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| 1 | MiR-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1显示文摘糖尿病和许多另外的新陈代谢症候群是仔细与肥胖有关。揭示胖免职的内在的机制,越来越多的研究在 adipocytes 开发期间正在集中于 miRNAs 的功能。以前的研究 haveproved 那出 miR-15a/b 戏在多重生理的过程的重要角色;然而,他们的功能在 adipogenesisremain 期间不清楚。揭示这,我们在猪的 pre-adipocyte 在 adipogenesis 期间检测了 miR-15a/b 的表示侧面,并且发现那他们层次在 adipocyte 区别的早阶段增加了并且在白天 4 .Moreover 以后落下的表示,在猪的 pre-adipocytes 的 miR-15a/b 的在表示上支持了 adipocyte 区别, miR-15a/b 的类脂化合物 accumulation.Target 基因被预言并且检验,它表明 Forkhead 盒子蛋白质 O1 ( FoxO1 )是目标 geneof miR-15a/b 。表示水平由 miR-15a/b 在表示上引起了的 FoxO1 的抑制在 adipogenesis.Thus 上有积极效果,我们断定 miR-15a/b 经由镇压在猪的 pre-adipocyte 支持 adipogenesis FoxO1。 | Peiyue Dong Yin Mai Zhenyu Zhang Lin Mi Guofang Wu Guiyan Chu Gongshe Yang Shiduo Sun | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 6 |
| 2 | A proapoptotic peptide for the treatment of solid tumors显示文摘 | Mai JC Mi Z Kim SH | 2001 | Cancer Res2001，61，21： | 1 |
| 3 | Identification of a synovial fibroblast-specific protein transduction domain for delivery of apoptotic agents to hyperplastic synovium显示文摘 | Mi Z Lu X Mai JC | 2003 | Mol Ther2003，8，2： | 1 |
| 4 | A proapoptotic peptide for the treatment of solid tumors显示文摘 | Mai JC Mi Z Kim SH | 2001 | Cancer Research2001，61，21： | 1 |
| 5 | A proapoptotic peptide for the treatment of solid tumors 显示文摘 | Mai JC Mi Z Kim SH | 2001 | Cancer Res2001，61，21： | 1 |
| 6 | A proapoptotie peptide for the treatment of solid tumors 显示文摘 | Mai JC Mi Z Kim SH | 2001 | Cancer Research2001，61，21： | 1 |
| 7 | Hutchinson-Gilford progeria versus mandibuloacral dysplasia 显示文摘 | Mehrez MAI Mostafa MI | 2014 | Indian J Dermatol2014，59，2： | 1 |
| 8 | A proapoptotic peptide for the treatment of solid tumors 显示文摘 | Mai JC Mi Z Kim SH | 2001 | Cancer Res2001，61，21： | 1 |
| 9 | Aproapoptotic Peptide for the reatment of solid tumors显示文摘 | Mai JC Mi Z Kim SH | 2001 | Cancer Res2001，61，21： | 1 |
| 10 | A preapoptotie peptide for the treat- ment of solid tumors 显示文摘 | Mai JC Mi Z Kim SH | 2001 | Cancer Res2001，61，21： | 1 |
| 11 | Effects of Dietary Soybean Stachyose and Phytic Acid on Gene Expressions of Serine Proteases in Japanese Flounder(Paralichthys olivaceus)显示文摘Soybean stachyose (SBS) and phytic acid (PA) are anti-nutritional factors (ANF) which have deleterious effects on the growth and digestibility in fish. The present research studied the effects of dietary SBS and PA on the expression of three serine protease genes in the liver of Japanese flounder (Paralichthys olivaceus). These genes are trypsinogen 1 (poTRY), elastase 1 (poEL) and chymotrypsinogen 1 (poCTRY). Eight artificial diets with graded levels of supplemented ANFs were formulated to 4 levels of SBS (0.00, 0.40, 0.80 and 1.50%), 4 levels of PA (0.00, 0.20, 0.40 and 0.80), respectively.Japanese flounder (initial weight 2.45 g ± 0.01 g) were fed with these diets for 10 weeks with three replications per treatment. At the end of 10 weeks, supplementation of 0.40% of dietary SBS or PA significantly increased the gene expression of poTRY and poCTRY (P<0.05). The same level of dietary SBS significantly decreased the gene expression of poEL. In