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| 1 | 游戏与学习研究新进展显示文摘随着计算机游戏在图形、复杂性、交互和描述等方面越来越复杂,多种类型的游戏已经在市场上占有重要地位,计算机游戏正成为文化的一部分。游戏与学习的关系成为越来越多的研究者关注的重点。本研究综述的目的是提供关于计算机游戏产业、市场和文化等现状的一个概述;对游戏与教育相关性研究的主要进展提供概览,并对该领域的相关文献进行概述;为教育研究共同体和游戏开发商等就如何在学习资源设计中使用游戏技术进行交流提供基础;为教育共同体在教育环境中使用数字游戏的讨论提供基础。同时本研究还以恰如其分的语气承认,在现有的教育体制和学习模式下,应用游戏的一些障碍和挑战。不仅如此,在这篇研究综述中,作者还为设计者、研究者和政策制定者提出了如何将游戏的一些本质特点融入学习资源和学习环境设计中的一些方法,而不仅仅是像今天教育游戏给学生提供的似乎像糖衣的'趣味性',只是使学生完全沉浸其中。 | John Kirriemuir Angela McFarlane 侯小杏(译) 杨玉芹(译) 焦建利(译) | 2007 | 远程教育杂志2007，25，5： | 17 |
| 2 | Mechanisms of triglyceride metabolism in patients with bile acid diarrhea显示文摘Bile acids(BAs) are essential for the absorption of lipids. BA synthesis is inhibited through intestinal farnesoid X receptor(FXR) activity. BA sequestration is known to influence BA metabolism and control serum lipid concentrations. Animal data has demonstrated a regulatory role for the FXR in triglyceride metabolism. FXR inhibits hepatic lipogenesis by inhibiting the expression of sterol regulatory element binding protein 1c via small heterodimer primer activity. Conversely, FXR promotes free fatty acids oxidation by inducing the expression of peroxisome proliferator-activated receptor α. FXR can reduce the expression of microsomal triglyceride transfer protein, which regulates the assembly of very low-density lipoproteins(VLDL). FXR activation in turn promotes the clearance of circulating triglycerides by inducing apolipoprotein C-Ⅱ, very low-density lipoproteins receptor(VLDL-R) and the expression of Syndecan-1 together with the repression of apolipoprotein C-Ⅲ, which increases lipoprotein lipase activity. There is currently minimal clinical data on triglyceride metabolism in patients with bile acid diarrhoea(BAD). Emerging data suggests that a third of patients with BAD have hypertriglyceridemia. Further research is required to establish the risk of hypertriglyceridaemia in patients with BAD and elicit the mechanisms behind this, allowing for targeted treatment. | Nidhi Midhu Sagar Michael McFarlane Chuka Nwokolo Karna Dev Bardhan Ramesh Pulendran Arasaradnam | 2016 | World Journal of Gastroenterology2016，22，30： | 5 |
| 3 | Livestock breeding for the 21st century: the promise of the editing revolution显示文摘In recent years there has been a veritable explosion in the use of genome editors to create sitespecific changes,both in vitro and in vivo,to the genomes of a multitude of species for both basic research and biotechnology.Livestock,which form a vital component of most societies,are no exception.While selective breeding has been hugely successful at enhancing some production traits,the rate of progress is often slow and is limited to variants that exist within the breeding population.Genome editing provides the potential to move traits between breeds,in a single generation,with no impact on existing productivity or to develop de novo phenotypes that tackle intractable issues such as disease.As such,genome editors provide huge potential for ongoing livestock development programs in light of increased demand and disease challenge.This review will highlight some of the more notable agricultural applications of this technology in livestock. | Chris PROUDFOOT Gus MCFARLANE Bruce WHITELAW Simon LILLICO | 2020 | Frontiers of Agricultural Science and Engineering2020，7，2： | 2 |
| 4 | Advances in nanomaterials for brain microscopy显示文摘 | Jackson T. Del Bonis-O'Donnell Linda Chio Gabriel F. Dorlhiac lan R. McFarlane Markita P. Landry | 2018 | Nano Research2018，11，10： | 2 |
| 5 | Viscosupplementation with hylan for the treatment of osteoarthritis:Findings from clinical practice in Canada显示文摘 | Lussier A Cividino AA McFarlane CA | | Journal of Rheumatology0，，： | 2 |
| 6 | Long-term Outcomes of Patients With Autoimmune Hepatitis Managed at a Nontransplant Center显示文摘 | Barbara Hoeroldt Elaine McFarlane Asha Dube Pandurangan Basumani Mohammed Karajeh Michael J. Campbell Dermot Gleeson | 2011 | Gastroenterology2011，，7： | 2 |
| 7 | Optimal guaranteed cost control and filtering for uncertain linear systems显示文摘 | Petersen I R Mcfarlane D C | 1994 | IEEE Trans Automat Control1994，39，9： | 1 |
| 8 | Mefformin: an update显示文摘 | Kirpichnikov D McFarlane SI Sowers JR | 2002 | Ann Intern Med2002，137，1： | 1 |
| 9 | Near-normoglycaemic remission in African-Americans with Type 2 diabetes mellitus is associated with recovery of beta cell function显示文摘 | McFarlane SI Chaiken RL Hirsch S | 2001 | Diabet Med2001，18，1： | 1 |
| 10 | Enlarged frontal P300 to stimulus change in panic disorder显示文摘 | McFarlane AC Weber DL Battersby M | 1996 | Biol Psychiatry1996，39，10： | 1 |
| 11 | The Canadian Climate Centre spectral atmospheric general circulation model显示文摘 | Boer G J McFarlane N A Laprise R | 1984 | Atmosphere-Ocean1984，22，： | 1 |
| 12 | Meeting report: International autoimmune hepatitis group显示文摘 | Johnson PJ Mcfarlan IJ | 1993 | Hepatology1993，18，： | 1 |
| 13 | Viscosupplementation with hyalans for the treatment of osteoarthritis:findings from clinical practice in Canada显示文摘 | Lussier A Cividino AA McFarlane CA | 1996 | J Rheum1996，23，9： | 1 |
| 14 | Obesity and hypertension 显示文摘 | El-Atat F Aneja A Mcfarlane S | 2003 | Endocrinol Metab Clin N Am2003，32，4： | 1 |
| 15 | The protein requirements of the house cricket,Acheta domesticus(L)显示文摘 | Mcfarlane J E | 1964 | Can J Zool1964，42，： | 1 |
| 16 | Information technology changes the wayyou compete显示文摘 | MCFARLAN F W | 1984 | Harvard Business Review1984，62，3： | 1 |
| 17 | CD44 potentiates the adherence of metastatic prostate and breast cancer cells to bone marrow endothelial cells显示文摘 | Draffin JE McFarlane S Hill A | 2004 | Cancer Res2004，64，16： | 1 |
| 18 | A sulfur isotope geothermometer for the trisulfide system galena-sphalerite-pyrite显示文摘 | Smith J W Doolan S McFarlanes E F | 1977 | Chemical Geology1977，19，14： | 1 |
| 19 | Portfolio approach to information systems 显示文摘 | McFarlan F W | 1981 | Harvard Business Review1981，59，5： | 1 |
| 20 | Diabetic cardiovascular disease predicts chronic kidney disease awareness in the kidney early evaluation program 显示文摘 | WhaleyConnell A Bomback AS McFarlane SI | 2011 | Cardiorenal Med2011，1，1： | 1 |
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