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| 1 | challenges of advanced hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is an aggressive malignancy,resulting as the third cause of death by cancer each year. The management of patients with HCC is complex,as both the tumour stage and any underlying liver disease must be considered conjointly. Although surveillance by imaging,clinical and biochemical parameters is routinely performed,a lot of patients suffering from cirrhosis have an advanced stage HCC at the first diagnosis. Advanced stage HCC includes heterogeneous groups of patients with different clinical condition and radiological features and sorafenib is the only approved treatment according to Barcelona Clinic Liver Cancer. Since the introduction of sorafenib in clinical practice,several phase Ⅲ clinical trials have failed to demonstrate any superiority over sorafenib in the frontline setting. Locoregional therapies have also been tested as first line treatment,but their role in advanced HCC is still matter of debate. No single agent or combination therapies have been shown to impact outcomes after sorafenib failure. Therefore this review will focus on the range of experimental therapeutics for patients with advanced HCC and highlights the successes and failures of these treatments as well as areas for future development. Specifics such as dose limiting toxicity and safety profile in patients with liver dysfunction related to the underlying chronic liver disease should be considered when developing therapies in HCC. Finally,robust validated and reproducible surrogate end-points as well as predictive biomarkers should be defined in future randomized trials. | Stefano Colagrande Andrea L Inghilesi Sami Aburas Gian G Taliani Cosimo Nardi Fabio Marra | 2016 | World Journal of Gastroenterology2016，22，34： | 19 |
| 2 | Application of Trichoderma harzianum (T22) and Trichoderma atroviride (P1) as plant growth promoters, and their compatibility with copper oxychloride显示文摘Trichoderma strains are used in agriculture because they provide to the plants the following benefits: i) are rhizosphere competence and establish stable rhizosphere microbial communities; ii) control plant disease caused by pathogenic and competitive microflora, by using a variety of mechanisms; iii) improve vegetative growth, root development and yield; iv) make nutrients more available to the plant. In this work we have investigated the ability of T. harzianum T22 and T. atroviride P1 to improve plant growth of locally important horticultural crops: lettuce, tomatoes and peppers and to prevent disease in the greenhouse and field. The effect of the Trichoderma treatment was evaluated by determining the weight of fresh and dry roots and above ground plant biomass, measuring plants height, counting the number of emerged leaves (lettuce, tomatoes and peppers) and quantifying production (tomatoes and peppers). No disease symptoms were found during production, although Fusarium sp. strains pathogenic to tomato were detected in the soil. Compounds containing copper oxychloride are frequently used for fungal disease control in agriculture. In order to investigate the compatibility of T. harzianum T22 and T. atroviride P1 with copper oxychloride applications, the effect on mycelia growth was monitored in both liquid and solid medium. In general, the tests indicated a high level of tolerance of the Trichoderma strains to concentrations of copper oxychloride varying from 0.1 to 5 mmol/L. | Francesco Vinale Gaetano D'Ambrosio Khalid Abadi Felice Scala Roberta Marra David Turrà Sheridan L Woo Matteo Lorito | 2004 | 浙江大学学报(农业与生命科学版)2004，30，4： | 7 |
| 3 | 显示文摘 | Meda L Marra G | 2005 | Composites Science and Technology2005，65，5： | 1 |
| 4 | Mechanisms of clearance of treponema pallidum from the CSF in a nonhuman primate model 显示文摘 | Marra CM Castro CD Kuller L | 1998 | Neurology1998，51，4： | 1 |
| 5 | A hospital-based matched case-control study to identify clinical outcome and risk factors asso- ciated with carbapenem-resistant Idebsiella pneumoniae infection 显示文摘 | Correa L Martino M Marra A | 2013 | BMC Infectious Diseases2013，13，1： | 1 |
| 6 | Radio frequency treatment of foods: Review of recent advances 显示文摘 | Marra F Zhang L Lyng J G | 2009 | Journal of Food Engineering2009，91，： | 1 |
| 7 | Onion extract gel versus petrolatum emollient on new surgical scars:prospective double-blinded study显示文摘 | KELLEY L MARRA D | 2006 | Dermatol Surg2006，32，2： | 1 |
| 8 | Radio frequency treatment of foods: Review of recent advances 显示文摘 | Marra F Zhang L Lyng J G | 2009 | Journal of Food Engineering2009，91，： | 1 |
| 9 | The biogenesis of the Golgi ribbon: the roles of membrane input from the ER and of GM130显示文摘 | Marra P Salvatore L Mironov A Jr | 2007 | Mol BM Cell2007，18，5： | 1 |
| 10 | Study on synthetic elastomers 显示文摘 | ROBINSON A E MARRA J V AMBERG L O | 1961 | Petroleum Science1961，6，4： | 1 |
| 11 | Phosphatidylinositol 3-kinase inhibition enhances human sperm motility显示文摘 | Luconi M Marra F Gandini L | 2001 | Hum Reprod2001，16，9： | 1 |
| 12 | A valuation of patients' willingness-to-pay for insulin delivery in diabetes显示文摘 | Guimaraes C Marra CA Colley L | 2009 | Int J Technol Assess Health Care2009，25，3： | 1 |
| 13 | Nano-aluminum as energetic material for rocket propellants显示文摘 | Meda L Marra G Galfetti L | 2007 | Mate- rials Science and Engineering C2007，27，5： | 1 |
| 14 | Hydrogenolysis of dichlorotetrafluoroethane isomeric mixtures for the formarion of 1, 1, 1,2-tetrafluoroethane 显示文摘 | Gervasutti C Marangoni L Marra W L | 1981 | J Fluorine Chem1981，19，1： | 1 |
| 15 | Health - related qualityof life trajectories among adults with tuberculosis: differences be- tween latent and active infection 显示文摘 | Marra CA Marra F Colley L | 2008 | Chest2008，133，2： | 1 |
| 16 | Rabbit calvarial wound healing by means of seeded Caprotite scaffolds显示文摘 | Bidic SM Calvert JW Marra K Kumta P Campbell P Mitchell R Wigginton W Hollinger JO Weiss L Mooney MP | | 0，，： | 1 |
| 17 | Phosphorylation-dependent interaction between plant plasma membrane H1-ATPase and 14-3-3 proteins显示文摘 | Camoni L Iori V Marra M Aducci P | 2000 | Biol Chem2000，275，： | 1 |
| 18 | Up-regulation of Skp2 after prostate cancer cell adhesion to basement membranes results in BRCA2 degradation and cell proliferation显示文摘 | Moro L Arbini AA Marra E | 2006 | J Biol Chem2006，281，22： | 1 |
| 19 | Wrist-ankle acupuncture as perineal pain relief after mediolateral episiotomy: a pilot study 显示文摘 | Marra C1 Pozzi I Ceppi L | 2011 | J Altem Complement Med2011，17，3： | 1 |
| 20 | Intravenous catecholamine administration affects mouse intestinal lymphocyte number and apoptosis显示文摘 | Marra S Bumett M Hoffman-Goetz L | 2005 | J Neuroimmunol2005，158，： | 1 |
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