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| 1 | Practical strategies for modulating foam cell formation and behavior显示文摘Although high density lipoprotein(HDL)-mediated reverse cholesterol transport is crucial to the prevention and reversal of atheroma, a recent meta-analysis makes evident that current pharmaceutical strategies for modulating HDL cholesterol levels lower cardiovascular risk only to the extent that they concurrently decrease low density lipoprotein(LDL) cholesterol. This corresponds well with findings of a recent Mendelian randomization analysis, in which genetic polymorphisms associated with HDL cholesterol but no other known cardiovascular risk factors failed to predict risk for myocardial infarction. Although it is still seems appropriate to search for therapies that could improve the efficiency with which HDL particles induce reverse cholesterol transport, targeting HDL cholesterol levels per se with current measures appears to be futile. Itmay therefore be more promising to promote reverse cholesterol transport with agents that directly target foam cells. Macrophage expression of the cholesterol transport proteins adenosine triphosphate binding cassette transporter A1, adenosine triphosphate binding cassette transporter G1, and scavenger receptor class B member 1 is transcriptionally up-regulated by activated liver X receptors(LXR), whereas nuclear factor(NF)-kappa B antagonizes their expression. Taurine, which inhibits atherogenesis in rodent studies, has just been discovered to act as a weak agonist for LXRalpha. Conversely, it may be possible to oppose NF-kappa B activation in macrophages with a range of measures. Induction of heme oxygenase-1, which can be attained with phase 2 inducer phytochemicals such as lipoic acid and green tea catechins, promotes reverse cholesterol transport in macrophages and inhibits atherogenesis in rodents, likely due to, in large part, NF-kappa B antagonism. Inhibition of macrophage nicotinamide adenine dinucleotide phosphate(NADPH) oxidase activity with the spirulina-derived bilirubin-mimetic phycocyanobilin may also oppose NF-kappa B activation, and salicylic acid similarly should be useful for this purpose. The 5' adenosine monophosphate-activated protein kinase activator berberine promotes macrophage reverse cholesterol transport in cell culture; metformin probably shares this property. Many of these measures could also be expected to promote plaque stability by suppressing foam cell production of inflammatory cytokines and matrix metalloproteinases, and to reduce intimal monocyte infiltration by anti-inflammatory effects on vascular endothelium. Direct targeting of foam cells with agents such as phase 2 inducers, spirulina, salicylate, taurine, and berberine or metformin, may hence have considerable potential for preventing and reversing atheroma, and for preventing the plaque rupture that triggers vascular thrombosis. | Elisabeth Uitz Babak Bahadori Mark F McCarty Mohammed H Moghadasian | 2014 | World Journal of Clinical Cases2014，2，10： | 6 |
| 2 | Role of pancreatography in the endoscopic management of encapsulated pancreatic collections-review and new proposed classification显示文摘Pancreatic fluids collections are local complications related to acute or chronic pancreatitis and may require intervention when symptomatic and/or complicated.Within the last decade,endoscopic management of these collections via endoscopic ultrasound-guided transmural drainage has become the gold standard treatment for encapsulated pancreatic collections with high clinical success and lower morbidity compared to traditional surgery and percutaneous drainage.Proper understanding of anatomic landmarks,including assessment of the main pancreatic duct and any associated lesions–such as disruptions and strictures-are key to achieving clinical success,reducing the need for reintervention or recurrence,especially in cases with suspected disconnected pancreatic duct syndrome.Additionally,proper review of imaging and anatomic landmarks,including collection location,are pivotal to determine type and size of pancreatic stenting as well as approach using long-term transmural indwelling plastic stents.Pancreatography to adequately assess the main pancreatic duct may be performed by two methods:Either non-invasively using magnetic resonance cholangiopancreatography or endoscopically via retrograde cholangiopancreatography.Despite