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422篇 您的检索式：作者名="MUCHA"

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	题名	作者	年代	出处	被引量
1	Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa显示文摘AIM: To analyze possible relationships between CA ⅠⅩ/CA Ⅻ and pVHL expression in normal and neoplastic colorectal mucosa.METHODS: Immunohistochemical staining of 42 tissue specimens obtained from 17 cancer patients was performed to evaluate the distribution and semi-quantitatively assess the levels of CA ⅠⅩ, CA Ⅻ and pVHL. VHL mRNAs from 14 fresh-frozen tumors was amplified by RT-PCR and subjected to sequencing. CA9 and CA12 mRNA levels were analyzed by semi-quantitative RT-PCR in comparison with VEGFas an indicator of hypoxia that uncouples the pVHL control.RESULTS: Tumor tissues were associated with a borderline increase of CA ⅠⅩ staining signal and slight but significant decrease of CA Ⅻ immunoreactivity, whereas no association was found for pVHL. Sequence analysis of RT-PCR-amplified VHL mRNAs revealed no deletions/mutations, suggesting that they were VHL-competent. We did not observe any correlation between pVHL and CA ⅠⅩ/CA Ⅻ proteins as well as between VEGF and CA9 mRNAs, but the tumor-associated changes in mRNA levels of VEGF and CA12 showed a significant inverse relationship.CONCLUSION: Our results indicate that CA9 and CA12 are regulated by different intratumoral factors and that lack of apparent relationship between the levels of CA ⅠⅩ/CA Ⅻ and pVHL cannot be fully assigned to uncoupling of negative regulatory function of pVHL by tumor hypoxia signified by induced VEGF transcription. The interplay between the functional pVHL and CA ⅠⅩ/CA Ⅻ in colorectal tumors seems rather complex and is not evident merely at the expression levels.	Antti J. Kivela Seppo Parkkila Juha Saarnio Tuomo J. Karttunen Jyrki Kivela Anna-Kaisa Parkkila Maria Bartosova Vojtech Mucha Michal Novak Abdul Waheed William S. Sly Hannu Rajaniemi Silvia Pastorekova Jaromir Pastorek	2005	World Journal of Gastroenterology2005，11，17：	10
2	Rigid fluid:animation the interplay between rigid bodies and fluid显示文摘	Carlson M Mucha P J Turk G	2004	ACM Transactions on Graphics2004，23，3：	1
3	Influence of the sea rush Juncus martitimus on metal concentration and speciation in estuarine sediment colonized by the plant显示文摘	Marisa C RAlmeida Ana P Mucha Teresa M S D Vasconce- los	2004	Environmental Science and Technology2004，38，：	1
4	Efficient patient identification strategies for women with osteoporosis显示文摘	Abbott TA 3rd Mucha L Manfredonia D		0，，03：	1
5	Fast dynamic transitive closure lookahead显示文摘	Sankowski P Mucha M	2010	Algorithmica2010，56，2：	1
6	Thermogravimetric and FTIR studies of chitosan blends显示文摘	Pawlak A Mucha M	2003	Termochim Acta2003，396，：	1
7	Heating as a Means of Preventing an Oxidized Flavor in Milk during Frozen Storage 显示文摘	BELL R MUCHA T	1951	Joumal of Dairy Science1951，，：	1
8	Echo-enhanced tran-scranial color-coded duplex sonography in the diagnosis of cerebrovascular events:a validation study 显示文摘	Kunz A Hahn G Mucha D	2006	AJNR Am J Neuroradiol2006，27，10：	1
9	Community structure in time-dependent, multiscale, and multiplex networks显示文摘	MUCHA P RICHARDSON T MACON K	2010	Science2010，328，5980：	1
10	Analysis of pelvic fracture management 显示文摘	Mucha P Famell MB	1984	J Trauma1984，24，5：	1
11	On the Navier-Stokes equations with slip boundary conditions in an infinite pipe显示文摘	MUCHA P B	2003	Acta Applicandae Mathematicae2003，76，：	1
12	Small intestinal obstruction显示文摘		1987	surg clin Noth Am1987，67，：	1
13	Comparison of montelukast and pseudoephedrine in the treatment of allergicrhinitis显示文摘	Mucha SM de Tineo M Naclerio RM	2006	Arch Otolaryngol Head Neck Surg2006，132，：	1
14	Structural requirement for conserved Args2 residue for interaction of the human immunodeficiency virus type 1 trans-activation responsive element with transactivator of transcription protein (49-57): Capillary eleetrophoresis mobility shift assay显示文摘	Piotr Mucha Agnieszka Szyk Piotr Rekowski	2002	Journal of Chormatography A2002，968，12：	1
15	Management of retropefito- neal sarcomas 显示文摘	Dalton RR Donohue JH Mucha P	1989	Surgery1989，106，4：	1
16	Echo-enhanced transcranial color-coded duplex sonography in the diagnosis of cerebrovascular events: a validation study显示文摘	Kunz A Hahn G Mucha D	2006	AJNR Am J Neuroradiol2006，27，：	1
17	Application of DSC to Study Crystallization Kinetics of Polypropylene Containing Fillers 显示文摘	M Mucha Z Krolikowski	2003	J Therm Anal Cal2003，74，2：	1
18	Nephrotic syndrome in the first year of life: Two thirds of cases are caused by mutations in 4 genes (NPHS1, NPHS2, WT1, and LAMB2) 显示文摘	Hinkes BG Mucha B Vlangos CN	2007	Pediatrics2007，119，4：	1
19	The clinching joints strength analysis in the aspects of changes in the form- ing technology and load conditions 显示文摘	MUCHA J WITKOWSKI W	2014	Thin-Walled Structures2014，82，：	1
20	Natural influenza A virus infection of mice elicits strong antibody response to HA2 glycopolypeptide显示文摘	Kostolansky F Mucha V Slov6kov6 R	2002	Acta Virolugica2002，46，4：	1

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