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| 1 | Diagnostic accuracy of endoscopic ultrasound in pancreatic neuroendocrine tumors: A systematic review and meta analysis显示文摘AIM: To detect pancreatic neuroendocrine tumors (PNETs) has been varied. This study is undertaken to evaluate the accuracy of endoscopic ultrasound (EUS) in detecting PNETs.METHODS: Only EUS studies confirmed by surgery or appropriate follow-up were selected. Articles were searched in Medline, Ovid journals, Medline nonindexed citations, and Cochrane Central Register of Controlled Trials and Database of Systematic Reviews. Pooling was conducted by both fixed and random effects model). RESULTS: Initial search identified 2610 reference articles, of these 140 relevant articles were selected and reviewed. Data was extracted from 13 studies (n = 456) which met the inclusion criteria. Pooled sensitivity of EUS in detecting a PNETs was 87.2% (95%CI: 82.2-91.2). EUS had a pooled specificity of 98.0% (95%CI: 94.3-99.6). The positive likelihood ratio of EUS was 11.1 (95%CI: 5.34-22.8) and negative likelihood ratio was 0.17 (95%CI: 0.13-0.24). The diagnostic odds ratio, the odds of having anatomic PNETs in positive as compared to negative EUS studies was 94.7 (95%CI: 37.9-236.1). Begg-Mazumdar bias indicator for publication bias gave a Kendall's tau value of 0.31 (P = 0.16), indication no publication bias. The P for χ2 heterogeneity for all the pooled accuracy estimates was > 0.10. CONCLUSION: EUS has excellent sensitivity and specificity to detect PNETs. EUS should be strongly considered for evaluation of PNETs. | Srinivas R Puli Nikhil Kalva Matthew L Bechtold Smitha R Pamulaparthy Micheal D Cashman Norman C Estes Richard H Pearl Fritz-Henry Volmar Sonu Dillon Michael F Shekleton David Forcione | 2013 | World Journal of Gastroenterology2013,19,23: | 14 |
| 2 | 单侧完全性唇裂解剖功能修复显示文摘目的研究单侧完全性唇裂修复同期矫正鼻、牙槽嵴裂畸形的方法。方法运用唇裂胚胎发育理论与Carstens的手术设计方法,唇裂修复同时行鼻翼软骨畸形的矫正,并运用基因重组成骨蛋白(rhBMP-2)修复牙槽嵴裂。结果2004至2008年在美国完成唇裂手术45例,随访3~5年;2007年至今在国内完成单侧唇裂手术10例,随访1年;均取得满意效果。结论运用Carstens技术能够早期矫正完全性唇裂鼻畸形与牙槽嵴裂。 | 赵宇 Carstens Micheal 陈秋思 | 2009 | 中华整形外科杂志2009,25,2: | 12 |
