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| 1 | 2,3-Diaryl-3H-imidazo[4,5-b]pyridine derivatives as potential anticancer and anti-inflammatory agents显示文摘In this study we examined the suitability of the 3H-imidazo[4,5-b]pyridine ring system in developing novel anticancer and anti-inflammatory agents incorporating a diaryl pharmacophore. Eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives retrieved from our in-house database were evaluated for their cytotoxic activity against nine cancer cell lines. The results indicated that the compounds showed moderate cytotoxic activity against MCF-7, MDA-MB-468, K562 and SaOS2 cells, with K562 being the most sensitive among the four cancer cell lines. The eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives were also evaluated for their COX-1 and COX-2 inhibitory activity in vitro. The results showed that compound 3f exhibited 2-fold selectivity with IC_(50) values of 9.2 and 21.8 mmol/L against COX-2 and COX-1, respectively. Molecular docking studies on the most active compound 3f revealed a binding mode similar to that of celecoxib in the active site of the COX-2 enzyme. | Erin Marie Kirwen Tarun Batra Chandrabose Karthikeyan Girdhar Singh Deora Vandana Rathore Chaitanya Mulakayala Naveen Mulakayala Amy Catherine Nusbaum Joel Chen Haneen Amawi Kyle Mc Intosh Sahabjada Neelam Shivnath Deepak Chowarsia Nisha Sharma Md Arshad Piyush Trivedi Amit KTiwari | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 3 |
| 2 | Clinical trials: healing of erosive oesophagitis with dexlansoprazole MR, aproton pump inhibi-tor with a novel dual delayed release formulation - results from two randomized controlled studies 显示文摘 | Sharma P Shaheen NJ Perez MC | 2009 | Aliment Pharmacol Ther2009，29，： | 1 |
| 3 | Parenchymal vol ume preservation and ischemia during partial nephrectomy: functional and volumetric analysis显示文摘 | Mir MC Campbell RA Sharma N | 2013 | Urology2013，82，2： | 1 |
| 4 | Neurocytoma:a comprehensive review显示文摘 | Sharma MC Deb P Sharma S | 2006 | Neurosurg Rev2006，29，4： | 1 |
| 5 | Glioblastoma multiforme with long term survival显示文摘 | Deb P Sharma MC Mahapatra AK | 2005 | Neurol India2005，53，3： | 1 |
| 6 | Meningioangiomatosis with meningioma: an uncommon association of a rare entity--report of a case and review of the literature 显示文摘 | Deb P Gupta A Sharma MC | 2006 | Childs Nerv Syst2006，22，1： | 1 |
| 7 | Natural history of primary precursor B lymphoblastic lymphoma of the ovary:Report of a rare case显示文摘 | Yadav R Sharma MC Karak AK | 2013 | J Obstet Gynaecol Res2013，39，2： | 1 |
| 8 | Valganciclovir in the treatment of cytomegalovirus retinitis in HIV-infected patients显示文摘 | Patil AJ Sharma A Kenney MC | 2010 | Clin Ophthalmol2010，50，4： | 1 |
| 9 | Neurocytoma: a comprehensive review 显示文摘 | Sharma MC Deb P Sharma S | 2006 | Neurosurg Rev2006，29，4： | 1 |
| 10 | Meningioangiomatosiswith meningioma : an uncommon association of a rareentity-report of a case and review of the literature 显示文摘 | Deb P Gupta A Sharma MC’ | 2006 | Childs Nerv Syst2006，22，1： | 1 |
| 11 | Lipid storage myop- athy显示文摘 | Mannan AA Ralte AM Sharma MC | 2004 | Indian J Pediatr2004，71，3： | 1 |
| 12 | Albumin adsorption on to aluminum oxide and polyurethane surfaces 显示文摘 | Sharma CP Sunny MC | 1990 | Biomatefials1990，11，： | 1 |
| 13 | Alveolar soft part sarcoma of the paranasal sinuses masquerading as a giant invasive pituitary adcnoma 显示文摘 | Singh G Sharma MC Suri V | 2013 | Ann Diagn Pathol2013，17，3： | 1 |
| 14 | Primary spinal epidural extraosseous Ewing's sarcoma:Report of five cases and literature review显示文摘 | Mukhopadhyay P Gairola M Sharma MC | 2001 | Australasian Radiology2001，45，3： | 1 |
| 15 | Hypertension caused by angiotensin Ⅱ infusion involves increased superoxide produc- tion in the cent ral nervous system显示文摘 | Zimmerman MC Lazartigues E Sharma RV | 2004 | Cire Res2004，95，2： | 1 |
| 16 | A clinieopathological and immunohistoehemical study of clinically non-functioning pituitary adenomas:a single institutional experience显示文摘 | Rishi A Sharma MC Sarkar C | 2010 | Neurol India2010，58，3： | 1 |
| 17 | Intraventricular Neurocytoma:a Clinicopathological Study of 20 Cases with Review of the Literature显示文摘 | Sharma MC Sarkar C Karak AK | 1999 | J Clin Neuroscience1999，6，4： | 1 |
| 18 | Angiostatin induced inhibition of endothelial cell proliferation/apoptosis is associated with the down regulation of cell cycle regulatory protein cdk5显示文摘 | Sharma MR Tuszynski GP Shzima MC | 2004 | J Cell Biochem2004，107，6： | 1 |
| 19 | Determination of the incidence and clinical characteristics of subsequent retinal tears following treatment of the acute posterior vitreous detachment - related initial retinal tears 显示文摘 | Sharma MC Regillo CD Shuler MF | 2004 | Am J Ophthalmol2004，138，： | 1 |
| 20 | Hallervorden spatz disease: MR and pathological findings of a rare case显示文摘 | Sharma MC Aggarwal N Bihari M | 2005 | Neurol India2005，53，： | 1 |
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