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| 1 | Blood Serum Levels of IL-2, IL-6, IL-8, TNF-α and IL-1β in Patients on Maintenance Hemodialysis显示文摘Cytokines 是有免疫力的反应和煽动性的反应的必要调停人。有长期的肾的失败(CRF ) 的病人通常与除了 dialyzer 膜的 bioincompatibility 与损害的肾功能和尿毒症的毒素的累积联系的有免疫力的功能的畸形介绍。在 hemodialysis (HD ) 期间会议, cytokines 主要被内毒素类型混合物在有 dialyzer 的 dialyzer 液体,补充因素和直接接触激活的单核白血球释放膜。学习包括了 15 个 CRF 病人, 36.4 吗?? | Jacek Rysz Maciej Banach Aleksandra Cialkowska-Rysz Robert Stolarek Marcin Barylski Jaroslaw Drozdz Piotr Okonski | 2006 | Cellular & Molecular Immunology2006，3，2： | 14 |
| 2 | Epithelioid hemangioendothelioma of the liver as a rare indication for liver transplantation显示文摘AIM: To investigate the indications and outcomes of liver transplantation for hepatic epithelioid hemangioendothelioma(HEHE). METHODS: Between 1989 and August 2013, in the Department of General, Transplant, and Liver Surgery, Medical University of Warsaw, 1306 orthotopic liver transplantations(OLTx) were performed, including 72 retransplantations. Unresectable HEHE was an indication for OLTx in 10 patients(0.8% of primary OLTx), the mean age of the patients was 40.5 ± 13.3 years(range 23-65 years), and the male-to-female ratio was 2:8. Kaplan-Meier survival analysis in HEHE, hepatocellular carcinoma(HCC), and other OLTx recipients groups was performed. The differences in mortality were compared using the χ2 test. A P-value < 0.05 indicated statistical significance.RESULTS: No concomitant liver disease was found in any patient. There was no neoadjuvant chemotherapy or radiotherapy. Liver function test results were normal in most of the patients. The levels of alpha-fetoprotein, carcinoembryonic antigen, and carbohydrate antigen 19-9 were normal. In immunohistochemical staining, the neoplastic cells were positive for factor Ⅷ-related antigen, CD31, and CD34, which are endothelial cell markers, and negative for cytokeratin 19, cytokeratin 7, and HepPar-1. Nine patients were alive without tumor recurrence. One patient died 2 mo after OLTx due to septic complications. No morbidity was observed. Maximum follow-up was 11.4 years, with a minimum of 1 mo. The cumulative survival rate at the end of followup in HEHE patients was 87.5% compared with 54.3% in the HCC group and 76.3% in the other OLTx recipients group(χ2 test = 1.784, df = 2, P = 0.409).CONCLUSION: Unresectable HEHE, without extrahepatic metastases is an excellent indication for liver transplantation. Long-term survival is very good and much better than in HCC patients and the entire group of OLTx patients. | Piotr Remiszewski Ewa Szczerba Piotr Kalinowski Beata Gierej Krzysztof Dudek Mariusz Grodzicki Marcin Kotulski Rafa Paluszkiewicz Waldemar Patkowski Krzysztof Zieniewicz Marek Krawczyk | 2014 | World Journal of Gastroenterology2014，20，32： | 10 |