| 3 | 用桡动脉脉搏波估测硝酸甘油对中心动脉压的影响显示文摘目的:通过测量桡动脉波定量硝酸甘油降低中心动脉反射波增压的效应。方法:19名志愿者,年龄54±7岁,无严重器质性疾病,试验前停用所有心血管药物至少3天,试验当天禁食。先测基础仰卧位肱动脉血压和桡动脉脉搏波,随后随机贴上安慰剂或 5 mg硝酸甘油贴剂,每隔半小时以同样的方式记录血压和脉搏波,共 5个小时后撕去贴膜,再记录 2 小时。动脉脉搏波分析仪实时把桡动脉脉搏波换算为中心动脉脉搏波,显示中心动脉反射波增压(AUG)和中心动脉反射波增压指数(AI)。结果:安慰剂组(9例),用药前后比较,心率(HR),射血时间(ED),肱动脉收缩压(PSP),肱动脉舒张压(PDP)和肱动脉平均压(PMP)及计算的中心动脉波增压、增压指数、中心动脉收缩压等各项参数均无显著变化。 5 mg硝酸甘油贴剂组 ( 10例)用药前后比较,射血时程、中心动脉波增压、增压指数、中心动脉收缩压在用药后半小时即显著下降,至3.5小时达高峰,撕去贴膜后2小时恢复到基础水平,但心率、肱动脉收缩压、肱动脉舒张压和肱动脉平均压无明显变化。结论:通过分析桡动脉脉搏波,可以定量中心动脉反射波增压,阐明硝酸甘油的作用,显示其起效、维持、撤除的动态变化。 | 蒋雄京 晋万强 刘力生 李臣文 台培春 张兴才 张淑珍 刘国仗 Micheal O’Rourke | 2000 | 高血压杂志2000,8,1: | 11 |
| 4 | Large-area nanopatterned graphene for ultrasensitive gas sensing显示文摘 | Alberto Cagliani David Micheal Angus Mackenzie Lisa Katharina Tschammer Filippo Pizzocchero Kristoffer Almdal Peter Boggild | 2014 | Nano Research2014,7,5: | 7 |
| 5 | 脂质抗氧化酶Peroxiredoxin 6对急性肺损伤的抗氧化保护作用显示文摘目的 确定脂质抗氧化酶Peroxiredoxin 6(Prdx 6)对急性肺损伤的抗氧化保护作用。方法应用100%O:吸入诱导雄性小鼠,建立急性肺损伤模型,用H2O2干预诱导,建立细胞损伤模型。分别观察Prdx6基因敲除(Prdx6-/-)小鼠、Prdx6基因过度表达(TgPrdx6)小鼠、胞浆谷胱甘肽过氧化物酶(Gpxl)基因敲除(Gpxl-/-)小鼠、野生(WT)小鼠及其肺Ⅱ型上皮细胞的生存率,支气管肺泡灌洗液(BALF)中蛋白和细胞总数;WesternBlot法检测Prdx6或Gpxl蛋白表达水平;观察肺Ⅱ型上皮细胞凋亡情况;采用硫代巴比妥酸反应物法和双苯酯-1-磷酸芘荧光测定法分别检测肺组织和肺Ⅱ型上皮细胞膜质脂氧化水平。结果Prdx6-/-小鼠生存时间较WT小鼠缩短约24h,TgPrdx6小鼠的生存时间较其他组延长;在细胞损伤模型中,Prdx6对细胞生存的保护作用与H2O2干预浓度相关;高氧吸入72h后,Prdx6-/-小鼠的肺内Gpxl蛋白表达水平下调7倍;Gpxl-/-小鼠的肺内Prdx6蛋白表达水平则无明显下调。H2O2干预处理后,肺Ⅱ型上皮细胞凋亡细胞数及百分率的增加与H2O2剂量正相关,并在Prdx6-/-小鼠表现最为明显,而TgPrdx6小鼠组则呈现了持续稳定的10%的凋亡细胞数;Prdx6-/-小鼠组的肺Ⅱ型上皮细胞的细胞膜脂质氧化水平升高,约为WT小鼠2倍,为TgPrdx6组4倍;Prdx6-/-小鼠肺组织的脂质氧化水平较其他组明显增高。结论Prdx6具有重要的抗氧化性肺损伤的保护作用,特别是Prdx6抗细胞凋亡和抗细胞膜脂质氧化的功能提示了其以细胞为单位独特的保护机制。 | 王燕 陆权 Feistein S.SHELDON Ye-Shih HO Shelley A.PHELAN Micheal F.BEERSA Aron B.FISHER | 2008 | 中华儿科杂志2008,46,10: | 6 |
| 6 | Metal concentrations of insects associated with the South African Ni hyperaccumulator Berkheya coddii (Asteraceae)显示文摘在亢奋的蓄电池种的金属的一些金属的高水平可以被转移到昆虫伙伴。我们调查了从南非的 Nihyperaccumulator Berkheya coddii 收集记录整个身体的金属集中的昆虫(公司, Cr, Cu, Mg, Mn, Ni, Pb, Zn ) 。我们也在叶子,茎和开花期记录了这些金属的集中,发现 Ni 的层次极其提高了(4 700—16 000 亩 g/g ) 并且高价值(5—34 亩 g/g ) 为公司, Cr,和 Pb。从 B 镇定的 26 昆虫 morphotypes。coddii,七 heteropterans,一只甲虫类之昆虫,和一只直翅类的昆虫包含了 Ni 的相对高的集中(>
500 亩 g/g ) 。high-Ni heteropterans 的 Thelarge 数字增加其它的发现(从加利福尼亚美国和新喀里多尼亚) 并且建议这份昆虫订单的成员可以是特别地 Ni 容忍。直翅类的昆虫(Stenoscepa ) 的美女包含了 3 500 亩 g Ni/g,最大的 Ni 集中还为一只昆虫报导了。我们也与 Mg 的提高的层次发现了二甲壳虫(>
