|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Biomarkers for radiation-induced small bowel epithelial damage:An emerging role for plasma Citrulline显示文摘Reduction of cancer treatment-induced mucosal injury has been recognized as an important target for improving the therapeutic ratio as well as reducing the economic burden associated with these treatment related sequellae. Clinical studies addressing this issue are hampered by the fact that specif ic objective parameters, which enable monitoring of damage in routine clinical practice, are lacking. This review summarizes pros and cons of currently available endpoints for intestinal injury. The metabolic background and characteristics of plasma citrulline, a recently investigated biomarker specifically for small intestinal injury, are discussed in more detail. | Ludy Lutgens Philippe Lambin | 2007 | World Journal of Gastroenterology2007，13，22： | 7 |
| 2 | Dried-leaf Artemisia annua: A practical malaria therapeutic for developing countries?显示文摘Artemisinin from the plant Artemisia annua(A. annua) L., and used as artemisinin combination therapy(ACT), is the current best therapeutic for treating malaria, a disease that hits children and adults especially in developing countries. Traditionally, A. annua was used by the Chinese as a tea to treat 'fever'. More recently, investigators have shown that tea infusions and oral consumption of the dried leaves of the plant have prophylactic and therapeutic efficacy. The presence of a complex matrix of chemicals within the leaves seems to enhance both the bioavailability and efficacy of artemisinin. Although about 1000-fold less potent than artemisinin in their antiplasmodial activity, these plant chemicals are mainly small molecules that include other artemisinic compounds, terpenes(mainly mono and sesqui), flavonoids, and polyphenolic acids. In addition, polysaccharide constituents of A. annua may enhance bioavailability of artemisinin. Rodent pharmacokinetics showed longer T? and T max and greater C max and AUC in Plasmodium chabaudi-infected mice treated with A. annua dried leaves than in healthy mice. Pharmacokinetics of deoxyartemisinin, a liver metabolite of artemisinin, was more inhibited in infected than in healthy mice. In healthy mice, artemisinin serum levels were > 40-fold greater in dried leaf fed mice than those fed with pure artemisinin. Human trial data showed that when delivered as dried leaves, 40-fold less artemisinin was required to obtain a therapeutic response compared to pure artemisinin. ACTs are still unaffordable for many malaria patients, and cost estimates for A. annua dried leaf tablet production are orders of magnitude less than for ACT, despite improvements in the production capacity. Considering that for > 2000 years this plant was used in traditional Chinese medicine for treatment of fever with no apparent appearance of artemisinin drug resistance, the evidence argues for inclusion of affordable A. annua dried leaf tablets into the arsenal of drugs to combat malaria and other artemisinin-susceptible diseases. | Pamela J Weathers Melissa Towler Ahmed Hassanali Pierre Lutgen Patrick Ogwang Engeu | 2014 | World Journal of Pharmacology2014，3，4： | 2 |
| 3 | CD40-CD40L interactions in atherosclerosis 显示文摘 | Lutgens E Daemen MJ | 2002 | Trends Cardiovasc Med2002，12，： | 1 |
| 4 | Genetic loss of Gas 6 induces plaque stability in experimental atherosclerosis显示文摘 | Lutgens E Tjwa M de Frutos PG | 2008 | J Pathol2008，216，1： | 1 |
| 5 | Fibroblast growth factor 2 endocytosis in endothelial cells proceed via synclecan-4-dependent activation of Racl and a Cdc42-dependent macropinocytic pathway显示文摘 | Tkachenko E Lutgens E Stan R V | 2004 | J Cell Sci2004，117，： | 1 |
| 6 | Both arly and delayed anti -CD40L antibody treatment induces a stable plaque phenotype 显示文摘 | Lutgens E Cleutjens KB Heeneman S | 2000 | Proc Natl Acad Sci U S A2000，97，13： | 1 |
| 7 | CD40 -CD40L interactions in atherosclerosis 显示文摘 | Lutgens E Daemen MJ | 2002 | Trends Cardiovasc Med2002，12，1： | 1 |
| 8 | Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation显示文摘 | Lutgens E Lutgens SP Faber BC | 2006 | Circulation2006，113，1： | 1 |
| 9 | Genetic loss ofGas6 induces plaque stability in experimental atherosclerosis显示文摘 | Lutgens E Tjwa M Garcia de frutos P | 2008 | J Pathol2008，216，1： | 1 |
| 10 | Removal of PCBs from wastewater using fly ash显示文摘 | NOLLET H ROELS M LUTGEN P | 2003 | Chemosphere2003，53，6： | 1 |
| 11 | Requirement for CD154 in the progression of atherosclerosis显示文摘 | Lutgens E Gorelik L Daemen MJ | 1999 | Nat Med1999，5，： | 1 |
| 12 | Both early and delayed anti-CD40L antibody treatment induces a stable plaque phenotype显示文摘 | Lutgens E Cleutjens KB Heeneman S | 2000 | Proc Natl Acad Sci USA2000，97，： | 1 |
| 13 | Loss of matrix metallo- proteinase-9 or matrix metalloproteinase-12 protects Apolipopro- tein E-deficient mice against atherosclerotic media destruction but differentially affects plaque growth显示文摘 | Luttun A Lutgens E Manderveld A | 2004 | Circulation2004，109，11： | 1 |
| 14 | Combined use of hyperthermia and radiation therapy for treating locally ad- vanced cervical carcinoma 显示文摘 | Lutgens L van der Zee J Pijls-Johannesma M | 2010 | Cochrane Database Syst Rev2010，，1： | 1 |
| 15 | Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques显示文摘 | Dhore CR Cleuqells JP Lutgens E | 2001 | Arterioseler Thromb Vase Biol2001，21，12： | 1 |
| 16 | Deficient CD 40-TRAF6sig-naling in leukocytes prevents atherosclerosis by skewing the im-mune response toward an antiinflammatory profile显示文摘 | Lutgens E Lievens D Beckers L | 2010 | J Exp Med2010，207，2： | 1 |
| 17 | Transforming growth factorβ mediates balance between inflammation and fibrosis during plaque progression 显示文摘 | Esther Lutgens Marion Gijbels Marjan Smook | 2002 | Arterioscler Thromb Vasc Biol2002，22，： | 1 |
| 18 | Differential ex- pression of bone matrix regulatory proteins in human athero- sclerotic plaques 显示文摘 | Dhore C-R Cleutjens J-P Lutgens E etal | 2001 | Arterioscler-Thromb-Vasc-Biol2001，21，12： | 1 |
| 19 | Both early and delayed anti-CD 40 L antibody treatment induces a stable plaquephenotype显示文摘 | Lutgens E Cleutjens K B Heeneman S | 2000 | Proe Nat[ Acad Sei2000，9，13： | 1 |
| 20 | Age-specific differences in treatment and survival of patients with cervical cancer in the southeast of the Netherlands,1986-t996显示文摘 | de Rijke JM van der Putten HW Lutgens LC | 2002 | Eur J Cancer2002，38，15： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员