| 3 | Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation显示文摘AIM:To investigate large tumor suppressor 1 (LATS1 ) expression, promoter hypermethylation, and microsatellite instability in colorectal cancer (CRC).METHODS:RNA was isolated from tumor tissue of 142 CRC patients and 40 colon mucosal biopsies of healthy controls. After reverse transcription, quantitative polymerase chain reaction (PCR) was performed, and LATS1 expression was normalized to expression of the ACTB and RPL32 housekeeping genes. To analyze hypermethylation, genomic DNA was isolated from 44 tumor CRC biopsies, and methylation-specific PCR was performed. Microsatellite instability (MSI) status was checked with PCR using BAT26, BAT25, and BAT40 markers in the genomic DNA of 84 CRC patients, followed by denaturing gel electrophoresis. RESULTS:Decreased LATS1 expression was found in 127/142 (89.4%) CRC cases with the average ratio of the LATS1 level 10.33 ± 32.64 in CRC patients vs 32.85 ± 33.56 in healthy controls. The lowest expression was found in Dukes' B stage tumors and G1 (welldifferentiated) cells. Hypermethylation of the LATS1 promoter was present in 25/44 (57%) CRC cases analyzed. LATS1 promoter hypermethylation was strongly associated with decreased gene expression; methylated cases showed 162× lower expression of LATS1 than unmethylated cases. Although high-grade MSI (mutation in all three markers) was found in 14/84 (17%) cases and low-grade MSI (mutation in 1-2 markers) was found in 30/84 (36%) cases, we found no association with LATS1 expression. CONCLUSION:Decreased expression of LATS1 in CRC was associated with promoter hypermethylation, but not MSI status. Such reduced expression may promote progression of CRC. | Piotr M Wierzbicki Krystian Adrych Dorota Kartanowicz Marcin Stanislawowski Anna Kowalczyk Janusz Godlewski Iwona Skwierz-Bogdanska Krzysztof Celinski Tomasz Gach Jan Kulig Bartlomiej Korybalski Zbigniew Kmiec | 2013 | World Journal of Gastroenterology2013，19，27： | 8 |
| 4 | Modeling of particle transport and combustion phenomena in a large-scale circulating fluidized bed boiler using a hybrid Euler-Lagrange approach显示文摘The constantly developing fluidized combustion technology has become competitive with a conventional pulverized coal(PC) combustion.Circulating fluidized bed(CFB) boilers can be a good alternative to PC boilers due to their robustness and lower sensitivity to the fuel quality.However,appropriate engineering tools that can be used to model and optimize the construction and operating parameters of a CFB boiler still require development.This paper presents the application of a relatively novel hybrid Euler-Lagrange approach to model the dense gas-solid flow combined with a combustion process in a large-scale industrial CFB boiler.In this work,this complex flow has been resolved by applying the ANSYS FLUENT 14.0commercial computational fluid dynamics(CFD) code.To accurately resolve the multiphase flow,the original CFD code has been extended by additional user-defined functions.These functions were used to control the boiler mass load,particle recirculation process(simplified boiler geometry),and interphase hydrodynamic properties.This work was split into two parts.In the first part,which is referred to as pseudo combustion,the combustion process was not directly simulated.Instead,the effect of the chemical reactions was simulated by modifying the density of the continuous phase so that it corresponded to the mean temperature and composition of the flue gases.In this stage,the particle transport was simulated using the