2 800 亩 g/g ) ,有提高的 Cu 的一甲壳虫(>
70 亩 g/g ) 并且有 Mn 的提高的水平的一 heteropteran (>
200 亩 g/g ) 。在一个 Ni 亢奋的蓄电池上喂的昆虫能动员的 Ourresults 表演 Ni 进食物网,尽管我们没在草食动物或食肉动物昆虫发现 Ni 简历放大的证据,征税一。我们也断定与亢奋的蓄电池联系的一些昆虫能包含足够高对脊椎动物有毒的 Ni 层次。 | ROBERT S. BOYD MICHEAL A. DAVIS MICHAEL A. WALL KEVIN BALKWILL | 2006 | Insect Science2006,13,2: | 5 |
| 7 | 论强劲知识产权的软肋显示文摘在这篇引人注目的具有历史意义的研究中,作者阐释了对专利权和版权的争斗将如何破坏人类进步。在近几十年中,知识产权得到进一步的加强。作者承认,他并没有成型的解决方案,但是他认为追求如此强大的产权将产生悲剧性的后果。 | Micheal Perelman 孙宁 | 2005 | 经济资料译丛2005,,2: | 5 |
| 8 | Host-herbivore studies of Stenoscepa sp. (Orthoptera:Pyrgomorphidae), a high-Ni herbivore of the South African Ni hyperaccumulator Berkheya coddii (Asteraceae)显示文摘Stenoscepa sp 的美女。在在在 Mpumalanga 省的蛇的地点的 Ni 亢奋的蓄电池 Berkheyacoddii 的叶子的 feed,南非。这些地点在正常范围与 Ni 集中包含 Nihyperaccumulators, Ni 蓄电池,和植物。Weconducted 学习到:(ⅰ) 决定美女的整个身体的金属集中(包括那些饥饿倒空他们的勇气) ;(ⅱ) 比较 Stenoscepa sp。对在为整个身体的金属集中的一样的产地的另外的蚂蚱的美女;并且(ⅲ) 当食物为 Stenoscepa sp 采购原料,比较 Nihyperaccumulator 和 Ni 蓄电池植物的适用性。并且另外的蚂蚱。Stenoscepa 美女有极其高整个身体的 Ni 集中(3 500 μ g Ni/g ) 。这是部分由于在内脏的食物使少些包含的昆虫饿了 .Stenoscepa 美女比另外的蚂蚱更好显著地熬过的 Ni (950 μ g Ni/g ) 从也收集了一 serpentine 或一个非蛇的地点当作为食物提供了 high-Ni 植物时。在在四 Berkheya 种(二个 Ni 亢奋的累加器和二个 Ni 累加器) 之中的主机偏爱测试, Stenoscepa sp.preferred Ni 亢奋的累加器种类离开。使用的一个偏爱实验 threeSenecio 种类离开(哪个种类, Senecio coronatus,被 Nihyperaccumulator 和一张 Ni 蓄电池人口代表) 显示出那 Stenoscepa sp。比较喜欢的 Niaccumulator Senecio coronatus 离开到所有另外的选择。我们结束那 Stenoscepa sp。是极其 Ni 容忍的。Stenoscepa sp。美女比较喜欢亢奋的蓄电池 Berkheya 种类的叶子,但是提高的 Ni 集中独自不决定他们的食物偏爱。我们建议 Stenoscepa 美女的极其高整个身体的 Ni 集中可以在这些蛇的社区影响食物网关系。 | ROBERT S. BOYD MICHEAL A. DAVIS MICHAEL A. WALL KEVIN BALKWILL | 2007 | Insect Science2007,14,2: | 4 |
| 9 | 肱骨近端支架治疗肱骨近端骨折研究进展显示文摘肱骨近端骨折是肩部常见骨折之一,随着发病率的增加,手术干预比例不断加大,本文对肱骨近端骨折治疗传统和新出现的治疗手段进行分析探究。锁定钢板技术是临床使用最多的方式,但是其螺钉切出、再手术并发症发生率过高。腓骨移植技术可以弥补钢板无法有效支撑等不足,但也存在手术创伤大、潜在血管破坏发生率高等不足。关节置换是复杂肱骨近端骨折的治疗方式之一,学习曲线长、花费高等是其固有缺点。近年出现了肱骨近端支架干预方式,此技术具备固有3D立体结构优势,可以为肱骨头提供有效承重支持,能够为螺钉提供灵活的置入角度。为减少术后并发症,提高患者康复安全性提供技术选择。全面把握肱骨近端骨折的治疗手段,合理选择干预措施将会给患者带来更多的收益。 | 卢帅 Micheal JGardner 蒋协远 | 2020 | 中国骨伤2020,33,12: | 4 |
