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| 1 | Burden of Clostridium difficile infection between 2010 and 2013:Trends and outcomes from an academic center in Eastern Europe显示文摘AIM:To analyze the incidence and possible risk factors in hospitalized patients treated with Clostridium difficile infection(CDI).METHODS:A total of 11751 patients were admitted to our clinic between 1 January 2010 and 1 May2013.Two hundred and forty-seven inpatients were prospectively diagnosed with CDI.For the risk analysis a 1:3 matching was used.Data of 732 patients matched for age,sex,and inpatient care period and unit were compared to those of the CDI population.Inpatient records were collected from an electronic hospital database and comprehensively reviewed.RESULTS:Incidence of CDI was 21.0/1000 admissions(2.1%of all-cause hospitalizations and 4.45%of total inpatient days).The incidence of severe CDI was 12.6%(2.63/1000 of all-cause hospitalizations).Distribution of CDI cases was different according to the unit type,with highest incidence rates in hematology,gastroenterology and nephrology units(32.9,25 and24.6/1000 admissions,respectively) and lowest rates in 1.4%(33/2312) in endocrinology and general internal medicine(14.2 and 16.9/1000 admissions)units.Recurrence of CDI was 11.3%within 12 wk after discharge.Duration of hospital stay was longer in patients with CDI compared to controls(17.6 ± 10.8d vs 12.4 ± 7.71 d).CDI accounted for 6.3%of allinpatient deaths,and 30-d mortality rate was 21.9%(54/247 cases).Risk factors for CDI were antibiotic therapy[including third-generation cephalosporins or fluoroquinolones,odds ratio(OR) = 4.559;P < 0.001],use of proton pump inhibitors(OR = 2.082,P< 0.001),previous hospitaiization within 12 mo(OR = 3.167,P < 0.001),previous CDI(OR = 15.32;P < 0.001),while presence of diabetes mellitus was associated with a decreased risk for CDI(OR = 0.484;P< 0.001).Treatment of recurrent cases was significantly different from primary infections with more frequent use of vancomycin alone or in combination(P < 0.001),and antibiotic therapy duration was longer(P < 0.02).Severity,mortality and outcome of primary infections and relapsing cases did not significantly differ.CONCLUSION:CDI was accounted for significant burden with longer hospitaiization and adverse outcomes.Antibiotic,PPI therapy and previous hospitaiization or CDI were risk factors for CDI. | Zsuzsanna Kurti Barbara D Lovasz Michael D Mandel Zoltan Csima Petra A Golovics Bence D Csako Anna Mohas Lorant Gnczi Krisztina B Gecse Lajos S Kiss Miklos Szathmari Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，21： | 6 |
| 2 | Inflammatory bowel disease course in Crohn's disease:Is the natural history changing?显示文摘Crohn’s disease(CD)is a multifactorial potentially debilitating disease.It has a variable disease course,but the majority of patients eventually develop penetrating or stricturing complications leading to repeated surgeries and disability.Studies on the natural history of CD provide invaluable data on its course and clinical predictors,and may help to identify patient subsets based on clinical phenotype.Most data are available from referral centers,however these outcomes may be different from those in population-based cohorts.New data suggest the possibility of a change in the natural history in Crohn’s disease,with an increasing percentage of patients diagnosed with inflammatory disease behavior.Hospitalization rates remain high,while surgery rates seem to have decreased in the last decade.In addition,mortality rates still exceed that of the general population.The impact of changes in treatment strategy,including increased,earlier use of immunosuppressives,biological therapy,and patient monitoring on the natural history of the disease are still conflictive.In this review article,the authors summarize the available evidence on the natural history,current trends,and predictive factors for evaluating the disease course of CD. | Petra A Golovics Michael D Mandel Barbara D Lovasz Peter L Lakatos | 2014 | World Journal of Gastroenterology2014，20，12： | 2 |
