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| 1 | Effects of intermittent fasting on health markers in those with type 2 diabetes:A pilot study显示文摘AIM To determine the short-term biochemical effects and clinical tolerability of intermittent fasting(IF) in adults with type 2 diabetes mellitus(T2DM).METHODS We describe a three-phase observational study(baseline 2 wk, intervention 2 wk, follow-up 2 wk) designed to determine the clinical, biochemical, and tolerability of IF in community-dwelling volunteer adults with T2DM. Biochemical, anthropometric, and physical activity measurements(using the Yale Physical Activity Survey) were taken at the end of each phase. Participants reported morning, afternoon and evening self-monitored blood glucose(SMBG) and fasting duration on a daily basis throughout all study stages, in addition to completing a remote food photography diary three times within each study phase. Fasting blood samples were collected on the final days of each study phase. RESULTS At baseline, the ten participants had a confirmed diagnosis of T2DM and were all taking metformin, and on average were obese [mean body mass index(BMI) 36.90 kg/m^2]. We report here that a short-term periodof IF in a small group of individuals with T2DM led to significant group decreases in weight(-1.395 kg, P = 0.009), BMI(-0.517, P = 0.013), and at-target morning glucose(SMBG). Although not a study requirement, all participants preferentially chose eating hours starting in the midafternoon. There was a significant increase(P < 0.001) in daily hours fasted in the IF phase(+5.22 h), although few attained the 18-20 h fasting goal(mean 16.82 ± 1.18). The increased fasting duration improved at-goal(< 7.0 mmol/L) morning SMBG to 34.1%, from a baseline of 13.8%. Ordinal Logistic Regression models revealed a positive relationship between the increase in hours fasted and fasting glucose reaching target values(χ~2 likelihood ratio = 8.36, P = 0.004) but not for afternoon or evening SMBG(all P > 0.1). Postprandial SMBGs were also improved during the IF phase, with 60.5% readings below 9.05 mmol/L, compared to 52.6% at baseline, and with less glucose variation. Neither insulin resistance(HOMAIR), nor inflammatory markers(C-reactive protein) normalized during the IF phase. IF led to an overall spontaneous decrease in caloric intake as measured by food photography(Remote Food Photography Method). The data demonstrated discernable trends during IF for lower energy, carbohydrate, and fat intake when compared to baseline. Physical activity, collected by a standardized measurement tool(Yale Physical Activity Survey), increased during the intervention phase and subsequently decreased in the follow-up phase. IF was well tolerated in the majority of individuals with 6/10 participants stating they would continue with the IF regimen after the completion of the study, in a full or modified capacity(i.e., every other day or reduced fasting hours).CONCLUSION The results from this pilot study indicate that shortterm daily IF may be a safe, tolerable, dietary intervention in T2DM patients that may improve key outcomes including body weight, fasting glucose and postprandial variability. These findings should be viewed as exploratory, and a larger, longer study is necessary to corroborate these findings. | Terra G Arnason Matthew W Bowen Kerry D Mansell | 2017 | World Journal of Diabetes2017，8，4： | 7 |
| 2 | lux基因发光菌的研究及其在食品科学中的应用显示文摘本文论述了细菌发光lux基因的研究及其在食品科学,特别是在乳品科学研究和食品工业中的应用,详细探讨了生物发光的化学机理、遗传基础及研究进展。同时,还重点探讨了lux基因发光乳球菌及影响其发光亮度(RLU)的主要因素和最新研究结果。另外,还探讨了带有lux基因噬菌体的构建原理和方法及在食品科学中的应用。 | 蒋爱民 魏素红 Wang Haifeng Griffiths Mansel W 杨公明 李元瑞 | 2003 | 中国食品学报2003，3，2： | 5 |
