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| 1 | 生精障碍的遗传因素显示文摘大概10%-15%的夫妇患有不孕不育,其中,男性因素导致的不育约占一半。部分是由男方的生精障碍导致的,但其根本原因,包括遗传性变异,仍知之甚少。迄今为止,男性不育症诊断中使用的唯一基因测试的目的是检测是否存在Y染色体长臂的微缺失或者染色体异常。各种其他单基因和多基因缺陷也己被提出与男性生育能力相关。但其致病作用仍有待验证。最近,全基因组技术和小鼠模型的大规模分析方面所取得的巨大进步可能有助于这方面的研究。利用基因敲除小鼠模型,至少有388个基因与小鼠生精相关的基因被发现了。但当前的主要问题在于如何把这些研究成果从小鼠转移应用到人类。 | Annelien Massart Willy Lissens Herman Tournaye Katrien Stouffs | 2012 | Asian Journal of Andrology2012，14，1： | 36 |
| 2 | Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity显示文摘Background:Obesity is often associated with nonalcoholic fatty liver disease(NAFLD),which refers to a large spectrum of hepatic lesions including fatty liver,nonalcoholic steatohepatitis(NASH)and cirrhosis.Different investigations showed or suggested that obesity and NAFLD are able to increase the risk of hepatotoxicity of different drugs.Some of these drugs could induce more frequently an acute hepatitis in obese individuals whereas others could worsen pre-existing NAFLD.Aim:The main objective of the present review was to collect the available information regarding the role of NAFLD as risk factor for drug-induced hepatotoxicity.For this purpose,we performed a data-mining analysis using different queries including drug-induced liver injury(or DILI),drug-induced hepatotoxicity,fatty liver,nonalcoholic fatty liver disease(or NAFLD),steatosis and obesity.The main data from the collected articles are reported in this review and when available,some pathophysiological hypotheses are put forward.Relevance for patients:Drugs that could pose a potential risk in obese patients include compounds belonging to different pharmacological classes such as acetaminophen,halothane,methotrexate,rosiglitazone,stavudine and tamoxifen.For some of these drugs,experimental investigations in obese rodents confirmed the clinical observations and unveiled different pathophysiological mechanisms which could explain why these pharmaceuticals are particularly hepatotoxic in obesity and NAFLD.Other drugs such as pentoxifylline,phenobarbital and omeprazole might also pose a risk but more investigations are required to determine whether this risk is significant or not.Because obese people often take several drugs for the treatment of different obesity-related diseases such as type 2 diabetes,hyperlipidemia and coronary heart disease,it is urgent to identify the main pharmaceuticals that can cause acute hepatitis on a fatty liver background or induce NAFLD worsening. | Julie Massart Karima Begriche Caroline Moreau Bernard Fromenty | 2017 | Journal of Clinical & Translational Research2017，3，1： | 4 |
| 3 | Rough sets theory显示文摘 | Walczak B Massart D L | 1999 | Chemometrics and Intelligent Laboratory Systems1999，47，： | 2 |
| 4 | Dealing with missing data Part 1显示文摘 | Walczak B Massart DL | 2001 | Chemometrics and Intelligent Laboratory Systems2001，，58： | 2 |
| 5 | Principal component analysis of dissolution data with missing elements显示文摘 | Adams E Walczak B Vervaet C Risha P G Massart D L | 1997 | Chemometrics and intelligent aboratory systems1997，，32： | 2 |
| 6 | Comparison of semirobust and robust partial least squares procedures显示文摘 | M.I. Griep I.N. Wakeling P. Vankeerberghen D.L. Massart | 1995 | Chemometrics and Intelligent Laboratory Systems1995，，1： | 2 |
| 7 | Identification of pharmaceutical excipients using NIR spectroscopy and SIMCA 显示文摘 | Candofi A Maesschalck R D Massart D L | 1999 | Journal of Pharmaceutical and Biomedical Analysis1999，19，： | 1 |
| 8 | Rough sets theory 显示文摘 | Walczak B Massart D L | 1999 | Chemometrics and Intelligent Laboratory Systems1999，47，1： | 1 |
| 9 | Preparation of aqueous magnetic liquids in alkaline and acidic media显示文摘 | MASSART R | 1981 | IEEE Trans Mag1981，17，： | 1 |
| 10 | Peak purity control in liquid chromatography with photodiode-array detection by a fixed size moving window evolving factor analysis显示文摘 | Keller H R Massart D L | 1991 | Anal Chim Acta1991，246，4： | 1 |
| 11 | The use of MODIS datato derive acreage estimations for larger fields: A casestudy in the south-western Rostov region of Russia显示文摘 | Fritz S Massart M Savin I | 2008 | International Journal of Applied Earth Observation andGeoinformation Modem Methods in Crop YieldForecasting and Crop Area Estimation2008，10，4： | 1 |
| 12 | Comparison of classification approaches applied to NIR-spectra of clinical study lots显示文摘 | Candolfi A Wu W Massart D L | 1998 | Journal of Pharmaceutical and Biomedical Analysis1998，16，8： | 1 |
| 13 | Feasibility study for the use of near infrared spectroscopy in the qualitative and quantitative analysis of green tea显示文摘 | Luypaert J Zhang M Massart D | 2003 | Anal Chim Acta2003，478，： | 1 |
| 14 | Genetic diversity among European cultivated spelt revealed by microsatellites显示文摘 | P. Bertin D. Grégoire S. Massart D. de Froidmont | 2001 | TAG Theoretical and Applied Genetics2001，，1： | 1 |
| 15 | Mycotoxin detection in infant formula milks in Italy显示文摘 | V. Meucci E. Razzuoli G. Soldani F. Massart | 2010 | Food Additives & Contaminants: Part A2010，，1： | 1 |
| 16 | Salivary alpha-amylase, cortisol and chromoganin A responses to a lecture: impact of sex显示文摘 | FILAIRE E DREUX B MASSART A | 2009 | Eur J Appl Physiol2009，106，1： | 1 |
| 17 | Carvedilol and lacidipine prevent cardiac hypertrophy and endothelin-1 gene overexpression after aortic banding显示文摘 | Massart PE Donckier J Kyselovic J | 1999 | Hypertension1999，34，： | 1 |
| 18 | The Mahalanobis distance显示文摘 | De Maesschalck R Jouan-Rimbaud D Massart D L | 2000 | Chemometrics and Intelligent Laboratory Systems2000，50，1： | 1 |
| 19 | Looking for Natural Patterns in Data显示文摘 | Daszykowski M Walczak B Massart D L | 2001 | Chemometrics and Intelligent Laboratory Systems2001，56，2： | 1 |
| 20 | Serum insulin-like growth factor-1 measurement in the follow-up of treated acromegaly:comparison of four immunoassays显示文摘 | Massart C Poirier JY | 2006 | Clin Chim Acta2006，373，： | 1 |
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