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| 1 | Duodenal gangliocytic paraganglioma with lymph node metastases: a case report and comparative review of 31 cases显示文摘Gangliocytic paraganglioma(GP) is a rare tumor of uncertain origin most often located in the second portion of the duodenum. It is composed of three cellular components: Epithelioid endocrine cells, spindlelike/sustentacular cells, and ganglion-like cells. While this tumor most often behaves in a benign manner, cases with metastasis are reported. We describe the case of a 62-year-old male with a periampullary GP with metastases to two regional lymph nodes who was successfully treated with pancreaticoduodenectomy. Using Pub Med, EMBASE, EBSCOhost MEDLINE and CINAHL, and Google Scholar, we searched the literature for cases of GP with regional lymph node metastasis and evaluated the varying presentations, diagnostic workup, and disease management of identified cases. Thirty-one cases of GP with metastasis were compiled(30 with at least lymph node metastases and one with only distant metastasis to bone), with age at diagnosis ranging from 16 to 74 years. Ratio of males to females was 19:12. The most common presenting symptoms were abdominal pain(55%) and gastrointestinal bleeding or sequelae(42%). Twenty-five patients underwent pancreaticoduodenectomy. Five patients were treated with local resection alone. One patient died secondary to metastatic disease, and one died secondary to perioperative decompensation. The remainder did well, with no evidence of disease at follow-up from the most recent procedure(except two in which residual disease was deliberately left behind). Of the 26 cases with sufficient histological description, 16 described a primary tumor that infiltrated deep to the submucosa, and 3 described lymphovascular invasion. Of the specific immunohistochemistry staining patterns studied, synaptophysin(SYN) stained all epithelioid endocrine cells(18/18). Neuron specific enolase(NSE) and SYN stained most ganglion-like cells(7/8 and 13/18 respectively), and S-100 stained all spindle-like/sustentacular cells(21/21). Our literature review of published cases of GP with lymph node metastasis underscores the excellent prognosis of GP regardless of specific treatment modality. We question the necessity of aggressive surgical intervention in select patients, and argue that local resection of the mass and metastasis may be adequate. We also emphasize the importance of pre-surgical assessment with imaging studies, as well as post-surgical follow-up surveillance for disease recurrence. | Sahara J Cathcart Aaron R Sasson Jessica A Kozel Jennifer M Oliveto Quan P Ly | 2017 | World Journal of Clinical Cases2017，5，6： | 9 |
| 2 | 巨峰和无核早红葡萄在越南谅山试种观察显示文摘[目的]观察巨峰、无核早红葡萄在越南谅山省的引种表现,为其在越南推广种植提供参考依据.[方法]2009年春从中国南宁引入巨峰、无核早红两个鲜食葡萄品种在越南谅山省试种,调查其枝蔓生长量、物候期、果实性状、产量等相关指标.[结果]至第1年抚育冬季,巨峰葡萄枝蔓总长234.5 cm,上架茎粗0.84 cm;无核早红葡萄枝蔓总长294.1 cm,上架茎粗0.86 cm.在物候期方面,巨峰葡萄从萌芽至果实成熟需141~151 d,表现中熟;无核早红从萌芽至果实成熟需142~151 d,未表现其应有的早熟特性.在果实性状方面,巨峰葡萄2010~2012年3年平均单果重8.9 g,种子数1.04粒,可溶性固形物(TSS)含量17.5%;无核早红葡萄2010~2012年3年平均单果重6.8 g,TSS含量13.9%.在产量方面,巨峰葡萄2010~2012年产量分别为13.69、17.50和16.24 t/ha;无核早红葡萄2010~2012年产量分别为10.81、16.02和20.92t/ha.[结论]巨峰葡萄在越南谅山省种植表现丰产稳产优质,具有较好的适栽性,可大面积推广种植;无核早红葡萄表现丰产稳产,但表现低糖低酸,极易裂果,着色困难,不宜在越南大面积发展. | 黄江流 PHAM Thi Thang 罗瑞鸿 NGUYN Thi Hà 吕荣华 LUONG Dǎng Ning CHU Vǎn DUòng NGUYN Manh Tòng 彭宏祥 Ly Ming Nguyet LU'O'NG i Thuy CHU Xun Tien VI Vǎn Dúc NGUYN Duy Dng Ly Dúc Khiêm 熊俏 | 2014 | 南方农业学报2014，45，7： | 5 |
| 3 | New serological markers in pediatric patients with inflammatory bowel disease显示文摘The spectrum of serological markers associated with inflammatory bowel disease(IBD)is rapidly growing.Due to frequently delayed or missed diagnoses,the application of non-invasive diagnostic tests for IBD,as well as differentiation between ulcerative colitis(UC)and Crohn’s disease(CD),would be useful in the pediatric population.In addition,the combination of pancreatic autoantibodies and antibodies against Saccharomyces cerevisiae antibodies/perinuclear cytoplasmic antibody(pANCA)improved the sensitivity of serological markers in pediatric patients with CD and UC.Some studies suggested that age-associated differences in the patterns of antibodies may be present,particularly in the youngest children.In CD,most patients develop stricturing or perforating complications,and a significant numberof patients undergo surgery during the disease course.Based on recent knowledge,serum antibodies are qualitatively and quantitatively associated with complicated CD behavior and CD-related surgery.Pediatric UC is characterized by extensive colitis and a high rate of colectomy.In patients with UC,high levels of antiCBir1 and pANCA are associated with the development of pouchitis after ileal pouch-anal anastomosis.Thus,serologic markers for IBD can be applied to stratify IBD patients into more homogeneous subgroups with respect to disease progression.In conclusion,identification of patients at an increased risk of rapid disease progression is of great interest,as the application of early and more aggressive pharmaceutical intervention could have the potential to alter the natural history of IBD,and reduce complications and hospitalizations. | Márta Kovács Katalin Eszter Müller Mária Papp Péter László Lakatos Mihály Cs?ndes Gábor Veres | 2014 | World Journal of Gastroenterology2014，20，17： | 4 |
