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| 1 | 黄瓜游离小孢子培养诱导成胚和植株再生显示文摘以10个不同基因型黄瓜为试材进行游离小孢子培养,通过对成胚条件的系统研究,从‘7447’和‘Poinsett97’中获得了子叶形胚和再生植株。研究结果表明:基因型和小孢子发育时期是限制黄瓜游离小孢子成胚的关键因子。不同品种间胚状体产量差异显著,每皿产胚1.5~33.4个。单核靠边期是进行黄瓜游离小孢子培养的最佳时期。低温预处理有利于胚状体的诱导,4℃预处理2~4d为宜,以处理2d的胚状体产量最高。外源激素在诱导胚状体时并非必需,但低浓度外源激素(0.5mg.L-12,4-D、0.2mg.L-16-BA)能促进小孢子成胚。NLN和B5两种基础培养基在诱导胚状体上无显著差异。子叶形胚易分化成苗,而其它类型的胚状体未能获得再生植株。 | 詹艳 陈劲枫 Ahmed Abbas Malik | 2009 | 园艺学报2009，36，2： | 25 |
| 2 | 溶胶-凝胶法制备用于分离极性有机化合物的毛细管气相色谱柱显示文摘采用溶胶 凝胶法制备了用于分离有机极性化合物的毛细管气相色谱柱 ,其制备工艺简单 ,制柱时间较传统工艺大为缩短。该柱涂层与毛细管内壁间形成的化学键使得其热稳定性好。游离的脂肪酸、有机碱可直接在该柱上得到很好的分离 ,其他极性化合物也在该柱上得到极好的分离。该类色谱柱不仅在同一色谱柱上显示了良好的分离重复性 ,而且不同柱间在容量因子、柱效。 | 王东新 MALIK Abdul | 2002 | 色谱2002，20，3： | 25 |
| 3 | 豆腐中库特氏菌生长动力学模型和货架期预测显示文摘以引起豆腐腐败的特定腐败菌库特氏菌为研究对象,研究不同温度对其生长的影响,定量评价温度对豆腐货架期的影响,为货架期快速有效的估测提供有效的手段。将库特氏菌接种到豆腐表面,在4、12、20、30℃条件下贮藏,由此建立一级和二级生长动力学模型以及剩余货架期预测模型。结果表明,Gompertz函数能够很好的描述豆腐中的微生物生长动态,建立了4种温度下豆腐的微生物生长动力学模型。采用平方根模型(Belehradek)描述温度对最大比生长速率(μmax)和延滞时间(Lag)的影响,结果表明呈现良好的线性关系。用豆腐在8℃和25℃的库特氏菌实测值进行验证,偏差度(Bf)和准确度(Af)分别为1.04、1.02和1.20、1.18。获得的剩余货架期的预测模型为:SL=Lag-[(8.6-N0)/(μmax·2.718)]·{ln[-ln(7.14-N0)/(8.6–N0)]-1},用豆腐贮藏在8℃和25℃的货架期实测值验证建立的模型,预测值和实测值的相对误差分别为-3.47%和4.89%,说明建立的模型能够快速可靠的预测豆腐的微生物学品质和剩余货架期。 | 李除夕 董明盛 陈晓红 姜梅 吕欣 努尔古丽.热合曼 Malik Muhammad Hashim | 2009 | 农业工程学报2009，25，S1： | 24 |
| 4 | Yes相关蛋白通过肿瘤坏死因子受体相关因子6控制内皮活化和血管炎症显示文摘继发于异常的内皮激活的微血管炎症和内皮功能障碍在败血症和器官衰竭的病理生理学中起关键作用。抑制内皮细胞过度活化的内在信号传导机制尚未完全明了。该研究旨在确定Yes相关蛋白(Yes-associated protein,YAP)(Hippo通路的主要转录共激活剂)在调节内皮活化和血管炎症的强度和程度中的中心作用。 | 刘青 叶鹏 Lv Y Kim K Sheng Y Cho J Qain Z Zhao YY Hu G Pan D Malik AB | 2018 | 中华高血压杂志2018，26，8： | 20 |
| 5 | Influence of ellagic acid on prostate cancer cell proliferation:A caspase-dependent pathway显示文摘Objective:To evaluate the effect of allagic acid treatment on the cell viability of human prostate cancer cells.Methods:Ellagic acid(10-100 mol/L) treatment(48 h) of human prostate carcinoma PC3 cells was found to result in a dose-dependent inhibition of cell growth and apoptosis of PC3 cells as assessed by MTT assay,western blotting.flow cytometry and confocal microscopy.Results:We observed that ellagic acid treatment of PC3 cells resulted in a dose dependent inhibition of cell growth/cell viability.This ellagic acid caused cell growth inhibition was found to be accompanied by induction of apoptosis,as assessed by the cleavage of poly (ADP-ribose) polymerase(PARP) and morphological changes.Further,induction of apoptosis accompanied a decrease in the levels of antiapoptotic protein Bcl-2 and increase in proapoptotic protein Bax.thus shifting the Bax:Bcl-2 ratio in favor of apoptosis.Ellagic acid treatment of PC3 cells was also found to result in significant activation of caspases,as shown by the dose dependent decrease in the protein expression of procaspase-3,-6.-8 and -9.This ellagic acid-mediated induction of apoptosis was significantly(80%-90%) inhibited by the caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone(Z-VAD-FMK).Thus these data suggested an essential role of caspases in ellagic acid-mediated apoptosis of PC3 cells.Conclusions:It is tempting to suggest that consumption of tropical pigmented fruits and vegetables could be an effective strategy to combat prostate cancer. | Arshi Malik Sarah Afaq Mohammad Shahid Kafil Akhtar Abdullah Assiri | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，7： | 18 |
