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| 1 | microRNA-455-5p alleviates neuroinflammation in cerebral ischemia/reperfusion injury显示文摘Neuroinflammation is a major pathophysiological factor that results in the development of brain injury after cerebral ischemia/reperfusion.Downregulation of microRNA(miR)-455-5p after ischemic stroke has been considered a potential biomarker and therapeutic target for neuronal injury after ischemia.However,the role of miR-455-5p in the post-ischemia/reperfusion inflammatory response and the underlying mechanism have not been evaluated.In this study,mouse models of cerebral ischemia/reperfusion injury were established by transient occlusion of the middle cerebral artery for 1 hour followed by reperfusion.Agomir-455-5p,antagomir-455-5p,and their negative controls were injected intracerebroventricularly 2 hours before or 0 and 1 hour after middle cerebral artery occlusion(MCAO).The results showed that cerebral ischemia/reperfusion decreased miR-455-5p expression in the brain tissue and the peripheral blood.Agomir-455-5p pretreatment increased miR-455-5p expression in the brain tissue,reduced the cerebral infarct volume,and improved neurological function.Furthermore,primary cultured microglia were exposed to oxygen-glucose deprivation for 3 hours followed by 21 hours of reoxygenation to mimic cerebral ischemia/reperfusion.miR-455-5p reduced C-C chemokine receptor type 5 mRNA and protein levels,inhibited microglia activation,and reduced the production of the inflammatory factors tumor necrosis factor-αand interleukin-1β.These results suggest that miR-455-5p is a potential biomarker and therapeutic target for the treatment of cerebral ischemia/reperfusion injury and that it alleviates cerebral ischemia/reperfusion injury by inhibiting C-C chemokine receptor type 5 expression and reducing the neuroinflammatory response. | Jian-Song Zhang Pin-Pin Hou Shuai Shao Anatol Manaenko Zhi-Peng Xiao Yan Chen Bing Zhao Feng Jia Xiao-Hua Zhang Qi-Yong Mei Qin Hu | 2022 | Neural Regeneration Research2022，17，8： | 2 |
| 2 | Beneficial effect of hy- perbaric oxygenation after neonatal germinal matrix hemor- rhage显示文摘 | Lekic T Manaenko A Rolland W | 2011 | Acta Neurochir Suppl2011，111，9： | 1 |
| 3 | PAR-1 antagonist SCH79797 ameliorates apoptosis following surgical brain injury through inhibition of ASK1-JNK in rats显示文摘 | Manaenko A Sun XJ Kim CH | 2013 | Neurobiol Dis2013，50，： | 1 |
| 4 | FTY720 is neuroprotective and improves functional outcomes after intracerebral hemorrhage in mice 显示文摘 | ROLLAND W B 2ND MANAENKO A LEKIC T | 2011 | Acta Neurochir Suppl2011，111，2： | 1 |
| 5 | Arginine-vasopressin Via receptor inhibition improves neurologic outcomes following an intracerebral hemorrhagic brain injury显示文摘 | Manaenko A Fathali N Khatibi NH | 2011 | Neurochem Int2011，58，： | 1 |
| 6 | Post-treatment with SR49059 improves outcomes following an intracerebral hemorrhagic stroke in mice显示文摘 | Manaenko A Fathali N Khatibi NH | 2011 | Acta Neurochir Suppl2011，111，： | 1 |
| 7 | Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model显示文摘 | Chen CH Manaenko A Zhan Y | 2010 | Neuroscience2010，169，1： | 1 |
| 8 | Comparison of different preclinical models of intracerebral hemorrhage显示文摘 | Manaenko A Chen H Zhang JH | 2011 | Acta Neurochir Suppl2011，111，： | 1 |
| 9 | Activation of dopamine D2 receptor suppresses neuroinflammation throughαBcrystalline by inhibition of NF-κB nuclear translocation in experimental ICH mice model显示文摘 | Zhang Y Chen YJ Wu J Manaenko A Yang P Tang JP | 2015 | Stroke2015，46，9： | 1 |
| 10 | 37 nicotinic acetyl- choline receptor agonist PNU-282987 attenuates early brain injury in a perforation model of subarachnoid hem- orrhage in rats显示文摘 | Duris K Manaenko A Suzuki H | 2011 | Stroke2011，42，12： | 1 |
| 11 | Fl'Y720 is neuroprotective and improves functional outcomes after intracerebral hemorrhage in mice 显示文摘 | ROLLAND W 2ND MANAENKO A LEKIC T | 2011 | Acta Neurochir Suppl2011，111，： | 1 |
| 12 | Liraglutide,a long-acting GLP-1 mimetic,and its metabolite attenuate inflammation after intracerebral hemorrhage显示文摘 | Hou J Manaenko A Hakon J | 2012 | J Cereb Blood Flow Metab2012，32，12： | 1 |
| 13 | Liraglutide, a long-acting GLP-1 mimetic, and its metabolite attenuate inflammation after intracerebral hemorrhage显示文摘 | HOUJ MANAENKO A HAKON J | 2012 | J Cereb Blood Flow Metab2012，32，12： | 1 |
| 14 | Hyperbaric oxygen therapy for post concussion symptoms: issues may affect the results 显示文摘 | Hu Q Manaenko A Guo Z | 2015 | Medical gas research2015，5，： | 1 |
| 15 | Protective effect of hydrogen gas therapy after germinal matrix hemorrhagein neonatal rats 显示文摘 | Lekic T Manaenko A Rolland W | 2011 | Acta Neurochir Suppl2011，111，： | 1 |
| 16 | Liraglutide, a long-acting GLP-1 mimetic, and its metabolite attenuate inflammation after in- tracerebral hemorrhage 显示文摘 | Hou J Manaenko A Hakon J | 2012 | J Cereb Blood Flow Metab2012，32，： | 1 |
| 17 | Combined systemic thrombolysis with alteplase and early hyperbaric oxygen therapy in experimental embolic stroke in rats: relationship to functional out- come and reduction of structural damage 显示文摘 | Kuppers-Tiedt L Manaenko A Michalski D | 2011 | Acta Neurochir Suppl2011，111，： | 1 |
| 18 | Rodent neonatal germinal matrix hemorrhage mimics the human brain inju- ry, neurological consequences, and post-hemorrhagic hydro- cephalus 显示文摘 | Lekic T Manaenko A Rolland W | 2012 | Exp Neurol2012，236，1： | 1 |
| 19 | Rodent neonatal germinal matrix hemorrhage mimics the human brain injury,neurological consequences,and post-hemorrhagic hydrocephalus显示文摘 | Lekic T Manaenko A Rolland W | 2012 | Exp Neurol2012，236，1： | 1 |
| 20 | Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model显示文摘 | Chen CH Manaenko A Zhan Y | 2010 | Neuroscience2010，169，3： | 1 |
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