| 3 | Prevalence and predictors of hospitalization in Crohn's disease in a prospective population-based inception cohort from 2000-2012显示文摘AIM: To analyze the prevalence, length and predictors of hospitalization in the biological era in the populationbased inception cohort from Veszprem province.METHODS: Data of 331 incident Crohn's disease(CD) patients diagnosed between January 1, 2000 and December 31, 2010 were analyzed(median age at diagnosis: 28; IQR: 21-40 years). Both in- and outpatient records were collected and comprehensively reviewed.RESULTS: Probabilities of first CD-related hospitalization and re-hospitalization were 32.3%, 45.5%,53.7% and 13.6%, 23.9%, 29.8%, respectively after one, three and five years of follow-up in Kaplan-Meier analysis. First-year hospitalizations were related to diagnostic procedures(37%), surgery or disease activity(27% and 21%). Non-inflammatory disease behavior at diagnosis(HR = 1.32, P = 0.001) and perianal disease(HR = 1.47, P = 0.04) were associated with time to first CD-related hospitalization, while disease behavior change(HR = 2.38, P = 0.002) and need for steroids(HR = 3.14, P = 0.003) were associated with time to first re-hospitalization in multivariate analyses.Early CD-related hospitalization(within the year of diagnosis) was independently associated with need for immunosuppressives(OR = 2.08, P = 0.001) and need for surgeries(OR = 7.25, P < 0.001) during the disease course.CONCLUSION: Hospitalization and re-hospitalization rates are still high in this cohort, especially during the first-year after the diagnosis. Non-inflammatory disease behavior at diagnosis was identified as the pivotal predictive factor of both hospitalization and rehospitalization. | Petra A Golovics Laszlo Lakatos Michael D Mandel Barbara D Lovasz Zsuzsanna Vegh Zsuzsanna Kurti Istvan Szita Lajos S Kiss Tunde Pandur Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 4 | Recent advances in cellulose technology显示文摘 | Mandel M Steinberg D | 1976 | Journal of Fermentation Technology1976，54，4： | 1 |
| 5 | Modeling of resin transfer molding of composite materials with oriented unidirectional plies显示文摘 | CAIRNS D S HUMBERT D R MANDELL J F | 1999 | Composites Part A:Applied Science and Manufacturing1999，30，3： | 1 |
| 6 | Mutiply attenuated lentiviral vector achieved efficient gene delivery in vivo显示文摘 | Zufferey R Nagy D Mandel RJ | 1997 | Nat Biotechnol1997，15，9： | 1 |
| 7 | Gastric colonization by Gram-negative bacilli and nosocomial pneumonia in the intensive care unit patient:evidence for causation显示文摘 | Heyland D Mandell LA | | 0，，： | 1 |
| 8 | Polymorphonuclear neutrophils: an effeetive antimierobial force 显示文摘 | SAWYER D W ODNOVITZ G R MANDELL G L | 1989 | Rev Infect1989，11，15： | 1 |
| 9 | Recent advance in cellulase technology 显示文摘 | MANDELS M STERNBERG D | 1976 | J Ferment Technol1976，54，： | 1 |
| 10 | Activation of mitogen- activated protein kinase associated with prostate cancer progression显示文摘 | Gioeli D Mandell JW Petroni GR | 1999 | Cancer Res1999，59，2： | 1 |
| 11 | Recent advances in cellulose technology显示文摘 | MANDELS M STERNBERG D | 1976 | J Ferment Technol1976，54，4： | 1 |
| 12 | Activation of mitogen-activate protein kinase associated with prostate cancer progression显示文摘 | Gioeli D Mandell J W Petroni G R | 1999 | Cancer Res1999，59，2： | 1 |
| 13 | The immunosuppressive effect of type Ⅱ mouse interferon preparations on antibody production显示文摘 | Sonnenfeld G Mandel A D Merigan T C | 1977 | Cell Immunol1977，34，2： | 1 |
| 14 | Time and dosage dependence of immunoenhancement by murine type Ⅱ interferon preparations显示文摘 | Sonnenfeld G Mandel A D Merigan T C | 1978 | Cell Immunol1978，40，2： | 1 |
| 15 | Auxin regulates the initiation and radial position of plant lateral organs 显示文摘 | Reinhardt D Mandel T Kuhlemeier C | 2000 | Plant Cell2000，12，4： | 1 |
| 16 | Regulated protein expression for in vivo gene therapy for neurological disor- ders: progress, strategies, and issues显示文摘 | Manfredsson F P Bloom D C Mandel R J | 2012 | Neurobiol Dis2012，48，2： | 1 |
| 17 | Non PUVA non- surgical therapies for vitiligo显示文摘 | Mandel AS Haberman HF Pawlowski D | 1997 | Clin Dermatol1997，15，6： | 1 |
| 18 | Critical role of chromium(Cr)-DNA interactions in the formation of Cr-induced polymerase arresting lesions显示文摘 | O'Brien T Mandel H G Pritchard D E | 2002 | Biochemistry2002，41，12： | 1 |
| 19 | Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo显示文摘 | Zufferey R Nagy D Mandel R J | 1997 | Nat Biotechnol1997，15，9： | 1 |
| 20 | Recent advances in cellulose technology 显示文摘 | Mandels M Sternbrg D | 1976 | J Ferment Technol1976，54，4： | 1 |
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