| 6 | 溶胶-凝胶毛细管气相色谱柱热稳定性的考察显示文摘溶胶 凝胶毛细管气相色谱柱是一类新型的色谱柱。通过与静态法涂渍并用自由基引发交联使固定相固载化的色谱柱比较 ,溶胶 凝胶色谱柱除了具有制作工艺简单、分离效果好等特点外 ,还具有很好的热稳定性和溶剂稳定性。其工作温度可高于 4 0 0℃。 | 王东新 Abdul Malik | 2003 | 分析化学2003，31，4： | 17 |
| 7 | 糖尿病神经病变的诊断显示文摘糖尿病神经病变检查积分系统能够用于判定感觉神经病变的特征以及病变的程度。活检技术作为神经病变的形态学检查手段仍有争议。在所有神经病理学检查方面,有髓鞘的神经纤维密度检查可能最有用处,因为神经密度与临床上神经功能障碍和电生理学所见相一致。免疫荧光组织化学的皮肤活检在评估周围神经病变形态学方面的作用逐渐被认识。另外还可采用无创的角膜共焦显微镜技术来评估外周神经病变。 | Rayaz Ahmed Malik 王玉珍 | 2004 | 国外医学(内分泌学分册)2004，24，5： | 16 |
| 8 | Pyogenic liver abscess: Changing patterns in approach显示文摘AIM: To define optimum management of the pyogenic liver abscess and assess new trends in treatment. METHODS: One hundred and sixty nine patients with pyogenic liver abscess managed at Sher-i-Kashmir In- stitute of Medical Sciences, Srinagar, Kashmir (India) from July 2001 to August 2006 were studied to evaluate and define the optimum treatment. RESULTS: Mortality in the surgically treated group of patients was 9.4% (12/119), while those treated non-surgically had a fatality rate of 16.66% (7/42). Multiple liver abscesses treated surgically had a surprisingly low mortality of 30%. The biliary tract (64.97%) was the most common cause of liver abscess. Multiple abscesses, mixed organisms and abscess complications are all associated with a significantly increased mortality. However, the lethality of the primary disease process was the most important factor in determining survival.CONCLUSION: Transperitoneal surgical drainage and antibiotics are the mainstay of treatment. Percutaneous drainage is recommended for high risk patients only. | Ajaz A Malik Shams UL Bari Khawaja Abdul Rouf Khurshid Alam Wani | 2010 | World Journal of Gastrointestinal Surgery2010，2，12： | 15 |
| 9 | Magnetic resonance elastography is accurate in detecting advanced fibrosis in autoimmune hepatitis显示文摘To assess the value of magnetic resonance elastography(MRE) in detecting advanced fibrosis/cirrhosis in autoimmune hepatitis(AIH).METHODS In this retrospective study, 36 patients(19 treated and 17 untreated) with histologically confirmed AIH and liver biopsy performed within 3 mo of MRE were identified at a tertiary care referral center. Liver stiffness(LS) with MRE was calculated by a radiologist, and inflammation grade and fibrosis stage in liver biopsy was assessed by a pathologist in a blinded fashion. Two radiologistsevaluated morphological features of cirrhosis on conventional magnetic resonance imaging(MRI). Accuracy of MRE was compared to laboratory markers and MRI for detection of advanced fibrosis/cirrhosis.RESULTS Liver fibrosis stages of 0, 1, 2, 3 and 4 were present in 4, 6, 7, 6 and 13 patients respectively. There were no significant differences in distribution of fibrosis stage and inflammation grade between treated and untreated patient groups. LS with MRE demonstrated stronger correlation with liver fibrosis stage in comparison to laboratory markers for chronic liver disease(r = 0.88 vs-0.48-0.70). A trend of decreased mean LS in treated patients compared to