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| 1 | Adipose-derived mesenchymal stem cell transplantation promotes adult neurogenesis in the brains of Alzheimer's disease mice显示文摘In the present study,we transplanted adipose-derived mesenchymal stem cells into the hippocampi of APP/PS1 transgenic Alzheimer’s disease model mice.Immunofluorescence staining revealed that the number of newly generated(BrdU+)cells in the subgranular zone of the dentate gyrus in the hippocampus was significantly higher in Alzheimer’s disease mice after adipose-derived mesenchymal stem cell transplantation,and there was also a significant increase in the number of BrdU+/DCX+neuroblasts in these animals.Adipose-derived mesenchymal stem cell transplantation enhanced neurogenic activity in the subventricular zone as well.Furthermore,adipose-derived mesenchymal stem cell transplantation reduced oxidative stress and alleviated cognitive impairment in the mice.Based on these findings,we propose that adipose-derived mesenchymal stem cell transplantation enhances endogenous neurogenesis in both the subgranular and subventricular zones in APP/PS1 transgenic Alzheimer’s disease mice,thereby facilitating functional recovery. | Yufang Yan Tuo Ma Kai Gong Qiang Ao Xiufang Zhang Yao Gong | 2014 | Neural Regeneration Research2014，9，8： | 16 |
| 2 | Effects of HMG on revascularization and follicular survival in heterotopic autotransplants of mouse ovarian tissue显示文摘 | Yanrong Wang Qing Chang Jing Sun Ling Dang Wenzhi Ma Changchun Hei Xinsheng Shen Chengjun Zhao Yufang Cai Xiuying Pei Xiaoguang Zhang Yin Wang Xiaohua Jiang | 2012 | Reproductive BioMedicine Online2012，，6： | 4 |
| 3 | Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospective cohort study显示文摘The association between serum uric acid and the risk of incident diabetes in Chinese adults remains unknown.This study aimed to investigate this association in a community-dwelling population aged≥40 years in Shanghai,China.Oral glucose tole3rance test was conducted during baseline and follow-up visits.Relative risk regression was utilized to examine the associations between baseline gender-specific serum uric acid levels and incident diabetes risk.A total of 613(10.3%)incident diabetes cases were identified during the follow-up visit after 4.5 years.Fasting plasma glucose,postload glucose,and glycated hemoglobin A1c during the follow-up visit progressively increased across the sex-specific quartiles of serum uric acid(all Ps<0.05).The incidence rate of diabetes increased across the quartiles of serum uric acid(7.43%,8.77%,11.47%,and 13.43%).Multivariate adjusted regression analysis revealed that individuals in the highest quartile had 1.36-fold increased risk of diabetes compared with those in the lowest quartile of serum uric acid(odds ratio(95%confidence interval)=1.36(1.06−1.73)).Stratified analysis indicated that the association was only observed in women.Accordingly,serum uric acid was associated with the increased risk of incident diabetes among middle-aged and elderly Chinese women. | Di Cheng Chunyan Hu Rui Du Hongyan Qi Lin Lin Xueyan Wu Lina Ma Kui Peng Mian Li Min Xu Yu Xu Yufang Bi Weiqing Wang Yuhong Chen Jieli Lu | 2020 | Frontiers of Medicine2020，14，6： | 3 |
| 4 | Promoting effect of polyoxyethylene octylphenol ether on Cu/ZnO catalysts for low-temperature methanol synthesis显示文摘Cu/ZnO catalysts were prepared by the co-precipitation method with the addition of OP-10(polyoxyethylene octylphenol ether) and were chemically and structurally characterized by means of XRD,BET,H2-TPR,CO-TPD and N2O-titration.The effect of OP-10 addition on the activity of Cu/ZnO for the slurry phase methanol synthesis at 150 ℃ was evaluated.The results showed that Cu/ZnO prepared with addition of 8% OP-10(denoted as C8) exhibited the promoted activity for the methanol synthesis.The conversion of CO and the STY(space time yield) of methanol were 42.5% and 74.6% higher than those of Cu/ZnO prepared without addition of OP-10(denoted as C0),respectively.The precursor of C8 contained more aurichalcite and rosasite,and the concerted effect of Cu-Zn in C8 was found to be stronger than that in C0.Compared with C0,C8 showed smaller particle size,lower reduction temperature and larger BET and Cu surface areas. | Ling Liu Tiansheng Zhao Qingxiang Ma Yufang Shen | 2009 | Journal of Natural Gas Chemistry2009，18，3： | 3 |