| 3 | Hepatocyte growth factor modulates vascular endothelial cadherin expression in human endothelial cells显示文摘 | MARTIN T A MANSEL R JIANG W G | 2001 | Clin Cancer Res2001，7，： | 1 |
| 4 | 浓缩苹果汁中扩展青霉菌实时PCR快速检测条件的优化显示文摘为了研究苹果汁生产中棒曲霉素产生菌的快速检测,利用实时PCR方法快速检测扩展青霉的可能性,对扩增条件进行优化。在polygatacturonase基因引物设计和传统PCR扩增扩展青霉DNA的基础上,研究实时PCR扩增时退火温度、引物浓度以及底物质量浓度对扩增效果的影响,以获得最佳的参数。结果表明,用Lightercy-cler实时PCR扩增扩展青霉DNA的最佳退火温度为61℃,最佳引物浓度为0.20-0.40μmol/L,底物质量浓度对实时PCR扩增的影响较小。在以上参数下,可以获得良好的PCR扩增曲线、产物溶解曲线以及清晰的产物条带。研究获得的快速检测扩展青霉的实时PCR参数,可用于浓缩苹果汁工业化生产中扩展青霉的快速检测,也可作为其他微生物实时PCR检测时的方法学参考。 | 樊明涛 毕静莹 刘邻渭 Mansel W Graffith Haifeng Wang | 2007 | 西北农林科技大学学报(自然科学版)2007，35，11： | 1 |
| 5 | benetie manipulation of stromal cell-derived-factor-2 attests the pivotal role of theAutoorine SDF-1-CXCR4 pathway in the aggressiveness of breast cancer cells显示文摘 | Kang H Mansel R E Jiang W G | 2005 | Int J Oncol2005，26，5： | 1 |
| 6 | Aberrant ex-pression of 5-lipoxygenase-activating protein(5-LOXAP)hasprognostic and survival significance in patients with breastcancer显示文摘 | Jiang W G Douglas-Jones A G Mansel R E | 2006 | Prostaglandins Leukot Essent Fatty Acids2006，74，2： | 1 |
| 7 | Aberrant expression of 5-lipoxygenase-Activation protein (5- LOXAP) has prognostic and survival significance in patients with breast cancer显示文摘 | Jiang W G Douglas-Jones A G Mansel R E | 2006 | Prostaglandins Leukot Essent Fatty Acid2006，72，2： | 1 |
| 8 | The dental cognitions questionnaire in CBT for dental phobia in an adolescent with multiple phobias 显示文摘 | W Mansell M Kathleen | 2003 | J Behav Ther Exp Psychiatry2003，34，： | 1 |
| 9 | The ascent into mania: A review of psychological processes associated with the development of manic symptoms显示文摘 | Mansell W Pedley R | 2008 | Clin Psychol Rev2008，28，： | 1 |
| 10 | A preliminary study of autobiographical memory in remitted bipolar and unipolar depression and role of imagery in the specificity of memory 显示文摘 | Mansell W Lam D | 2004 | Memory2004，12，： | 1 |
| 11 | Perfectionism and psychopathology: A review of research and treatment显示文摘 | Shafran R Mansell W | 2001 | Clinical Psychology Review2001，21，6： | 1 |
| 12 | Perfectionism and psychopathology: a review of research and treatment显示文摘 | Shafran R Mansell W | 2001 | Clin Psyehol Rev2001，21，6： | 1 |
| 13 | Effect of environmental and chemotactic stimuli on the activity of the Campylobacter jejuin flaA d28 promoter显示文摘 | Kevin J A Mansel W G | 2001 | FEMS Microbiology Letters2001，205，： | 1 |
| 14 | E-cadherin Complex and Its Abnormalities in Human Breast Cancer显示文摘 | Jiang W G Mansel R E | 2000 | Surg Oncol2000，9，： | 1 |
| 15 | The mRNA expression of SATB1 and SATB2 in human breast cancer显示文摘 | Patani N Jiang W Mansel R | 2009 | Cancer Cell Int2009，9，： | 1 |
| 16 | Molecular and cellular mechanisms of lymphangiogenesis显示文摘 | AL-RAWI M A MANSEL R E JIANG W G | 2005 | Eur J Surg Oncol2005，31，2： | 1 |
| 17 | A variational model for the arrest of projectiles by woven cloth and nets 显示文摘 | Hearle J W S Mansell J | 1979 | J Textile Ist1979，70，11： | 1 |
| 18 | Perfectionism and psychopathology: a revie- w of research and treatment 显示文摘 | Shafran R Mansell W | 2001 | Clin Psychol Rev2001，21，6： | 1 |
| 19 | The dental congnitions questionnaire in CBT for dental phobia in an adolescent with multiple phobias显示文摘 | Mansell W Morris K | 2003 | Journal of Behavior Therapy and Experimental Psychiatry2003，，3： | 1 |
| 20 | The mRNA expression of SATB1 and SATB2 in human breast cancer显示文摘 | Patani N Tiang W Mansel R | 2009 | Cancer Cell Int2009，9，1： | 1 |
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