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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Simultaneous mandibular and maxillary distraction in hemifacial microsomia in adults:avoiding occlusal disasters显示文摘 | Ortiz Monasterio F Molina F Andrade L | 1997 | Plast Reeonstr Surg1997，100，4： | 1 |
| 3 | Preparation of activated carbon by chemical activation with ZnCl2显示文摘 | CATURLA F SABIO M Molina RODRIGUEZNOSO F | 1991 | Carbon1991，29，7： | 1 |
| 4 | Cerebrospinal fluid levels of transition metals in patients with Alzheimer's disease 显示文摘 | Molina J A Jimenez-Jimenez F J Aguilar M V | 1998 | J Neural Transm1998，105，45： | 1 |
| 5 | Stratospheric sink for chlorofluorometh- anes: Chlorine atomc-atalysed detruction of ozone 显示文摘 | Molina M J Rowland F S | 1974 | Nature1974，249，： | 1 |
| 6 | Autoinduction in Erwinia amylovora: evidence of an acy|-homoserine lactone signal in the fire blight pathogen 显示文摘 | Molina L Rezzonico F Defago G | 2005 | J Bacteriol2005，187，9： | 1 |
| 7 | The whole relationship between environmental variables and finn performance: competitive advantage and firm resources as mediator variables 显示文摘 | LOPEZ- GAMERO M D MOLINA -AZORIN J F CLAVER- CORTeS E | 2009 | Journal of environmental management2009，90，10： | 1 |
| 8 | MiR - 107 and miR -99a -3p predict chemotherapy response in patients with advanced colorectal cancer显示文摘 | Molina - Pinelo S Carnero A Rivera F | 2014 | BMC Cancer2014，14，： | 1 |
| 9 | Influence of organic matter transformations on the bioavailability of heavy metals in a sludge based compost 显示文摘 | Ingelmo F Molina M J Sofiano M D | 2012 | Journal of Environmental Management2012，，： | 1 |
| 10 | Nitric oxide destruction during coal and char oxidation under pulverized-coal combustion conditions显示文摘 | MOLINA A EDDINGS E G PERSHING D W SAROFIM A F | 2004 | Combust Flame2004，136，： | 1 |
| 11 | Determination of the third generation oral cephalosporin cefpodoxime in biological fluids by high-speed high-performance liquid chromatography 显示文摘 | Molina F Jehl F Gallion C | 1991 | J Chromatogr1991，563，1： | 1 |
| 12 | Pathways forconversion of char nitrogen to nitric oxide during pulver-ized coal combustion 显示文摘 | Molina A Murphy J J Winter F | 2009 | Combustion and Flame2009，156，3： | 1 |
| 13 | Environmental practices and firm performance: an empirical analysis in the Spanish hotel industry 显示文摘 | MOLINA - AZORIN J F CLAVER - CORTeS E PEREIRA - MO- LINER J | 2009 | Journal of Cleaner Production2009，17，5： | 1 |
| 14 | Identification of novel soybean microRNAs involved in abiotic and biotic stresses 显示文摘 | Kulcheski F R de Oliveira L F Molina L G | 2011 | BMC Genomics2011，12，： | 1 |
| 15 | Hydroconversion of heptane over a Colombian montmorillonite modified with mixed pillars of Al Zr and Al-Si显示文摘 | Molina M F Molina R Moreno S | 2005 | Catalysis Today2005，，： | 1 |
| 16 | 显示文摘 | Almansa C Molina S M Rodriguez R F | 2004 | Microporous and Mesoporous Materials2004，76，3： | 1 |
| 17 | Allografting with nonmyeloablative conditioning following cytoreductive autografts for the treatment of patients with multiple myeloma显示文摘 | Maloney DG Molina AJ Sahebi F | 2003 | Blood2003，102，9： | 1 |
| 18 | Development of porosity in combined phosphoric acid-carbon dioxide activation 显示文摘 | MOLINA Sabio M RODRI'GUEZ REINOSO F CATURLA F | 1996 | Carbon1996，34，： | 1 |
| 19 | High-Temperature Internal Friction in Polycrystalline Zirconium and Zircaloy-4显示文摘 | Molinas B J | 1983 | J Nucl Mater1983，114，： | 1 |
| 20 | Scale-up of tubu- lar photobioreactors 显示文摘 | Molina E M Fernandez F G Camacho F G | 2000 | J Appl Phycol2000，12，3： | 1 |
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