standard Euler-Euler and novel hybrid Euler-Lagrange approaches.The obtained results were compared against measured data,and both models were compared to each other.In the second part,the numerical model was enhanced by including the chemistry and physics of combustion.To the best of the authors' knowledge,the use of the hybrid Euler-Lagrange approach to model combustion is a new engineering application of this model.In this work,the combustion process was modeled for air-fuel combustion.The simulation results were compared with experimental data.The performed numerical simulations showed the applicability of the hybrid dense discrete phase model approach to model the combustion process in large-scale industrial CFB boilers. | Wojciech P.Adamczyk Gabriel Wecel Marcin Klajny Pawel Kozolub Adam Klimanek Ryszard A.Bialecki | 2014 | Particuology2014，12，5： | 7 |
| 5 | Anisotropic singular integrals in product spaces显示文摘In this paper, the authors introduce a class of product anisotropic singular integral operators, whose kernels are adapted to the action of a pair A := (A1, A2) of expansive dilations on R n and R m , respectively. This class is a generalization of product singular integrals with convolution kernels introduced in the isotropic setting by Fefferman and Stein. The authors establish the boundedness of these operators in weighted Lebesgue and Hardy spaces with weights in product A∞ Muckenhoupt weights on R n × R m . These results are new even in the unweighted setting for product anisotropic Hardy spaces. | BOWNIK Marcin | 2010 | Science China Mathematics2010，53，12： | 7 |
| 6 | Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis显示文摘ABM: To determine the effect of pioglitazone, a specific peroxisome proliferator-activated receptor-γ(PPARγ) ligand, on the development of acute pancreatitis (AP) and on the expression of heat shock protein 70 (HSP70) in the pancreas. METHODS: AP was induced in rats by subcutaneous infusion of cerulein for 5 h. Pancreatic blood flow was measured by laser Doppler flowmetry. Plasma lipase activity, interleukin-1β (IL-1β) and IL-10 were determined, Pancreatic weight and histology were evaluated and pancreatic DNA synthesis and blood flow as well as pancreatic mRNA for IL-1β and HSP70 were assessed in rats treated with pioglitazone alone or in combination with cerulein. RESULTS: Pioglitazone administered (10-100 mg/kg i.g.) 30 min before cerulein, attenuated dose-dependently the pancreatic tissue damage in cerulein-induced pancreatitis (CIP) as demonstrated by the improvement of pancreatic histology, reduction in plasma lipase activity, plasma concentration of pro-inflammatory IL-1β and its gene expression in the pancreas and attenuation of the pancreatitis-evoked fall in pancreatic blood flow. CIP increased pancreatic HSP70 mRNA and protein expression in the pancreas and this effect was enhanced by pioglitazone treatment. CONCLUSION: Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1β and to the over-expression of HSP70. PPARγ ligands could represent a new therapeutic option in the treatment of AP. | Peter C Konturek Artur Dembinski Zygmunt Warzecha Grzegorz Burnat Piotr Ceranowicz Eckhart G Hahn Marcin Dembinski Romana Tomaszewska Stanislaw J Konturek | 2005 | World Journal of Gastroenterology2005，11，40： | 7 |