| 5 | Late Quaternary Activity of the Huashan Piedmont Fault and Associated Hazards in the Southeastern Weihe Graben,Central China显示文摘The Weihe Graben is not only an important Cenozoic fault basin in China but also a significant active seismic zone. The Huashan piedmont fault is an important active fault on the southeast side of the Weihe Graben and has been highly active since the Cenozoic. The well–known Great Huaxian County Earthquake of 1556 occurred on the Huashan piedmont fault. This earthquake, which claimed the lives of approximately 830000 people, is one of the few large earthquakes known to have occurred on a high–angle normal fault. The Huashan piedmont fault is a typical active normal fault that can be used to study tectonic activity and the associated hazards. In this study, the types and characteristics of late Quaternary deformation along this fault are discussed from geological investigations, historical research and comprehensive analysis. On the basis of its characteristics and activity, the fault can be divided into three sections, namely eastern, central and western. The eastern and western sections display normal slip. Intense deformation has occurred along the two sections during the Quaternary; however, no deformation has occurred during the Holocene. The central section has experienced significant high–angle normal fault activity during the Quaternary, including the Holocene. Holocene alluvial fans and loess cut by the fault have been identified at the mouths of many stream valleys of the Huashan Mountains along the central section of the Huashan piedmont fault zone. Of the three sections of the Huashan piedmont fault, the central section is the most active and was very active during the late Quaternary. The rate of normal dip–slip was 1.67–2.71±0.11 mm/a in the Holocene and 0.61±0.15 mm/a during the Mid–Late Pleistocene. As is typical of normal faults, the late Quaternary activity of the Huashan piedmont fault has produced a set of disasters, which include frequent earthquakes, collapses, landslides, mudslides and ground fissures. Ground fissures mainly occur on the hanging–wall of the Huashan piedmont fault, with landslides, collapses and mudslides occurring on the footwall. | DU Jianjun LI Dunpeng WANG Yufang MA Yinsheng | 2017 | Acta Geologica Sinica(English Edition)2017，91，1： | 3 |
| 6 | Molecular identification of Echinococcus species from eastern and southern Qinghai, China, based on the mitochondrial cox1 gene显示文摘 | Junying Ma Hu Wang Gonghua Lin Philip S. Craig Akira Ito Zhenyuan Cai Tongzuo Zhang Xiumin Han Xiao Ma Jingxiao Zhang Yufang Liu Yanmei Zhao Yongshun Wang | 2012 | Parasitology Research2012，，1： | 2 |
| 7 | Overexpression of sigma-1 receptor inhibits ADAM10 and ADAM17 mediated shedding in vitro显示文摘The sigma-1 receptor is a molecular chaperone protein highly enriched in the brain.Recent studies linked it to many diseases,such as drug addition,Alzheimer’s disease,stroke,depression,and even cancer.Sigma-1 receptor is enriched in lipid rafts,which are membrane microdomains essential in signaling processes.One of those signaling processes is ADAM17-and ADAM10-dependent ectodomain shedding.By using an alkaline phosphatase tagged substrate reporter system,we have shown that ADAM10-dependent BTC shedding was very sensitive to both membrane lipid component change and sigma-1 receptor agonist DHEAS treatment while ADAM17-dependent HB-EGF shedding was not;and overexpression of sigma-1 receptor diminished ADAM17-and ADAM10-dependent shedding.Our results indicate that sigma-1 receptor plays an important role in modifying the function of transmembrane proteases. | Juan Li Bin Liu Xiaofei Gao Zhixing Ma Tianyi CaoSong Yan-ai Mei Yufang Zheng | 2012 | Protein & Cell2012，3，2： | 2 |