comparison with the control group (ANF-free),dietary PA (0.2% and 0.8%) significantly decreased the gene expression of poTRY, poCTRY and poEL (P<0.05). However, excessive supplement of dietary SBS (1.5%) has no significant effects on these gene expressions (P>0.05). These results suggested that dietary SBS and dietary PA could directly affect the serine protease genes at the transcriptional level in Japanese flounder, and these genes'expression was more sensitive to dietary PA than to SBS under the current experimental conditions. | MI Haifeng MAI Kangsen ZHANG Wenbing WU Chenglong CAI Yinghua | 2011 | Journal of Ocean University of China2011，10，3： | 1 |
| 12 | Ap roapop totic Pep tide for the reatment of solid tumors显示文摘 | Mai JC Mi Z Kim SH | 2001 | Cancer Res2001，61，21： | 1 |
| 13 | A proapoptotic peptide for the treatment of solid tumors 显示文摘 | Mai JC Mi Z Kim SH | 2001 | Cancer Res2001，61，21： | 1 |
| 14 | A proapoptotic peptide for the treatment of solid tumors 显示文摘 | MAI J C MI Z KIM S H | 2001 | Cancer Res2001，，61： | 1 |
| 15 | A proapoptotic peptide for the treatment of solid tumors 显示文摘 | Mai JC Mi Z Kim SH | 2001 | Cancer Res2001，61，21： | 1 |
| 16 | Occurrence of brominated flame retardants (BFRs), organochlorine pesticides (OCPs), and polychlorinated biphenyls (PCBs) in agricultural soils in a BFR-manufacturing region of North China显示文摘 | Zhi-Cheng Zhu She-Jun Chen Jing Zheng Mi Tian An-Hong Feng Xiao-Jun Luo Bi-Xian Mai | 2014 | Science of the Total Environment2014，，： | 1 |
| 17 | A proapoptotic peptide for the treatment of solid tumors 显示文摘 | Mai JC Mi Z Kim SH | 2001 | Cancer Res2001，61，21： | 1 |
| 18 | Characterization of a class of cationic peptides able to facilitate efficient protein transduction in vitro and in vivo显示文摘 | Mi Z Mai J Lu X | | 0，，04： | 1 |
| 19 | A proapoptotic peptide for the treatment of solid tumors显示文摘 | Mai JC Mi Z Kim SH | 2001 | Cancer Res2001，61，21： | 1 |
| 20 | Effects of strain rate on austenite stability and mechanical properties in a 5Mn steel显示文摘The austenite stability and the mechanical properties in a typical medium Mn grade steel,i.e.,5Mn steel,were investigated under a wide range of strain rates through the combination of experimental and theoretical methodologies.The obtained results indicate that austenite is more stable at a high strain rate,which is due to the suppression of the austenite to martensite transformation.This suppression is attributed to the increased stacking fault energy and the high deformation energy barrier.Moreover,the suppression of martensitic transformation also leads to the decrease in the ultimate tensile strength and the uniform elongation.Owing to the increase in an adiabatic heating temperature,an increase in the uniform elongation is acquired at a high strain rate.The obtained fundamental study results shed light on a wide application of the medium Mn steel under different strain rate conditions. | Yong-gang Yang Wang-zhong Mu Xiao-qing Li Hai-tao Jiang Mai Wang Zhen-li Mi Xin-ping Mao | 2022 | Journal of Iron and Steel Research(International)2022，29，2： | 1 |
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