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| 1 | Unsuccessful oocyte retrieval: technical artefact or genuine ‘empty follicle syndrome’?显示文摘 | María Bustillo | 2004 | Reproductive BioMedicine Online2004，，1： | 1 |
| 2 | Mesenchymal stem cells from different sources and their derived exosomes: A pre-clinical perspective显示文摘Since the introduction of cell therapy as a strategy for the treatment of many diseases,mesenchymal stem cells have emerged as ideal candidates,yet the underlying mechanisms of their beneficial effects are only partially understood.At the start of the 21st century,a paracrine effect was proposed as a mechanism of tissue repair by these cells.In addition,a role was suggested for a heterogeneous population of extracellular vesicles in cell-to-cell communication.Some of these vesicles including exosomes have been isolated from most fluids and cells,as well as from supernatants of in vitro cell cultures.Recent research in the field of regenerative medicine suggests that exosomes derived from mesenchymal stem cells could be a powerful new therapeutic tool.This review examines the therapeutic potential of these exosomes obtained from the sources most used in cell therapy:bone marrow,adipose tissue,and umbilical cord. | María álvarez-Viejo | 2020 | World Journal of Stem Cells2020，12，2： | 13 |
| 3 | PDRG1 at the interface between intermediary metabolism and oncogenesis显示文摘PDRG1 is a small oncogenic protein of 133 residues. In normal human tissues, the p53 and DNA damageregulated gene 1(PDRG1) gene exhibits maximal expression in the testis and minimal levels in the liver. Increased expression has been detected in several tumor cells and in response to genotoxic stress. High-throughput studies identified the PDRG1 protein in a variety of macromolecular complexes involved in processes that are altered in cancer cells. For example, this oncogene has been found as part of the RNA polymerase Ⅱ complex, the splicing machinery and nutrient sensing machinery, although its role in these complexes remains unclear. More recently, the PDRG1 protein was found as an interaction target for the catalytic subunits of methionine adenosyltransferases. These enzymes synthesize S-adenosylmethionine, the methyl donor for, among others, epigenetic methylations that occur on the DNA and histones. In fact, downregulation of S-adenosylmethionine synthesis is the first functional effect directly ascribed to PDRG1. The existence of global DNA hypomethylation, together with increased PDRG1 expression, in many tumor cells highlights the importance of this interaction as one of the putative underlying causes for cell transformation. Here, we will review the accumulated knowledge on this oncogene, emphasizing the numerous aspects that remain to be explored. | Maríaángeles Pajares | 2017 | World Journal of Biological Chemistry2017，8，4： | 2 |
| 4 | The economics of wind energy显示文摘 | María Isabel Blanco | 2008 | Renewable and Sustainable Energy Reviews2008，，6： | 1 |
| 5 | Education is a key determinant of health in Europe:a comparative analysis of 11 countries显示文摘 | Cecilia Albert María A.Davia | | 0，，02： | 1 |
| 6 | Fiber-optic biosensors-an overview显示文摘 | | 2002 | Analytical and Bioanalytical Chemistry2002，372，56： | 1 |
| 7 | 显示文摘 | María Marazuela María Moreno-Bondi | 2002 | Analytical and Bioanalytical Chemistry (-)2002，，5： | 1 |
| 8 | Analysis of knowledge organization systems as complex systems:A new approach to deal with changes in the Web显示文摘 | Bonome María G | 2012 | Knowledge Organization2012，39，2： | 1 |
| 9 | Testing the group polarization hypothesis by using logit models显示文摘 | María F.Rodrigo ManuelAto | 2001 | Eur J Soc Psychol2001，，1： | 1 |
| 10 | Subconjunctival Bevacizumab for Corneal Neovascularization in Herpetic Stromal Keratitis显示文摘 | María Alejandra Carrasco | 2008 | Cornea2008，，6： | 1 |
| 11 | Rheological properties of acidic soybean protein gels:salt addition effect显示文摘 | María C P María C A | 1999 | Food Hydrocolloids1999，13，： | 1 |
| 12 | Increasing frequency of class 1 and 2 integrons in multidrug-resistant clones of Acinetobacter baumannii reveals the need for continuous molecular surveillance显示文摘 | María Soledad Ramírez | 2010 | International Journal of Antimicrobial Agents2010，，2： | 1 |
| 13 | UV-polymerized butyl methacrylate monoliths with embedded carboxylic single-walled carbon nanotubes for CEC applications显示文摘 | María N P A | 2014 | Analytical and Bioanalytical Chemistry2014，406，： | 1 |
| 14 | Genes and type 2 diabetes mellitus显示文摘 | María T T L | 2005 | Archives of Medical Research2005，36，3： | 1 |
| 15 | Fiber-optic biosensors--an overview显示文摘 | María Marazuela María Moreno-Bondi | 2002 | Analytical & Bioanalytical Chemistry (S1618-2642)2002，372，56： | 1 |