untreated patients was observed(3.7 k Pa vs 3.84 k Pa) but was not statistically significant. MRE had an accuracy/sensitivity/specificity/positive predictive value/negative predictive value of 0.97/90%/100%/100%/90% and 0.98/92.3%/96%/92.3%/96% for detection of advanced fibrosis and cirrhosis, respectively. The performance of MRE was significantly better than laboratory tests for detection of advanced fibrosis(0.97 vs 0.53-0.80, P < 0.01), and cirrhosis(0.98 vs 0.58-0.80, P < 0.01) and better than conventional MRI for diagnosis of cirrhosis(0.98 vs 0.78, P = 0.002).CONCLUSION MRE is a promising modality for detection of advanced fibrosis and cirrhosis in patients with AIH with superior diagnostic accuracy compared to laboratory assessment and MRI. | Jin Wang Neera Malik Meng Yin Thomas C Smyrk Albert J Czaja Richard L Ehman Sudhakar K Venkatesh | 2017 | World Journal of Gastroenterology2017，23，5： | 15 |
| 10 | 树木年代学在高寒山区泥石流历史事件重建中的应用——以磨西河流域倒灶沟为例显示文摘如何确定人类历史活动稀少、植被覆盖率较高的高寒山区泥石流历史活动次数及时间较为困难。树木年代学分析方法可通过树木年轮生长变化对泥石流活动的响应特征,重建过去一定时间内的泥石流历史活动事件。通过对我国四川省境内贡嘎山东坡磨西河流域内倒灶沟泥石流堆积扇上140个桤木的树木年轮样本取样及树木年代学分析,重建了该沟在过去20 a间的2次较大规模泥石流活动事件(分别为1996年和2005年)和5次小规模洪水(或泥石流)事件。研究结果表明,在过去20 a间,倒灶沟大规模泥石流每隔约10 a便会发生一次,而小规模的泥石流或洪水则每隔2~3 a便会发生一次。同时,研究还发现,磨西河流域内泥石流堆积扇上有利于类似桤木生长特征的树种生长(最大树木年轮可达1.4 cm),为该地区泥石流生物防治工程中优势树种的选择提供了科学依据。 | 铁永波 Ireneusz Malik Piotr Owczarek | 2014 | 山地学报2014，32，2： | 13 |
| 11 | Soil Microbiological Activity and Carbon Dynamics in the Current Climate Change Scenarios:A Review显示文摘Microbial activities are affected by a myriad of factors with end points involved in nutrient cycling and carbon sequestration issues.Because of their prominent role in the global carbon balance and their possible role in carbon sequestration, soil microbes are very important organisms in relation to global climate changes. This review focuses mainly on the responses of soil microbes to climate changes and subsequent effects on soil carbon dynamics. An overview table regarding extracellular enzyme activities(EAA) with all relevant literature data summarizes the effects of different ecosystems under various experimental treatments on EAA. Increasing temperature, altered soil moisture regimes, and elevated carbon dioxide significantly affect directly or indirectly soil microbial activities.High temperature regimes can increase the microbial activities which can provide positive feedback to climate change, whereas lower moisture condition in pedosystem can negate the increase, although the interactive effects still remain unanswered. Shifts in soil microbial community in response to climate change have been determined by gene probing, phospholipid fatty acid analysis(PLFA),terminal restriction length polymorphism(TRFLP), and denaturing gradient gel electrophoresis(DGGE), but in a recent investigations,omic technological interventions have enabled determination of the shift in soil microbe community at a taxa level, which can provide very important inputs for modeling C sequestration process. The intricacy and diversity of the soil microbial population and how it responds to climate change are big challenges, but new molecular and stable isotope probing tools are being developed for linking fluctuations in microbial diversity to ecosystem function. | Javid A.SOFI Aabid H.LONE Mumtaz A.GANIE Naseer A.DAR Sajad A.BHAT Malik MUKHTAR Mohd Ashraf DAR Shazia RAMZAN | 2016 | Pedosphere2016，26，5： | 13 |
