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| 1 | Probiotic Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cells显示文摘AIM:To investigate the effects of four probiotic bacteria and their combination on human mast cell gene expression using microarray analysis.METHODS:Human peripheral-blood-derived mast cells were stimulated with Lactobacillus rhamnosus (L.rhamnosus) GG (LGG),L.rhamnosus Lc705 (Lc705),Propionibacterium freudenreichii ssp.shermanii JS (PJS) and Bifidobacterium animalis ssp.lactis Bb12 (Bb12) and their combination for 3 or 24 h,and were subjected to global microarray analysis using an Affymetrix GeneChip Human Genome U133 Plus 2.0 Array.The gene expression differences between unstimulated and bacteria-stimulated samples were further analyzed with GOrilla Gene Enrichment Analysis and Visualization Tool and MeV Multiexperiment Viewer-tool.RESULTS:LGG and Lc705 were observed to suppress genes that encoded allergy-related high-affinity IgE receptor subunits α and γ (FCER1A and FCER1G,respectively) and histamine H4 receptor.LGG,Lc705 and the combination of four probiotics had the strongest effect on the expression of genes involved in mast cell immune system regulation,and on several genes that encoded proteins with a pro-inflammatory impact,such as interleukin (IL)-8 and tumour necrosis factor alpha.Also genes that encoded proteins with anti-inflammatory functions,such as IL-10,were upregulated.CONCLUSION:Certain probiotic bacteria might diminish mast cell allergy-related activation by downregulation of the expression of high-affinity IgE and histamine receptor genes,and by inducing a pro-inflammatory response. | Anna Oksaharju Matti Kankainen Riina A Kekkonen Ken A Lindstedtt Petri T Kovanen Riitta Korpela Minja Miettinen | 2011 | World Journal of Gastroenterology2011，17，6： | 3 |
| 2 | An α-glucuronidase of Schizophyllum commune acting on polymeric xylan显示文摘 | MAIJA T MATTI S A | 2000 | J Biochem2000，78，： | 1 |
| 3 | Endoxylanase Ⅱ from Trichoderma reesei has several isoforms with different isoelectric points显示文摘 | Arja L Matti S A Nisse K | 2000 | Biotechnology and Applied Biochemistry2000，31，1： | 1 |
| 4 | Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52)显示文摘 | Byrne J A Mattie M G Basset P | 1996 | Genomics1996，35，3： | 1 |
| 5 | Changes in the blood chemistry of rainbow trout, Salmo gairdneri fish, in relation to dietary pro- tein level, and an anabolic steroid hormone, ethylestrenol显示文摘 | Lone K P Ince B W Matty A J | 1982 | Journal of Fish Biology1982，20，： | 1 |
| 6 | Adaptive combination of adaptive classifiers for handwritten character recognition显示文摘 | Matti A Jorma L | 2007 | Pattern Recognition Letters2007，28，1： | 1 |
| 7 | Band structure and optical parameters of the Sn02 ( 110 ) surface 显示文摘 | Matti A Jaskari M Tapio T R | 2001 | Physical Review B2001，64，07： | 1 |
| 8 | Molecular characterization of patient-derived human pancreatic tumor xenograft models for preclinical and translational development of cancer therapeutics显示文摘 | Mattie M Christensen A Chang MS | 2013 | Neoplasia2013，15，10： | 1 |
| 9 | Multiresolu- tion gray-scale and rotation invariant texture classification with local binary patterns显示文摘 | Timo Ojala Matti Pietika inen Topi M a enpa a | 2002 | IEEE Transactions on Pattern Analysis and Machine Intelligence2002，24，： | 1 |
| 10 | Initial conditions or process of development? Critical incidents in the early stages of new ventures 显示文摘 | MATTI A K | 2003 | R&D Management2003，2，33： | 1 |
| 11 | Nuerophysiological correlates of age-related changes in human motor function 显示文摘 | Matty VS Fera F Tessitore A | 2002 | Nuerology2002，58，： | 1 |
| 12 | Determination of the degree of substitution of acetylated starch by hydrolysis, ^1H NMR and TGA/IR 显示文摘 | Matti E Tomas A | 2004 | Carbohydrate Polymers2004，57，： | 1 |
| 13 | Closure study o~optical and microphysical properties of a mixed urban and Arctic haze air mass observed with Rarnan lidar and sunphotometer 显示文摘 | Mtiller D Mattis I Ansmann A | 2004 | Journal of Geophysical Research2004，109，13： | 1 |
| 14 | Pharmacodynam- ics and safety of a new calcium sensitizer,levosimendan, and its metabolites during an extended infusion in patients with severe heart failure显示文摘 | Matti D Kivikko MD Saila A | 2002 | Clin Pharmacol2002，42，1： | 1 |
| 15 | Transoral power-assisted marsupialization of vallecular cysts under local anesthesia显示文摘 | PAGELLA F PUSATERI A MATTI E | 2013 | Laryngoscope2013，123，： | 1 |
| 16 | An efficient channel block diagonalization method for generalized zero forcing assisted MIMO broad- casting systems 显示文摘 | Li Wei Matti L A | 2011 | IEEE Transactions on Wireless Commu- nications2011，10，3： | 1 |
| 17 | Transoral power-assisted mar- supialization of vaUecular cysts under local anesthesia 显示文摘 | PageUa F Pusateri A Matti E | 2013 | Laryn- goscope2013，123，3： | 1 |
| 18 | Intratu- moral heterogeneity in breast carcinoma revealed by la- ser- microdissection and comparative genomic hybrid- ization 显示文摘 | Aubele M Mattis A Zitzelsberger H | 1999 | Cancer genetics and cytogenetics1999，110，2： | 1 |
| 19 | Effects of dietary carbohydrate and fiber on the tilapia Oreoehromis nilotieus (Linn)显示文摘 | Anderson J Jackson A J Matty A J | 1984 | Aquaculture1984，37，： | 1 |
| 20 | How we do it:a combined method of traditional curette and power-assisted endoscopic adenoidectomy显示文摘 | Pagella F Matti E Colombo A | 2009 | Acta Otolaryngol2009，129，5： | 1 |
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