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| 1 | 神经元性一氧化氮合酶活性在app/ps1双转基因AD模型小鼠皮质和海马的分布显示文摘本实验用 4~ 5月龄和 15~ 16月龄的 app/ ps1dtg小鼠各 5只 ,同龄野生型小鼠每个年龄组各 5只 ,用β-NADPH组织化学染色显示神经元一氧化氮合酶活性 ,刚果红组织学染色显示神经炎性斑 ,无偏性体视学计量皮质和海马神经炎斑的总体积 ,研究神经元一氧化氮合酶活性在 app/ ps1双转基因 (app/ ps1dtg) AD模型小鼠大脑皮质和海马的异常分布 ,探讨其在该模型小鼠及 AD患者脑内病理改变中的作用。结果显示 ,n NOS阳性神经元在各组小鼠皮质和海马内的分布没有区别 ,4~ 5月龄 app/ps1dtg小鼠皮质和海马可见神经炎斑 (NP)和营养不良性 NOS阳性神经突 (DTN) ;15~ 16月龄 app/ ps1dtg小鼠皮质和海马内NP的体积分别是 4~ 5月龄 app/ ps1dtg小鼠皮质 NP的 5倍 (P<0 .0 0 5 )和 8倍 (P<0 .0 0 1) ;15~ 16月龄 app/ ps1dtg小鼠皮质内 DTN的体积明显增大 (P<0 .0 1) ;且伴有 NOS阳性神经元形态的改变及海马 CA1 区 NOS阳性神经元数量的减少 (P<0 .0 5 ) ,DTN的形成与 NP呈正相关关系 (r=0 .85 ,P<0 .0 5 )。本实验结果表明 ,app/ ps1dtg小鼠能够模拟 AD患者脑内 NOS阳性神经元的病理改变 ,DTN的形成可能与 Aβ的毒性作用有关 ,DTN产生的 NO可能参与 app/ ps1dtg小鼠和 AD的神经病理过程。 | 雷德亮 罗学港 Peter R. Mouton Donald K. Ingram | 2004 | 神经解剖学杂志2004，20，4： | 4 |
| 2 | 雌激素对老年雌性小鼠齿状回和海马CA1区神经胶质细胞的影响——形态学观察和无偏性体视学定量分析显示文摘切除 2 0~ 2 4月龄 C5 7BL /6NIA小鼠双侧卵巢 ,随后于颈部皮下植入可持续释放 60 d的含 1.7mgβ-雌二醇 (E2 )或含等剂量胆固醇的安慰剂。用免疫组织化学结合无偏性体视学方法 ,分析小鼠齿状回和海马 CA1区小胶质细胞和星形胶质细胞形态和数量的变化。结果发现 :60 d E2处理老年雌性小鼠不仅可以抑制神经胶质细胞的激活 ,而且可以明显降低小胶质细胞和星形胶质细胞的总数 ;神经胶质细胞在脑内免疫和炎症反应过程中起着非常重要的作用。本实验的结果提示 ,雌激素可能通过调节胶质细胞介导的脑内炎症反应通路 ,发挥其神经保护作用。 | 雷德亮 罗学港 Peter R. Mouton Donald K. Ingram | 2004 | 神经解剖学杂志2004，20，4： | 3 |
| 3 | Chemometric analysis of femtosecond transient absorption spectroscopy data:Study of the photochromism of anils显示文摘Chemometric methods are applied for the purpose of extracting relevant information from transient absorption spectroscopy data probing the photochromism of molecules from the family of salicylidene aniline. The process consists of an ultrafast excited state intramolecular proton transfer occurring from an enol form which is then followed by a cis-trans isomerization to finally reach a trans-keto photo-product. This work focuses on the potential of combining multivariate curve resolution for modeling pure profiles and two dimensional correlation spectroscopy data analysis for providing information on the dynamics of spectral features. The results obtained for one derivative of salicylidene aniline provide information regarding the number of species created after the proton transfer and characterization of their absorption spectra and their kinetics in the picosecond time scale. The spectral resolution of two cis-keto* forms is proposed for the first time. It is also found that both cis-keto* species are involved in the formation of the trans-keto photo-product. The main precursor of the trans-keto photo-product is the cis-keto* form which has the shortest characteristic time. | Cyril RUCKEBUSCH Nicolas MOUTON Thomas GLADYTZ Anika RENDELMANN Guy BUNTINX Michel SLIWA | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，6： | 3 |
| 4 | Therapeutic drug monitoring of voriconazole and posaconazole for invasive aspergillosis显示文摘 | Seyedmousavi S Mouton JW Verweij PE | 2013 | Expert Rev Anti Infect Ther2013，11，9： | 1 |
