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| 1 | Survival factors after resection of small hepatocellular carcinoma显示文摘Early resection of hepatocellular carcinoma is a key measure to prolong the survival of patients. This study was designed to summarize our experience in surgical resection of small hepatocellular carcinoma (HCC), and to analyze the factors influencing the postoperative survival of patients. METHODS:The clinicopathologic data of 105 patients with small HCC after resection from 1986 through 2003 were analyzed ; the patients had been followed up for more than half a year (median 33 months). Nine clinicopathologic factors, preoperative α-fetoprotein (AFP) level, liver cirrhosis, Child-Pugh score, tumor size (>2cm vs.≤2 cm) and number (single vs. multiple), capsule formation, portal vein tumor thrombi (PVTT), Edmondson tumor grade and surgical method, were analyzed by the log-rank test and the Cox proportional harzards model analysis. RESULTS:The cumulative 1-,3- and 5-year survival rates after the operation were 86.5%, 70.3% and 55.2%, respectively, and the 1-, 3- and 5-year disease-free survival rates were 78%, 58. 9% and 45. 6%, respectively. One patient died from esophagogastric varices hemorrhage in 2 weeks after reoperation. Thirty-six patients had intrahepatic recurrence or metastasis postoperatively and 34 patients died. The Kaplan-Meier method and the Cox proportional harzards model analysis indicated that poor Child-Pugh score, tumor more than 2 cm in diameter, PVTT and multiple lesions (including satellitic lesions) were adverse factors affecting postoperative survival. The Cox proportional harzards model analysis indicated that tumor size, PVTT and multiple lesions were the factors influencing postoperative disease-free survival. CONCLUSIONS:Limited hepatectomy with a margin more than 1 cm is an appropriate surgical approach. Adverse preoperative Child-Pugh score and postoperative intrahepatic recurrences are the main factors leading to the death of patients with small HCC. | Departments of Surgical Oncology (Wu FS, Zhao WH, Ma ZM, Teng LS and Wang M) and General Surgery ( Liang TB and Zheng SS) , First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 5 |
| 2 | The path to personalized medicine显示文摘 | HAMBURG MA COLLINS FS | 2010 | N Engl JMed2010，363，4： | 1 |
| 3 | Acute ischemie stroke patterns in infective and nonbacterial thrombotic endoearditis: a diffusion -weighted magnetic resonance imaging study 显示文摘 | Singhal AB Topeuoglu MA Buonanno FS | 2002 | Stroke2002，33，5： | 1 |
| 4 | Assessment of turbulent transport models including Non-Linear RNG eddy-Viscosity formulation and second-moment closure 显示文摘 | LIEN FS LESCHAINER MA | 1994 | Comouters and fluids1994，23，8： | 1 |
| 5 | The risk factors for inections acquired by cerebral hemorrhage and cerebral in- farct patients in a neurology intensive care unit in Turkey显示文摘 | Yilmaz GR Cevik MA Erdinc FS | 2007 | Jpn J infect Dis2007，60，23： | 1 |
| 6 | Revision of Failed bariatric procedures to Roux-en-Y gastric bypass (RYGB)显示文摘 | Khoursheed MA A1-Bader IA Al-asfar FS | 2011 | Obes Surg2011，21，： | 1 |
| 7 | The path Io personalized medicine显示文摘 | Hamburg MA Collins FS | 2010 | N Engl J Med2010，363，4： | 1 |
| 8 | Microcalorimetric study of the effects of long-term fertilization on soil microbial activity in a wheat field on the Loess Plateau 显示文摘 | Zhang Q Liu XM Ma XJ Fang J Fan TL Wu FS An LZ Feng HY | 2014 | Ecotoxicology2014，1315，： | 1 |
| 9 | ' 'eatment of osteoarthritis with infrapateilar fat pad derived mesenchymal stem cells in rabbit显示文摘 | Toghraie FS Chenari N Gholipour MA | 2011 | Knee2011，18，2： | 1 |
| 10 | Surgical treatment of occipitocervical instability显示文摘 | Finn MA Bishop FS Dailey AT | 2008 | Neurosurgery2008，63，5： | 1 |
| 11 | Relationship between hyperglycemia and symptomatic vasospasm after subara-chnoid hemorrhage显示文摘 | Badjaria N Topeuoglu MA Buonanno FS | 2005 | J Crit Care Med2005，33，7： | 1 |
| 12 | Surgical approach for hepatic caudate lobectomy: Review of 401 cases显示文摘 | Chaib E Ribeiro MA Silva FS | 2007 | J Am Coll Surg2007，204，1： | 1 |
| 13 | The path to personalized medicine 显示文摘 | Hamburg MA Collins FS | 2010 | N Engl J Med2010，363，4： | 1 |
| 14 | DNA barcoding a highly diverse group of parasitoid wasps(Braconidae:Doryctinae)from a Mexican nature reserve显示文摘 | Zaldivar-Riverón A Martínez JJ Ceccarelli FS De Jesús-Bonilla VS Rodríguez-Pérez AC Reséndiz-Flores A Smith MA | | 0，，1： | 1 |
| 15 | Microcosm studyof the long term effect of endosulfan on enzyme andmicrobial activities on two agricultural soils of Yaounde-Cameroon显示文摘 | Defo MA Njine T Nola M Beboua FS | 2011 | African Journal of Agricultural Research2011，6，20： | 1 |
| 16 | Butein inhibits the migration andinvasion of SK-HEP-1 human hepatocarcinoma cells throughsuppressing the ERK,JNK,p38,and uPA signaling multiplepathways显示文摘 | Ma CY’Ji WT Chueh FS | 2011 | J Agric Food Chem2011，59，16： | 1 |
| 17 | Submandibular swelling in pa - tients with fibrodysplasia ossificans progressiva显示文摘 | Janof HB Zasloff MA Kaplan FS | 1996 | Otolaryngol Head Neck Surg1996，114，： | 1 |
| 18 | The role of BDNF genetic polymorphisms in bipolar disorder with psychiatric comorbidities显示文摘 | Neves FS Malloy-Diniz L Romano-Silva MA | 2011 | J Affect Disord2011，131，13： | 1 |
| 19 | Quality system implementation in a Brazilian university laboratory 显示文摘 | Fernandes EADN Bacchi MA Tagliaferro FS | 2006 | Accred Qual Assur2006，10，11： | 1 |
| 20 | Currarino triad associated with malrotation of the colon显示文摘 | Daoud FS AbuRub MA Hadidy AM | 2007 | Saudi Med J2007，28，： | 1 |
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