|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | Evo-lution of Networks 显示文摘 | S N DOROGOVTSEV J F F MENDES | 2002 | Adv Phys2002，51，： | 1 |
| 3 | Short- term electricity prices forecasting in a competitive market by a hybrid intelligent approach显示文摘 | Catal:o J P S Pousinho H M I Mendes V M F | 2011 | Energy Conversion and Management2011，52，： | 1 |
| 4 | One dimensional model of phase holdups in three phase stratified flow显示文摘 | Khor S H Mendes Tatsis M A Hewitt G F | 1997 | Int J Muhiphase Flow1997，23，5： | 1 |
| 5 | Evolving of Networks显示文摘 | S N Dorogovtsev J F F Mendes | 2002 | Adv Physics2002，51，： | 1 |
| 6 | The Effect of a Psychosocial Intervention and Quality of Life after Acute Myocardial Infarction: The Enhancing Recovery in Coronary Heart Disease (ENRICHD) Clinical Trial显示文摘 | Mendes de Leon C F Czajkowski S M | 2006 | J Cardiopulm Rehabil2006，26，1： | 1 |
| 7 | Handgrip strength at ad- mission and time to discharge in medical and surgical inpatients 显示文摘 | Mendes J Azevedo A Amaral T F | 2013 | Journal of Parenteral and Enteral Nutrition2013，，： | 1 |
| 8 | Growing community networks with local events显示文摘 | Xu X J Zhang X Mendes J F F | 2009 | Physica A2009，388，： | 1 |
| 9 | Retreating chronic hepatitis C with daily interferon alfacon-1/ribavirin after nonresponse to pegylated interferon/ribavirin:DIRECT results显示文摘 | Bacon BR Shiffman ML Mendes F | 2009 | Hepatology2009，49，6： | 1 |
| 10 | Evolution of networks显示文摘 | S N Dorogovtsev J F F Mendes | 2002 | Adv Phys2002，51，： | 1 |
| 11 | Travel and Tourism: Into a Com- plex Network显示文摘 | Migu6ns J I L Mendes J F F | 2008 | Physica A2008，387，： | 1 |
| 12 | Thermal actions for concrete bridge design 显示文摘 | Branco F A Mendes P A | 1993 | Journal of Structural Engineering1993，119，8： | 1 |
| 13 | Obstruction of pipelines due to paraffin deposition during the flow of crude oils显示文摘 | Ribeiro F S Mendes P R S Braga S L | 1997 | International Journal of Heat Mass Transfer1997，18，1： | 1 |
| 14 | A genetic algorithm for the resource constrained multi-project scheduling problem显示文摘 | Goncalves J F Mendes J J M Resende M G C | 2008 | European Journal of Operational Research2008，189，3： | 1 |
| 15 | Structure of growing networks with preferential linking显示文摘 | Dorogovtsev S N Mendes J F F Samukhin A N | 2000 | Phys Rev Lett2000，85，21： | 1 |
| 16 | flavicarpa) 显示文摘 | Trevisan F Mendes B M J Optimization of in vitro organogenesisin Passion fruit {Passiflora edulis f | 2005 | Sci Agric2005，62，： | 1 |
| 17 | Pseudofractal scale-free web显示文摘 | DOROGOVTSEV S N GOLTSEV A V MENDES J F F | 2002 | Phys Rev E2002，65，： | 1 |
| 18 | Evolution of networks显示文摘 | Mendes J F | 2002 | Advances in Physics2002，51，4： | 1 |
| 19 | Microbial conversion of gIycerol to 1,8 propanediol: physiological comparison of a natural producer, Clostridium butyricum VPI 3266, and an engineered strain, Clostridium acetobutylicum DGI(pSPDS) 显示文摘 | Gonzalez Pajuelo M Meynial-Salles I Mendes F Soucaille P Vasconcelos I | 2006 | Appl Environ Microbial2006，72，1： | 1 |
| 20 | A hy- brid genetic algorithm for the job shop scheduling problem显示文摘 | Goncalves J F de Magalhaes Mendes J J Resende M G C | 2005 | European Journal of Operational Research2005，167，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员