| 7 | 人类少突胶质细胞在髓鞘修复中的作用显示文摘有关髓鞘和少突胶质细胞的研究大部分与脱髓鞘疾病相关,如多发性硬化、脑白质营养不良或脊髓损伤。髓鞘慢性脱失,慢慢导致神经退行性变,最终导致永久而严重的神经功能丧失。因此,尽快恢复髓鞘是修复脱髓鞘疾病的最有效方法。移植外源性的髓鞘再生细胞是一个有希望的治疗方法。已有多项在体和离体实验将各种具有髓鞘形成功能细胞(少突胶质细胞、施万细胞、嗅鞘细胞等)进行移植,观察其髓鞘修复功能。本综述对将人类少突胶质细胞用于治疗脱髓鞘疾病的相关研究进行总结。首先,对人类少突胶质细胞从胚胎发育晚期到产后早期的发育过程进行简要的综述。然后,对各种内源性和外源性的少突胶质细胞调节因子的研究进行总结。在离体实验中,必须调控好各种调节因子才能使培养的少突胶质细胞达到足够的数量用于移植。之后,探讨了人类少突胶质细胞的可能来源,包括一些新型的少突胶质细胞生产策略,如诱导多能干细胞诱导直接分化为少突胶质细胞。最后,本综述对人类少突胶质细胞的髓鞘再生功能和效率进行了系统的回顾。 | Marcin Czepiel Erik Boddeke Sjef Copray 唐颖馨 | 2015 | 神经损伤与功能重建2015，10，2： | 6 |
| 8 | A review on Eph/ephrin,angiogenesis and lymphangiogenesis in gastric,colorectal and pancreatic cancers显示文摘Erythroprotein-producing human hepatocellular carcinoma receptors(Eph receptors)compose a subfamily of transmembrane protein-tyrosine kinases receptors that takes part in numerous physiological and pathological processes.Eph family receptor-interacting proteins(Ephrins)are ligands for those receptors.Eph/ephrin system is responsible for the cytoskeleton activity,cell adhesion,intercellular connection,cellular shape as well as cell motility.It affects neuron development and functioning,bone and glucose homeostasis,immune system and correct function of enterocytes.Moreover Eph/ephrin system is one of the crucial ones in angiogenesis and lymphangiogenesis.With such a wide range of impact it is clear that disturbed function of this system leads to pathology.Eph/ephrin system is involved in carcinogenesis and cancer progression.Although the idea of participation of ephrin in carcinogenesis is obvious,the exact way remains unclear because of complex bi-directional signaling and cross-talks with other pathways.Further studies are necessary to find a new target for treatment. | julia rudno-rudzińska wojciech kielan ewelina frejlich krzysztof kotulski wojciech hap krzysztof kurnol przemyslaw dzierzek marcin zawadzki agnieszka haloń | 2017 | Chinese Journal of Cancer Research2017，29，4： | 4 |
| 9 | Fatty acid changes help to better understand regression of nonalcoholic fatty liver disease显示文摘AIM: To investigate whether liver steatosis reduction due to a six-month dietary intervention results in significant changes in the concentrations of fatty acids.METHODS: A group of 35 Caucasian individuals diagnosed with different levels of steatosis were prospectively enrolled in the present study.Analysis of the fatty acid profiles was performed according to changes in liver steatosis(liver steatosis reduction by one or two degrees) after a six-month dietary intervention.The diet helped reduce body mass in obese and overweight patients,and stabilize both glycemia and dyslipidemia.Fatty acids were extracted according to the Folch method and analyzed by gas chromatography.RESULTS: This study showed significant changes in fatty acid profiles in patients who had reduced liver steatosis by one as well as two degrees.A reduction in liver steatosis by one degree caused a significant increase in the level of the n-3 family: eicosapentaenoic acid(P < 0.055),docosapentaenoic acid-C 22:5(P < 0.05) and docosahexaenoic acid(P < 0.05).A reduction