|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Electrochemical behaviour of chemically lithiated LixV2O5 phases显示文摘 | MILLET M PEREIRA-RAMOS T P | 1999 | Power Sources1999，8182，： | 1 |
| 3 | Electrochemical sodium insertion into MnCo oxide显示文摘 | BACH S MILLET M PERIERA-RAMOS J P | 1999 | Electrochemical and Solid-State Letters1999，2，： | 1 |
| 4 | Formation of Gallium Nitride by a Novel Hot Mechanical Alloying Process显示文摘 | Millet P Calka A Williams J S | 1993 | Appl Phys Lett1993，63，： | 1 |
| 5 | J Catal显示文摘 | Kumbhar P S Sanchez-Valente J Millet J M Figueras F | 2000 | 2000,191 (2) :4672000，191，2： | 1 |
| 6 | Design and performance of a solid polymer electrolyte water electrolyzer显示文摘 | Millet P Andolfatto F Durand R | 1996 | Hydl:gen Ener- gy1996，21，2： | 1 |
| 7 | High activity of inclusion bodies formed in Escherichia coli overproducing Clostridum thermocellum endoglucanaseD显示文摘 | Tokatlidis K Dhurjati P Millet J | 1991 | FEMS Microbiol Lett1991，282，1： | 1 |
| 8 | Relationship between spermatogenesis and serum gonadotropin levels in azoospermia and oligospermia显示文摘 | FRANCHIMONT P MILLET D VENDRELY E | 1972 | J Clin Endocrinol Metab1972，34，6： | 1 |
| 9 | Analytical method using gas chromatography and ion trap tandem mass spectrometry for the determination of S-triazines and their metabolites in the atmosphere显示文摘 | Sauret N Millet M Herckes P Mirabel P Wortham H | | 0，，： | 1 |
| 10 | Air quality assessment by tree bark biomonitoring in urban,industrial and rural environments of the Rhine Valley : PCDD/Fs, PCBs and trace metal evidence 显示文摘 | GUEGUEN F STILLE P MILLET M | 2011 | Chemosphere2011，85，2： | 1 |
| 11 | Formation and Behaviour Study of an Environment-friendly Corrosion Inhibitor by Electrochemical Methods 显示文摘 | BOMMERSBACH P ALEMANY-DUMONT C MILLET J P | 2005 | Electrochimica Acta2005，51，6： | 1 |
| 12 | Benige cutaneous Degos disease 显示文摘 | Ojeda Cuchillero RM Sanchez Regana M Umbert Millet P | 2003 | Clin Exp Dermatol2003，28，： | 1 |
| 13 | Protection against Plasmodium falciparum malaria in chimpanzees by immunization with the conserved pre-erythrocytic liver-stage antigen 3 显示文摘 | Daubersies P Thomas AW Millet P | 2000 | Nat Med2000，6，11： | 1 |
| 14 | Catalytic combustion of methane on substituted barium hexaalumi- nates显示文摘 | Artizzu-Duart P Millet J M Guilhaume N | 2000 | Catalysis Today2000，59，： | 1 |
| 15 | A solid polymer electrolyte-- based ethanol gas sensor 显示文摘 | Millet P Michas A Durand R | 1996 | Journal of Applied Electrochemistry1996，26，9： | 1 |
| 16 | Mathematical modeling of high-pressure PEM water electrolysis显示文摘 | Grigoriev SA Kalinnikov AA Millet P | 2010 | Appl Electrochem2010，40，： | 1 |
| 17 | Serum levels of parathyroid hormone and parathyroid-related peptide in psoriasis 显示文摘 | REGANA M S EZQUERRA G M MILLET P U | 2005 | Acta Derm Venercol2005，85，5： | 1 |
| 18 | Mg-Fe hydrotalcite as a catalyst for the reduction of aromatic nitrocompounds with hydrazine hydrate显示文摘 | Kumbhar P S Millet J M M Figueras F | 2000 | Journal of Catalysis2000，191，2： | 1 |
| 19 | Amyloid - beta peptide triggers Fas - independent apoptosis and differentiation of neural progenitor cells显示文摘 | Millet P Lages CS Haik S | 2005 | Neurobiol Dis2005，19，12： | 1 |
| 20 | Cushing's syndrome in pregnancy and neonatal hypertophic obstructive cardiomyopathy 显示文摘 | Fayol L Masson P Millet V | 2004 | Acta Padiatr2004，93，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员