|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation显示文摘AIM: To study the genesis of neointima formation in pulmonary hypertension(PH), we investigated the role of caveolin-1 and related proteins. METHODS: Male Sprague Dawley rats were given monocrotaline(M, 40 mg/kg) or subjected to hypobaric hypoxia(H) to induce PH. Another group was given M and subjected to H to accelerate the disease process(M + H). Right ventricular systolic pressure, right ventricular hypertrophy, lung histology for medial hypertrophy and the presence of neointimal lesions were examined at 2 and 4 wk. The expression of caveolin-1 and its regulatory protein peroxisome proliferator-activated receptor(PPAR) γ, caveolin-2, proliferative and antiapoptotic factors(PY-STAT3, p-Erk, Bcl-x L), endothelial nitric oxide synthase(e NOS) and heat shock protein(HSP) 90 in the lungs were analyzed, and the results from M + H group were compared with the controls, M and H groups. Double immunofluorescence technique was used to identify the localization of caveolin-1 in pulmonary arteries in rat lungs and in human PH lung tissue. RESULTS: In the M + H group, PH was more severe compared with M or H group. In the 4 wk M+H group, several arteries with reduced caveolin-1 expression in endothelial layer coupled with an increased expression in smooth muscle cells(SMC), exhibited neointimal lesions. Neointima was present only in the arteries exhibiting enhanced caveolin-1 expression in SMC. Lung tissue obtained from patients with PH also revealed neointimal lesions only in the arteries exhibiting endothelial caveolin-1 loss accompanied by an increased caveolin-1 expression in SMC. Reduction in e NOS and HSP90 expression was present in the M groups(2 and 4 wk), but not in the M + H groups. In both M groups and in the M + H group at 2 wk, endothelial caveolin-1 loss was accompanied by an increase in PPARγ expression. In the M + H group at 4 wk, increase in caveolin-1 expression was accompanied by a reduction in the PPARγ expression. In the H group, there was neither a loss of endothelial caveolin-1, eNOS or HSP 90, nor an increase in SMC caveolin-1 expression; or any alteration in PPARγ expression. Proliferative pathways were activated in all experimental groups. CONCLUSION: Enhanced caveolin-1 expression in SMC follows extensive endothelial caveolin-1 loss with subsequent neointima formation. Increased caveolin-1 expression in SMC, thus, may be a prelude to neointima formation. | Jing Huang John H Wolk Michael H Gewitz James E Loyd James West Eric D Austin Rajamma Mathew | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 2 | Adaptive Sampling for Network Management显示文摘 | Edwin A Hernandez Mathew C Chidester Alan D George | 2001 | JNSM2001，9，4： | 1 |
| 3 | Detection of cerebral hypoperfusion during trial carotid occlusion with reversal following extracranialintracranial bypass prior to permanent occlusion显示文摘 | Walker BS Mathews D Batjer H | 1994 | Clin Nucl Med1994，19，： | 1 |
| 4 | Synthesis, phase transition and thermal expansion studies on M2 MgWO6 ( M -: Ba^2+ and Sr^2+ ) double perovskites显示文摘 | Patwe S J Achary S N Mathews M D | 2005 | Journal of Alloys and Compounds2005，390，12： | 1 |
| 5 | An analysis of clinical outcomes using color doppler testicular ultrasound for testicular torsion显示文摘 | Baker L A Sigman D Mathews R I | 2000 | Pediatrics2000，105，31： | 1 |
| 6 | Multiple type-B re-sponse regulators mediate cytokinin signal transduction in Arabidopsis显示文摘 | MASON M G MATHEWS D E ARGYROS D A | 2005 | Plant Cell2005，17，： | 1 |
| 7 | Uhrasound guided vacuumassisted excision in the diagnosis and treatment of clinically benign breast lesions显示文摘 | Mathew J Crawford D J Lwin M | 2007 | Ann R Coll Surg Engl2007，5，4： | 1 |
| 8 | Clinical Inquiry: Do anti-biotics improve outcomes for patients hospitalized withCOPD exacerbations? 显示文摘 | Mathew SZeitlin D Rickett K | 2012 | J Fam Pract2012，61，9： | 1 |
| 9 | Dynalign: an algorithmfor finding the secondary structure common to two RNA se-quences 显示文摘 | MATHEWS D H TURNER D H | 2002 | J Mol Biol2002，317，2： | 1 |
| 10 | Cardio- vascular risks with azithromycin and other antibacterial drugs 显示文摘 | Mosholder A D Mathew J Alexander J J | 2013 | N Engl J Med2013，368，18： | 1 |
| 11 | Posterior vitreous detachment following cataract surgery显示文摘 | Hilford D Hilford M Mathew A | 2009 | Eye2009，23，6： | 1 |
| 12 | Wind and water erosion and transport in semi-arid shrubland,grassland and forest ecosystems:quantifying dominance of horizontal wind-driven transport显示文摘 | David D B Jeffrey J W Mathew P J | 2003 | Earth Surface Processes and Landforms2003，28，： | 1 |
| 13 | Annual summary of vital statistics:2004显示文摘 | Hoyert D Mathews TJ Menacker F | 2006 | Pediatrics2006，117，2： | 1 |
| 14 | Eigenstructure techniques for 2-D angle estimation with uniform circular array显示文摘 | Mathews C P Zoltowski M D | 1994 | IEEE Trans on SP1994，42，9： | 1 |
| 15 | Type B responseregulators of Arabidopsis play key roles in cytokinin signaling and plant de-velopment显示文摘 | ARGYROS R D MATHEWS D E CHIANG Y H | 2008 | Plant Cell2008，20，： | 1 |
| 16 | Mechanistic and kinetic aspects of the curing of phthalonitrile monomers in the presence of propargyl groups显示文摘 | Augustine D Mathew D Reghunadhan Nair C P | 2015 | Polym2015，60，： | 1 |
| 17 | Deter- mining embedding dimension for phase-space recon- struction using a geometrical construction显示文摘 | Kennel Mathew B Brown R Abarbanel H D I | 1992 | Phy Rev A1992，45，： | 1 |
| 18 | Domains of elF1A that mediate binding to elF2, elF3 and elF5B and promote ternary complex recruitment in vivo 显示文摘 | Olsen D A S Savner E M Mathew A | 2003 | The EM- BO journal2003，22，2： | 1 |
| 19 | Application of the indicators of hydrologic alteration software in environmental flow setting 显示文摘 | Mathews R Richter B D | 2007 | Journal of American Water Resources Association2007，43，6： | 1 |
| 20 | Data mining for simple sequence repeats in expressed sequence tags from barley,maize,rice,sorghum and wheat显示文摘 | Rota M L Mathews D V | 2002 | Plant Molecular biology2002，48，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员