|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 2 | Supercritical fluid extraction and high -performance liquid chromatography -fluorescence detection method for pelycyclic aromatic hydrocarbons investigation in vegetable oil显示文摘 | Lage Yusty M A Cortizo Davina J L | 2005 | Food Control2005，16，： | 1 |
| 3 | Bethesda criteria for microsatellite instability testing: impact on the detection of new cases of Lynch syn- drome显示文摘 | Serrano M Lage P Belga S | 2012 | Faro Cancer2012，1，4： | 1 |
| 4 | Comparison of Different Measures for Hand-arm Vibration Exposure显示文摘 | Lage Burstrǒm Ronnie Lundstrǒm Mats Hagberg | 1998 | Safety Science1998，28，1： | 1 |
| 5 | Multiple mechanisms confer different drug-resistant phenotypes in pancreatic carcinoma cells显示文摘 | Lage H Dietel M | 2002 | J Cancer Res Clin Oncol2002，128，7： | 1 |
| 6 | Fractionation of eucalyptus wood in acetic acid media显示文摘 | VASQUEZ D LAGE M A PARAJ0 J C | 1992 | Bioresource Technology1992，40，2： | 1 |
| 7 | (2000)Inverting the classroom: A gateway to creating an inelusive learning enviromnent显示文摘 | Lage MJ & Platt GJ & Tregiia M | 2000 | The Journal af Eeconomic Education2000，31，1： | 1 |
| 8 | Multiple mechanisms confer different drug-resistant phenotypes in pancreatic carcinoma cells显示文摘 | Lage H Dietel M | 2002 | J Cancer Res Clin Oncol2002，128，7： | 1 |
| 9 | Treatment of gastric MALT lymphoma by helicobacter pylori eradication: a study controlled by endoscopic ultrasonography显示文摘 | Lage P Cravo M | 1998 | Am J Gastroenterol1998，93，5： | 1 |
| 10 | Cloning and characterization of human cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5显示文摘 | Lage H Dietel M | 1997 | Gene1997，188，2： | 1 |
| 11 | Modulation of DNA topoisomerase Ⅰ activity and expression in melanoma cell with acquired drug resistance显示文摘 | Lage H Helmbach H Dietel M | 2000 | Br J Cancer2000，82，2： | 1 |
| 12 | MicroRNA and target protein pat- terns reveal physiopathological features of glioma subtypes 显示文摘 | Lages E Guttin A E1 Atifi M | 2011 | PLoS One2011，6，20： | 1 |
| 13 | Membrane vesicle formation due to acquired mitoxantrone resistance in human gastric carcinoma cell line EPG85-257显示文摘 | Dietel M Arps H Lage H | 1990 | Cancer Res1990，50，18： | 1 |
| 14 | Genetic analysis of gestational trophoblastic disease 显示文摘 | Wolf N G Lage J M | 1995 | Semin Oncol1995，22，： | 1 |
| 15 | Cloning and characterization of human cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5显示文摘 | Dietel M | 1997 | Gene1997，188，： | 1 |
| 16 | Inverting the classroom:a gateway to creat ing an inclusive learning environment显示文摘 | Lage MJ Treglia M | 2000 | Journal of Economi Education2000，31，1： | 1 |
| 17 | Supercritical fluid extraction of polycyclic aromatic hydrocarbons from liver samples and deter mination by HPLC-FL显示文摘 | González Amigo S García Falcón M S Lage Yusty M A Simal Lozano1 J | 2000 | Freseniu''s Journal of Analytical Chemistry2000，367，6： | 1 |
| 18 | Modulation of DNA topoisomeraseⅡactivity and expression in melannoma cell with acquired drug resistance显示文摘 | Lage HH Dietel M | 2000 | Br J Cancer2000，82，2： | 1 |
| 19 | Contextual Factors and the Creativity of Frontline Employees:The Mediating Effects of Role Stress and Intrin- sic Motivation显示文摘 | Coelho F Augusto M Lages L F | 2011 | Journal of Retailing2011，87，1： | 1 |
| 20 | Effect of the breast-cancer resistance protein on atypical multidrug resistance显示文摘 | Lage H Dietel M | 2000 | Lancet Oncol2000，1，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员