| 8 | Production of human lysozyme-transgenic cloned porcine embryos by somatic nuclear transfer显示文摘Due to their physiology and organ size, pigs have significant potential as human disease models and as organ transplantation donors. Genetic modification of pigs could provide benefits for both agriculture and human medicine. In this study, five fetal pig fibroblast cell lines from two species (Wuzhishan and Landrace pigs) were transfected using double-marked human lysozyme (HLY) plasmids (pBC1-HLY-GFP-NEO) by a liposome-mediated method. The ratio of green fluorescent protein (GFP)-expressing cells was >95% in sw7, sw8, slw3 and slw6 cell lines, but only 49.3% in slw9 cells. Cells from the four highly transgenic lines were used as nuclear donors to construct embryos, which were then cultured after fusion and activation by electric stimulation. The rate of cleavage was 76.7%, 48 h after activation. After 7 days, 18.5% of cleaved eggs had developed to the blastocyst stage and 93.3% of blastocysts were GFP-positive. These results indicate that transgenic fetal pig flbroblast cell lines could be obtained by a liposome-mediated method, though the transfection efficiency varied between cell lines. Reconstructed embryos derived from transgenic cells could successfully develop into blastocysts, most of which were GFP-positive. | Qiuyan Li Hengxi Wei Ying Guo Yan Li Rui Zhao Yufang Ma Zhengquan Yu Bo Tang Lei Zhang Yunping Dai Ning Li | 2009 | Progress in Natural Science:Materials International2009，19，6： | 2 |
| 9 | A Disintegrin and Metalloprotease 10 in neuronal maturation and gliogenesis during cortex development显示文摘The multiple-layer structure of the cerebral cortex is important for its functions. Such a structure is generated based on the proliferation and differentiation of neural stem/progenitor cells. Notch functions as a molecular switch for neural stem/progenitor cell fate during cortex development but the mechanism remains unclear. Biochemical and cellular studies showed that Notch receptor activation induces several proteases to release the Notch intracellular domain (NICD). A Disintegrin and Metalloprotease 10 (ADAM10) might be a physiological rate-limiting S2 enzyme for Notch activation. Nestin-driven conditional ADAM10 knockout in mouse cortex showed that ADAM10 is critical for maintenance of the neural stem cell population during early embryonic cortex development. However, the expression pattern and function of ADAM10 during later cerebral cortex development remains poorly understood. We performed in situ hybridization for ADAM10 mRNA and immunofluorescent analysis to determine the expression of ADAM10 and NICD in mouse cortex from embryonic day 9 (E14.5) to postnatal day 1 (P1). ADAM10 and NICD were highly co-localized in the cortex of E16.5 to P1 mice. Comparisons of expression patterns of ADAM10 with Nestin (neural stem cell marker), Tuj1 (mature neuron marker), and S100β (glia marker) showed that ADAM10 expression highly matched that of S100β and partially matched that of Tuj1 at later embryonic to early postnatal cortex developmental stages. Such expression patterns indicated that ADAM10-Notch signaling might have a critical function in neuronal maturation and gliogenesis during cortex development. | Zhixing Ma Qingyu Li Zhengyu Zhang Yufang Zheng | 2013 | Neural Regeneration Research2013，8，1： | 1 |