| 16 | The Convex-Set Algebra and Intersection Theory on the Toric Riemann–Zariski Space显示文摘In previous work of the author,a top intersection product of toric b-divisors on a smooth complete toric variety is defined.It is shown that a nef toric b-divisor corresponds to a convex set and that its top inetersection number equals the volume of this convex set.The goal of this article is to extend this result and define an intersection product of sufficiently positive toric b-classes of arbitrary codimension.For this,we extend the polytope algebra of McMullen to the so called convex-set algebra and we show that it embeds in the toric b-Chow group.In this way,the convex-set algebra can be viewed as a ring for an intersection theory for sufficiently positive toric b-classes.As an application,we show that some Hodge type inequalities are satisfied for the convex set algebra. | Ana María BOTERO | 2022 | Acta Mathematica Sinica,English Series2022，38，3： | 0 |
| 17 | Methods and management in ancient Egyptian and Greek medicine显示文摘Objective:Demonstrate that some ancient Egyptian medical treatments are still used today while Greeks appropriated many concepts that have partially disappeared.Methods:Through the study of classical authors,Egyptian papyri,ancient medical sources and historical and recent research,this article examines some neglected aspects in the traditional picture of ancient Egyptian medicine,now considered the cradle of scientific inquiry.Results:A framework of important health conditions must be highlighted in Egypt:accurate diagnosis similar to the present,training of highly skilled specialists,a health care system,greatly advanced for its time,although including magical practices and spells,because all types of healers coexisted peacefully.Hippocratic medicine also adopted Egyptian incubation,the same scientific and rational systems in patient therapy and older Egyptian ideas and remedies.The brilliant Egyptian hypothesis about gastrointestinal residuals or wxdw,a methodical approach to interpreting internal diseases,opened the road to a coherent and scientific therapy.Based on the Egyptian idea of self-intoxication through dangerous materials and of pathogenic decay that survives in the modern use of the Greek word sepsis,different Greek medical schools have been influenced and are even well developed in modern times.When they realized that putrefaction began in the intestine,they applied mummification and embalming for corpses and employed emetics,purges and enemas in patients.Greeks,by contrast,to avoid contamination,adopted dead cremation and their false humoral theory remained until the 17th century AC,as well as the false benign pus.Conclusions:Egyptian physicians,still ignoring the concept of infection or inflammation,clearly recognized local purulence and identified the presence and growth of pathogenic agents in infections.Thus,they were pioneers in solving pyogenic lesion debridement and diagnose the feverish profile of a noxious laceration,starting the prevention and control of infection used today. | Ana María Rosso | 2023 | History & Philosophy of Medicine2023，5，3： | 0 |
| 18 | 西班牙记忆——比拉尔·爱巴拉琴的艺术显示文摘比拉尔·爱巴拉琴是西班牙当代艺术圈最耀眼的女艺术家之一,同时也是凭借参加世界权威博览会,如第51届威尼斯双年展和第1届莫斯科双年展,而获得巨大国际名誉的女艺术家之一。 | María José Balcells | 2010 | 东方艺术2010，，1： | 0 |
| 19 | 成熟度和贮期对仙人掌浆果(Myrtillocactus geometrizans)酚类物质、VC、甜菜碱和抗氧化物质的影响显示文摘研究了不同成熟度与贮期对仙人掌浆果果实的颜色、总酚、甜菜碱和VC含量的影响,同时研究了这些抗氧化物质对果实总抗氧化力(TEAC)和氧自由基吸收能力(ORAC)的影响。酚采用高效液相色谱法——二极管阵列检测器(HPLC-DAD)测定。结果表明,经过贮藏后熟的果实,其颜色与成熟和过熟的果实颜色类似,而总酚和VC含量则分别下降了82.4%和68.5%,与此相反,β-花青苷含量上升了51.8%;甜菜碱的抗氧化作用在TEAC和ORAC中分别占58.4%和43.4%;没食子酸和槲皮黄酮是主要的单酚物质。这些抗氧化物质在果实中的含量和抗氧化活性可以很好地保持浆果果实的品质。 | María G.Herrera-Hernández | 2011 | 保鲜与加工2011，11，6： | 0 |
| 20 | Reactivation of hepatitis B virus infection after cytotoxic chemotherapy or immunosuppressive therapy显示文摘Reactivation of hepatitis B is defined as the recurrence or an abrupt rise in hepatitis B virus(HBV) replication,often accompanied by an increase in serum transaminase levels,and both events occurring in a patient with a previous inactive hepatitis B infection.This reactivation can occur in situations in which the ratio of HBV replication and immune response is altered.It can happen during the treatment of hemato-oncological malignancies with chemotherapy and in immunosuppression of autoimmune diseases.Clinical manifestations of hepatitis B reactivation are variable and can range from asymptomatic to acute hepatitis,which are sometimes serious and result in acute liver failure with risk of death,and usually occur in the periods between cycles or at the end of chemotherapy.Immunosuppressive drugs such as corticosteroids or azathioprine can induce HBV reactivation in patients carrying hepatitis B virus surface antigen(HBsAg) or anti-HBc,but much less frequently than chemotherapy treatments.The tumor necrosis factorαinhibitors infliximab,etanercept and adalimumab may cause reactivation of hepatitis B,and the overall frequency with infliximab may be similar(50%-66%) to that caused by chemotherapy.Baseline HBV serology is recommended for all patients receiving chemotherapy and immunosuppressive drugs,and HBsAg positive patients should receive anti-HBV prophylaxis to decrease virus reactivation and death rates. | María Luisa Manzano-Alonso Gregorio Castellano-Tortajada | 2011 | World Journal of Gastroenterology2011，17，12： | 31 |
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