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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Phosphorus diagenesis in lake sediments:investigation using fractionation techniques显示文摘 | Michael R P Martin T A Eric L V | 1995 | Mar Freshwater Res1995，46，： | 1 |
| 3 | A review of production planning and scheduling models in the semiconductor industry part Ⅱ: shop-floor control 显示文摘 | Uzsoy R L C Martin V L A | 1994 | IIE Transactions1994，26，5： | 1 |
| 4 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 5 | Relationship between total transit time and fecal quality in dogs differing body size显示文摘 | Hernot D C Blourge V C Martin L J | | 0，，： | 1 |
| 6 | Effects of paradoxical sleep deprivation on blood parameters associated with cardiovascular risk in aged rats 显示文摘 | Andersen M L Martins P G F D'Almeida V | 2004 | Exp Gerontol2004，39，6： | 1 |
| 7 | Multistage expansion planning for active distribution networks under demand and distributed generation uncertainties显示文摘 | BORGES C L T MARTINS V F | 2012 | International Journal of Electrical Power Energy Systems2012，36，1： | 1 |
| 8 | A decadal satellite analysis of the origins and impacts of smoke in Colorado 显示文摘 | MARTIN M V HEALD C L FORD B | 2013 | Atmospheric Chemistry Physics2013，13，3： | 1 |
| 9 | Search Strategies for Feeder Bus Network Design Problem显示文摘 | Martins C L Pato M V | 1998 | European Journal of Operation Research1998，106，： | 1 |
| 10 | Single-crystal growth and structure determination of misfit layer oxide 显示文摘 | Markus V Martin V Sven L | 2007 | Journal of Crystal Growth2007，306，： | 1 |
| 11 | Structural insights into the innate immune recognition specifici- ties of L- and H-ficolins显示文摘 | Garlatti V Belloy N Martin L Lacroix M Matsushita M Endo Y | 2007 | EMBO J2007，26，2： | 1 |
| 12 | A new shortest paths rank- ing algorithm显示文摘 | E Q V Martins J L E Santos | 2000 | Investigacao Operaeional2000，20，1： | 1 |
| 13 | Effects of lateseason nitrogen fertilizer on irrigated soybean yield and composition 显示文摘 | Wesley T L Lamond R E Martin V L | 1998 | Journal of Production Agriculture1998，11，3： | 1 |
| 14 | Endocrinological and catecholaminergic alterations during sleep deprivation and recovery in male rats显示文摘 | Andersen M L Martins P J D 'Almeida V | 2005 | J Sleep Res2005，14，1： | 1 |
| 15 | Active distribution network integrated planning incorporating distributed generation and load response uncertainties显示文摘 | MARTINS V F BORGES C L T | 2011 | IEEE Trans on Power Systems2011，26，4： | 1 |
| 16 | Unlocking the hidden value of concepts: A cognitive approach to business model innovation显示文摘 | Martins L L Rindova V P Greenbaum B E | 2015 | Strategic Entrepreneurship Journal2015，9，： | 1 |
| 17 | Template synthesis of graphitic nanotubules显示文摘 | Parthasarathy R V Phani K L Martin C R | 1995 | Adv Mater1995，7，： | 1 |
| 18 | Multipass Optical Cell Based Upon Two Cylindrical Mirrors for Tunable Diode Laser Absorption Spectroscopy 显示文摘 | Kasyutich V L Martin P A | 2007 | Applied Physics2007，88，： | 1 |
| 19 | Active distribution net- work integrated planning incorporating distributed generation and load response uncertainties显示文摘 | V F Martins C L T Borges | 2011 | Power Systems IEEE Transactions on2011，26，4： | 1 |
| 20 | Active distribution network integrated planning incorporating distributed generation and load response uncertainties显示文摘 | Martins V F Borges C L T | 2011 | IEEE Transactions Power System2011，26，4： | 1 |
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