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| 1 | Effects of Helicobacterpyloriinfection on gastric emptying rate in patients with non-ulcer dyspepsia显示文摘AIM: The pathogenesis of delayed gastric emptying in patients with non-ulcer dyspepsia (NUD) remains unclear. We aimed to examine whether gastric emptying rate in NUD patients was associated with Helicobacterpylori(Hpylori) infection and whether it was affected by eradication of the infection. METHODS: Gastric emptying rate of a mixed solid-liquid meal was assessed by the paracetamol absorption method in NUD patients and asymptomatic controls (n=-17). Hpylori status was assessed by serology and biopsy urease test. Hpylori-positive NUD patients (n=-23) received 10-day triple eradication therapy. H pylori status was re-assessed by biopsy urease test four weeks later, and if eradication was confirmed, gastric emptying rate was re-evaluated. RESULTS: Thirty-three NUD patients and 17 controls were evaluated. NUD patients had significantly delayed gastric emptying compared with controls. The mean maximum plasma paracetamol concentration divided by body mass (Cmax/BM) was 0.173 and 0.224 mg/L.kg respectively (P=0.02), the mean area under plasma paracetamol concentration-time curve divided by body mass (AUC/BM) was 18.42 and 24.39 mg.min/L.kg respectively (P=-0.01). Gastric emptying rate did not differ significantly between H pylori-positive and H pylori-negative NUD patients. The mean Cmax/BM was 0.172 and 0.177 mg/Ukg respectively (P=-0.58), the mean AUC/BM was 18.43 and 18.38 rag.min/L.kg respectively (P=0.91). Among 14 NUD patients who were initially H pylori-positive, confirmed eradication of the infection did not significantly alter gastric emptying rate. The mean Cmax/BM was 0.171 and 0.160 mg/Ukg before and after Hp eradication, respectively (P=0.64), the mean AUC/BM was 17.41 and 18.02 mg.min/Ukg before and after eradication, respectively (P=-0.93). CONCLUSION: Although gastric emptying is delayed in NUD patients compared with controls, gastric emptying rate is not associated with H pylori status nor it is affected by eradication of the infection. | Grigoris I Leontiadis George I Minopoulos Efstratios Maltezos Stamatia Kotsiou Konstantinos I Manolas Konstantinos Simopoulos Dimitrios Hatseras | 2004 | World Journal of Gastroenterology2004，10，12： | 9 |
| 2 | Awake Systolic Blood Pressure Variability Correlates With Target-Organ Damage in Hypertensive Subjects显示文摘 | Alfonso Tatasciore Giulia Renda Marco Zimarino Manola Soccio Grzegorz Bilo Gianfranco Parati Giuseppe Schillaci Raffaele De Caterina | 2007 | Hypertension2007，，2： | 3 |
| 3 | Conservative laser microsurgery for T1 glottic carcinoma显示文摘 | MANOLA M MOSCILLO L COSTA G | 2008 | Auris Nasus Larynx2008，35，： | 1 |
| 4 | Phase 111 study of interferon alfa-NL as adjuvant treatment for resectable renal cell carcinoma: an Eastern Cooperative Oneology Group/ Intergroup trial显示文摘 | Messing EM Manola J Wilding G | 2003 | J Clin Oncol2003，21，7： | 1 |
| 5 | TP53 mutations and survival in squamous-cell carcinoma of the head and neck显示文摘 | Poeta ML Manola J Goldwasser MA | 2007 | N Engl J Med2007，357，25： | 1 |
| 6 | Cytogenetic abnormalities in acute leukaemia of ambiguous lineage: an overview显示文摘 | Manola KN | 2013 | BrJ Haematol2013，163，1： | 1 |
| 7 | Technologies for a web object model显示文摘 | Frank Manola | 1999 | IEEE Internet Computing1999，1999，： | 1 |
| 8 | The Ligamp TP53 Assay for Detection of Minimal Residual Disease in Head and Neck Squamous Cell Carcinoma Surgical Margins显示文摘 | Poeta ML Manola J Goldenberg D | 2009 | Clin Cancer Res2009，15，24： | 1 |
| 9 | Immediate hormonal therapy compared with observation after radical prostatectomy and pelvic lymphadenectomy in men with node-positive prostate cancer显示文摘 | Messing EM Manola J Sarosdy M | 1999 | N Engl J Med1999，341，24： | 1 |