| 12 | Breath tests and irritable bowel syndrome显示文摘Breath tests are non-invasive tests and can detect H2and CH4 gases which are produced by bacterial fermentation of unabsorbed intestinal carbohydrate and are excreted in the breath.These tests are used in the diagnosis of carbohydrate malabsorption,small intestinal bacterial overgrowth,and for measuring the orocecal transit time.Malabsorption of carbohydrates is a key trigger of irritable bowel syndrome(IBS)-type symptoms such as diarrhea and/or constipation,bloating,excess flatulence,headaches and lack of energy.Abdominal bloating is a common nonspecific symptom which can negatively impact quality of life.It may reflect dietary imbalance,such as excess fiber intake,or may be a manifestation of IBS.However,bloating may also represent small intestinal bacterial overgrowth.Patients with persistent symptoms of abdominal bloating and distension despite dietary interventions should be referred for H2 breath testing to determine the presence or absence of bacterial overgrowth.If bacterial overgrowth is identified,patients are typically treated with antibiotics.Evaluation of IBS generally includes testing of other disorders that cause similar symptoms.Carbohydrate malabsorption(lactose,fructose,sorbitol)can cause abdominal fullness,bloating,nausea,abdominal pain,flatulence,and diarrhea,which are similar to the symptoms of IBS.However,it is unclear if these digestive disorders contribute to or cause the symptoms of IBS.Research studies show that a proper diagnosis and effective dietary intervention significantly reduces the severity and frequency of gastrointestinal symptoms in IBS.Thus,diagnosis of malabsorption of these carbohydrates in IBS using a breath test is very important to guide the clinician in the proper treatment of IBS patients. | Satya Vati Rana Aastha Malik | 2014 | World Journal of Gastroenterology2014，20，24： | 12 |
| 13 | 在 polycystic 定义 bariatric 外科的角色卵巢的症候群病人显示文摘 Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women.To meet PCOS criteria,women must have a combination of hyperandrogenism,anovulation and ultrasound findings.Almost 10% of all reproductive age women worldwide show signs of PCOS.Although women often seek care for gynecological or body image concerns,many PCOS women are at risk for metabolic syndrome (MS).Many of the metabolic consequences are overlooked and un-dertreated by physicians because these patients tend to be young,reproductive age women.MS and obesity coexist commonly with PCOS.These young women are predisposed to glucose abnormalities and ulti-mately diabetes mellitus,dyslipidemia and eventually cardiovascular disease.Bariatric surgery can be an ef-fective means of weight loss in PCOS women.Surgical techniques have become safer and less invasive over time and have been found to be effective in achieving significant weight loss.Surgical options have also in-creased,giving patients more choices.Bariatric surgery