| 4 | Multiband emission from single β-NaYF_(4)(Yb,Er) nanoparticles at high excitation power densities and comparison to ensemble studies显示文摘Ensemble and single particle studies of the excitation power density (P)-dependent upconversion luminescence (UCL) of core and core-shell β-NaYF_(4):Yb,Er upconversion nanoparticles (UCNPs) doped with 20% Yb^(3+) and 1% or 3% Er^(^(3+)) performed over a P regime of 6 orders of magnitude reveal an increasing contribution of the emission from high energy Er^(3+) levels at P > 1 kW/cm^(2). This changes the overall emission color from initially green over yellow to white. While initially the green and with increasing P the red emission dominate in ensemble measurements at P < 1 kW/cm^(2), the increasing population of higher Er^(^(3+)) energy levels by multiphotonic processes at higher P in single particle studies results in a multitude of emission bands in the ultraviolet/visible/near infrared (UV/vis/NIR) accompanied by a decreased contribution of the red luminescence. Based upon a thorough analysis of the P-dependence of UCL, the emission bands activated at high P were grouped and assigned to 2–3, 3–4, and 4 photonic processes involving energy transfer (ET), excited-state absorption (ESA), cross-relaxation (CR), back energy transfer (BET), and non-radiative relaxation processes (nRP). This underlines the P-tunability of UCNP brightness and color and highlights the potential of P-dependent measurements for mechanistic studies required to manifest the population pathways of the different Er^(3+) levels. | Florian Frenzel Christian Würth Oleksii Dukhno Frédéric Przybilla Lisa MWiesholler Verena Muhr Thomas Hirsch Yves Mély Ute Resch-Genger | 2021 | Nano Research2021，14，11： | 3 |
| 5 | Modulation of long- term memory for object recognition via HDAC inhibition 显示文摘 | STEFANKO D P BARRETT R M LY A R | 2009 | Proc Nail Acad Sci U S A2009，106，23： | 1 |
| 6 | Isolation and structural elucidation of some glycosides from the rhizomes of smaller galangal (Alpinia officinarum Hance) 显示文摘 | LY T N YAMAUCHI R SHIMOYAMADA M | 2002 | Journal of Agricultural and Food Chemistry2002，50，17： | 1 |
| 7 | 查看详情显示文摘 | László P Juan F G R Péter F Attila G Mihály D László A Bienvenida G Antonio M | | 0，，03： | 1 |
| 8 | Association of warfarin dose with genes involved in its action and metab- olism显示文摘 | Wadelius M Chen LY Erikesson N | 2007 | Hum Genet2007，121，1： | 1 |
| 9 | The influence of preoperative MRI findings on lumbar fusion clinical outcomes显示文摘 | Djurasovic M Carreon LY Cmwford Ⅲ CH | 2012 | Eu- ropean spine journal: official publication of the European Spine Soci- ety the European Spinal Deformity Society and the European Sec- tion of the Cervical Spine Research Society2012，21，8： | 1 |
| 10 | Inflammatory pseudotumor of the bladder in chronic granulomatous disease显示文摘 | Kis E Verebély T Mészner Z | 2002 | Pediatr Nephrol2002，17，： | 1 |
| 11 | Aflatoxin exposure and risk of hepatocellular carcinoma in Taiwan显示文摘 | Wang LY Hatch M Chen CJ | 1996 | Int J Cancer1996，67，5： | 1 |
| 12 | HILIC-MS-MS for the quantification of pidotimod in human plasma 显示文摘 | Chen HS Shen M Chefi LY | 2011 | Chromatographia2011，73，78： | 1 |
| 13 | Inhibition by propofol (2,6 di-isopropylphenol) of the N-methyl-D-as- partate subtype of glutamate receptor in cultured hippo- campal neurones 显示文摘 | ORSER BA BERTLIK M WANG LY | 1995 | Br J Pharmacol1995，116，2： | 1 |
| 14 | Phosphoramidate derivatives of hydroxysteroids as inhibitors of prostate-specific membrane antigen 显示文摘 | Wu LY Do JC Kazak M | 2008 | Bioorg Med Chem Lett2008，18，1： | 1 |
| 15 | Frequencies of defective CYP2C19 alleles in a Hong Kong Chinese population 显示文摘 | Garcia- Barcelo M Chow LY Kum Chiu HF | 1999 | Clinical Chemistry1999，45，12： | 1 |
| 16 | Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors显示文摘 | LY K S LETAVIC M A KEITH J M | 2008 | Bioorg Med Chem Lett2008，18，1： | 1 |
| 17 | The largest prospective warfarin-treated cohort supports genetic forecasting显示文摘 | Wadelius M Chen LY Lindh JD | 2009 | Blood2009，113，4： | 1 |
| 18 | Effects of L-carnitine supplementation of diets differing in energy levels on performance,abdominal fat content,and yield and composition of edible meat of broilers显示文摘 | RABIE M H MIH(A)LY SZIL(A)GYI | 1998 | British Journal of Nutrition1998，80，： | 1 |
| 19 | Association of warfarin dose with genes involved in its action and metabolism显示文摘 | Wadelius M Chen LY Eriksson N | 2007 | Hum Gen- et2007，121，1： | 1 |
| 20 | Exemestane is superior to megestrol acetate after tamoxifen failure in postmenopausal women with advanced breast cancer:, resuits of a phase Ⅲ randomized double-blind trial 显示文摘 | Kaufmann M Bajetta E Dirix LY | 2000 | J Clin Oncol2000，18，7： | 1 |
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