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| 1 | Methanolic extract of Momordica cymbalaria enhances glucose uptake in L6 myotubes in vitro by up-regulating PPAR-γ and GLUT-4显示文摘The present study was undertaken to evaluate the influence of the methanolic fruit extract of Momordica cymbalaria(MFMC) on PPARγ(Peroxisome Proliferator Activated Receptor gamma) and GLUT-4(Glucose transporter-4) with respect to glucose transport. Various concentrations of MFMC ranging from 62.5 to 500 μg·mL-1 were evaluated for glucose uptake activity in vitro using L6 myotubes, rosiglitazone was used as a reference standard. The MFMC showed significant and dose-dependent increase in glucose uptake at the tested concentrations, further, the glucose uptake activity of MFMC(500 μg·mL-1) was comparable with rosigilitazone. Furthermore, MFMC has shown up-regulation of GLUT-4 and PPARγ gene expressions in L6 myotubes. In addition, the MFMC when incubated along with cycloheximide(CHX), which is a protein synthesis inhibitor, has shown complete blockade of glucose uptake. This indicates that new protein synthesis is required for increased GLUT-4 translocation. In conclusion, these findings suggest that MFMC is enhancing the glucose uptake significantly and dose dependently through the enhanced expression of PPARγ and GLUT-4 in vitro. | Puttanarasaiah Mahesh Kumar Marikunte V Venkataranganna Kirangadur Manjunath Gollapalle L Viswanatha Godavarthi Ashok | 2014 | Chinese Journal of Natural Medicines2014，12，12： | 2 |
| 2 | Morphologieal Variations of the Lung Fissures and Lobes 显示文摘 | Meenakshi S Manjunath KY Balasubramanyam V | 2004 | Indian J Chest Dis Allied Sci2004，46，3： | 1 |
| 3 | Color and texture descriptors 显示文摘 | Manjunath B S Ohm J R Vasudvan V V | 2001 | IEEE Transactions on Circuits and Systems for Video Technology2001，11，6： | 1 |
| 4 | Pharmacokinetics,tissue distribution and bioavailability of clozap ine solid lip id nanoparticles afterintravenous and intraduodenal administration显示文摘 | Manjunath K Venkateswarlu V | 2005 | J Controlled Release2005，107，23： | 1 |
| 5 | Characterization,and in vitro and in vivo evaluation of lovastatin solid lipid nanoparticles显示文摘 | Suresh G Manjunath K Venkateswarlu V | 2007 | AAPS Pharm Sci Tech2007，8，1： | 1 |
| 6 | Significance of free radical injury in laryngeal and hypopharyngeal cancers显示文摘 | MANJUNATH M K ANNAM V SURESH D R | 2010 | Laryngol Otol2010，124，： | 1 |
| 7 | Preparation,characterization and in vitro release kinetics of clozapine solid lipid nanopartides显示文摘 | Venkateswarlu V Manjunath K | 2004 | J Control Rel2004，95，3： | 1 |
| 8 | Color and texture descriptors 显示文摘 | Manjunath B S Ohm Jens-Rainer Vasudevan Vinod V | 2001 | IEEE Transactions on Circuits and Systems for Video Technology2001，11，6： | 1 |
| 9 | Carcinosarcoma of the urinary bladder I an ag- gressive tumor with diverse histogenesis 显示文摘 | DMITRY Y B JANNY H C MANJUNATH S V | 2000 | Arch Path Lab Med2000，124，： | 1 |
| 10 | Color and texture descriptors显示文摘 | MANJUNATH B S VASUDEVAN V V | 2001 | IEEE Transactions on Circuits and Systems for Video Technology2001，11，6： | 1 |
| 11 | Color and text descriptors显示文摘 | Manjunath B S Ohm J R Vasudevan V V | 2001 | IEEE Circuit and System for Video Technology2001，11，6： | 1 |
| 12 | Color and texture de- scriptors显示文摘 | Manjunath B S Ohm J R Vasudevan V V | 2001 | IEEE Transactions on Circuits and Systems for Video Technology2001，11，6： | 1 |
| 13 | Color and texture descriptors 显示文摘 | Manjunath B S Ohm J R Vasudevan V V | 2001 | Circuits & Systems for Video Technology IEEE Transactions on2001，11，6： | 1 |
| 14 | Color and texture deseriptors显示文摘 | Manjunath B S Ohm J R Vasudevan V V | 2001 | IEEE Trans CSVT2001，11，6： | 1 |
| 15 | Color and texture descriptors 显示文摘 | MANJUNATH B S OHM J R VASUDEVAN V V | 2001 | IEEE Transaction on Circuits and System for Video Technology2001，11，6： | 1 |
| 16 | Experimental and numerical studies of geosynthetic-reinforced sand slopes loaded with a footing 显示文摘 | Lee K M Manjunath V R | 2000 | Canadian Geotechnical Journal2000，37，4： | 1 |
| 17 | Experimental and numerical studies of geosynthetic-reinforced sand slopes loaded with a footing显示文摘 | Lee K M Manjunath V R | 2000 | Canadian Geotechnical Journal2000，37，4： | 1 |
| 18 | Skew Detection Technique for Binary Document Images based on Hough Transform 显示文摘 | Manjunath Aradhya V N Hemantha Kumar G and Shivakumara P | 2006 | International Journal of Information Technology2006，3，1： | 1 |
| 19 | Varia- tions of the location of the greater palatine foramina in dry human skulls显示文摘 | Sujatha N Manjunath KY Balasubramanyam V | 2005 | Indian J Dent Res2005，16，3： | 1 |
| 20 | Pharmaeokineties, tissue distri bution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration 显示文摘 | Manjunath K Venkateswarlu V | 2005 | J Contro Release2005，107，2： | 1 |
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