in liver steatosis by two degrees caused a significant decrease in serum palmitoleic acid-C 16:1(P < 0.05).CONCLUSION: Liver steatosis reduction is associated with changes in fatty acid profiles,and these changes may reflect an alteration in fatty acid synthesis and metabolism.These findings may help better understand regression of nonalcoholic fatty liver disease. | Dominika Maciejewska Arleta Drozd Piotr Ossowski Karina Ryterska Dominika Jamio-Milc Marcin Banaszczak Joanna Raszeja-Wyszomirska Magorzata Kaczorowska Anna Sabinicz Ewa Stachowska | 2015 | World Journal of Gastroenterology2015，21，1： | 4 |
| 10 | 每日1次利拉鲁肽与每日2次艾塞那肽治疗2型糖尿病比较:一项为期26周的随机、平行组、多国开放标记试验(LEAD-6)显示文摘背景与大多数抗高血糖药物不同,胰高血糖素样肽-1(GLP-1)受体激动剂的药理作用依赖于葡萄糖水平,并且有助于减轻患者体重。本研究比较了利拉鲁肽(一种人GLP-1类似物)与艾塞那肽(一种基于醋酸艾塞那肽的GLP-1受体激动剂)治疗2型糖尿病的疗效和安全性。方法对于用最大耐受剂量二甲双胍或(和)磺脲仍控制不良的2型糖尿病成年患者,根据之前服用的抗糖尿病药物进行分层,并随机分配这些患者额外接受利拉鲁肽1.8mg每El1次(n=233)或艾塞那肽10μg每日2次(n=231),进行为期26周的开放标记、平行组、多国(15个国家)研究。主要终点是糖化血红蛋白(HbA1c)水平的变化,疗效分析采用意向性治疗分析。本试验在Clinical Trial.gov注册,注册号为NCT00518882。结果受试者的HbA1c平均基线水平为8.2%。与艾塞那肽相比,利拉鲁肽能显著降低HbA1c平均水平[-1.12%(s=0.08%)vs-0.79%(s=0.08%);疗效差异估计值为-0.33%,95%CI-0.47%~-0.18%;P〈0.0001],并且利拉鲁肽组有更多患者HbA1c水平低于7%(54%vs543%;OR 2.02,95%CI 1.31~3.11;P=0.0015)。利拉鲁肽降低平均空腹血糖的能力也显著优于艾塞那肽[-1.61mmol/Lb=0.20)vs-0.60mmol/L(s=0.20);疗效差异估计值为-1.01mmol/L,95%CI-1.37—-0.65;P〈0.0001],但是其降低早餐和晚餐后血糖的能力较艾塞那肽差。两种药物促进患者体重减轻的作用相似(利拉鲁肽组~3.24kg vs艾塞那肽组-2.87地)。耐受性均较好,但与艾塞那肽组相比,利拉鲁肽组患者恶心的持续时间较短(估计的治疗相关事件率比值为0.448,P〈0.0001),轻度低血糖的发生率也较低(每患者每年的事件发生数为1.93vs2.60;发生率比值为0.55,95%C10.34~0.88:P=0.0131;轻度低血糖的发生率为25.5%掷33.6%)。2例同时注射艾塞那肽和一种磺脲类药物的患者发生了严重的低血糖。结论相对于艾塞那肽每日2次,利拉鲁肽每日1次能显著改善血糖控制水平,且患者的耐受性更好。研究结果提示利拉鲁肽或许是2型糖尿病的一种治疗选择,特别是在减轻体重和低血糖风险作为主要考虑因素的情况下。 | John B Buse Julia Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde 赵乐(译) | 2009 | 世界临床医学2009，，11： | 3 |
| 11 | AUGMENTED REALITY SYSTEM FOR AIDING ENGINEERING DESIGN PROCESS OF MACHINERY SYSTEMS显示文摘纸为帮助产品设计和机械系统的开发论述扩充现实的应用程序。扩充现实技术以如此的一个方法用一个交互真实的词集成一个交互产生计算机的词,他们作为一环境出现。AR 技术能与不实际上是景色的部分,但是与在场的用户相关的信息提高真实世界的一种用户感觉活动。在 AR 系统介绍了 3D 建模的为特别改变数据的看法的一个模式正在允许用户以一个更全面的方法理解未来的机械系统,因此使设计进程比那更有效由常规今日的 CAD 系统支持了。介绍原型系统包含与 AR 系统综合的一个专家系统并且允许关于一个活动机器人的设计过程和认识到的构造上的问题的实际答案的连续的步送到知识设计者。有关 AR 的一条途径使系统用户能分析并且验证解决方案(作为 3D 代表了模型) 相对真实景色 / 目标。因为在我们附近的真实环境经常提供是困难的在一台计算机复制的信息的广阔数量,这条途径是有益的。在一些情况中,一个 AR 系统的应用程序能是验证发达产品的一个最佳的方法。 | Marcin JANUSZKA Wojciech MOCZULSKI | 2011 | Journal of Systems Science and Systems Engineering2011，20，3： | 3 |
| 12 | Competing for enhancers: PVT1 fine-tunes MYC expression显示文摘 | Abhijit Parolia Marcin Cieslik Arul M. Chinnaiyan | 2018 | Cell Research2018，28，8： | 3 |
| 13 | 胸腺瘤微创切除术的基本原则和标准术语的定义显示文摘根治性手术切除是胸腺瘤的主要治疗手段,手术目的在于完整切除肿瘤及胸腺组织,并且进行彻底的探查排除可能存在的非连续但可切除的病灶。通常主张胸骨劈开的整块切除,R0切除是公认的关乎远期疗效的重要因素。近年随着胸腔镜技术的不断进步,微创手术在胸腺瘤手术中的应用受到了极大地关注,但存在许多值得注意的问题,如何保护膈神经?膈神经切除后是否需要行膈肌折叠术?如何在腔镜下判断是否有上腔静脉和肺静脉的浸润?在微创手术时若切缘很近是否更容易发生胸膜播散?如果一次面对的问题太多,很有可能让微创手术的适用范围又回到从前。如果术后出现不良的结果就更难继续去探索微创技术和如何避免这些问题。多数学者仍对微创手术的结果持谨慎态度,如何确保这些结果与标准开放性手术相当是值得重视的问题。尽管微创手术缩短了住院时间并减轻了患者的疼痛,但与开放手术相比微创手术的肿瘤学优势还没能很好地被报道[1]。只有时间能告诉我们这些微创技术和目前的标准治疗是否相当。虽然有经验的术者采用微创手术可以切除邻近的累及器官,然而在快速拓展微创手术之前必须首先通过直接案例小心评估微创手术的预后结果。普遍认为应避免微创手术切除膈神经和大血管。由于胸腺恶性肿瘤的低发病率特点和微创手术的稀少性特点亟需有共同标准的国际合作。为此国际胸腺肿瘤协作组织(International Thymic Malignancy Interest Group, ITMIG)先由有胸腺瘤微创切除术经验的医生组成初步工作组,在回顾了目前文献中针对胸腺瘤微创切除术的定义、术语和策略后提出了初步建议,由拓展工作组进一步完善后由ITMIG工作组中的更多不同背景的专家进行讨论,最终由ITMIG的成员一致通过。内容涉及胸腺瘤微创手术策略、手术方法的基本概念、基本原则和必须遵守的特定标准等定义。以便在前瞻性的数据库采用连续和系统的方式收集数据来更恰当地评估微创手术。使不同中心之间使用这项技术应用共同的语言,便于中心之间的合作和数据资源共享。 | 付浩 中国胸腺瘤协作组全体成员 Alper Toker Joshua Sonett Marcin Zielinski Federico Rea Victor Tomulescu Frank C.Detterbeck | 2014 | 中国肺癌杂志2014，17，2： | 3 |
