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	题名	作者	年代	出处	被引量
1	Proteomic analysis for developing new biomarkers of hepatocellular carcinoma显示文摘AIM: To identify new markers of hepatocellular carcinoma (HCC) using a proteomic analysis. METHODS: Patients with liver cirrhosis of the three most frequent etiologies: hepatitis C virus, hepatitis B virus and alcoholic liver disease, were included in the study. The samples were analysed by 2D-electrophoresis in order to determine the differential protein expression. The proteins were separated according to the charge in immobilized pH 3-10 gradient strips and then by sodium dodecyl sulfate polyacrylamide gel electrophoresis. Proteins of interest were excised, digested with trypsin and the resulting peptides were separated and identified. RESULTS: Three differentially expressed apolipoproteins (Apo) were identified based on the protein profile using proteomic techniques: Apo-A1, Apo-A4 and Apo-E. Apo-A4 levels were significantly lower in HCC than in non-HCC patients regardless of etiology (P < 0.01). Multivariate logistic regression showed that Apo-A4 and Apo-A1 were the only independent factors related to HCC diagnosis (P < 0.05). The receiver operating characteristic (ROC) curve including both Apo-A4 and Apo-A1 showed an area under the ROC of 0.944 (P < 0.001), a sensitivity of 0.89 and a specificity of 0.81 for diagnosis of HCC. CONCLUSION: Apo-A4 and Apo-A1 may be used clinically as biomarkers of HCC with a high sensibility and specificity. These findings may provide additional insights into the mechanism of HCC development and progression.	Maria Pleguezuelo Laura M Lopez-Sanchez Antonio Rodriguez-Ariza Jose L Montero Javier Briceno Ruben Ciria Jordi Muntane Manuel de la Mata	2010	World Journal of Hepatology2010，2，3：	3
2	Retrograde approach for complex popliteal and tibioperoneal occlusions 显示文摘	Montero - Baker M Schmidt A Braunlich S	2008	J Endovasc Ther2008，15，5：	1
3	Effect of freezing fish skins on molecular and rheological properties of extracted gelatin显示文摘	P Montero M D Fernández-Díaz M C Gómez-Guillén	2003	Food Hydrocolloids2003，17，5：	1
4	Electron Injection Sand Avalanche during the Anoxic Oxidation of Tantalum 显示文摘	Albella J M Montero I	1984	J Electrochem Soc1984，131，6：	1
5	Effect of vitamin E and C dietary supplementation on some immune parameters of gilthead seabream (Sparus aurata)juveniles subjected to crowding stress显示文摘	Montero D Marrero M Izquierdo M S	1999	Aquac1999，171，：	1
6	High-pressure-induced gel of sardine (Sardina pilchardus) washed mince as affected by pressure- time-temperature显示文摘	PEREZ-MATEOS M MONTERO P	1997	Journal of Food Science1997，62，6：	1
7	Rheological and biochemical characteristic of high pressure and heatinducedgels from blue whiting (Micromesistius poutassou) muscle protein显示文摘	PE'REZ-MATEOS M LOURENC H MONTERO P	1997	Journal of Agricultural and Food Chemistry1997，45，1：	1
8	Anodization and Breakdown Model of Ta2O5 Films 显示文摘	Montero I Albella J M Martinez-Duart J M	1985	J Electrochem Soc1985，132，4：	1
9	The membrane-proximal external region of the human immunodeficiency virus type 1 envelope:dominant site of antibody neutralization and target for vaccine design显示文摘	Montero M Houten NE Wang X	2008	Microbiol Mol Biol Rev2008，72，1：	1
10	Spectral do- main optical coherence tomography findings in acute posterior multifocal placoid pigment epitheliopathy显示文摘	Montero JA Ruiz-Moreno JM Fernandez-Munoz M	2011	Oeul lmmunol In- flamm2011，19，1：	1
11	Molecular mapping and confirmation of QTLs associated with oleic acid content in N003350 soybean显示文摘	Monteros M J Burton J W Boerma H R	2008	Crop Science2008，48，：	1
12	Forward Trading and Collusion in Oligopoly 显示文摘	LISKI M MONTERO J-P	2006	Journal of Economic Theory2006，131，1：	1
13	Effect of vitamin E and C dietary supplementation on some immune parameters of gilthead seabream(Sparus aurata)juveniles subjected to crowding显示文摘	Montero D Marrero M Izquierdo M S	1999	Aquaculture1999，171，：	1
14	Hematological recovery in Sparus aurata after bleeding显示文摘	Montero D Tort L Lzquierdo M S	1995	Rev Esp Fis1995，51，：	1
15	Acute and clinically relevant drug-induced liver injury:a population based case-control study显示文摘	Abajo FJ Montero D Madurga M	2004	Br J Clin Pharmacol2004，58，：	1
16	Oyster preservation by high-pressure treatment显示文摘	Lopez-Caballero M Perez-Mateos M Montero P	2000	Journal of Food Protection2000，63，2：	1
17	Effect of vitamin E and C dietary supplementation on some immune parameters of gilthead seabream (Sparus aurata) juveniles subjected to crowding stress显示文摘	MONTERO D MARRERO M IZQUIERDO M S	1999	Aquaculture1999，171，：	1
18	Novel casein-derived peptides with antihypertensive activity 显示文摘	CONTRERAS M D CARRON R MONTERO M J	2009	International Dairy Journal2009，19，10：	1
19	Induction of c-fos protein by patterned visual stimulation in central visual pathways of the rat显示文摘	MONTERO V M JIAN S	1995	Brain Res1995，690，2：	1
20	Singlet oxygen-mediated DNA photocleavage with Ru ( Ⅱ ) polypyridyl complexes 显示文摘	HERGUETA B A JIMENEZ H M E MONTERO F	2002	J Phys Chem B2002，106，：	1

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