| 10 | Btype natriuretic peptide as predictor of heart failure in patients with acute ST elevation myocardial infarction, single-vessel disease, and complete revascularization: follow-up study显示文摘 | Manola S Pavlovic N Radebic V | 2009 | Croat Med J2009，50，5： | 1 |
| 11 | Cisplatin-based therapy for elderly patients with advanced non-small-cell lung cancer: implications of eastern cooperative oncology group 5592, a randomized trial显示文摘 | Langer CJ Manola J Bernardo P | 2002 | J Natl Cancer Inst2002，94，3： | 1 |
| 12 | Her - 2 - neu expression and progression toward androgen independence in human prostate cancer显示文摘 | Signoretti S Monfironi R Manola J | 2000 | J Nail Cancer Inst2000，92，23： | 1 |
| 13 | Blood-based bio- markers of SU11248 activity and clinical outcome in pa- tients with metastatic imatinib-resistant gastrointestinal stro- mal tumor 显示文摘 | Norden-Zfoni A Desai J Manola J | 2007 | Clin Cancer Res2007，13，9： | 1 |
| 14 | Phase Ill study of interferon alfa-NL as adjuvant treatment for resectable renal ceil carcinoma: an eastern cooperative oncology group/intergroup trial显示文摘 | MESSING EM MANOLA J WILDING G | 2003 | J Clin Oncol2003，21，7： | 1 |
| 15 | Conservative laser microsurgery for T1 glottic carcinoma显示文摘 | Manola M Moscillo L Costa G | 2008 | Auris Nasus Lar- ynx2008，35，1： | 1 |
| 16 | Cisplain-based therapy for elderly patients with advanced non-small cell lung cancer:implications of eastern cooperative oncology group 5592,a randomized trial显示文摘 | Langer CJ Manola J Bernardo P | 2002 | J Natl Cancer Inst2002，94，： | 1 |
| 17 | A pooled analysis of eastern cooperative oncology group and intergroup trials of adjuvant high- dose interferon for melanoma 显示文摘 | Kirkwood JM Manola J Ibrahim J | 2004 | Clin Cancer Res2004，10，5： | 1 |
| 18 | Immediate versus def-erred androgen deprivation treatment in patients with node-positiveprostate cancer after radical prostatectomy and pelvic lymphadenec-tomy显示文摘 | MESSING E M MANOLA J YAO J | 2006 | Lancet Oncol2006，7，6： | 1 |
| 19 | A research progress review on regional extreme events显示文摘An extreme (weather and climate) event does not only mean that an extreme occurs at a location, but more generally it can impact a certainarea and last a certain period of time, which is defined as a regional extreme event (REE) with a certain impacted area and duration. The conceptof REE has been defined to allow mainly objective assessment of the events without a pre-determined boundary and duration. This paper reviewsthe studies on REEs published during the past 20 years, especially recent years. Mainly in view of methodology, these studies can be divided intothree types studies focusing on spatial simultaneity, studies focusing on temporal persistence, and studies identifying REEs. The methodsidentifying REEs include two kinds, e.g., type-I methods stressing REE's temporal persistence within a relatively certain area and type-IImethods focusing on catching a complete REE. Identification methods proposed in this paper could provide valuable information for variouspurposes, such as real-time monitoring, estimating long-term changes, mechanism diagnosis, forecasting study and even attribution analysis.Research on REEs is important for objectively defining extreme weather and climate events, which depends on the spatial and temporal scales ofinterest. Such an objective definition will support ongoing climate monitoring and improve the assessment of how regional extreme events havechanged over time. | REN Fu-Min Blair TREWIN Manola BRUNET Pattanaik DUSHMANTA Andreas WALTER Omar BADDOUR Maya KORBER | 2018 | Advances in Climate Change Research2018，9，3： | 1 |
| 20 | A pooled analysis of Eastern Cooperative Oncology Group and intergroup trials of adjuvant high-dose interferon for melanoma显示文摘 | Kirkwood JM Manola J Ibrahim J | 2004 | Clin Cancer Res2004，10，： | 1 |
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