| 14 | Noninvasive ventilation in trauma显示文摘Trauma patients are a diverse population with heterogeneous needs for ventilatory support. This requirement depends mainly on the severity of their ventilatory dysfunction, degree of deterioration in gaseous exchange, any associated injuries, and the individual feasibility of potentially using a noninvasive ventilation approach. Noninvasive ventilation may reduce the need to intubate patients with traumarelated hypoxemia. It is well-known that these patientsare at increased risk to develop hypoxemic respiratory failure which may or may not be associated with hypercapnia. Hypoxemia in these patients is due to ventilation perfusion mismatching and right to left shunt because of lung contusion, atelectasis, an inability to clear secretions as well as pneumothorax and/or hemothorax, all of which are common in trauma patients. Noninvasive ventilation has been tried in these patients in order to avoid the complications related to endotracheal intubation, mainly ventilator-associated pneumonia. The potential usefulness of noninvasive ventilation in the ventilatory management of trauma patients, though reported in various studies, has not been sufficiently investigated on a large scale. According to the British Thoracic Society guidelines, the indications and efficacy of noninvasive ventilation treatment in respiratory distress induced by trauma have thus far been inconsistent and merely received a low grade recommendation. In this review paper, we analyse and compare the results of various studies in which noninvasive ventilation was applied and discuss the role and efficacy of this ventilator modality in trauma. | Marcin K Karcz Peter J Papadakos | 2015 | World Journal of Critical Care Medicine2015，4，1： | 3 |
| 15 | Synthesis, structural and spectroscopic studies on GdBO_3:Yb^(3+)/Tb^(3+)@SiO_2 core-shell nanostructures显示文摘The presented study concerned up-converting core/shell type nanomaterials based on lanthanide(Ⅲ) ions, Ln(Ⅲ), doped orthoborates. The system studied composed of the GdBO3 doped with Yb3+/Tb3+ luminescent core ensured an effective cooperative sensitization up-conversion, resulting in a bright green luminescence. The silica coating process was performed by a modified St?ber method, which resulted in the formation of core-shell nanostructures, making them suitable for bioapplications. The nanophosphors and nanocomposites were obtained by various methods, such as co-precipitation in the presence of Triton X-100 and micelle synthesis with ethylenediaminetetraacetic acid(EDTA) as organic modifiers/surfactants. The synthesized nanomaterials were characterized with the use of powder X-ray diffraction(XRD), infrared light absorption with Fourier transform FT-IR spectra, transmission electron microscopy(TEM), up-conversion emission spectra under IR light, as well as excitation spectra, emission spectra and fluorescence lifetimes under UV light, and their photophysical properties were compared. | Konrad Kubasiewicz Marcin Runowski Stefan Lis Agata Szczeszak | 2015 | Journal of Rare Earths2015，33，11： | 2 |