may prevent or reverse metabolic syndrome.Bariatric surgery may also have reproductive benefits in PCOS patients.Although bariatric surgery has historically been performed in older,reproductive aged women,it has recently gained favor in adolescents as well.This is of particular importance due to the prevalence of both PCOS and MS in adolescents.Treatment of PCOS and MS certainly requires a combination of medical therapy,psychological support and lifestyle modifications.These treatments are difficult and often frustrating for pa-tients and physicians.Bariatric surgery can be effective in achieving significant weight loss,restoration of the hypothalamic pituitary axis,reduction of cardiovascular risk and even in improving pregnancy outcomes.Ulti-mately,bariatric surgery should be considered part of the treatment in PCOS women,especially in those with MS. | Shaveta M Malik Michael L Traub | 2012 | World Journal of Diabetes2012，3，4： | 12 |
| 14 | 施工总承包模式下建筑供应链成本管理优化决策模型研究显示文摘建筑供应链成本控制是建筑企业和业主进行工程项目管理的关键内容,在大型城市建设项目管理中尤其重要。本文分析了以施工总承包商为核心的建筑供应链的结构和特征,构建了该类建筑供应链的结构模型,对供应链中建筑材料供给、运输、劳务与专业分包、建筑产品建造等环节的费用情况进行详细分析;在考虑到运输商运输能力、供应商供给能力、分包商建造能力等约束的基础上,建立了以施工总包商为核心的建筑供应链成本的多因素综合决策优化模型,最后对模型的应用进行了案例分析,结果表明该模型对施工总承包模式下建筑供应链成本优化决策具有较好的指导性、实用性和可拓展型。 | 李先光 李启明 刘颖 Khalfan Malik M A | 2009 | 华中科技大学学报(城市科学版)2009，26，1： | 12 |
| 15 | 不同人工泪液对体外培养的人角结膜上皮细胞的毒性作用比较显示文摘干眼是泪液分泌量不足、泪膜稳定性受损所致的眼部疾病[1-2].流行病学研究表明,在世界范围内,干眼发病率很高,与老龄、妇女围绝经期、配戴隐形眼镜及自身免疫性疾病等有关[3-5],其中亚洲人群中发病率约为17% ~ 33% [6-9],而白种人发病率相对较低,约为7%~14.6%[3,10].目前,干眼最常用的治疗方法是眼表滴用人工泪液,由于干眼是慢性疾患,大部分患者需长期用药,因此其长期疗效和安全性值得关注.本研究比较了不同成分的人工泪液对体外培养的人角膜和结膜上皮细胞的毒性作用,以期为临床用药提供试验依据. | Malik Kahook Cullen T. Vogelson Usha Sivaprasad David A. Ammar | 2012 | 中华眼科杂志2012，48，2： | 11 |
| 16 | Efficacy of combined cataract extraction and endoscopic cyclophotocoagulation for the reduction of intraocular pressure and medication burden显示文摘AIM: To report on the efficacy of combined endoscopic cyclophotocoagulation(ECP) and phacoemulsification cataract extraction(PCE) with intraocular lens placement for reduction of intraocular pressure(IOP) and medication burden in glaucoma.·METHODS: A retrospective case review of 91 eyes(73patients) with glaucoma and cataract that underwent combined PCE/ECP surgery was performed. Baseline demographic and ocular characteristics were recorded,as well as intraocular pressure, number of glaucoma medications, and visual acuity postoperatively with 12-month follow-up. Treatment failure was defined as less than 20% reduction in IOP from baseline on two consecutive visits(at 1, 3, 6, or 12 mo postoperatively),IOP ≥21 mm Hg or ≤5 mm Hg on two consecutive visits, or additional glaucoma surgery performed within12 mo after PCE/ECP.·RESULTS: Overall, mean medicated IOP was reduced from 16.65 mm Hg at baseline to 13.38 mm Hg at 12mo(P <0.0001). Mean number of glaucoma medications was reduced from 1.88 medications at baseline to 1.48 medications at 12mo(P =0.0003). At 3mo postoperatively,the success rate was 73.6%(95%CI: 63.3, 81.5), 57.1% at6mo(95% CI: 46.3, 66.6), and 49.7% at 12mo(95% CI:38.9, 59.6). Patient demographic characteristics were not associated with treatment success. The only ocular characteristic associated with treatment success was a higher baseline IOP.· CONCLUSION: Combined PCE/ECP surgery is an effective surgical option for the reduction of IOP and medication burden in glaucoma patients. Patients withhigher baseline IOP levels are most likely to benefit from this procedure. | Sammie J.Roberts Matthew Mulvahill Jeffrey R.SooHoo Mina B.Pantcheva Malik Y.Kahook Leonard K.Seibold | 2016 | International Journal of Ophthalmology(English edition)2016，9，5： | 11 |