| 10 | Targeting Tumor-Associated Macrophages by Anti-tumor Chinese Materia Medica显示文摘Tumor-associated macrophages(TAMs) play a key role in all stages of tumorigenesis and tumor progression. TAMs secrete different kinds of cytokines, chemokines, and enzymes to affect the progression, metastasis, and resistance to therapy depending on their state of reprogramming. Therapeutic benefit in targeting TAMs suggests that macrophages are attractive targets for cancer treatment. Chinese materia medica(CMM) is an important approach for treating cancer in China and in the Asian region. According to the theory of Chinese medicine(CM) and its practice, some prescriptions of CM regulate the body's internal environment possibly including the remodeling the tumor microenvironment(TME). Here we briefly summarize the pivotal effects of TAMs in shaping the TME and promoting tumorigenesis, invasion, metastasisand immunosuppression. Furthermore, we illustrate the effects and mechanisms of CMM targeting TAMs in antitumor therapy. Finally, we reveal the CMM's dual-regulatory and multi-targeting functions on regulating TAMs, and hopefully, provide the theoretical basis for CMM clinical practice related to cancer therapy. | PU Wei-ling SUN Li-kang GAO Xiu-mei Curzio Rüegg Muriel Cuendet Micheal O.Hottiger ZHOU Kun MIAO Lin ZHANG Yun-sha Margaret Gebauer | 2017 | Chinese Journal of Integrative Medicine2017,23,10: | 3 |
| 11 | 即刻种植与常规种植的临床效果观察显示文摘目的:评价即刻种植与常规种植两种治疗方法用于缺牙区种植修复的近期临床效果。方法:临床选择53例患者,对骨量充足的23例患者进行即刻种植修复,并于24小时内完成。另30例患者进行常规种植手术。共植入Xive种植体112枚,并对其进行定期的临床和放射学检查。结果:53例患者中有23例患者接受即刻种植修复,涉及67个种植体,经12个月以上负重观察,在最终修复前因过载失败1枚,1枚因植入角度过大弃用。30例患者接受常规种植修复,无失败病例。观察期最短12个月,最长24个月。两种治疗方法植入的种植体在最终修复后无感染、无脱落,骨内种植体周无x线透影区。结论:严格掌握适应症和选用适当种植系统及临床修复标准,两种种植修复方法的临床效果是满意的。 | 郎荣建 张青松 Micheal Schmiz 孙庚林 | 2007 | 中国口腔种植学杂志2007,12,1: | 3 |
| 12 | Serrated lesions:A challenging enemy显示文摘The serrated pathway accounts for 30%-35%of colorectal cancer(CRC).Unlike hyperplastic polyps,both sessile serrated lesions(SSLs)and traditional serrated adenomas are premalignant lesions,yet SSLs are considered to be the principal serrated precursor of CRCs.Serrated lesions represent a challenge in detection,classification,and removal–contributing to post-colonoscopy cancer.Therefore,it is of the utmost importance to characterize these lesions properly to ensure complete removal.A retrospective cohort study