| 16 | Correlations between skin lesions induced by anti-tumor necrosis factor-α and selected cytokines in Crohn's disease patients显示文摘AIM:To investigate the correlation between the appearance of skin lesions and concentration of interleukin(IL)-17A,IL-23 and interferon-γ(IFN-γ)in Crohn’s disease(CD)patients during anti-tumor necrosis factor-α(TNF-α)therapy METHODS:A prospective study included 30 adult patients with CD of Caucasian origin(19 men and 11women;mean age±SD 32.0±8.6 years)during biological therapy with anti-TNF-αantibodies from January2012 to March 2013.Eighteen patients were treated with infliximab,seven with adalimumab and five withcertolizumab.Inclusion criteria were exacerbation of the underlying disease,Crohn’s Disease Activity Index over 300 and the ineffectiveness of previously used non-biological therapies.Patients with a history of psoriasis,atopic dermatitis and other autoimmune skin lesions were excluded from the study.The control group consisted of 12 healthy subjects.A diagnostic survey was carried out,blood tests and careful skin examination were performed,and the serum levels of IL-17,IL-23 and IFN-γwere measured using an enzyme-linked immunosorbent assays technique.Dermatoses that have developed in the course of biological therapy in patients who had no pre-existing skin lesions of similar character were qualified as skin lesions induced by antiTNF-αtherapy.RESULTS:Skin manifestations occurred in 18 of CD patients during the anti-TNF-αtherapy(60%),in the average time of 10.16±3.42 mo following the beginning of the 52-wk treatment cycle.Skin lesions observed in CD patients during biological therapy included psoriasiform lesions(44.4%),and eczema forms lesions(22.2%).In CD patients with drug induced skin lesions significantly higher levels of hemoglobin(13.3±1.5 g/dL vs 10.8±1.9 g/dL,P=0.018)and hematocrit(39.9%±4.5%vs 34.3%±5.4%,P=0.01),as well as a significantly lower level of platelets(268±62×103/μL vs 408±239×103/μL,P=0.046)was observed compared with CD patients without skin manifestations.The concentrations of IL-17A and IL-23in CD patients with skin lesions developed under antiTNF-αtherapy were significantly higher compared to those in patients without lesions(IL-17A:39.01±7.03pg/mL vs 25.71±4.90 pg/mL,P=0.00004;IL-23:408.78±94.13 pg/mL vs 312.15±76.24 pg/mL,P=0.00556).CONCLUSION:Skin lesions in CD patients during bio-logical therapy may result from significantly increased concentrations of IL-17A and IL-23,which are strongly associated with TNF-α/Th1 immune pathways. | Marcin Wodarczyk Aleksandra Sobolewska Bartosz Wójcik Karolina Loga Jakub Fichna Maria Wisniewska-Jarosińska | 2014 | World Journal of Gastroenterology2014，20，22： | 2 |
| 17 | Stewart-Treves syndrome angiosarcoma expresses phenotypes of both blood and lymphatic capillaries显示文摘 | Marek Stanczyk Magdalena Gewartowska Marcin Swierkowski Bartlomiej Grala Marek Maruszynski | 2013 | Chinese Medical Journal2013，，2： | 2 |