| 17 | 山羊酸奶加工工艺研究显示文摘山羊奶含有丰富的蛋白质、脂肪、乳糖、矿物质及多种维生素,Ca、P及某些生物活性物质(如cAMP,cGMP等)含量高于牛奶。采用响应曲面法研究了山羊酸奶的发酵温度、加糖量、球杆菌比例和接种量。结果表明:在38℃,蔗糖添加量6%,嗜热链球菌接种量1.5%,保加利亚乳杆菌接种量0.5%的条件下,山羊酸奶品质最好。 | 李莹 周剑忠 努尔古丽.热合曼 Malik Muhammad Hashim 王国涛 董明盛 | 2008 | 乳业科学与技术2008，31，3： | 11 |
| 18 | Role of endoscopic therapy in early esophageal cancer显示文摘Esophageal carcinoma is a highly lethal cancer associated with high morbidity and mortality. Esophageal squamous cell carcinoma and esophageal adenocarcinoma are the two distinct histological types. There has been significant progress in endoscopic diagnosis and treatment of early stages of cancer using resection and ablation techniques, as shown in several trials in the recent past. Earlier detection of esophageal cancer and advances in treatment modalities have lead to improvement in the 5-year survival from 5% to about 20% in the past decade. Endoscopic eradication therapy is the preferred modality of treatment in cancer limited to mucosal layer of the esophagus as there is very low risk of lymph node metastasis, leading to high cure rates, low risk of recurrence and with few adverse effects. The most common adverse events seen are strictures, bleeding and rarely perforation which can be endoscopically managed. In patients with recurrent advanced disease or invasive tumor, esophagectomy with lymph node dissection remains the mainstay of treatment. There is debate on post-endoscopic surveillance with some studies suggesting closer follow up with upper endoscopy every 6 mo for the first 1-2 years and then annually for the 3 years while others recommending the appropriate action only if symptoms or other abnormalities develop. Overall, the field of endoscopic therapy is still evolving and focus should be placed on careful patient selection using a multidisciplinary approach. | Sonika Malik Gautam Sharma Madhusudhan R Sanaka Prashanthi N Thota | 2018 | World Journal of Gastroenterology2018，24，35： | 10 |
| 19 | 长期食用含糖和人工甜味剂的饮料与美国成年人死亡风险的关系显示文摘摄入含糖饮料(sugar-sweetened beverages,SSB)或含人工甜味剂饮料(artificially sweetened beverages,ASB)是否与死亡风险相关,这关乎公共卫生利益。研究者分析了卫生专业人员随访研究(1986-2014年)中男性37 716人和护士健康研究(1980-2014年)中女性80 647人(基线无慢性病)的SSB和ASB的消费与总死亡率和病因特异性死亡率之间的关系。应用Cox比例风险回归估计风险比和95%CI。结果显示,在随访3415564人年期间,研究者记录了36436例死亡,其中心血管病死亡7896例,癌症死亡12380例。 | 刘青(译) 叶鹏(摘、审校) Malik VS Li Y Pan A De Koning L Schernhammer E Willett WC Hu FB | 2019 | 中华高血压杂志2019，27，5： | 9 |
| 20 | 聚二甲基硅氧烷溶胶凝胶气相色谱毛细管柱与传统毛细管柱的柱容量比较显示文摘将十一烷和荧蒽分别注入溶胶 凝胶法涂渍的聚二甲基硅氧烷气相色谱毛细管柱和传统的聚二甲基硅氧烷毛细管柱并测量柱效率。在注射量增加到一定程度以后,柱效率迅速下降。能引起柱效率下降10%的注射量称之为柱容量。实验结果表明溶胶 凝胶聚二甲基硅氧烷柱的柱容量远高于传统聚二甲基硅氧烷柱的柱容量。对溶胶 凝胶聚二甲基硅氧烷柱有较高柱容量的原因进行了探讨。 | 王东新 MALIK Abdul | 2002 | 色谱2002，20，6： | 8 |
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