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| 1 | Weight gain following breast cancer diagnosis: Implication and proposed mechanisms显示文摘Weight gain occurs in the majority of women following breast cancer treatment. An overview of studies describing weight gain amongst women treated with early to modern chemotherapy regimens is included. Populations at higher risk include women who are younger, closer to ideal body weight and who have been treated with chemotherapy. Weight gain ranges between 1 to 5 kg, and may be associated with change in body composition with gain in fat mass and loss in lean body mass. Women are unlikely to return to pre-diagnosis weight. Possible mechanisms including inactivity and metabolic changes are explored. Potential interventions are reviewed including exercise, dietary changes andpharmacologic agents. Although breast cancer prognosis does not appear to be significantly impacted, weight gain has negative consequences on quality of life and overall health. Future studies should explore change in body composition, metabolism and insulin resistance. Avoiding weight gain in breast cancer survivors following initial diagnosis and treatment should be encouraged. | Grace Makari-Judson Barry Braun D Joseph Jerry Wilson C Mertens | 2014 | World Journal of Clinical Oncology2014，5，3： | 8 |
| 2 | Bcl-2 degradation is an additional pro-apoptotic effect of polo-like kinase inhibition in cholangiocarcinoma cells显示文摘AIM To examine the influence on apoptotic mechanisms following inhibition of polo-like kinases as therapeuticallyapproach for cholangiocellular cancer treatment. METHODS As most cholangiocarcinomas are chemotherapyresistant due to mechanisms preventing tumor cell death, we investigated the effect of Cisplatin on cholangiocellular carcinoma(CCA) cell lines KMCH-1 and Mz-Ch-1. Polo-like kinases(PLK) are important regulators of the cell cycle and their inhibition is discussed as a potential therapy while PLK inhibition can regulate apoptotic mediators. Here, cells were treated with PLK inhibitor BI6727(Volasertib), Cisplatin, and in combination of both compounds. Cell viability was assessed by MTT; apoptosis was measured by DAPI staining and caspase-3/-7 assay. Western blot and q RT-PCR were used to measure expression levels of apoptosis-related molecules Bax and Bcl-2. RESULTS The cell viability in the CCA cell lines KMCH-1 and Mz-Ch-1 was reduced in all treatment conditions compared to vehicle-treated cells. Co-treatment with BI6727 and cisplatin could even enhance the cytotoxic effect of cisplatin single treatment. Thus, co-treatment of cisplatin with BI6727 could slightly enhance the cytotoxic effect of the cisplatin in both cell lines whereas there was evidence of increased apoptosis induction solely in Mz-Ch-1 as compared to KMCH-1. Moreover, PLK inhibition decreases protein levels of Bcl-2; an effect that can be reversed by the proteasomal degradation inhibitor MG-132. In contrast, protein levels of Bax were not found to be altered by PLK inhibition. These findings indicate that cytotoxic effects of Cisplatin in Mz-Ch-1 cells can be enhanced by co-treatment with BI6727.CONCLUSION In conclusion, BI6727 treatment can sensitize CCA cells to cisplatin-induced apoptosis with proteasomal Bcl-2 degradation as an additional pro-apoptotic effect. | Svenja Sydor Sami Jafoui Lena Wingerter Sandra Swoboda Joachim C Mertens Guido Gerken Ali Canbay Andreas Paul Christian D Fingas | 2017 | World Journal of Gastroenterology2017，23，22： | 5 |
