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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Organization of tension wood fibers with special reference to the gelatinous layerin Populus tremuloides Michx 显示文摘 | Mia A J | 1968 | Wood Science1968，，1： | 1 |
| 3 | Identification of the virus of rabbit haemorrhagic in Tunisia显示文摘 | Bouslama A De Mia G M Hammami S | 1996 | Vet Res1996，138，： | 1 |
| 4 | Photodegradation and stability of chlorothalonil in water by solid-phase disk extraction,followed by gas chromatographic techniques显示文摘 | Penuela G A Da mia B | 1998 | Chromatography A1998，，823： | 1 |
| 5 | Entrained oxide films in TiAl castings显示文摘 | MIA J HARDINGB R A WICKINSB M | 2003 | Intermetallics2003，，11： | 1 |
| 6 | Dimethyl Dioctadecyl Ammonium Bromide(DDA)-induced Arthritis in Rats:a Model of Experimental Arthritis显示文摘 | Mia M Y Zhang L Hossain A | 2000 | J Autoimmun2000，14，4： | 1 |
| 7 | Effect of Material Properties on Long-Term Deflection of GFRP Reinforced Concrete Beams 显示文摘 | Mias C Torres L Turon A | 2013 | Construction and Building Material2013，，41： | 1 |
| 8 | Dimethyl dioctadecyl ammonium bromide(DDA)-induced arthritis in rats:A model of experimental arthritis显示文摘 | Mia MY Zhang L Hossain A | 2000 | Journal of Autoimmunity2000，14，4： | 1 |
| 9 | Evaluation of hormone replacement therapy 显示文摘 | Siddiqui N I Rabman S Mia A R et a| | 2005 | Mymensingh Med J2005，14，2： | 1 |
| 10 | The Built En- vironment and Obesity 显示文摘 | Papas Mia A Alberg Anthony J Ewing Reid | 2007 | Epidemiologic Reviews2007，29，1： | 1 |
| 11 | Comparative Study of Partial Least Squares and a Modification of Hybrid Linear Analysis Calibration in the Simultaneous Spectrophotometric Determination of Rifampicin,Pyrazinamide and Isoniazid显示文摘 | Espinosa-Mansilla A Valenzuela MIA Pea A M | 2001 | Anal Chim Acta2001，427，： | 1 |
| 12 | Rhizobium as a crop enhancer and biofertilizer for increased cereal production显示文摘 | Baset Mia M A Shamsuddin Z H | 2010 | African J Biotechnol2010，9，37： | 1 |
| 13 | Influence of di-methoate on testicular and epididymal organs, testosteroneplasma level and their tissue residues in rats 显示文摘 | Afifi NA Ramadan A E1 - Aziz MIA | 1991 | Dtsch Tier-arztl Wschr1991，98，11： | 1 |
| 14 | Estimation of genetic and phenotypic parameters of some reproductive traits of Black bengal does显示文摘 | Mia M M Khandoker M A M Y Husain S S | 2013 | Ira- nian Journal of Applied Animal Science2013，3，4： | 1 |
| 15 | The use of management accounting systems in hotels: an exploratory study显示文摘 | Mia L Patiar A | 2001 | International Journal of Hospitality Management2001，20，： | 1 |
| 16 | An optimized protocol for human M2 macrophages using M-CSF and IL- 4/IL-lO/TGF-beta yields a dominant immunosuppressive phenotype显示文摘 | Mia S Warnecke A Zhang XM | 2014 | Scand J Immunol2014，79，5： | 1 |
| 17 | Evaluation of hormone replacement therapy显示文摘 | Siddiqui N I Rahman S Mia A R | 2005 | Mymensingh Med J2005，14，2： | 1 |
| 18 | Evaluation of Hor-mone repla-cementtherapy 显示文摘 | SiddiquiN I Rahman S Mia A R | 2005 | Mymensingh Med J2005，14，2： | 1 |
| 19 | Influence of dimethoate on testicular and epididymal organs, testosterone plasma level and theia tissue residues in rats显示文摘 | Afifi N A Ramadan A El-aziz MIA | 1991 | Dtsch Tierarztl Wschr1991，98，11： | 1 |
| 20 | Release of canine parvovirusfrom endocytic vesicles显示文摘 | Sanna S Mia A Anne J | 2003 | Virology2003，316，： | 1 |
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