| 10 | Manganese-Doped Calcium Silicate Nanowire Composite Hydrogels for Melanoma Treatment and Wound Healing显示文摘Melanoma is a serious malignant skin tumor.Effectively eliminating melanoma and healing after-surgical wounds are always challenges in clinical studies.To address these problems,we propose manganese-doped calcium silicate nanowire-incorporated alginate hydrogels(named MCSA hydrogels)for in situ photothermal ablation of melanoma followed by the wound healing process.The proposed MCSA hydrogel had controllable gelation properties,reasonable strength,and excellent bioactivity due to the incorporated calcium silicate nanowires as the in situ cross-linking agents and bioactive components.The doping of manganese into calcium silicate nanowires gave them excellent photothermal effects for eradicating melanoma effectively under near infrared(NIR)irradiation.Moreover,the synergistic effect of manganese and silicon in the MCSA hydrogel effectively promotes migration and proliferation of vascular endothelial cells and promotes angiogenesis.Hence,such bifunctional bioactive hydrogels could achieve combined functions of photothermal therapy and wound healing,showing great promise for melanoma therapy and tissue regeneration. | Zhongcao Wu Hui Zhuang Bing Ma Yin Xiao Bahattin Koc Yufang Zhu Chengtie Wu | 2021 | Research2021，，1： | 1 |
| 11 | Effect of leptin on oocyte maturation and subsequent pregnancy rate of cloned embryos reconstructed by somatic cell nuclear transfer in pigs显示文摘由原子转移(SCNT ) 有的体的房间克隆猪在基本研究,人的药和农业生产的宽应用。到改善克隆效率,二基本成熟媒介的效果, NCSU-23 和 TCM199,被比较,并且 TCM199 为有 leptin 的下列实验被选择。我们系统地在 vitro 成熟(IVM ) 在卵母细胞上学习了 leptin 补充的效果,在激活的单性生殖的联盟者(PA ) 和 SCNT 胚胎的 vitro 开发并且在在胚胎转移(et ) 以后的 SCNT 胚胎的 vivo 开发。结果证明进成熟媒介的 100 或 200 ng/ml leptin 的补充极大地没影响 PA 和 SCNT 的卵母细胞,或劈开率的原子成熟(P >
0.05 ) 。当 100 或 200 ng/ml leptin 在 PA 胚囊被加到房间的成熟媒介,和数字时, PA 和 SCNT 胚胎的胚囊率显著地被改进也被改进(P <
0.05 ) 。在 SCNT 的胚囊的房间的数字被改进,当 100 ng/ml leptin 被增加时(P <
0.05 ) 。而且,到 IVM 媒介的 100 或 200 ng/ml leptin 的补充可以在猪克隆改进怀孕率和交货率。 | Hengxi Wei Qiuyan Li Jun Li Yan Li Yunping Dai Yufang Ma Kai Xue Ning Li | 2008 | Progress in Natural Science:Materials International2008，18，12： | 1 |
| 12 | Manganese silicate nanospheres-incorporated hydrogels:starvation therapy and tissue regeneration显示文摘To prevent postoperative skin tumor recurrence and repair skin wound,a glucose oxidase(GOx)-loaded manganese silicate hollow nanospheres(MS HNSs)-incorporated alginate hydrogel(G/MS-SA)was constructed for starvation-photothermal therapy and skin tissue regeneration.The MS HNSs showed a photothermal conversion efficiency of 38.5%,and endowed composite hydrogels with satisfactory photothermal effect.Taking advantage of the catalytic activity of Mn ions,the composite hydrogels could decompose hydrogen peroxide(H2O2)into oxygen(O2),which can alleviate the problem of tumor hypoxia microenvironment and endow GOx with an ability to consume glucose in the presence of O2 for tumor starvation.Meanwhile,hyperthermia triggered by near infrared(NIR)irradiation could not only accelerate the reaction rate of H2O2 decomposition by MS HNSs and glucose consumption by GOx,but also ablate tumor cells.The anti-tumor results showed that synergistic effect of starvation-photothermal therapy led to the highest death rate of tumor cells among all groups,and its anti-tumor effect was obviously improved as compared with that of single photothermal treatment or starvation treatment.Interestingly,the introduction of MS HNSs into hydrogels could distinctly promote the epithelialization of the wound beds by releasing Mn ions as compared with the hydrogels without MS HNSs.It is expected that such a multifunctional platform with starvation-photothermal therapy will be promising for treating tumor-caused skin defects in combination of its regeneration bioactivity in the future. | Hongshi Ma Qingqing Yu Yu Qu Yufang Zhu Chengtie Wu | 2021 | Bioactive Materials2021，6，12： | 1 |