developed a diagnostic scoring system for SSLs to facilitate their detection endoscopically and subsequent removal.From the study,it can be ascertained that both indistinct border and mucus cap are essential in both recognizing and diagnosing serrated lesions.The proximal colon poses technical challenges for some endoscopists,which is why high-quality colonoscopy plays such an important role.The indistinct border of some SSLs poses another challenge due to difficult complete resection.Overall,it is imperative that gastroenterologists use the key features of mucus cap,indistinct borders,and size of at least five millimeters along with a high-quality colonoscopy and a good bowel preparation to improve the SSL detection rate. | Alexa Trovato Alla Turshudzhyan Micheal Tadros | 2021 | World Journal of Gastroenterology2021,27,34: | 3 |
| 13 | 通过分析脉搏波形研究硝酸甘油对血管的作用显示文摘目的 用无创脉搏波分析方法揭示硝酸甘油 (GTN)对不同特性血管的剂量依赖效应。方法 46名志愿者随机给予安慰剂或不同剂量的缓释GTN贴剂 ( 0 1~ 0 6mg h) ,记录桡动脉脉搏波 ,并与传统的袖带血压计测量结果对照。中心动脉脉搏波通过已验证的转换函数从桡动脉脉搏波实时生成。结果 除了 2个最大剂量组的肱动脉收缩压下降外 ,心率及肱动脉血压没有明显变化。通过脉搏波分析获得的中心动脉收缩压、反射波增压、积分平均压和左室射血分数均有一致的剂量依赖的改变。结论 脉搏波分析比传统袖带血压计有优势 ,揭示了很低剂量的GTN影响血流动力学的证据 ,其机制是传输动脉扩张 ,波反射降低 ,更大剂量的GTN可进一步引起静脉及阻力小动脉扩张。 | 蒋雄京 晋万强 刘力生 李臣文 台培春 张兴才 张淑真 刘国仗 Micheal O'Rourke | 2003 | 中华心血管病杂志2003,31,4: | 2 |
| 14 | Xive种植系统的临床效果观察显示文摘目的:评价Xive种植系统用于缺牙区种植修复的临床效果。方法:临床选择53例患者,对骨量充足的23例患者进行即刻种植修复,并于24小时内完成。另30例患者进行常规种植手术。共植入Xive种植体112枚,并对其进行定期的临床和放射学检查。结果:53例患者中有23例患者接受即刻种植修复,涉及67枚种植体,经6个月以上观察,失败1枚,1枚弃用。30例患者接受常规种植修复,无失败病例。观察期最短8个月,最长20个月。种植体成功率为98.2%。结论:Xive种植系统用于种植修复的临床效果是满意的。 | 郎荣建 张青松 Micheal Schmiz 孙庚林 | 2005 | 中国口腔种植学杂志2005,10,4: | 2 |
| 15 | 蜱传脑炎病毒东北株E蛋白的核酸和氨基酸序列显示文摘从我国东北林区死者脑组织中,分离到蜱传脑炎病毒HLJ-1株,测定了它的E蛋白基因序列和推导的氨基酸序列,以及E蛋白抗原位点反应图谱。将该株与远东亚型Sofyn株和中欧亚型Neuderfl株做了同源性比较,HLJ-1株与Sofyn株E蛋白基因的核苷酸及氨基酸的同源性分别为94.3%和98.8%;与Neudoerfl的核苷酸和氨基酸的同源性分别为83.7%和96%,在E蛋白的核苷酸序列中,HLJ-1和Sofyn株之间存在着85个碱基的变异和6个氨基酸的改变,变化的氨基酸分别是Ser-438→Gly,Arg-451→Lys,Ala-612→Val,Met-638→Ile,Asn-646→Thr,Val-682→Ala。从E蛋白的模型得知,变异的氨基酸位于E蛋白的保守区域,故对抗原性影响不大。另E蛋白位点总图谱显示,HLJ-1与Sofyn株在C位点的反应存在差异,这可能是由于培养液低pH引起HLJ-1的空间结构改变所致。本文首次从基因水平证实了从东北林区分离的蜱传脑炎病毒属于远东型蜱传脑炎病毒。 | 侯宗柳 Franz X Heinz Micheal Ecker 白登云 刘瑞璋 俞永新 | 1997 | 病毒学报1997,13,1: | 2 |
