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	题名	作者	年代	出处	被引量
1	Proteomic analysis for developing new biomarkers of hepatocellular carcinoma显示文摘AIM: To identify new markers of hepatocellular carcinoma (HCC) using a proteomic analysis. METHODS: Patients with liver cirrhosis of the three most frequent etiologies: hepatitis C virus, hepatitis B virus and alcoholic liver disease, were included in the study. The samples were analysed by 2D-electrophoresis in order to determine the differential protein expression. The proteins were separated according to the charge in immobilized pH 3-10 gradient strips and then by sodium dodecyl sulfate polyacrylamide gel electrophoresis. Proteins of interest were excised, digested with trypsin and the resulting peptides were separated and identified. RESULTS: Three differentially expressed apolipoproteins (Apo) were identified based on the protein profile using proteomic techniques: Apo-A1, Apo-A4 and Apo-E. Apo-A4 levels were significantly lower in HCC than in non-HCC patients regardless of etiology (P < 0.01). Multivariate logistic regression showed that Apo-A4 and Apo-A1 were the only independent factors related to HCC diagnosis (P < 0.05). The receiver operating characteristic (ROC) curve including both Apo-A4 and Apo-A1 showed an area under the ROC of 0.944 (P < 0.001), a sensitivity of 0.89 and a specificity of 0.81 for diagnosis of HCC. CONCLUSION: Apo-A4 and Apo-A1 may be used clinically as biomarkers of HCC with a high sensibility and specificity. These findings may provide additional insights into the mechanism of HCC development and progression.	Maria Pleguezuelo Laura M Lopez-Sanchez Antonio Rodriguez-Ariza Jose L Montero Javier Briceno Ruben Ciria Jordi Muntane Manuel de la Mata	2010	World Journal of Hepatology2010，2，3：	3
2	Robust wide-baseline stereo from maximally stable extremal regions显示文摘	J Matas O Chum M Urban T Pajdla	2004	Image and Vision Computing2004，，10：	2
3	A reevaluation of the key factors that influence tomato fruit softening and integrity显示文摘	Sladie M Matas A J Isaacson T	2007	Plant Physiology2007，144，：	1
4	Contact deformation regimes around sharp indentations and the concept of the characteristic strain显示文摘	Mata M Angtada M Alcala J	2002	Journal of Materials Research2002，17，5：	1
5	Development of a PCR assay for Streptococcus iniae based on the lactate oxidase(lctO )gene with potential diagno- sticvalue显示文摘	I ANA M MATA BLANCO MAR	2004	Veterinary Microbiology2004，101，：	1
6	Linear Current Control Scheme With Series Resonant Harmonic Compensator for Single-Phase Grid-Con nected Photovoltaic Inverters显示文摘	Castilla M Miret J Matas J		0，，07：	1
7	Reduction of voltage gated sodium channelprotein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy 显示文摘	Chattopadhyay M Zhou Z Hao S Mata M Fink D J	2012	Mol Pain2012，8，：	1
8	Wireless- Control Strategy for Parallel Operation of Distributed-Gener- ation Inverters显示文摘	J M Guerrero J Matas L Cz de Vicuna	2006	IEEE Transactions on Industrial lectron- ics2006，53，5：	1
9	Herpes simplex virus vectormediated expression of Bcl-2 protects spinal motor neurons from degeneration following root avulsion显示文摘	Yamada M Natsume A Mata M	2001	Exp Neurol2001，168，2：	1
10	Wireless control strategy for parallel operation of distributed generation inverters显示文摘	Guerrero J M Matas J Devicuna L G	2006	IEEE Transactions on Industrial Electronics2006，53，5：	1
11	Bcl-2 and GDNF delivered by HSV-mediated gene transfer act additively to protect dopaminergic neurons from 6-OHDA-induceddegeneration显示文摘	Mata M Goss J	2001	Exp Neurol2001，169，：	1
12	Feedback linearization of direct-drive synchronous wind-turbines via a sliding mode approach显示文摘	Matas J Castilla M Guerrero J M	2008	IEEE Transactions on Power Electronics2008，23，3：	1
13	Mechanical property evaluation through sharp indentations in elastoplastic and fully plastic contact regimes显示文摘	Mata M Alcala J	2003	Journal of Materials Research2003，18，7：	1
14	Production of paradoxical sensory hypersensitivity by alpha 2 -adrenoreceptor agonists显示文摘	Quartilho A Mata H P Ibrahim M M	2004	Anesthesiology2004，101，6：	1
15	Traffic sign recognition and analysis for intelligent vehicles显示文摘	Escalera A de la Armingol J M Mata M	2003	Image and Vision Computing2003，21，3：	1
16	Output impedance design of parallel-connected UPSinverters with wireless load-sharing control显示文摘	Guerrero J M de Vicuna L G Matas J	2005	IEEE Transactions on Industrial Electronics2005，52，4：	1
17	Transsul- furafion, protein synthesis rate and follicle mRNA in the skin of young Merino lambs in response to infu- sions of methionine and serine 显示文摘	LIU S M MATA G FIGLIOMENI S	2000	British Journal of Nutrition2000，83，4：	1
18	A dopamine D2 receptor generelated polymorphism is associa ted with schizophrenia in a Spanish population isolate显示文摘	Parsons MJ Mata I Beperet M	2007	Psychiatr Genet2007，17，3：	1
19	Bcl-2 and GDNF delivered by HSV-mediated gene transfer after spinal root avulsion provide a synergistic effect显示文摘	Natsume A Mata M Wolfe D	2002	J Neurotrauma2002，19，1：	1
20	Risky innovation: the impact of internal and external R&D strategies upon the distri- bution of returns 显示文摘	MATA J WOERTER M	2013	Research Policy2013，，42：	1

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