| 13 | Overexpression of sigma-1 receptor inhibits ADAM10 and ADAM17 mediated shedding in vitro显示文摘Erratum to:Protein Cell 2012,3(2):153-159 DOI 10.1007/s13238-012-2006-9 Two mistakes in Fig.3A and 4A,respectively,were made due to typesetting errors.Figure 3A,on the left column of page 156,should be cor-rected as follows.Figure 4A,on the left column of page 157,should be cor-rected as follows. | Juan Li Bin Liu Xiaofei Gao Zhixing Ma Tianyi CaoSong Yan-ai Mei Yufang Zheng | 2012 | Protein & Cell2012，3，5： | 0 |
| 14 | A network pharmacology- and transcriptomics-based investigation reveals an inhibitory role of β-sitosterol in glioma via the EGFR/MAPK signaling pathway显示文摘Glioma is characterized by rapid cell proliferation,aggressive invasion,altered apoptosis and a poor prognosis.β-Sitosterol,a kind of phytosterol,has been shown to possess anticancer activities.Our current study aims to in-vestigate the effects ofβ-sitosterol on gliomas and reveal the underlying mechanisms.Our results show thatβ-sitosterol effectively inhibits the growth of U87 cells by inhibiting proliferation and inducing G2/M phase arrest and apoptosis.In addition,β-sitosterol inhibits migration by downregulating markers of epithelial-mesenchymal tran-sition(EMT).Mechanistically,network pharmacology and transcriptomics approaches illustrate that the EGFR/MAPK signaling pathway may be responsible for the inhibitory effect ofβ-sitosterol on glioma.Afterward,the results show thatβ-sitosterol effectively suppresses the EGFR/MAPK signaling pathway.Moreover,β-sitosterol significantly inhibits tumor growth in a U87 xenograft nude mouse model.β-Sitosterol inhibits U87 cell proliferation and migration and induces apoptosis and cell cycle arrest in U87 cells by blocking the EGFR/MAPK signaling pathway.These results suggest thatβ-sitosterol may be a promising therapeutic agent for the treatment of glioma. | Yufang Xie Zhijian Chen Shuang Li Meijuan Yan Wenjun He Li Li Junqiang Si Yan Wang Xinzhi Li Ketao Ma | 2024 | Acta Biochimica et Biophysica Sinica2024，56，2： | 0 |
| 15 | Seasonal influence on the development of parthenotes and cloned embryos in pigs显示文摘Seasonal influence on the developmental ability of porcine embryos was studied by comparisons of the number of cumulus-oocytes-complexes (COCs) per ovary pair and meiotic maturation ability of oocytes in different seasons; and by the observations on developmental competence of the parthenogenetic oocytes and cloned embryos collected from different seasons. We found that the number of COCs per ovary pairs was significantly higher in spring compared to the other seasons (P<0.05). However, no significant difference was found in the rate of oocytes progressing to MⅡ in four seasons (P<0.05). In addition, the rate of blastocyst formation of parthenogenetic embryos in summer was obviously declined compared to the other seasons (P<0.05), and an increased blastocyst rate of cloned porcine embryos was found in spring compared to autumn and winter (P<0.05). The results suggest that there should be a seasonal influence on the developmental competence of porcine embryos. | Zhang Kun Zhang Yunhai Pan Dengke Ma Yufang Wei Hengxi Zhang Jian Li Xuyang Wang Shaohua Li Yan Dai Yunping Li Ning | 2007 | Progress in Natural Science:Materials International2007，17，10： | 0 |
| 16 | Multi-objective robust design optimization of a novel negative Poisson's ratio bumper system显示文摘Negative Poisson's ratio(NPR) structure has outstanding performances in lightweight and energy absorption, and it can be widely applied in automotive industries. By combining the front anti-collision beam, crash box and NPR structure, a novel NPR bumper system for improving the crashworthiness is first proposed in the work. The performances of the NPR bumper system are detailed studied by comparing to traditional bumper system and aluminum foam filled bumper system. To achieve the rapid design while considering perturbation induced by parameter uncertainties, a multi-objective robust design optimization method of the NPR bumper system is also proposed. The