| 16 | 结构胶和结构泡沫——改善碰撞性能的可行技术(英文)显示文摘为了新能源车的整车轻量化并保证其安全性,Henkel公司完成了两项新技术——结构泡沫和结构胶。该文测量了该组材料的物理、化学特性,以便实际应用和提高整车性能。结果表明:一种结构泡沫具有质量轻、强度和刚度高的优点,应用该种泡沫可减轻车辆自重,节省成本,在碰撞情况下提高车辆骨架对能量的吸收;另一种结构胶可提供有效连接方式,优化连接处应力分布,提高结构整体的强度和刚度,防止不同金属材料之间的电腐蚀,从而也降低生产成本。许多汽车生产商已经将该两项技术用于整车生产线上。 | Kyle Royston Martin Hornung Micheal Hajj | 2010 | 汽车安全与节能学报2010,1,4: | 2 |
| 17 | 氢燃料电动汽车—21世纪汽车产品的方向显示文摘基于节能和环保的要求 ,国际知名汽车集团都在研制代用燃料和电动汽车 .电动汽车的能源和传动方式成为研究的关键 .通过对四个主要汽车生产国的六大汽车集团在代用燃料和电动汽车传动方面研究与进展的分析 ,认为研发使用氢燃料电池的电动汽车是近期汽车产品最有前途的新方向 . | 张晨阳 常治斌 Micheal Bruechle | 2002 | 湖北工学院学报2002,17,2: | 2 |
| 18 | Current use of transgenic herbicide - resistant soybean and corn in the USA显示文摘 | Owen Micheal D K | 2000 | Crop Protection2000,19,: | 2 |
| 19 | 4D Design and Simulation Technologies and Process Design Patterns to Support Lean Construction Methods显示文摘The objective of this ongoing joint research program is to determine how 3D/4D modeling, simulation and visualization of Products (buildings), Organizations and Processes (POP) can support lean construction. Initial findings suggest that Process Design Pattern may have the potential to intuitively support ICT based lean construction. We initiated a 'Process Archeology' in order to reveal the requirements for tools that can support the planning, simulation and control of lean construction methods. First findings show that existing tools provide only limited support and therefore, we started to develop new methodologies and technologies to overcome these shortcomings. Through the introduction of Process Design Patterns, we intent to establish process thinking in the interdisciplinary POP design. Optimized construction processes may be synthesized with semi-automatic methods by applying Process Design Patterns on building structures. By providing process templates that integrate problem solution and expert knowledge, Process Design Patterns may have the potential to ensure high quality process models. | Manfred Breit Manfred Vogel Fritz Hubi Fabian Mrki Micheal Raps | 2008 | Tsinghua Science and Technology2008,13,S1: | 2 |
| 20 | Chaotic vibration of a quarter-car model excited by the road surface profile 显示文摘 | GRZEC ORZ L MAREK B MICHEAL I F | 2008 | Communications in Nonlinear Science and Numerical Simulation2008,13,5: | 1 |