| 18 | Synthesis of luminescent KY_3F_(10) nanopowder multi-doped with lanthanide ions by a co-precipitation method显示文摘A series of KY_3F_(10) nanophosphors doped with Gd^(3+), Ce^(3+) and Eu^(3+) ions were obtained with the use of a co-precipitation method. The resulting products were white precipitates, consisting of spherical particles with diameter about 150–200 nm, which was confirmed using transmission electron microscopy(TEM) technique. Powder X-ray diffraction(XRD) and energy dispersive X-ray analysis(EDX) measurements confirmed appropriate structures of the nanoparticles obtained. Spectroscopic properties of the products were examined on the basis of the measured excitation/emission spectra and luminescence decay curves. The synthesized samples showed orange-red luminescence, characteristic for Eu^(3+) ions. The reaction process was performed in required alkaline pH adjusted with the use of ethylenediaminetetraacetic acid(EDTA) and potassium hydroxide. The samples containing large amounts of Gd^(3+) dopant ions exhibited a tendency to form products with different morphologies. | Szymon Goderski Marcin Runowski Stefan Lis | 2016 | Journal of Rare Earths2016，34，8： | 2 |
| 19 | Breaking wheat yield barriers requires integrated efforts in developing countries显示文摘Most yield progress obtained through the so called 'Green Revolution', particularly in the irrigated areas of Asia, has reached a limit, and major resistance genes are quickly overcome by the appearance of new strains of disease causing organisms.New plant stresses due to a changing environment are difficult to breed for as quickly as the changes occur.There is consequently a continual need for new research programs and breeding strategies aimed at improving yield potential, abiotic stress tolerance and resistance to new, major pests and diseases.Recent advances in plant breeding encompass novel methods of expanding genetic variability and selecting for recombinants, including the development of synthetic hexaploid, hybrid and transgenic wheats.In addition, the use of molecular approaches such as quantitative trait locus(QTL) and association mapping may increase the possibility of directly selecting positive chromosomal regions linked with natural variation for grain yield and stress resistance.The present article reviews the potential contribution of these new approaches and tools to the improvement of wheat yield in farmer's fields, with a special emphasis on the Asian countries, which are major wheat producers, and contain the highest concentration of resource-poor wheat farmers. | Saeed Rauf Maria Zaharieva Marilyn L Warburton ZHANG Ping-zhi Abdullah M AL-Sadi Farghama Khalil Marcin Kozak Sultan A Tariq | 2015 | Journal of Integrative Agriculture2015，14，8： | 2 |
| 20 | U-FAST在先进材料研发中的应用显示文摘本文介绍了升级版的电场辅助烧结技术U-FAST(SPS)技术,该技术采用了现代电源技术,具有更快的加热速度,可以广泛的应用于先进材料的研发。如应用在烧结碳化物(WC-Co)、热电材料(PbTe)、Zr-Cu-Al-Nb(块状金属玻璃)、复合材料、透明陶瓷材料、生物材料、金刚石增加复合材料(EDC)等,并介绍了应用U-FAST工艺生产的特点。在较低温度和较短时间下开始烧结过程且不会产生任何不利的晶粒生长,使U-FAST技术成为生产纳米晶和亚微米材料的理想工艺,将电场辅助烧烧结技术提升到新高度。 | Marcin Rosiński 丁海宁 | 2022 | 粉末冶金工业2022，32，1： | 2 |
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