parametric model of the bumper system is constructed by combining the full parametric model of the traditional bumper system and the parametric model of the NPR structure. Optimal Latin hypercube sampling technique and dual response surface method are combined to construct the surrogate models. The multi-objective robust optimization results of the NPR bumper system are then obtained by applying the multi-objective particle swarm optimization algorithm and six sigma criteria. The results yielded from the optimizations indicate that the energy absorption capacity is improved significantly by the NPR bumper system and its performances are further optimized efficiently by the multi-objective robust design optimization method. | ZHOU Guan ZHAO WanZhong MA ZhengDong WANG ChunYan LI YuFang | 2017 | Science China(Technological Sciences)2017，60，7： | 0 |
| 17 | Potential Secretory Transporters and Biosynthetic Precursors of Biological Nitrification Inhibitor 1,9-Decanediol in Rice as Revealed by Transcriptome and Metabolome Analyses显示文摘Biological nitrification inhibitors(BNIs)are released from plant roots and inhibit the nitrification activity of microorganisms in soils,reducing NO_(3)^(‒)leaching and N2O emissions,and increasing nitrogenuse efficiency(NUE).Several recent studies have focused on the identification of new BNIs,yet little is known about the genetic loci that govern their biosynthesis and secretion.We applied a combined transcriptomic and metabolomic analysis to investigate possible biosynthetic pathways and transporters involved in the biosynthesis and release of BNI 1,9-decanediol(1,9-D),which was previously identified in rice root exudates.Our results linked four fatty acids,icosapentaenoic acid,linoleate,norlinolenic acid,and polyhydroxy-α,ω-divarboxylic acid,with 1,9-D biosynthesis and three transporter families,namely the ATP-binding cassette protein family,the multidrug and toxic compound extrusion family,and the major facilitator superfamily,with 1,9-D release from roots into the soil medium.Our finding provided candidates for further work on the genes implicated in the biosynthesis and secretion of 1,9-D and pinpoint genetic loci for crop breeding to improve NUE by enhancing 1,9-D secretion,with the potential to reduce NO_(3)^(‒)leaching and N2O emissions from agricultural soils. | DI Dongwei MA Mingkun ZHANG Xiaoyang LU Yufang Herbert J.KRONZUCKER SHI Weiming | 2024 | Rice science2024，31，1： | 0 |
| 18 | Saponins Content in Fibrous Roots of Pseudostellaria heterophylla and Optimization of the SEP Extraction Technology显示文摘[Objectives]To explore the saponins resources in fibrous roots of Pseudostellaria heterophylla and optimize the SEP technology for extracting saponins.[Methods]Saponins contents in fibrous roots and root tubers of P.heterophylla were compared;with the fibrous roots as host materials,this experiment applied Box-Behnken design to analyze the influence of steam pressure,maintenance pressure time,moisture content of host materials on the content of saponins extracts.[Results]Saponins content was higher in fibrous roots than in tuberous roots of P.heterophylla;the response surface optimization showed that SEP(steam explosion pretreatment)promoted the contents of saponins and extracts in fibrous roots,and the optimal extracting conditions were stream pressure 1.50 Mpa,maintenance pressure time 54 s,and moisture content of host materials 30%.Under this extracting conditions,the verification value of saponins content experiment was 0.441%,36.53%higher than the untreated control group.[Conclusions]This research offered a new method of exploring saponins resources from fibrous roots of P.heterophylla,and provided a reference for developing new medicinal parts of P.heterophylla. | Yanda ZHANG Huiqing PAN Yufang MA Xiaotan YUAN Hegui LIN Qi ZHAO | 2020 | Medicinal Plant2020，11，4： | 0 |