| 3 | Risk of disease recurrence and second neoplasms in survivors of childhood cancer treatment with growth hormone:a report from the childhood cancer survivors study显示文摘 | Mertens A C Mitby P | 2002 | J Clin Endocrinol Metab2002，87，7： | 1 |
| 4 | Human cytomegalovirustegument protein ppUL35 is important for viral replication andparticle formation 显示文摘 | Schierling K Buser C Mertens T | 2005 | J Virol2005，79，5： | 1 |
| 5 | Five-year re- sults of vitrectomy and silicone oil in patients with prolifera- tive vitreoretinopathy 显示文摘 | van Menrs J C Mertens D A Peperkamp E | 1993 | Retina1993，13，4： | 1 |
| 6 | Reduetive splitting of cellulose in the ionic liquid 1-butyl-3-methylimidazolium chloride显示文摘 | Ignatyev I A Doorslanr C V Mertens P G N | 2010 | ChemSusChem2010，3，1： | 1 |
| 7 | Global histone acetyla- tion levels: prognostic relevance in patients with renal cell carci- noma显示文摘 | Mosashvilli D Kahl P Mertens C | 2010 | Cancer Sci2010，101，12： | 1 |
| 8 | Reductive splitting of cellulose in the ionic liquid l-butyl-3-methylimidazolium chloride显示文摘 | IGNATYEV I A DOORSLAER C V MERTENS P G | 2010 | Chem Sus Chem2010，3，1： | 1 |
| 9 | Using genetic algorithms in sub-pixel mapping显示文摘 | Mertens K C Verbeke L P Ducheyne E I | 2003 | International Journal of Remote Sensing2003，24，21： | 1 |
| 10 | Sub-pixel mapping and sub-pixel sharpening using neural network predicted wavelet coefficients显示文摘 | Mertens K C Verbeke L P Westra T | 2004 | Remote Sensing of Environment2004，91，2： | 1 |
| 11 | Usinggenetic algorithms in sub-pixel mapping 显示文摘 | Mertens K C Verbeke L P C Ducheyne E I | 2003 | InternationalJournal of Remote Sensing2003，24，21： | 1 |
| 12 | A Sub-pixel Mapping Algorithm Based on Sub-pixel/pixe| Spatial Attraction Models 显示文摘 | MERTENS K C DE BAETS B VERBEKE L P C | 2006 | International Journal of Remote Sensing2006，27，15： | 1 |
| 13 | Sub-pixelmapping and sub-pixel sharpening using neural networkpredicted wavelet coefficients显示文摘 | Mertens K C Verbeke L P C Westra T | 2004 | Remote Sensing ofEnvironment2004，91，2： | 1 |
| 14 | Sociocultural Determinants of Anticipated Vaccine Acceptance for Acute Watery Diarrhea in Early Childhood in Katanga Province, Democratic Republic of Congo 显示文摘 | Merten S Schaetti C Manianga C | 2013 | Am J Trop Med Hyg2013，89，41： | 1 |
| 15 | Using Genet- ic Algorithms in Sub-pixel Mapping显示文摘 | Mertens K C Verbeke L P Ducheyne E I etal | 2003 | International Journal of Remote Sensing2003，24，21： | 1 |
| 16 | A sub-pixel mapping algorithm based on sub-pixel/pixel spatial attraction models显示文摘 | Mertens K C de Baets B Verbeke L P C | 2006 | International Journal of Remote Sensing2006，27，15： | 1 |
| 17 | Competitive ELISA for the detection of antibodies against epizootic haemorrhagic disease of deer virus 显示文摘 | Mertens P P C Burroughs J N | 1995 | Journal of Virological Methods1995，55，： | 1 |
| 18 | Asub-pixel mapping algorithm based on sub-pixel/pixelspatial attraction models显示文摘 | Mertens K C De Baets B Verbeke L P C | 2006 | International Journal ofRemote Sensing2006，27，15： | 1 |
| 19 | Using Genetic Algorithms in Sub-pixel Mapping 显示文摘 | MERTENS K C VERBEKE L DUCHEYNE E I | 2003 | International Journal of Remote Sensing2003，24，21： | 1 |
| 20 | Detection and differentiation of epizootic haemorrhagic disease of deer and EHD by serogroup-specific sandwich ELISA显示文摘 | Wellby M P Mertens P P C | 1996 | Journal of Virological Methods1996，56，： | 1 |
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