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	题名	作者	年代	出处	被引量
1	Divergent expression of bacterial wall sensing toll-like receptors 2 and 4 in colorectal cancer显示文摘AIM To characterize the expression of toll-like receptors(TLR) 2 and 4 in colorectal cancer(CRC) and in normal colorectal mucosa.METHODS We analysed tissue samples from a prospective series of 118 unselected surgically treated patients with CRC. Sections from formalin fixed, paraffin embedded specimens were analysed for TLR2 and TLR4 expression by immunohistochemistry. Two independent assessors evaluated separately expression at the normal mucosa, at the invasive front and the bulk of the carcinoma, and in the lymph node metastases when present. Expression levels in different locations were compared and their associations with clinicopathological features including TNM-stage and the grade of the tumour and 5-year follow-up observations were analysed.RESULTS Normal colorectal epithelium showed a gradient of expression of both TLR2 and TLR4 with low levels in the crypt bases and high levels in the surface. In CRC, expression of both TLRs was present in all cases and in the major proportion of tumour cells. Compared to normal epithelium, TLR4 expression was significantly weaker but TLR2 expression stronger in carcinoma cells. Weak TLR4 expression in the invasive front was associated with distant metastases and worse cancerspecific survival at 5 years. In tumours of the proximal colon the cancer-specific survival at 5 years was 36.9% better with strong TLR4 expression as compared with those with weak expression(P = 0.044). In contrast, TLR2 expression levels were not associated with prognosis. Tumour cells in the lymph node metastases showed higher TLR4 expression and lower TLR2 expression than cells in primary tumours.CONCLUSION Tumour cells in CRC show downregulation of TLR4 and upregulation of TLR2. Low expression of TLR4 in the invasive front predicts poor prognosis and metastatic disease.	Karoliina Paarnio Sara Vayrynen Kai Klintrup Pasi Ohtonen Markus J Makinen Jyrki Makela Tuomo J Karttunen	2017	World Journal of Gastroenterology2017，23，26：	8
2	Hantavirus nucleocapsid protein interacts with the Fas-mediated apoptosis enhancer Daxx显示文摘	Li X D Makela T P Guo D	2002	J Gen Virol2002，83，4：	2
3	Vaccines,coming of age after 200 years 显示文摘	Makela P H	2000	FEMS Microbiology Review2000，24，：	1
4	Ligans and flavonoids inhibit aromatase enzyme in human preadipocytes 显示文摘	Wang C F Makela T Hase T	1994	J Steriod Biochem Mol Biol1994，50，：	1
5	IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization 显示文摘	Makela MJ Kanehiro A Borish L	2000	Proc Natl Acad Sci USA2000，97，11：	1
6	Differentiation between vasculoprotective and uterotrophic effects of ligands with different binding affinities to estrogen receptors alpha and beta显示文摘	Savolainen H Aavik E etal	1999	Proc Natl Acad Sci USA1999，96，12：	1
7	IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization显示文摘	MAKELA M J KANEHIRO A BORISH L	2000	Proc Natl Acad Sci USA2000，97，11：	1
8	Detection of intracranial aneurysms with two-dimensional and three-dimensional multislice helical computed tomographic angiography 显示文摘	Kangasniemi M Makela T Koskinen S	2004	Neurosurgery2004，54，5：	1
9	Effi-cient hybrid methods for global continuous optimization based on simulated annealing显示文摘	MIETTINEN K MAKELA M M MAARANEN H		0，，10：	1
10	Relation between frontal 3-7 Hz MEG activity and the efficacy of ECT in major depression 显示文摘	Heikman P Salmelin R Makela IP	2001	J ECT2001，17，：	1
11	Effects of pH management during selective antegrade cerebral perfusion on cerebral microcirculation and metabolism:alpha-stat versus pH-stat显示文摘	Dahlbacka S Alaoja H Makela J	2007	Ann Thorac Surg2007，84，3：	1
12	Mechanisms of estrogen action显示文摘	Nilsson S Makela S Treuter E	2001	Physiol Rev2001，，81：	1
13	Pharmacological properties of the ubiquitous natural product betulin显示文摘	Alakurtti S Makela T Koskimies S	2006	Eur J Pharm Sci2006，29，1：	1
14	Selective serotonin-reuptake inhlbitors in the treatment of premature ejaculation显示文摘	MORELAND AJ MAKELA EH	2005	Ann Pharmacother2005，39，78：	1
15	Prior airway exposure to allergen increases virus-induced airway hyperresponsiveness 显示文摘	Makela MJ Tripp R Dakhama A	2003	J Allergy Clin Immunol2003，112，5：	1
16	Selective serotonin-reuptake inhibitors in the treatment of premature ejaculation显示文摘	Moreland AJ Makela EH	2005	Ann Pharmacother2005，39，78：	1
17	Inhibition of serum phospholipaseA2 in acute pancreatitis by pharmacological agents in vitro显示文摘	Makela A Kuusi T Schrdder T		0，，05：	1
18	Diagnosis and treatment of acute lower gastreintestinal bleeding显示文摘	Makela JT Kiviniemi H Laitinen S	1993	Scand J Gastroenterol1993，28，：	1
19	Genistein exerts estrogen-like effects in male mouse reproductive tract 显示文摘	Strauss L Makela S Joshi S	1998	Mol Cell Endocrinol1998，144，：	1
20	HF radiation emitted by chaotic leader processes 显示文摘	MAKELA J S EDIRISINGHE M FERNANDO M	2007	Journal of Atmospheric and Solar-Terrestrial Physics2007，69，6：	1

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