetes,leading to persistent inflammation and delayed wound healing.In addition,the treatment of diabetic foot infections is challenging due to difficulty in accurate identification of pathogenic microorganisms and the widespread issue of antimicrobial resistance.As a further complicating factor,the warning signs and symptoms of diabetic foot problems can easily be overlooked.Issues associated with diabetic foot complications include peripheral arterial disease and osteomyelitis;accordingly,the risk of these complications in people with diabetes should be assessed annually.Although antimicrobial agents represent the mainstay of treatment for diabetic foot infections,if peripheral arterial disease is present,revascularization should be considered to prevent limb amputation.A multidisciplinary approach to the prevention,diagnosis,and treatment of diabetic patients,including those with foot ulcers,is of the utmost importance to reduce the cost of treatment and avoid major adverse consequences such as amputation. | Tatjana Matijević Jasminka Talapko Tomislav Meštrović Marijan Matijević Suzana Erić Ivan Erić IvanaŠkrlec | 2023 | World Journal of Clinical Cases2023，11，8： | 2 |
| 7 | 十五肽BPC157减弱慢性苯丙胺诱导的行为障碍(英文)显示文摘AIM: To investigate the effect of pentadecapeptide BPC 157 on chronic exposure to amphetamine in rats, particularly the changes commonly referred in chronic amphetamine studies as tolerance ( lesser grade of stereotyped behavior, without increased excitability) and reverse tolerance (ie, prominent stereotyped behavior and heightened startle response upon late amphetamine challenges). METHODS: After initial application (initial single dose-regimen), amphetamine (10 mg/kg, ip) was given once daily till d 5 ( continuous administration-regimen), and thereafter on d 8, 16, and 46 (intermittent administration regimen). For stereotyped behavior and heightened startle response the observation period was 120 min after amphetamine application, and each animal was observed for 10 s in 5 min intervals. Pentadecapeptide BPC 157 (10 μg/kg or 10 ng/kg, ip) or saline (5.0 mL/kg, ip) were given only at the beginning of the experiment, simultaneously with the initial dose of amphetamine. RESULTS: In relation to | Predrag SIKIRIC, Nikola JELOVAC, Andjelka JELOVAC-GJELDUM, Goran DODIG, Mario STARESINIC, Tornislav ANIC, Ivan ZORICIC, Davor RAK, Darko PEROVIC, Gorana ARALICA, Gojko BULJAT, Ingrid PRKACEV, Martina LOVRIC-BENCIC, Jadranka SEPAROVIC, Sven SEIWERTH, Rudolf RUCMAN, Marijan PETEK, Branko TURKOVIC, Tihomil ZIGER, AJenka BOBAN-BLAGAIC, Vlado BEDEKOVIC, Ante TONKIC, Slaven BABIC ( Department of Pharmacology, Medical Faculty University of Zagreb, Croatia) | 2002 | Acta Pharmacologica Sinica2002，23，5： | 2 |
| 8 | Electrocatalytic activity and anodic stability of electrodeposited rutheniumrhodium coatings on titanium显示文摘 | Vukovic M Marijan D Gukman D | 1999 | J Mater Sci1999，34，4： | 1 |
| 9 | Electrochemical quartz crystal microbalance study of electrodeposited ruthenium显示文摘 | MARIJAN V DUNJA C | 1999 | Journal of Electroanalytical Chemistry1999，474，： | 1 |
| 10 | Laparoscopic visualization of the cystic artery anatomy显示文摘 | Milivoj Balija MD Marijan Huis MD Vasilije Nikolic MD | 1999 | World J Surg1999，23，3： | 1 |
| 11 | Electrochemical quartz crystal microbalance study of electrodeposited ruthenium显示文摘 | MARIJAN V DUNJA C | 1999 | Journal of Electroanalytical Chemistry1999，474，： | 1 |
| 12 | Subclinical hypothyroid-ism and risk to carotid atherosclerosis 显示文摘 | Valentina VN Marijan B Chedo D | 2011 | Arq Bras EndocrinolMetabol2011，55，7： | 1 |
| 13 | Subclinical hypothyroidismand risk to carotid atherosclerosis 显示文摘 | Valentina VN Marijan B Chedo D | 2011 | Arq Bras Endocrinol Metab2011，55，47： | 1 |
| 14 | Photokilling Squamous Carcinoma Cells SCCVII with Ultrafine Particles of Selected Metal Oxides显示文摘 | Sinisa Ivankovic Marijan Gotic Mislav Jurin | 2003 | J Sol-gel Sci Technol2003，27，： | 1 |
| 15 | Risk factors for infection with herpes simplex virus type 2:role of smoking , douching, uncircumcised males, and vaginal flora 显示文摘 | Thomas L Leslie A Marijane A | 2003 | Sex Transm Dis2003，30，： | 1 |
| 16 | Electrochemical quartz crystal microbalance study of electrodeposited ruthenium显示文摘 | MARIJAN V DUNJA C | 1999 | Journal of Electroanalytical Chemistry1999，，474： | 1 |
| 17 | Laparoscopic visualization of the cystic artery anatomy显示文摘 | Milivoj B Marijan H Vasilije N | 1999 | World J Surg1999，23，3： | 1 |
| 18 | Subclinical hypothyroidism and risk to carotid atherosclerosis显示文摘 | Valentina VN Marijan B Chedo D | 2011 | Arq Bras Endocrinol Metab2011，55，： | 1 |
| 19 | Aqueous solubility of alkylphenols and alkylphenol polyethoxylates显示文摘 | Marijan A Walter G | 1993 | Chemosphere1993，26，8： | 1 |
| 20 | Partitioning of alkylphenols and alkylphenol polyethoxylates between water and organic solvents显示文摘 | Marijan A Walter G | 1993 | Chemosphere1993，26，8： | 1 |
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