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| 1 | Placental accommodations for transport and metabolism during intra-uterine crowding in pigs显示文摘Litter size and birth weights are limited by uterine capacity, defined as the ability of the uterus to maintain the appropriate development of some number of conceptuses. Uterine capacity is the result of the combined effects of uterine, placental and embryo/fetal function. The number of living conceptuses that the uterus is capable of supporting is greater during early gestation compared to later gestation. Plots of log fetal weight versus log placental weight also indicate that fetal weights are less sensitive to reduced placental weight(and therefore reduced intrauterine space) in early gestation compared to late gestation. However, even in late gestation,mechanisms still exist that maintain fetal growth when the size of the placenta is reduced. One such mechanism is likely to be improved development of the folded placental-epithelial/maternal-epithelial bilayer. Fold depth, and therefore the maternal fetal interactive surface, increases as gestation advances and is greater in placenta from small fetuses. On the fetal side of the placenta, the epithelial bilayer is embedded in stromal tissue. Glycosaminoglycans are major components of stroma, including hyaluronan and heparan sulfate. Hyaluronidases and heparanases are present within placental tissues, and likely play roles in modification of stromal components to facilitate fold development. Glycosaminoglycans are polymers of forms of glucose(glucosamine, glucuronic acid, iduronic acid)suggesting that glycosaminoglycan synthesis may compete with the glucose needs of the developing fetus.Pig conceptuses are fructogenic, such that a substantial portion of glucose transferred from mother to fetus is converted to fructose. Fructose is an intermediate product in the synthesis of glucosamine from glucose, and glucosamine is linked to regulation of trophoblast cell proliferation through regulation of m TOR. These findings suggest a link between glucose, fructose, glucosamine synthesis, GAG production, and placental morphogenesis,but the details of these interactions remain unclear. In addition, recent placental epithelial transcriptome analysis identified several glucose, amino acid, lipid, vitamin, mineral and hormone transporter mechanisms within the placenta. Further elucidation of mechanisms of placental morphogenesis and solute transport could provide clues to improving nutrient transport to the pig fetus, potentially increasing litter size and piglet birth weights. | Jeffrey L Vallet Anthony K Mc Neel Jeremy R Miles Bradley A Freking | 2015 | Journal of Animal Science and Biotechnology2015，6，2： | 5 |
| 2 | Examination of swirling flow using electrical resistance tomography 显示文摘 | STEVENSONA R HARRISON T L MILES N | 2006 | Powder Technology2006，162，2： | 1 |
| 3 | Combustion-properties of biomass 显示文摘 | Jenkins B M Baxter L L Miles T R | 1998 | Fuel Processing Technology1998，54，： | 1 |
| 4 | Nitricoxide sythaseactivity in human breast cancer显示文摘 | Thomsen LL Miles DW Happerfield L | 1995 | Br J Cancer1995，72，： | 1 |
| 5 | Developing Stakeholder Theory 显示文摘 | Friedman A L Miles S | 2002 | Journal of Management Sudies2002，39，1： | 1 |
| 6 | Hydrogen peroxide production by Mycoplasma bovis and Mycoplasma agalactiae and effect of in vitro passage on a Mycoplasma bovis strain producing high levels of hydrogen peroxides 显示文摘 | Khan L A Miles R J Nicholas R A | 2005 | Vet Res2005，29，： | 1 |
| 7 | Trastuzumab emtansine (TDM-1) for Her2-positive advanced breast cancer显示文摘 | Verma S Miles D Gianni L | 2012 | N Engl J Med2012，367，19： | 1 |
| 8 | A priori crystal structure prediction of native cellulose显示文摘 | Remco J V Karim M Miles L | | 0，，： | 1 |
| 9 | Nitric oxide synthase activity in human breast cancer显示文摘 | ThomsenL L Miles D W Haperfield L | 1995 | BrJ Cancer1995，72，1： | 1 |
| 10 | A combination of mild hypothermia and sevoflurane affords long-term protection in a modified neonatal mouse model of cerebral hypoxia-ischemia 显示文摘 | Lin EP Miles L Hughes EA | 2014 | Anesth Analg2014，119，5： | 1 |
| 11 | Phase Ⅲ study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer显示文摘 | MILES D W CHAN A DIRIX L Y | 2010 | J Clin Oncol2010，28，20： | 1 |
| 12 | Endophytic fungi in indigenous Australian grasses associated with toxicity to livestock显示文摘 | Miles C O di Menna M E Jacob S W L | 1998 | Applied and Environmental Microbiology1998，64，： | 1 |
| 13 | Boiler deposits from firing biomass fuels显示文摘 | Miles T R Miles Jr T R Baxter L L | 1996 | Biomass and Bioenergy1996，10，23： | 1 |
| 14 | Adult neurological function following neonatal hypoxia-ischemia in a mouse model of the term neonate:water maze performance is dependent on separable cognitive and motor components显示文摘 | McAuliffe JJ Miles L Vorhees CV | 2006 | Brain Res2006，1118，1： | 1 |
| 15 | Nitric oxide synthase activity in human breast cancer显示文摘 | Thomsen LL Miles DW Happerfield L | 1995 | Br J Cancer1995，72，1： | 1 |
| 16 | Granular cell astrocytoma of the cerebellum:report of the first case显示文摘 | Saad A Mo J Miles L | 2006 | Am J Clin Pathol2006，126，： | 1 |
| 17 | Trasmzumab emtansine for HER-2-positive advanced breast cancer显示文摘 | Verma S Miles D Gianni L | 2012 | N Engt J Med2012，367，19： | 1 |
| 18 | Scanning Probe Microscopy Studies of Cereal Seed Storage Protein Structures显示文摘 | Shewry P R Miles M J Humphris A D L | 1999 | Scanning1999，21，： | 1 |
| 19 | Atmospheric ammonia is detrimental to the performance of modern commercial broilers显示文摘 | Miles D M Branton S L Lott B D | 2004 | Poultry Science2004，83，： | 1 |
| 20 | Trastuzumab emtansine for HER2-positive advanced breast cancer显示文摘 | Verma S Miles D Gianni L | 2012 | N Engl J Med2012，367，19： | 1 |
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