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| 1 | The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection显示文摘This review describes the woodchuck and the woodchuck hepatitis virus (WHV) as an animal model for pathogenesis and therapy of chronic hepatitis B virus (HBV) infection and disease in humans. The establishment of woodchuck breeding colonies, and use of laboratory-reared woodchucks infected with defined WHV inocula, have enhanced our understanding of the virology and immunology of HBV infection and disease pathogenesis, including major sequelae like chronic hepatitis and hepatocellular carcinoma. The role of persistent WHV infection and of viral load on the natural history of infection and disease progression has been firmly established along the way. More recently, the model has shed new light on the role of host immune responses in these natural processes, and on how the immune system of the chronic carrier can be manipulated therapeutically to reduce or delay serious disease sequelae through induction of the recovery phenotype. The woodchuck is an outbred species and is not well defined immunologically due to a limitation of available host markers. However, the recent development of several key host response assays for woodchucks provides experimental opportunities for further mechanistic studies of outcome predictors in neonatal- and adult-acquired infections. Understanding the virological and immunological mechanisms responsible for resolution of self-limited infection, andfor the onset and maintenance of chronic infection, will greatly facilitate the development of successful strategies for the therapeutic eradication of established chronic HBV infection. Likewise, the results of drug efficacy and toxicity studies in the chronic carrier woodchucks are predictive for responses of patients chronically infected with HBV. Therefore, chronic WHV carrier woodchucks provide a well-characterized mammalian model for preclinical evaluation of the safety and efficacy of drug candidates, experimental therapeutic vaccines, and immunomodulators for the treatment and prevention of HBV disease sequelae. | Stephan Menne Paul J Cote | 2007 | World Journal of Gastroenterology2007，13，1： | 22 |
| 2 | 轿车用柴油机的现状和发展趋势显示文摘近10年是柴油机、尤其是轿车用柴油机在技术和环境保护领域飞跃发展的10年。全球就柴油机排放危害展开了激烈的讨论,德国现已修改了税收法规,其将持续不断影响着购买观念和环境保护。描述了轿车用柴油机的现状和发展趋势,除介绍现今柴油机的技术外,还着重陈述了福特公司在柴油机电控系统,燃烧过程,喷油系统和废气净化方面所进行的开发研究。 | Menne,RJ 吴新潮 | 1995 | 国外内燃机1995，27，4： | 2 |
| 3 | Sustained efllcacy and ~emi~m with the Toll-like ~ 7 agonist C-S-9620 in the Woodchuck model of chronic hepatitis B 显示文摘 | Menne S Tmrt~ D B Liu KH | 2015 | J Hepatol2015，62，6： | 1 |
| 4 | Hypersensitivity to local anaesthetics-update and proposal of evaluation algorithm显示文摘 | Thyssen JP Menn'e T Elberling J | 2008 | Contact Dermatitis2008，59，2： | 1 |
| 5 | Howl arge a proportion of contact sensitivities are diagnosed with the European standard series?显示文摘 | Menne T Dooms-Goossens A Wahlberg JE | 1992 | Contact Dermatitis1992，26，： | 1 |
| 6 | Expression of matrix metalloproteinases and their inhibitors in the woodchuck model of hepatocellular carcinoma显示文摘 | Laura Ochoa‐Callejero Ilia Toshkov Stephan Menne Alfredo Martínez | 2013 | J. Med. Virol2013，，7： | 1 |
| 7 | Revised European standard series显示文摘 | Menne T | 1988 | Contact Dermatitis1988，19，： | 1 |
| 8 | The epidemiology of contact allergy in the general populationprevalence and main findings显示文摘 | Thyssen JP Linneberg A MennéT | 2007 | Contact Dermatitis2007，57，： | 1 |
| 9 | Impact of High Temperatures on Mortality: Is There an Added Heat Wave Effect?显示文摘 | Shakoor Hajat Ben Armstrong Michela Baccini Annibale Biggeri Luigi Bisanti Antonio Russo Anna Paldy Bettina Menne Tom Kosatsky | 2006 | Epidemiology2006，，6： | 1 |
| 10 | Allergic con- tact sensitization in an adult Danish population:two cross sectional surveys eight years apart (the Copenhagen Al- lergy study) 显示文摘 | Nielsen NH Linneberg A Menne T | 2001 | Acta Derm Venereol2001，81，1： | 1 |
| 11 | Insulin resistance and renal disease 显示文摘 | Fliser D Kielstein JT Menne J | 2006 | Contrib Nephrol2006，151，： | 1 |
| 12 | Skin reactivity to metallic cobalt in patients with a positive patch test to cobalt chloride 显示文摘 | De Fine Olivarius F Menne T | 1992 | Contact Derm1992，27，： | 1 |
| 13 | Linking inter-individual differences in neural activation and behavior to intrinsic brain dynamics显示文摘 | Mennes M Zuo XN Kelly C | 2011 | Neuroimage2011，54，4： | 1 |
| 14 | Associations between baseline al- lergens and polysensitization 显示文摘 | Carlsen BC Menne T Johansen JD | 2008 | Contact Dermatitis2008，59，2： | 1 |
| 15 | Concentration thresholds of nonoccluded nickel exposure in nickel sensitive individuals and controls with and without surfactants显示文摘 | MennéT Calvin G | 1993 | Contact Dermatitis1993，29，： | 1 |
| 16 | Effect of barrier perturbation on cutaneous salicylic acid in human skin: in vivo pharmacokinetics using microdialysis and non-invasive quantification of barrier func- tion显示文摘 | Benfeldt E Serup PJ Menne T | 1999 | Br J Dermatol1999，140，4： | 1 |
| 17 | Targeting the protein kinase C family in the diabetic kidney:lessons from analysis of mutant mice显示文摘 | Meier M Menne J Hailer H | 2009 | Diabeto- logia2009，52，5： | 1 |
| 18 | A dimensional analysis of college student satisfaction 显示文摘 | BETZ E L MENNE JW etal | 1971 | Measurement and Evalua- tion Guidance1971，4，2： | 1 |
| 19 | Trends of contact allergy to fragrance mix I and Myroxylon pereirae among Danish eczema patients tested between 1985 and 2007显示文摘 | Thyssen JP Carlsen BC Menne T | 2008 | Contact Dermatitis2008，59，： | 1 |
| 20 | Clinical trial:the effects of adding ranitidine at night to twice daily omeprazole therapy on nocturnal acid breakthrough and acid reflux in patients with systemic sclerosis-a randomized controlled,cross-over trial显示文摘 | Janiak P Thumshirn M Menne D | | 0，，9： | 1 |
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