the critical need to understand anatomy via pancrea tography and assess the main pancreatic duct,a standardized approach or uniform assessment strategy has not been described in the literature.Therefore,the aim of this review was to clarify the role of pancreatography in the endoscopic management of encapsulated pancreatic collections and to propose a new classification system to aid in proper assessment and endoscopic treatment. | Igor Mendonca Proença Marcos Eduardo Lera dos Santos Diogo Turiani Hourneaux de Moura Igor Braga Ribeiro Sergio Eiji Matuguma Spencer Cheng Thomas R McCarty Epifanio Silvino do Monte Junior Paulo Sakai Eduardo Guimaraes Hourneaux de Moura | 2020 | World Journal of Gastroenterology2020，26，45： | 3 |
| 3 | 白内障的发展及其相关危险因素视力损害调查项目显示文摘目的:评估澳大利亚居民白内障的发展及其相关危险因素。
方法:对在维多利亚9个随机抽取的城区共3721个参加者做调查,进行全面的标准化的访谈和眼科检查作基线纪录及5年随访。根据Wilmer白内障分级系统对晶体混浊进行临床分级并照相。皮质性、核性、后囊下性白内障分别观察其发展和其相关危险因素。白内障发展的危险因素包括不同的社会人口统计,饮食。遗传性,医药干预和眼部特征。危险因素分析用单一和多元logistic回归法。 | Bickol N. Mukesh Anhchuong Le Peter N. Dimitrov Shazia Ahmed Hugh R. Taylor Catherine A. McCarty 刘亮(译) | 2006 | 美国医学会眼科杂志(中文版)2006，18，4： | 2 |
| 4 | BROWN P J, Distribution of water in USGA recommended sands as affected by bridging factor 显示文摘 | BURNETr S QUISENBERRY V L MCCARTY L B | 2005 | International Turfgrass Society Research Journal2005，10，： | 1 |
| 5 | Inferior joint space arthrography and characteristics of condylar paths in internal derangements of the TMJ显示文摘 | FARRAR WB MCCARTY WL | 1979 | J Prosthet Dent1979，41，： | 1 |
| 6 | PAH-DNA adducts, cigarette smoking, GST polymorphisms, and breast cancer risk显示文摘 | McCarty K M Santella R M Steck S E | 2009 | Environ Health Perspect2009，117，4： | 1 |
| 7 | The NIDDM eqidemic:global estimates and projec-tion:a look into the crystal ball显示文摘 | McCarty D | 1995 | IDF Bulletin1995，40，： | 1 |
| 8 | Full scale case studies of a simplified aerated filter(BAF) for organics and nitrogen removal显示文摘 | Chen J J Mccarty D Slack D | 2000 | Water Science and Technology2000，41，45： | 1 |
| 9 | Abiotic and Biotic Trans-formations of 1,1,1-Trichloroethane under MethanogenicConditions显示文摘 | VOGEL T M MCCARTY P L | 1987 | Environmental Science and Technology1987，21，12： | 1 |
| 10 | Comparison of Fixed Film Reactors with a Modeled Sludge Blanket Reactor显示文摘 | Bachmann A Beard V L McCarty P L | 1983 | Fixed Film Biological Processes for Wastewater Treatment1983，，： | 1 |
| 11 | Does postprandial storage of triglycerides in endothelial cells contribute to the endothelial dysfunction associated with insulin resistance and fatty diets显示文摘 | McCarty MF | 2003 | Med Hypotheses2003，61，2： | 1 |
| 12 | Favorable impact of a vegan diet with exercise on hemorheology:implications for control of diabetic neuropathy显示文摘 | McCarty MF | 2002 | Med Hypotheses2002，58，6： | 1 |
| 13 | Nonoperative treatment of spondylolysis and grade I spondylolisthesis in children and young adults: a meta-analysis of observational studies 显示文摘 | Klein G Mehlman CT McCarty M | 2009 | J Pediatr Orthop2009，29，2： | 1 |
| 14 | Leaf senes- cence-like characteristics contribute to cotton's premature photo- synthetic decline显示文摘 | PETTIGREW W T McCarty J C Vaughn K C | 2000 | Photosynthesis Research2000，65，2： | 1 |
| 15 | Improving stem cell mobilization strategies: future directions 显示文摘 | Bensinger W DiPersio JF McCarty JM | 2009 | Bone MarrowTransplant2009，43，3： | 1 |
| 16 | Iatrogenic radial never injury with cannulate fixation of medial epicondyle fracrure in the pediatric humerus:a repore of 2 case显示文摘 | Marcu DM Balts J McCarty JJ | | 0，，02： | 1 |
| 17 | Increased incidence of corneal perforation after topical fluoroquinolone treatment for microbial keratitis显示文摘 | Mallari PL McCarty D J Daniell M | | 0，，： | 1 |
| 18 | GenK-catalyzed C-6' rnethylation in the biosynthesis of gentamicin: isolation and characterization of a cobalamin-dependent radical SAM enzyme显示文摘 | Kim HJ McCarty MR Ogasawara Y | 2013 | Journal of the American Chemical Society2013，135，22： | 1 |
| 19 | Characterisation and developmental potential of ovine bone marrow derived mesenchymal stem cells显示文摘 | MCCARTY R C GRONTHOS S ZANNETYINO A C | 2009 | J Cell Physiol2009，219，2： | 1 |
| 20 | Short-term changes in soil carbon and nitrogen pools during till- age management transition显示文摘 | McCarty G W Lysenko N Starr J L | 1998 | Soil Science Society of America Journal1998，62，6： | 1 |
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