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| 1 | Is autophagy an elective strategy to protect neurons from dysregulated cholesterol metabolism?显示文摘The balance of autophagy, apoptosis and necroptosis is crucial to determine the outcome of the cellular response to cholesterol dysregulation. Cholesterol plays a major role in regulating the properties of cell membranes, especially as regards their fluidity, and the regulation of its biosynthesis influences the shape and functions of these membranes. Whilst dietary cholesterol can easily be distributed to most organs, the central nervous system, whose membranes are particularly rich in cholesterol, mainly relies on de novo synthesis. For this reason, defects in the biosynthesis of cholesterol can variably affect the development of central nervous system. Moreover, defective synthesis of cholesterol and its intermediates may reflect both on structural cell anomalies and on the response to inflammatory stimuli. Examples of such disorders include mevalonate kinase deficiency, and Smith-Lemli-Opitz syndrome, due to deficiency in biosynthetic enzymes, and type C Niemann-Pick syndrome, due to altered cholesterol trafficking across cell compartments. Autophagy, as a crucial pathway dedicated to the degradation of cytosolic proteins and organelles, plays an essential role in the maintenance of homeostasis and in the turnover of the cytoplasmic material especially in the presence of imbalances such as those resulting from alteration of cholesterol metabolism. Manipulating the process of autophagy can offer possible strategies for improving neuronal cell viability and function in these genetic disorders. | Elisa Piscianz Liza Vecchi Brumatti Alberto Tommasini Annalisa Marcuzzi | 2019 | Neural Regeneration Research2019，14，4： | 2 |
| 2 | Expression of matrix metalloproteinase(MMP)-2,MMP-9,MMP-13,and MT1-MMP in skin tumors of human papillomavirus type 8 transgenic mice显示文摘 | Akgul B Pfefferle R Marcuzzi GP | 2006 | Exp Dermatol2006，15，1： | 1 |
| 3 | Targeting faraesyl-transferase as a novel therapeutic strategy for mevalonate kinase deficiency: in vitro and in vivo approaches 显示文摘 | De Leo L Marcuzzi A Decorti G | 2010 | Pharmacol Res2010，61，6： | 1 |
| 4 | Expression of-matrix metalloproteinase (MMP -2 MMP - 9 MMP - 13 and MTI - MMP ) in skin tumors of human papillom avirus type 8 transgenicmce显示文摘 | Akgul B Ptetterle R Marcuzzi GP | 2006 | Exp Dematol2006，15，1： | 1 |
| 5 | Expression of matrix metalloproteinase (MMP)-2, MMP-9, MMP-13, and MT1-MMP in skin tumors of human papillomavims Type 8 transgenic mice显示文摘 | Akgul B Pfefferle R Marcuzzi G | 2006 | Exp Dermatol2006，15，1： | 1 |
| 6 | Surgical-lnvis-align treatment of a patient with Class III malocclusion andmultiple missing teeth 显示文摘 | Marcuzzi E Galassini G Procopio O | 2010 | J Clin Orthod2010，44，6： | 1 |
| 7 | Expression of matrix metalloproteinase ( MMP)-2, MMP-9, MMP-13, and MT1- MMP in skin tumors of human papillomavirus type 8 trans- genic mice显示文摘 | Akgl B Pfefferle R Marcuzzi GP | 2006 | Exp Dermatol2006，15，1： | 1 |
| 8 | Ultrasound-guided renal biopsy: experience using an automated core biopsy system显示文摘 | Chan R Common AA Marcuzzi D | 2000 | Can Assoc Radiol J2000，51，2： | 1 |
| 9 | Curcumin and Inflammatory Bowel Dis- ease: Potential and Limits of Innovative Treatments 显示文摘 | VECCHI BRUMATTI L MARCUZZI A TRICARI- CO PM | 2014 | Molecules2014，19，： | 1 |
| 10 | Expression of matrix metallo-proteinase( MMP) -2 ,MMP-9,MMP-13,and MT1-MMP in skin tumors of humanpapillomavirus type 8 transgenicmice显示文摘 | Akgul B Pfefferle R Marcuzzi GP | 2006 | Exp Dermatol2006，15，1： | 1 |
| 11 | Expression of matrix met alloproteinase(MMP)-2,MMP-9,MMP-13,and MT1 -MMP in skin tumors of human papillomavirus type 8 transgenic mice显示文摘 | Akgul B Pfefferle R Marcuzzi GP | 2006 | Exp Dermatol2006，15，1： | 1 |
| 12 | Spontaneous tumor development in human papillonmvirus type 8 E6 transgenic mice and rapid induction by UV-light exposure and wounding 显示文摘 | Marcuzzi GP Hufbauer M Kasper HU | 2009 | J Gen Virol2009，90，12： | 1 |
| 13 | Acute posterior interosseous nerve palsy caused by a synovial haemangioma of the elbow joint 显示文摘 | Busa R Adani R Marcuzzi A | 1995 | J Hand Surg Br1995，20，： | 1 |
| 14 | An experimental study of a cyanoacrylate biological adhensive in view of its use in the fixation of various fractures of the fingers显示文摘 | Caroli A Marcuzzi A Limonini S | 1997 | Ann Chir Main Memb Super1997，16，2： | 1 |
| 15 | Mevalonate kinase deficiency and neurointlammation: balance between apoptosis and pyroptosis显示文摘 | Tricarico P M Marcuzzi A Piscianz E | 2013 | Int J Mol Sci2013，2614，23： | 1 |
| 16 | Development of skin tumors in mice transgenic for early genes of human papillomavirus type 8显示文摘 | Schaper ID Marcuzzi GP Weissenborn SJ | 2005 | Cancer Res2005，65，4： | 1 |
| 17 | Targeting farnesyl-trans- ferase as a novel therapeutic strategy for mevalonate kinase defi- ciency: in vitro and in vivo approaches 显示文摘 | De Leo L Marcuzzi A Decorti G | 2010 | Pharmacol Res2010，61，6： | 1 |
| 18 | Expression of mat metalloproteinase (MMP)-2, MMP-9, MMP13, MT1-MMP in skin tumors of human papillomavirus type ransgenic mice显示文摘 | Akgul B Pfefferle R Marcuzzi G P | 2006 | Exp Derma tol2006，15，1： | 1 |
| 19 | First application of the information theory to the study of human ecology 显示文摘 | Marcuzzi G Camuffo A | 1968 | Rivista di biologia1968，，61： | 1 |
| 20 | The human papillo-mavirus type 8E2protein induces skin tumors in transgenic mice显示文摘 | Pfefferle R Marcuzzi GP Akgul B | 2008 | J Invest Dermatol2008，128，： | 1 |
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