| 5 | Pain after laparosoecopy显示文摘 | Mouton WG Bessell JR Otten KT etal | 1999 | Surg Endosc1999，13，5： | 1 |
| 6 | Outcomein a post- cardiac surgery population with acute renalfailure requiring dialysis: does age make a difference显示文摘 | Van-Den-Noortgate N Mouton V Lamot C | 2003 | Nephrol Dial Transplant2003，18，4： | 1 |
| 7 | Age and gender effects on microglia and astrocyte numbers in brains of mice显示文摘 | Mouton PR Long JM Lei DL | 2002 | Brain Res2002，956，： | 1 |
| 8 | Data-driven fuzzy habitat suitability models for brown trout in SpanishMediterranean rivers 显示文摘 | MOUTON A M ALCARAZ-HERNANDEZ J D DE-BAETS B | 2011 | Environmental Modelling & Software2011，26，5： | 1 |
| 9 | Geometry parameter ization and computational mesh deformation by physics- based direct manipulation approaches显示文摘 | Yamazaki W Mouton S Carrier G | 2010 | AIAA Journal2010，48，8： | 1 |
| 10 | Analysis of the cervical spine sagittal alignment in young idiopathic scoliosis:a morphological classification of 120 cases显示文摘 | Yu M Silvestre C Mouton T | 2013 | Eur Spine J2013，22，11： | 1 |
| 11 | Rapid formation of the Bi2-xPbxSr2Ca2Cu3Oy high TC-phase,using spray-dried nitrate precursor powders显示文摘 | Van Driessche I Mouton R Hoste S | 1996 | Materials Research Bulletin1996，31，8： | 1 |
| 12 | Biopsy technique and biopsy schenes for a first series of prostatic biopsies 显示文摘 | Villers A Mouton D Rebilard X | 2004 | J Urol2004，14，2： | 1 |
| 13 | Pain after laparoscopy 显示文摘 | Mouton WG Bessell JR Otten KT | 1999 | SurgEndosc1999，13，5： | 1 |
| 14 | Comparative pharmacokinetics of the carbapenems: clinical implications显示文摘 | Mouton JW Touzw DJ Horrevorts AM | 2000 | Clin Pharmacokinet2000，39，3： | 1 |
| 15 | Blunt thorscic trauma with bronchial rupture显示文摘 | Mouton W Lardinois D Wursten HU | 1997 | Swiss Surg1997，3，4： | 1 |
| 16 | Knowledge-based versus data-driven fuzzy habitat suitability modelsfor river management显示文摘 | MOUTON A M DE-BAETS B GOETHALS P L M | 2009 | Environmental Modeling & Software2009，24，： | 1 |
| 17 | A randomized controlled trial assessing he benefit of humidified insufflation gas during laparoscopic surgery显示文摘 | Mouton WG Bessell JR Millard SH | 1998 | Surg Endosc1998，13，： | 1 |
| 18 | Evluation of nine animated high sensitivity C-reactive protein methods:im-plications for clinical and epidemiological applications 显示文摘 | Rberts WL Mouton L Law TC | 2001 | Clin Chem2001，47，： | 1 |
| 19 | Case report:perioperative immediate hypersensitivity involves only allergy but also masttocytosis显示文摘 | Renauld V Goudet V Mouton Faivre C | | 0，，5： | 1 |
| 20 | Iron status in runners of various running specialties显示文摘 | Mouton G Sluse FE Bertrand A | 1990 | Arch Int Physiol Biochim1990，98，1： | 1 |
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