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| 1 | NG2 Cell Response in the CNP-EGFP Mouse After Contusive Spinal Cord Injury显示文摘成年动物中枢神经系统中的NG2细胞具有异质性。脊髓损伤(SCI)后,具有少突胶质前体细胞(OPCs)功能的NG2细胞亚型如何产生反应性变化及对其正常的发育过程有何影响目前还不清楚。本文采用少突胶质细胞系细胞表达EGFP的CNP-EGFP小鼠,研究正常和SCI后的NG2细胞的特征。在正常小鼠的白质中,对EGFP+NG2+双极细胞和EGFPnegNG2+多极细胞进行鉴别。SCI后,白质损伤边缘区中的EGFP+NG2+细胞3 d增殖达高峰,损伤中心区的EGFPnegNG2+细胞增殖在损伤后7 d达高峰。损伤后EGFP+NG2+细胞的Olig2、Sox10、Sox17等转录因子、基本的膜电生理参数以及钾电流表型均与发育过程增殖的OPCs一致。EGFPnegNG2+细胞不表达少突胶质发生中的转录因子。EGFP+CC1+少突胶质细胞6周时包含在EGFP+NG2+细胞增殖峰时表达BrdU的细胞。EGFPnegCC1+少突胶质细胞未被观察到。神经胶质生长因子2和成纤维细胞生长因子2处理促进少突胶质发生,提高EGFPnegNG2+细胞数量。因此,通过EGFP和转录因子表达,时空增殖类型及对生长因子的反应,两种类型的NG2+细胞对SCI刺激发生反应。SCI后EGFP+NG2+细胞经受细胞和生理变化特征,与在早期出生后的少突胶质发生过程中NG2+细胞中的变化类似。 | JUDITH M LYTLE RAMESH CHITTAJALLU JEAN R WRATHALL VITTORIO GALLO | 2009 | 神经损伤与功能重建2009，4，1： | 7 |
| 2 | TargetmRNAs are repressed as efficiently by microRNA-binding sites in the 5'UTR as in the 3-UTR显示文摘 | LYTLE J R YARIO T A STEITZ J A | 2007 | ProcNat Acad Sci2007，104，： | 1 |
| 3 | Service orientation in transitional markets:does it matter?显示文摘 | LYNN M L LYTLE R S BOBEK S | 2000 | European Journal of Marketing2000，34，3： | 1 |
| 4 | Submerged-melt welding with multiple electrodes in series显示文摘 | LYTLE A R FROST E L | 1951 | Welding Journal1951，30，2： | 1 |
| 5 | SERV*OR:A managerial measure of organizational service orientation 显示文摘 | Lytle R S Hom P W Mokwa M P | 1998 | J ournal of Retailing1998，74，4： | 1 |
| 6 | Target mRNAs are re- pressed as efficiently by microRNA-binding sites in the 5' UTR as in the 3'-UTR显示文摘 | LYTLE J R YARIO T A STEITZ J A | 2007 | Proc Natl Acad Sci USA2007，104，23： | 1 |
| 7 | Exercise level and cognitive de- cline:The MOVIES project 显示文摘 | Lytle M Vander Bilt J Pandav R | 2004 | Alzheimer Dis Assoc Disord2004，18，2： | 1 |
| 8 | Adap- ting a Teleoperated Device for Autonomous Control Using Three-dimensional Positioning Sensors: Ex- periences with the Nist RoboCrane显示文摘 | Lytle A M Saidi K S Bostelman R V | 2004 | Automation in Construction2004，13，1： | 1 |
| 9 | Characterization of Cu/Al2O3 catalysts显示文摘 | Friedman R M Freeman J J Lytle F W | 1978 | J Cata1978，55，1： | 1 |
| 10 | Target Mrnas Are Repressed as Efficiently by Mierorna-Binding Sites in the 5'Utr as in the 3'Utr显示文摘 | LYTLE J R YARIO T A STEITZ J A | 2007 | Proceedings of the National Academy of Sciences of the United States of America2007，104，23： | 1 |
| 11 | Iterative ray tracing between boreholes for underground image reconstruction 显示文摘 | LYTLE R J DINES K A | 1980 | IEEE Trans Geosci Remote Sensing1980，18，： | 1 |
| 12 | Target mR- NAs are repressed as efficiently by microRNA-binding sites in the 5' UTR as in the 3' UTR显示文摘 | LYTLE J R YARIO T A STEITZ J A | 2007 | Proc Natl Acad Sci U S A2007，104，： | 1 |
| 13 | BCNU downregulates anti-apoptotic proteins bcl-xL and bcl-2 in association with cell death in oligodendroglioma-derived cells显示文摘 | JIANG Z ZHENG X | 2004 | J Neuroonconl2004，68，3： | 1 |
| 14 | Durability of mitral valve repair for degenerative disease 显示文摘 | Gillinov A M Cosgrove D M Blaekstone E H Diaz R Arnold JH Lytle BW | 1998 | J Thorae Cardiovasc Surg1998，116，： | 1 |
| 15 | Characterization of Cu/Al2O3 catalysts显示文摘 | FRIEDMAN R M FREEMAN J J LYTLE F W | 1978 | J Catal1978，55，1： | 1 |
| 16 | Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5 ' UTR as in the 3 ' UTR显示文摘 | Lytle J R Yario T A Steitz J A | 2007 | Proe Natl Acad Sei U S A2007，104，23： | 1 |
| 17 | Simulating the cumu- lative effects of multiple forest management strategies on land- scape measures of forest sustainability显示文摘 | Gustafson E J Lytle D E Swaty R | 2007 | Landscape Ecology2007，22，： | 1 |
| 18 | Three-year ma- intenance of improved diet and physical activity: The catch co- hort显示文摘 | NADER P R STONE E J LYTLE L A etal | 1999 | Archly Pediatr Adolescent Med1999，153，7： | 1 |
| 19 | The body image and relationships scale: development and valida tion of a measure of body image in female breast cancer survivors显示文摘 | Hormes J M Lytle L A Gross C R | 2008 | J Clin Oncol2008，26，12： | 1 |
| 20 | Computerized geophysical tomography 显示文摘 | DINES K A LYTLE R J | 1979 | Proc IEEE1979，67，2： | 1 |
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