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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Posttreatment of a brewery wastewater using a sequencing batch reactor 显示文摘 | Rordrigues Ana C Brito Antonio G Melo Luis F | 2001 | Water Environment Research2001，73，1： | 2 |
| 3 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 4 | Role of myofibroblasts, macrophages, transforming growth factor-beta endothelin, angiotensin- Ⅱ , and fibronectin in the progression of tubulointerstitial nephritis induced by gentamicin 显示文摘 | Geleilete T J Melo G C Costa R S | 2002 | J Nephrol2002，15，6： | 1 |
| 5 | Simultaneous Transfer Capability Assessment by Combining Imerior Point Methods and Monte Casrlo Simulation显示文摘 | Mello J C O Melo A C G Granville S | 1997 | IEEE Trans on Power Systems1997，12，2： | 1 |
| 6 | Effect of a highly concentrated lipopeptide extract of Bacillus subtilis on fungal and bacterial cells 显示文摘 | Etchegaray A de Castro Bueno C de Melo I S | 2008 | Archives of Microbiology2008，190，2： | 1 |
| 7 | Assessing the applicabil- ity of fault-proneness models across object-oriented software projects显示文摘 | Briand L C Melo W L Wrist J | 2002 | IEEE Transactions on Software En- gineering2002，28，7： | 1 |
| 8 | Differential activity of a lectin from Solieria filiformis against human pathogenic bacteria 显示文摘 | Holanda M L Melo V M M Silva L M C M | 2005 | Brazilian Journal of Medical and Biological Research2005，38，12： | 1 |
| 9 | Infection following treatment of mandible fractures:the role of and polysubstance abuse显示文摘 | Senel F C Jessen G S Melo M D | 2007 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2007，103，1： | 1 |
| 10 | Towards a functional classification of the freshwater phytoplankton显示文摘 | Reynolds C S Huszar V Kruk C Naselli-Flores L Melo S | 2002 | Journal of Plankton Research2002，24，5： | 1 |
| 11 | Adsorption of chromium (VI) ion from aqueous solution by succinylated mercerized cellulose functionalized with quaternary ammonium groups显示文摘 | Leandro Vinícius Alves Gurgel Júlio César Perin de Melo Jorge Carvalho de Lena Laurent Frédéric Gil | 2009 | Bioresource Technology2009，，13： | 1 |
| 12 | Cytogenetic studies in peripheral blood of bovines afflicted by pap- illomatosis显示文摘 | Melo T C Diniz N Campos S R et ai | 2011 | Vet Comp Oncol2011，9，4： | 1 |
| 13 | Mental health among perimenopausal women attending a menopause clinic:possible association with premenstrual syndrome?显示文摘 | Novaes C Almeida OP de Melo NR | 1998 | Climacteric1998，，4： | 1 |
| 14 | Identification of a Candida parapsilosls strain producing extracellular serine peptidase with keratinolytic activity显示文摘 | Vennelho A B Mazotto A M de Melo A C N | 2010 | Mycopathologia2010，169，1： | 1 |
| 15 | Preparation of ethylenediamine-anchored cellulose and determination of thermochemical data for the interaction between cations and basic centers at the solid/liquid interface显示文摘 | da Silva Filho E C de Melo J C P Airoldi C | 2006 | Carbohydrate research2006，341，17： | 1 |
| 16 | Optimization of the extraction conditions of the volatile compounds from chili peppers by headspace solid phase micro- extraction显示文摘 | Bogusz Junior S de Marchi Tavares de Melo A Zini C A | 2011 | Journal of Chromatography A2011，1218，21： | 1 |
| 17 | Parallel strategies for the local biological sequence alignment in a cluster of workstations显示文摘 | Boukerche A Alves de Melo A C M Ayala-Rincon M | 2007 | Journal of Parallel and Distributed Computing2007，67，2： | 1 |
| 18 | An experimental analysis of adiabatic capillary tubes 显示文摘 | Melo C Ferreira R T S Neto C B | 1999 | Applied Thermal Engineering1999，19，6： | 1 |
| 19 | ANP in regulation of arterial pressure and fluid-electrolyte balance:lessons from genetic mouse models 显示文摘 | MELO L G STEINHELPER M E PANG S C | 2000 | Physiol Genomics2000，3，1： | 1 |
| 20 | Odontogenie keratocyst in maxillary sinus with invasive behavior 显示文摘 | Vencio EF Mota A de Melo Pinho C | 2006 | J Oral Pathol Med2006，35，4： | 1 |
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