| 19 | A review of gas-phase chemical mechanisms commonly used in atmospheric chemistry modelling显示文摘The atmospheric chemical mechanism is an essential component of airshed models used for investigating the chemical behaviors and impacts of species.Since the first tropospheric chemical mechanism was proposed in the 1960s,various mechanisms including Master Chemical Mechanism(MCM),Carbon Bond Mechanism(CBM),Statewide Air Pollution Research Center(SAPRC)and Regional Atmospheric Chemistry Mechanism(RACM)have been developed for different research purposes.This work summarizes the development and applications of these mechanisms,introduces their compositions and lumping methods,and compares the ways the mechanisms treat radicals with box model simulations.CBM can reproduce urban pollution events with relatively low cost compared to SAPRC and RACM,whereas the chemical behaviors of radicals and the photochemical production of ozone are described in detail in RACM.The photolysis rates of some oxygenated compounds are low in SAPRC07,which may result in underestimation of radical levels.As an explicit chemical mechanism,MCM describes the chemical processes of primary pollutants and their oxidation products in detail.MCM can be used to investigate certain chemical processes;however,due to its large size,it is rarely used in regional model simulations.A box model case study showed that the chemical behavior of OH and HO_(2)radicals and the production of ozone were well described by all mechanisms.CBM and SAPRC underestimated the radical levels for different chemical treatments,leading to low ozone production values in both cases.MCM and RACM are widely used in box model studies,while CBM and SAPRC are often selected in regional simulations. | Yanhui Liu Jiayin Li Yufang Ma Ming Zhou Zhaofeng Tan Limin Zeng Keding Lu Yuanhang Zhang | 2023 | Journal of Environmental Sciences2023，，1： | 0 |
| 20 | Increasing Fusarium verticillioides resistance in maize by genomicsassisted breeding:Methods,progress,and prospects显示文摘Maize(Zea mays L.)is an indispensable crop worldwide for food,feed,and bioenergy production.Fusarium verticillioides(F.verticillioides)is a widely distributed phytopathogen and incites multiple destructive diseases in maize:seedling blight,stalk rot,ear rot,and seed rot.As a soil-,seed-,and airborne pathogen,F.verticillioides can survive in soil or plant residue and systemically infect maize via roots,contaminated seed,silks,or external wounds,posing a severe threat to maize production and quality.Infection triggers complex immune responses:induction of defense-response genes,changes in reactive oxygen species,plant hormone levels and oxylipins,and alterations in secondary metabolites such as flavonoids,phenylpropanoids,phenolic compounds,and benzoxazinoid defense compounds.Breeding resistant maize cultivars is the preferred approach to reducing F.verticillioides infection and mycotoxin contamination.Reliable phenotyping systems are prerequisites for elucidating the genetic structure and molecular mechanism of maize resistance to F.verticillioides.Although many F.verticillioides resistance genes have been identified by genome-wide association study,linkage analysis,bulkedsegregant analysis,and various omics technologies,few have been functionally validated and applied in molecular breeding.This review summarizes research progress on the infection cycle of F.verticillioides in maize,phenotyping evaluation systems for F.verticillioides resistance,quantitative trait loci and genes associated with F.verticillioides resistance,and molecular mechanisms underlying maize defense against F.verticillioides,and discusses potential avenues for molecular design breeding to improve maize resistance to F.verticillioides. | Yufang Xu Zhirui Zhang Ping Lu Ruiqi Li Peipei Ma Jianyu Wu Tao Li Huiyong Zhang | 2023 | The Crop Journal2023，11，6： | 0 |
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